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Analysis of language comprehension and expression abilities in children with language barrier  Ma Liang, Shan Yanchun, Liu Xiaomei, Fu Peng, Ran Ni, Yi Mingji International Medicine and Health Guidance News    2022, 28 (14): 2028-2032.   DOI: 10.3760/cma.j.issn.1007-1245.2022.14.023 Abstract （1910）            Knowledge map    Save Objective To explore the language expression and language comprehension abilities in children with language barrier, and to provide important references for the diagnosis and differential diagnosis. Methods From May 2020 to March 2022, 60 children with expressive language barrier and 60 children with receptive language barrier who were diagnosed in Department of Child Health, Affiliated Hospital of Qingdao University were selected as the experimental group, and 70 children with global developmental delay who were treated in the outpatient clinic during the same period were selected as the disease control group, and 64 normal children who underwent the developmental screening of outpatient physical examination during the same period were selected as the normal control group. In the expressive language barrier group, there were 38 males and 22 females, aged (29.13±4.99) months; in the receptive language barrier group, there were 36 males and 24 females, aged (31.67±9.33) months; in the disease control group, there were 45 males and 25 females, aged (29.44±7.95) months; in the normal control group, there were 43 males and 21 females, aged (30.05±6.64) months. The language comprehension and expression abilities were evaluated by the Infant-Toddler Language Development Scale, and the neuropsychological development was assessed by the Neuropsychological Development Scale for Children 0-6 Year-Old. Statistical analysis was performed by one-way ANOVA, SNK-q test, and χ 2 test. Results In the expressive language barrier group, the expressive language age was (15.962±7.410) months, the comprehensible language age was (22.863±6.235) months, the expressive language score was (52.885±19.216) points, and the comprehensible language score was (78.205±17.100) points; those in the receptive language barrier group were (16.183±7.253) months, (18.770±7.652) months, (49.050±14.038) points, and (58.043±12.050) points; there were statistically significant differences compared with those in the normal control group [(35.939±11.127) months, (35.908±11.211) months, (117.804±22.277) points, and (117.857±22.498) points] and the disease control group [(11.461±5.360) months, (12.506±3.321) months, (37.640±10.732) points, and (44.353±14.106) points] (all P<0.05). There were statistically significant differences in the comprehensible language age and comprehensible language score between the expressive language barrier group and the receptive language barrier group (all P<0.05). In the expressive language barrier, the actual age difference of expressing, actual age difference of understanding, and actual age difference of understanding-then-expressing were (-13.172±4.225) months, (-6.270±4.337) months, and (-5.622±5.274) months, there were statistically significant differences compared with those in the normal control group [(5.877±6.820) months, (5.839±6.865) months, and (-0.188±1.053) months], the disease control group [(-17.231±5.534) months, (-16.866±7.317) months, and (-3.574±3.036) months], and the receptive language barrier group [(-15.483±4.318) months, (-12.897±4.048) months, and (-3.580±1.872) months] (all P<0.05). There were statistically significant differences in the above aspects between the normal control group and the receptive language barrier group (all P<0.05). There was a statistically significant difference in the actual age difference of understanding between the disease control group and the receptive language barrier group ( P<0.05). Conclusions The language comprehension and expression abilities in children with expressive language barrier and receptive language barrier are lagging behind those in the normal control group. The actual age difference of expressing, actual age difference of understanding, and actual age difference of understanding- then-expressing have important references for distinguishing the types of language barrier. Reference | Related Articles | Metrics

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Risk factors of intracranial hemorrhage in premature infants with gestational age less than 34 weeks Wang Hairu, Zhang Youxiang, Ou Qiaoqun, Luo Meijuan, Lin Zexuan International Medicine and Health Guidance News    2022, 28 (14): 2023-2027.   DOI: 10.3760/cma.j.issn.1007-1245.2022.14.022 Abstract （1789）            Knowledge map    Save Objective To analyze the risk factors of intracranial hemorrhage in premature infants with gestational age less than 34 weeks. Methods The clinical data of 187 premature infants with gestational age less than 34 weeks who were hospitalized in neonatal intensive care unit (NICU) of Guangzhou First People's Hospital from January 2016 to December 2021 were selected for analysis. Fifty-three premature infants with gestational age <34 weeks whose imaging findings indicated intracranial hemorrhage were selected as a intracranial hemorrhage group, and 134 premature infants with gestational age <34 weeks whose imaging findings did not indicate intracranial hemorrhage were selected as a control group. The clinical data of the two groups were collected for a retrospective study. Univariate analysis [independent sample t test, χ 2 test, and Fisher's exact probability method] and multivariate logistic regression analysis were used to analyze the risk factors for intracranial hemorrhage in premature infants. Results In the intracranial hemorrhage group, there were 26 males and 27 females, with a gestational age of (30.22±2.31) weeks; in the control group, there were 70 males and 64 females, with a gestational age of (32.04±1.49) weeks. Univariate analysis showed that there were no statistically significant differences in the rates of cesarean section, mother ≥35 years old, test tube baby, twins, amniotic fluid contamination, gestational diabetes, gestational hypertension, placental abruption, premature rupture of membrane, and placenta previa between the two groups (all P>0.05); the rates of gestational age <30 weeks, body weight <1.5 kg, prenatal chorioamnionitis, intrauterine distress, intrauterine infection, Apgar score ≤7 at birth, neonatal respiratory distress syndrome, patent ductus arteriosus, mechanical ventilation, pulmonary hemorrhage, and platelet count (PLT) <150×10 9/L in the intracranial hemorrhage group were 43.40% (23/53), 58.49% (31/53), 50.94% (27/53), 43.40% (23/53), 28.30% (15/53), 47.17% (25/53), 83.02% (44/53), 52.83% (28/53), 84.91% (45/53), 11.32% (6/53), and 16.98% (9/53), which were higher than those in the control group [10.45% (14/134), 30.60% (41/134), 34.33% (46/134), 8.21% (11/134), 12.69% (17/134), 20.15% (27/134), 58.21% (78/134), 26.12% (35/134), 55.22% (74/134), 1.49% (2/134), and 0.75% (1/134)], with statistically significant differences (all P<0.05); the prenatal usage rates of magnesium sulfate and dexamethasone in the intracranial hemorrhage group were 60.38% (32/53) and 49.06% (26/53), respectively, which were lower than 85.82% (115/134) and 71.64% (96/134) in the control group, with statistically significant differences (both P<0.05). Multivariate logistic regression analysis showed that gestational age <30 weeks, intrauterine infection, intrauterine distress, and PLT <150×10 9/L were independent risk factors for intracranial hemorrhage in premature infants, while prenatal usage of magnesium sulfate was an independent protective factor for intracranial hemorrhage in premature infants (all P<0.05). Conclusion To reduce the incidence of intracranial hemorrhage in premature infants, comprehensive evaluation, early detection, early diagnosis, and early treatment should be conducted in clinical work. Reference | Related Articles | Metrics

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Application of 256-slice spectral CT imaging parameters in the diagnosis and treatment guidance of lung adenocarcinoma Zeng Yanni, Wei Huihui, Mei Zou International Medicine and Health Guidance News    2022, 28 (14): 2018-2022.   DOI: 10.3760/cma.j.issn.1007-1245.2022.14.021 Abstract （1404）            Knowledge map    Save Objective To explore the value of 256-slice spectral CT imaging parameters in the diagnosis and treatment guidance of lung adenocarcinoma. Methods A total of 120 patients with lung adenocarcinoma and 83 patients with lung squamous cell carcinoma who were admitted to Hubei Third People's Hospital Affiliated to Jianghan University from May 2018 to January 2022 were selected as the research subjects. All patients underwent 256-slice spectral CT imaging, and the spectral CT imaging parameters were compared between the two groups. The value of spectral CT imaging parameters in the diagnosis of lung adenocarcinoma and lung squamous cell carcinoma was analyzed. The patients with lung adenocarcinoma were grouped according to the curative effect of targeted therapy, and the spectral CT imaging parameters before and after treatment were compared between the effective group and the ineffective group. The relationship between spectral CT imaging parameters and curative effect was analyzed. t test, χ 2 test, receiver operating characteristic curve (ROC), and Spearman correlation analysis were used. Results There were 76 males and 44 females in the lung adenocarcinoma group, with an age of (45.26±2.95) years old; there were 58 males and 25 females in the lung squamous cell carcinoma group, with an age of (45.11±2.07) years old. The calcium content, effective atomic number, iodine concentration, and slope of energy spectrum curve in the lung adenocarcinoma group were (3.16±0.86) mg/ml, (7.79±0.05), (6.76±0.96) g/L, and (0.94±0.24), respectively, which were lower than those in the lung squamous cell carcinoma group [(4.71±1.09) mg/ml, (7.84±0.06), (7.92±1.13) g/L, and (1.24±0.32)], with statistically significant differences (all P<0.05); there was no statistically significant difference in the water base value between the lung adenocarcinoma group and the lung squamous cell carcinoma group ( P>0.05). The areas under the curve (AUC) of the above parameters to diagnose lung adenocarcinoma and lung squamous cell carcinoma were 0.832, 0.754, 0.792, and 0.722, respectively, and the AUC of combined diagnosis with these parameters was 0.932. After treatment, the calcium content, effective atomic number, iodine concentration, and slope of energy spectrum curve were significantly reduced in both groups (all P<0.05). The calcium content, effective atomic number, iodine concentration, and slope of energy spectrum curve in the effective group were lower than those in the ineffective group before and after treatment (all P<0.05); the difference values of these parameters before and after treatment in the effective group were higher than those in the ineffective group (all P<0.05). Spearman correlation analysis showed that calcium content, effective atomic number, iodine concentration, and slope of energy spectrum curve were negatively correlated with curative effect ( r=-0.413, -0.628, -0.527, and -0.385; all P<0.05). Conclusion 256-slice spectral CT imaging parameters are helpful in the diagnosis of lung adenocarcinoma, which can reflect the curative effect, and provide references for condition and curative effect evaluation. Reference | Related Articles | Metrics

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Effects of oral and nasal enteral nutrition supports for elderly patients  Bao Qinwen, Gong Chen, Liao Jingxian, Bai Xueling International Medicine and Health Guidance News    2022, 28 (15): 2144-2149.   DOI: 10.3760/cma.j.issn.1007-1245.2022.15.017 Abstract （1394）            Knowledge map    Save Objective To compare the effects of oral nutritional supplements (ONS) and nasal feeding nutrition (NF), including nasogastric tube nutrition (NGT) and naso-jejunal tube nutrition (NJT), on nutritional support for elderly hospitalized patients (≥ 80 years old). Methods One hundred and eight elderly patients admitted to the Geriatric Department, Respiratory Department, Emergency Department, Gastrointestinal Surgery Departmet, Hepatobiliary Surgery Departmet, Pepartment Neurosurgery Department, and Critical Medicine Department of Lianyungang Hospital, Jiangsu University from September 2018 to December 2021 were selected. The support of enteral nutrition (EN) was analyzed. According to the EN support methods, they were divided into an ONS group (50 cases, including 31 males and 19 females) and an NF group (58 cases, including 38 males and 20 females). The NF group included 40 cases in the NGT group and 18 cases in NJT group. The patients were 80-98 years old. The average age was 85.7 in the ONS group and 84.9 in the NF group. The EN support time was more than 14 days, and the intake of the amount of calories and nitrogen was the same. The serum prealbumin (PA), total protein (TP), albumin (ALB), hemoglobin (Hb), and red blood cell (RBC) counts, as well as inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), and tumor necrosis factor α (TNF-α)] and the immune indicators [CD3+, CD4+, CD8+, immunoglobulin (Ig) G, IgA, and IgM], were compared between the ONS group, the NGT group, and the NJT group. The SPSS 18.0 software was used for the data analysis, t test and F test for the measurement data, and χ 2 test for the counting data. If P≤0.05, there is a statistical difference. Results There was no statistical difference in protein nutritional status between the three groups before EN support ( P>0.05). After EN support, the levels of serum PA, TP, and ALB significantly increased (all P<0.05), the levels of CRP, IL-6, PCT, and TNF-α obviously decreased (all P<0.05), but the Hb and RBC count did not increase significantly (all P>0.05) in all the 3 groups. The IgG, IgA, IgM, CD3+, and CD4+ of the ONS group were higher than those of the NGT group and the NJT group at the same time points (all P<0.05), and the CD8+ was lower than those of the NGT group and the NJT group (both P<0.05). Fourteen days after the treatment, the incidences of diarrhea (6%, 3/50), reflux (8%, 4/50), and gastrointestinal bleeding (2%, 1/50) in the ONS group were statistically different from those in the NGT group and the NJT group (all P<0.05); and the incidences of vomiting (4%, 2/50) and recurrent pulmonary infection (4%, 2/50) in the ONS group were statistically different from those in the NGT group at the same time points (both P < 0.05), but were not statistically different from those in the NJT group at the same time points (both P > 0.05). Conclusions In the EN support of elderly patients (≥ 80 years old), ONS and NF supports can effectively improve their protein nutritional status, and ONS has more significant effect. EN for elderly patients can significantly alleviate the disease severity, improve the levels of inflammatory mediators and oxidative stress, and reduce the incidence of complications, and has definite effect. Reference | Related Articles | Metrics

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Effect of Jianpiyiqi prescription combined with acupoint application in prevention and treatment of chemotherapeutic gastrointestinal reactions after colorectal cancer surgery Peng Shuling, Zhang Weihua, Zhong Yubo, Liu Lili, Huang Hongzhen International Medicine and Health Guidance News    2022, 28 (11): 1516-1520.   DOI: 10.3760/cma.j.issn.1007-1245.2022.11.009 Abstract （1353）            Knowledge map    Save Objective To investigate the clinical effect of Jianpiyiqi prescription combined with acupoint application in the prevention and treatment of chemotherapeutic gastrointestinal reactions after colorectal cancer surgery. Methods A total of 90 patients taking chemotherapy after colorectal cancer surgery at Department of Gastrointestinal Surgery, Foshan Second People 's Hospital between January 2019 and November 2021 were selected for the case control study, including 49 males and 41 females, and they were (58±13) years old. They were divided into a control group (group A), a traditional Chinese medicine group (group B), and an integrated traditional Chinese and western medicine group (group C), with 30 cases in each group. Group A was given dexamethasone 10 mg, tropisetron 5 mg, and metoclopramide 10 mg by intramuscular injection before the chemotherapy. Group B began to take Jianpiyiqi prescription 3 days before chemotherapy, 1 dose a day, until 3 days after chemotherapy; at the same time, apply acupoints once a day for 12 hours until 3 days after chemotherapy. On the basis of group A, group C began to take Jianpiyiqi prescription 3 days before chemotherapy, and acupoint application was performed until 3 days after chemotherapy. The scores of nausea, vomiting, abdominal pain, diarrhea, and functional status were compared between the three groups. Analysis of variance and chi-square test were used. Results The nausea scores of group A, group B, and group C were 1.00 (2.00), 1.00 (2.00) and 1.00 (1.00), the vomiting scores 1.00 (2.00), 1.00 (2.00) and 1.00 (1.00), and the diarrhea abdominal pain scores 1.00 (2.00), 0.00 (1.00) and 0.00 (1.00) (all P<0.05). The functional status scores before chemotherapy of group A, group B, and group C were (96.3±4.9), (97.7±5.0), and (96.3±5.6); the scores of functional status after chemotherapy of group A, group B, and group C were (91.0±8.4), (96.0±6.2), and (95.7±5.7), with a statistical difference between the 3 groups ( F=4.943, P=0.009). The effective rates of nausea, vomiting prevention and treatment were 80.00% (24/30), 73.33% (22/30), and 96.67% (29/30) in group A, group B, and group C, respectively, with a statistical difference between the 3 groups ( χ 2=6.240, P=0.044). The effective rates of prevention and treatment of diarrhea and abdominal pain were 80.00% (24/30), 96.67% (29/30), and 96.67% (29/30) in group A, group B, and group C, respectively, with a statistical difference between the 3 groups ( χ 2=6.860, P=0.032). Compared with those in group A, the scores of nausea and vomiting in group B and group C were significantly decreased (all P<0.05), the diarrhea abdominal pain score in group B was significantly lower ( P<0.05), and the functional status scores after chemotherapy in group B and group C were significantly increased (both P<0.05). Conclusion On the basis of routine use of western medicine antiemetic drugs, Jianpiyiqi prescription combined with acupoint application has good effect in preventing and treating chemotherapeutic gastrointestinal reactions after colorectal cancer surgery. Reference | Related Articles | Metrics

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Screening of lncRNA related to prognosis of colon cancer based on TCGA database and establishment of prognostic risk model  He Tian, Cao Tiansheng International Medicine and Health Guidance News    2022, 28 (13): 1864-1871.   DOI: 10.3760/cma.j.issn.1007-1245.2022.13.018 Abstract （1313）            Knowledge map    Save Objective To screen long non-coded RNA (lncRNA) associated with the prognosis of colon cancer, and to build a prognostic risk model of colon cancer. Methods The data were collected from the establishment to March 1,2022. The transcriptome data of colon cancer were downloaded and sorted from The Cancer Genome Atlas (TCGA), then we constructed an expression matrix of lncRNA about paired samples. Differentially expressed lncRNAs (DElncRNAs) were obtained by R-packet "edgeR". For DElncRNAs, univariate COX regression analysis, Lasso regression analysis, Kaplan-Meier (K-M) survival analysis, and multivariate COX regression analysis were performed to obtain the prognostic associated lncRNAs. The prognostic risk model of colon cancer was established based on the coefficient of multivariate COX regression model. Then we evaluated the accuracy through C-index value, time-dependent receiver operating characteristic curve (ROC), area under ROC (AUC) value, and K-M survival analysis. CeRNA network was constructed for the lncRNAs in our model. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed for related mRNAs to explore the mechanism of lncRNA affecting the progression of colon cancer. Results Five thousand four hundred and sixty lncRNAs were screened by arranging the transcriptome data. Eight hundred and sixty-eight DElncRNAs were obtained by paired-sample analysis, including 548 up-regulated genes and 320 down-regulated genes. After univariate COX regression analysis, 40 lncRNAs were obtained. Through lasso regression analysis, we got 34 lncRNAs. Fourteen lncRNAs remained after K-M survival analysis. Multivariate COX regression analysis revealed 7 prognostic related lncRNAs (down-regulated genes: LINC01132; up-regulated genes: ELFN1-AS1, RP5-884M6.1, LINC00461, RP1-79C4.4, RP4-816N1.7, and RP3-380B8.4). The prognostic assessment model was constructed according to the regression coefficient. The C-index value of the model was 0.82; the AUC values at 3 and 5 years were 0.79 and 0.84; K-M survival analysis showed a statistical difference in the survival rate between the high and low risk groups ( P<0.000 1). Next, we constructed the ceRNA network, and the KEGG enrichment analysis suggested that the down-regulation lncRNA inhibited the progression of colon cancer possibly through the pathways of regulation of actin cytoskeleton, proteoglycans in cancer, and PI3K-Akt signaling pathway; up-regulation lncRNAs promoted colon cancer possibly through the pathways of cellular adhesion molecules, focal adhesions, and phagosomes. Conclusions In our study, we constructed a prognostic risk model of colon cancer with 7 lncRNAs. It has a nice accuracy in predicting the patients' survival prognosis. Each lncRNA is a potential independently prognostic biomarker. The prognostic risk model has certain value for clinical prognostic assessment of colon cancer patients. Reference | Related Articles | Metrics

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The effect of ultrasound-guided erector spinae plane block on postoperative analgesia in patients with laparoscopic cholecystectomy Zhang Xiaodan, Wang Hongyu, Zhang Yong, Han Liu International Medicine and Health Guidance News    2021, 27 (6): 813-817.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.007 Abstract （1281）      PDF （1357KB）（605）       Knowledge map    Save Objective To investigate the effectiveness and safety of ultrasound-guided erector spinae plane block (ESPB) combined with oxycodone patient controlled intravenous analgesia (PCIA) for postoperative analgesia in patients undergoing laparoscopic cholecystectomy (LC). Methods A total of 58 patients underwent laparoscopic cholecystectomy under general anesthesia, including 22 males and 36 females, with ASA I or II, they were randomly divided into two groups: single ESPB combined with PCIA group (group EP) and simple PCIA group (Group P). Patients in the group EP received ultrasound-guided ESPB before induction of anesthesia. Both groups were evaluated according to the numerical rating scale (NRS). When the NRS score was ≥4 points, oxycodone titration was administered intravenously until the NRS score was <4 points and then PCIA was used. Postoperative oxycodone titration; NRS scores before titration, at the end of titration, 1 h, 4 h, 8 h, 12 h, 16 h, 24 h later at rest and cough; the dose of oxycodone within 0~4 h, 4~8 h, 8~12 h, 12~16 h, and 16~24 h after surgery; the number of effective press of analgesic pump within 0~4 h, 4~8 h, 8~12 h, 12~16 h, and 16~24 h after surgery; the number of postoperative remedial analgesia and postoperative adverse reactions in the two groups were recorded. Results The postoperative titrated oxycodone dosage and the PCIA oxycodone dosage with 0~4 h and 4~8 h after surgery of the group EP were significantly less than those of the group P [0.0 (1.0, 2.0) mg vs.2.0 (0.0, 4.0) mg, 0.4 (0.4, 1.4) mg vs.0.4 (0.4, 1.4) mg, 0.4 (0.4, 0.4) mg vs.0.4 (1.4, 2.4) mg] (all P<0.05). The NRS scores at 1 hour after surgery at rest and cough in the group EP were significantly lower than those in the group P [(1.38±0.86) points vs.(1.92±0.83) points, (1.93±0.80) points vs.(2.50±0.59) points] (both P<0.05); the NRS scores at 4 hours after surgery at rest and cough in the group EP were significantly lower than those in the group P [(1.21±0.68) points vs.(1.71±0.69) points, (1.90±0.62) points vs.(2.29±0.69) points] (both P<0.05); the NRS scores at 8 hours after surgery at rest and cough in the group EP were significantly lower than those in the group P [(1.41±0.73) points vs.(2.00±0.59) points, (1.66±0.67) points vs.(2.21±0.83) points] (both P<0.01). The number of effective press of analgesic pump within 0~4 h and 4~8 h after surgery in the group EP were significantly lower than those in the group P [0.4 (0.4, 1.4) times vs.1.4 (0.4, 3.1) times, 0.4 (0.4, 0.4) times vs.1.4 (0.4, 2.4) times] (both P<0.05). Conclusion Ultrasound-guided ESPB can significantly reduce the PCIA dosage of oxycodone after LC, which is a safe and effective way of analgesia. Reference | Related Articles | Metrics

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Clinical observation on the effect of sodium zirconium cyclosilicate powder on short-term potassium lowering in patients with severe hyperkalemia of chronic kidney disease Li Rugang, Huang Jieping, Kuang Shuanghong, Liang Zezhi, Zhong Jinghua International Medicine and Health Guidance News    2022, 28 (6): 854-858.   DOI: 10.3760/cma.j.issn.1007-1245.2022.06.030 Abstract （1242）            Knowledge map    Save Objective To observe the short-term potassium lowering effect of sodium zirconium cyclosilicate powder in patients with severe hyperkalemia of chronic kidney disease. Methods The clinical data of 11 patients with chronic kidney disease complicated with severe hyperkalemia who refused emergency hemodialysis and took sodium zirconium cyclosilicate powder in Yuebei People's Hospital from November 2020 to May 2021 were retrospectively analyzed, and the short-term treatment effect and drug safety were analyzed. Paired t test was used to compare the measurement data with normal distribution before and after medication. The correlation between potassium reduction range and intravenous potassium level before medication was analyzed by Pearson correlation analysis. Results Among the 11 patients, 8 cases were male and 3 cases were female, aged (75.5±12.5) years; there were 10 cases (90.91%) with hypertension, 3 cases (27.27%) with diabetes, 1 case (9.09%) with coronary heart disease, and 1 case (9.09%) with heart failure; the estimated glomerular filtration rate (eGFR) was <15 ml·min -1· (1.73 m 2) -1 in 7 cases (63.64%), and ≥15 ml·min -1· (1.73 m 2)-1 in 4 cases (36.36%). The intravenous potassium level of 11 patients was (7.02±0.54) mmol/L before medication, and (4.62±0.76) mmol/L in morning reexamination on the second day after medication, and the potassium reduction range on the first day was (2.40±0.43) mmol/L, with a statistically significant difference before and after medication ( P<0.001). According to the initial intravenous potassium level, 4 patients in the ≥7.00 mmol/L group were decreased by (3.26±0.70) mmol/L on the first day, 7 patients in the 6.50-7.00 mmol/L group were decreased by (1.91±0.64) mmol/L on the first day; there was a statistically significant difference in the potassium reduction range between the two groups on the first day ( P=0.024). The potassium reduction range on the first day was positively correlated with the level of intravenous potassium before medication ( r=0.318, P=0.047). Hypokalemia occurred in 1 case and vomiting in 2 cases, and no other adverse reactions were found. Conclusion Sodium zirconium cyclosilicate powder can effectively reduce the blood potassium level in patients with chronic kidney disease and severe hyperkalemia within 24 hours, with high safety. Reference | Related Articles | Metrics

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Effect of dapagliflozin on renal function and glucose and lipid metabolism in patients with type 2 diabetes mellitus Ji Gaode, Jiang Lihua, Li Qun International Medicine and Health Guidance News    2022, 28 (11): 1579-1583.   DOI: 10.3760/cma.j.issn.1007-1245.2022.11.023 Abstract （1204）            Knowledge map    Save Objective To observe the effect of dapagliflozin on renal function and glucose and lipid metabolism in patients with type 2 diabetes mellitus (T2DM). Methods This was a prospective study. Eighty-six patients with T2DM admitted to Jinan Second People's Hospital from July 2019 to July 2021 were selected as the research objects. They were divided into a control group and an observation group by the random number table method, with 43 cases in each group. The control group had 25 males and 18 females, and they were (52.80±5.77)years old. The obser vation group had 28 males and 15 females, and they were (53.19±5.82)years old, All the patients were given conventional treatment, and the observation group were treated with dapagliflozin on this basis. The clinical effects, the levels of blood glucose [fasting blood glucose (FBG), 2h postprandial blood glucose (2hPG), and glycosylated hemoglobin (HbA 1c)], blood lipids [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], oxidative stress indicators [malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px)], and renal function indicators [blood urea nitrogen (BUN), serum creatinine (Scr), and urine microalbumin (UMA)], and the incidences of adverse reactions were compared between these two groups. The independent-sample t test, paired t test, and χ 2 test were applied. Results The treatment response rate in the observation group was higher than that in the control group [93.02% (40/43) vs. 74.42% (32/43)], with a statistical difference ( χ2=5.161, P=0.023). After the treatment, the levels of FBG, 2hPG, HbA 1c, TC, TG, LDL-C, MDA, BUN, Scr, and UMA were (6.50±1.33) mmol/L, (8.35±1.44) mmol/L, (6.01±0.54)%, (4.58±0.23) mmol/L, (1.41±0.22) mmol/L, (2.23±0.34) mmol/L, (3.20±0.33) μmol/L, (6.33±1.07) mmol/L, (110.53±18.77) μmol/L, and (10.34±3.21) mg/L in the observation group, which were significantly lower than those in the control group [(7.39±1.50) mmol/L, (11.29±2.53) mmol/L, (7.02±1.19)%, (5.23±0.70) mmol/L, (1.95±0.44) mmol/L, (3.31±0.52) mmol/ L, (4.50±0.52) μmol/L, (9.86±2.55) mmol/L, (178.41±25.36) μmol/L, and (18.55±5.27) mg/L], with statistical differences ( t=2.911, 6.623, 5.068, 5.785, 7.198, 11.399, 13.842, 8.371, 14.108, and 8.725; all P<0.05). The levels of HDL-C and SOD were (1.74±0.65) mmol/L and (43.96±8.22) U/ml in the observation group, which were significantly higher than those in control group [(1.46±0.53) mmol/L and (36.77±7.03) U/ml], with statistical differences ( t=2.189 and 4.359; both P<0.05). There was no statistical difference in GSH-Px between the two groups ( t=0.206, P=0.837). There was no statistical difference in the incidence of adverse reactions between the two groups [4.65% (2/43) vs. 9.30% (4/43); χ2=0.677, P=0.410]. Conclusion Dapagliflozin is effective in the treatment of T2DM, and can effectively control blood glucose level and improve lipid metabolism, oxidative stress, and renal function. Reference | Related Articles | Metrics

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Therapeutic effect of painting therapy on tension type headache Liu Yunyun, Fu Bing, Li Min, Liu Huaiying International Medicine and Health Guidance News    2021, 27 (6): 822-824.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.009 Abstract （1164）      PDF （1017KB）（457）       Knowledge map    Save Objective To explore the effect of painting therapy in the treatment of tension type headache (TTH). Methods A total of 113 female patients with TTH from November 2016 to June 2018 in Boya Women's College of Lianyungang were randomly divided into observation group and control group. The control group was given routine treatment (relieving pain, regulating emotion, improving sleep, and so on), and the observation group was given painting therapy (free painting) on the basis of the control group. Visual analogue scale (VAS) was used to evaluate the degree of headache of the patients, Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to evaluate the mental state of the patients. The patients were followed up for 90 days after admission. Results Follow-up on the 90th day showed that the HAMA and HAMD scores of the observation group were (5.88±2.31) points, (6.48±2.76) points respectively, and those of the control group were (6.91±2.67) points, (7.72±3.11) points respectively, with statistically significant differences (both P<0.05); the VAS score of the observation group was (1.23±0.63) points, which was significantly lower than that of the control group [(1.60±0.88) points] ( P<0.05); the frequency of headache attack in the observation group was (5.50±2.61) times, which was significantly lower than that of the control group [(6.67±2.85) times] ( P<0.05); the proportion of taking analgesics in the observation group was significantly lower than that in the control group [5.4%(3/56) vs 17.9%(10/57)] ( P=0.042). Compared with the control group, the proportion of anti-anxiety and depression drugs used in the observation group decreased on the 60th and 90th days, and there was statistically significant difference between the two groups on the 90th day ( P<0.05). Conclusion Combined painting therapy can relieve the degree of headache, reduce the frequency of headache attacks, alleviate anxiety and depression symptoms in patients with tension type headache. Reference | Related Articles | Metrics

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Effect of H2H management model on self-efficacy and mood state of leukemia patients Gong Qinying, Chen Shuyan, Zhang Zhenli, Gong Shengzhu International Medicine and Health Guidance News    2021, 27 (6): 818-821.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.008 Abstract （1155）      PDF （1017KB）（560）       Knowledge map    Save Objective To explore the application value of H2H management model in improving self-efficacy and mood state of leukemia patients. Methods A total of 68 patients with leukemia admitted to our hospital from June 1, 2019 to April 30, 2020 were divided into observation group and control group with the random number table method with 34 cases in each group. The control group was given routine nursing management, oral education for patients, such as drug guidance, regular review, nutrition, hygiene, complications protection and so on. The observation group was given H2H management on the basis of routine nursing. Before and after 4 weeks of intervention, the self-efficacy and mood state of the two groups were evaluated by GSES and POMS-SF respectively, the differences were compared and analyzed. Results There were no statistically significant differences in self-efficacy and mood state scores between the two groups before intervention (all P>0.05). After 4 weeks of intervention, the self-efficacy score of the observation group was (32.41±3.58), significantly higher than that of the control group [(23.47±3.10)]; the total score and scores of six dimensions of mood state in the observation group were significantly lower than those in the control group, the total score of mood state in the observation group was (65.00±5.34), significantly lower than that of the control group [(98.24±6.70)], with statistically significant differences between the two groups (all P<0.05). Conclusion The implementation of H2H management model can effectively improve the self-efficacy and mood state of leukemia patients. Reference | Related Articles | Metrics

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Disinfection effects of four disinfection products on CT examination beds Ren Yanmin, Wu Fengjiao, Li Ailan, Zhu Xin, Zhang Yu, Sun Lina International Medicine and Health Guidance News    2022, 28 (15): 2117-2121.   DOI: 10.3760/cma.j.issn.1007-1245.2022.15.011 Abstract （1068）            Knowledge map    Save Objective By using four disinfection products, to disinfect the CT examination beds, to compare their disinfection effects, bacterial colonies on the surfaces of the objects, and the economic cost, and to provide references for the convenient, effective, and economical disinfection method of clinical use. Methods From April 2020 to January 2021, the CT examination bed surfaces at Hospital Affiliated to Heze Medical College, Heze Municipal Hospital and Dingtao District People's Hospital were wiped by quaternary ammonium disinfection wipes (199 samples), 75% alcohol wipes (194 samples), 500 mg/L chlorine disinfectant wiping (180 samples), and bed unit disinfection machine (82 samples) for surface disinfection. The disinfection effects after disinfection and the numbers of bacteria on the surfaces of the CT beds were compared, and the economic costs of the four disinfection methods were analyzed. The comparison between multiple samples was did by Kruskal-Wallis test; the counting data was expressed as a rate, and were compared by χ 2 test. Results The qualified rates of quaternary ammonium disinfection wipes, 75% alcohol wipes, 500 mg/L chlorine disinfectant wiping, and bed unit disinfection machine were 98.99% (197/199), 98.45% (191/194), 99.44% (179/180), and 100.00% (82/82), respectively, with no statistical difference ( χ 2=1.882, P=0.597); and there was no statistical difference in the disinfection effects between the four disinfection products. The bacterial colony numbers after disinfection of the four disinfection products were 0.1(0.3) cfu/cm 2, 0.6(1.0) cfu/cm 2, 1.0(0.7) cfu/cm 2, and 0.0(0.1) cfu/cm 2, respectively, with a statistical difference ( H=17.857, P<0.05); the removal effects from high to low were as below: bed unit disinfection machine, quaternary ammonium disinfection wipes, 75% alcohol, and 500 mg/L chlorine-containing disinfectant; the economic use costs from high to low were as below: bed unit disinfection machine (22.00 yuan/time) > 75% alcohol = 500 mg/L chlorine disinfectant (1.74 yuan/time) > quaternary ammonium disinfection wipes (1.25 yuan/time). Conclusion After comparison, quaternary ammonium disinfection wipes have the advantages of reliable disinfection effect, simple and convenient operation, time saving, and low cost of use, and can be promoted in hospitals. Reference | Related Articles | Metrics

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Myopia prevention and control knowledge and prevention behaviors of adolescent parents Wu Min, Yu Na, Zhai Xiangjuan, Fu Te, Huang Shuo, Wang Lingyun International Medicine and Health Guidance News    2022, 28 (15): 2203-2208.   DOI: 10.3760/cma.j.issn.1007-1245.2022.15.031 Abstract （1040）            Knowledge map    Save Objective To investigate the myopia prevention and control knowledge and behaviors of adolescent parents, and to guide the prevention and treatment of myopia in adolescents. Methods A cross-sectional survey method was used to select the adolescent parents who brought their children for vision diagnosis and treatment in Eye Clinic, Jinan Second People's Hospital from August 2021 to January 2022. And the parents' general information was investigated by the General Information Scale. The Adolescent Parents' Myopia Prevention Cognition Questionnaire and Parents' Myopia Prevention Behavior Questionnaire designed by the senior physicians in Eye Clinic, Jinan Second People's Hospital were used to investigate the knowledge and prevention behaviors of the adolescent parents on myopia prevention and control. The data were analyzed by SPSS 22.0, and compared between the groups by χ 2 test. Results A total of 664 adolescent parents were surveyed, including 292 males (45.06%) and 356 females (54.94%), and 648 valid questionnaires were obtained; 69 (10.65%) were <30 years old, 439 (67.75%) 30-40 years old, and 140 (21.60%) >40 years old; 66 ones' education level was junior high school or below (10.19%), 351 ones' high school or technical secondary school (54.17%), and 231 ones' junior college or above (35.65%). According to the presence or absence of myopia in the children, the parents were divided into a myopic adolescent parent group and a normal vision adolescent parent group. The aware rates of "the reading light intensity at night should be ≥200 Lux", "the writing distance, the distance from the chest to the table, and the distance from the book to the eyes should be kept at 3.3 cm, 6.0-7.0 cm, and 33.0 cm, respectively", "even if desk lamp lighting is used, the incident light should be from the opposite side of the dominant hand", "vision training can delay the increase of myopia diopter", "wearing overcorrected myopia glasses can aggravate the progression of myopia", "refractive surgery is an effective way to correct the vision of people ≥18 years old with stable diopter, but reasonable expectations should be maintained", and "every day outdoor activities or physical exercise for 1 to 2 hours helps prevent myopia" in the myopic adolescent parent group were lower than those in the normal vision adolescent parent group [69.21% (281/406) vs. 76.86% (186/242), 55.17% (224/406) vs. 71.07% (172/242), 74.88% (304/406) vs. 85.95% (208/242), 77.09% (313/406) vs. 84.30% (204/242), 79.80% (324/406) vs. 89.26% (216/242), 74.14% (301/406) vs. 81.82% (198/242), and 88.18% (358/406) vs. 93.80% (227/242)], with statistical differences ( χ 2=4.405, 16.133, 11.212, 4.879, 9.756, 4.614, and 5.465; all P<0.05). There were statistical differences in the prevention behaviors, such as "the parents regularly urge or bring their children to the ophthalmology institutions to check their vision", "the parents often urge their children to maintain good sleep", "the parents often urge their children to go outdoors", "the parents often supervise their children to maintain good eye habits", "while they live together, the parents control the teenagers' screen time", "the parents frequently discuss or share topics related to the hazards and prevention of myopia with teenagers", "compared with good eyesight, the parents insist on excellent academic performance and put it into action", etc. between these two groups (all P<0.05). Conclusions The parents of adolescents who received the questionnaire survey in Jinan Second People's Hospital were not optimistic about the awareness rate of knowledge related to myopia prevention. Parents of normal vision adolescents are better than parents of myopia adolescents in knowledge awareness rate and myopia prevention behaviors. Reference | Related Articles | Metrics

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The value of popliteal sciatic nerve block in multi-modal analgesia after Hallux Valgus surgery Liu Linlin, Jian Chaojun, Wang Yanpin, Niu Qiang, Xu Xuebing International Medicine and Health Guidance News    2021, 27 (6): 810-812.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.006 Abstract （1000）      PDF （1016KB）（430）       Knowledge map    Save Objective To evaluate the efficacy and safety of popliteal sciatic nerve block (PSNB) in multi-modal analgesia after Hallux Valgus surgery. Methods Forty-nine patients who underwent unilateral or bilateral Hallux Valgus surgery under intraspinal anesthesia from September 2014 to March 2020 were retrospective analyzed. The PSNB group ( n=14) underwent postoperative ultrasound guided PSNB with 15 ml of 0.5% ropivacaine, and oral analgesics (paracetamol, tramadol, and celecoxib); the Oral group ( n=35) only received aforementioned oral analgesics for pain control. The postoperative 6 h and 24 h rest/active pain NRS scores, the incidence of moderate to severe pain within postoperative 24 h, the requirement of rescue opioid analgesics, side effects, and patients' subjective satisfaction rating were observed and compared between the two groups. Results The median of postoperative 6 h rest NRS score in the PSNB group and the Oral group were 2.0 and 3.0 ( P<0.05); the median of postoperative 24 h rest/active pain NRS scores were 0.0/1.5 and 1.0/3.0, the incidences of moderate to severe pain within postoperative 24 h were 14.3% (2/14) and 22.9% (8/35), the incidences of remedial opioid analgesics were 7.1% (1/14) and 2.9% (1/35), there were no statistically significant differences in the above mentioned indices (all P>0.05). No side effect was found in the PSNB group, there was a case of post-dural puncture headache in the Oral group, and the subjective satisfaction rate was 100% in both groups. Conclusion Adding PSNB to multi-modal analgesia management strategy for Hallux Valgus surgery may improve short term postoperative pain control, but has no impact on the need of rescue analgesics after surgery. Reference | Related Articles | Metrics

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Apatinib combined with tegafur in treatment of patients with advanced gastric cancer and its influence on prognosis Qi Youtao, Wang Dongmei, Bai Yuhuan, Kong Lingjia, Jing Changchun, Ji Bei International Medicine and Health Guidance News    2022, 28 (13): 1815-1819.   DOI: 2022001750 Abstract （970）            Knowledge map    Save Objective To analyze the clinical effect of apatinib combined with tegafur in the treatment of patients with advanced gastric cancer, and to observe the effect of the combination regimen on the levels of inflammatory factors and the cytokines of T helper 1 cells (Th1) and T helper 2 cells (Th2). Methods Eighty-eight patients with advanced gastric cancer who were admitted to Department of Gastroenterology, Liaocheng Second People's Hospital from March 2019 to February 2020 was selected for the study. They were divided into a control group and an observation group by the random number table method, with 44 cases in each group. There were 24 males and 20 females in the control group; they were (65.25±2.42) years old; they were treated with tegafur. There were 25 males and 19 females in the observation group; they were (65.33±2.35) years old; they were treated with tegafur and apatinib. χ 2 test was used for the enumeration data, and t test for the measurement data. The clinical efficacies, serum tumor marker levels before and after the treatment, Th1 and Th2 cytokine levels, adverse reactions, and survival were compared between the two groups. Results The disease control rate (DCR) was 59.09% (26/44) in the control group, and was 79.55% (35/44) the observation group, with a statistical difference ( χ 2=4.328, P=0.037). The levels of cancer-associated carbohydrate antigen (CA19-9), carcinoembryonic antigen (CEA), and tumor-specific growth factor (TSGF) after the treatment were (9.20±4.23) U/ml, (2.53±0.41) μg/L, and (61.75±14.25) U/ml in the control group, and were (4.98±2.87) U/ml, (1.96±0.39) μg/L, and (53.20±16.37) U/ml in the observation group, with statistical differences between these two groups ( t=5.476, 6.682, and 2.613; all P<0.05). After the treatment, the levels of interferon-γ (INF-γ), tumour necrosis factor-α (TNF-α), interleukin (IL)-4, and IL-10 were (9.83±1.68) μg/L, (4.98±0.83) pg/ml, (5.62±1.58) μg/L, and (12.83±2.41) μg/L in the control group, and were (12.45±1.65) μg/L, (6.12±1.47) pg/ml, (3.18±1.17) μg/L, and (8.76±2.11)  μg/L in the observation group, with statistical differences between these two groups ( t=7.380, 4.479, 8.232, and 8.428; all P<0.05). The median progression time and survival time were (7.23±1.31) months and (5.10±1.39) months in the control group, and were (5.31±0.75) months and (9.33±2.54) months in the observation group, with statistical differences ( t=8.437 and 9.691; both P<0.05). Conclusion Apatinib combined with tegafur in the treatment of patients with advanced gastric cancer can effectively improve their clinical symptoms and signs, the levels of serum tumor markers, and Th1 and Th2 cytokines, and does not increase the incidence of adverse reactions, and the patients have better survival. Reference | Related Articles | Metrics

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Isolation and purification of flavonoid glycosides from Clinacanthus nutans (Burm.f.) Lindau and its antitumor effect on epithelial ovarian cancer Sui Hongmei, He Fengxi, Li Aihua, Li Aifeng, Wang Li, Lu Huanxi International Medicine and Health Guidance News    2022, 28 (13): 1784-1789.   DOI: 10.3760/cma.j.issn.1007-1245.2022.13.002 Abstract （941）            Knowledge map    Save Objective To provide theoretical references for developing the medicinal value of Clinacanthus nutans (Burm.f.) Lindau by separating and purifying its flavonoid glycosides and studying its antitumor effects on epithelial ovarian cancer. Methods The research time was from October 2019 to March 2022.The flavonoid glycosides were isolated and purified by macroporous adsorption resins and semi-preparative high performance liquid chromatography, and their structures were identified by nuclear magnetic resonance spectrum. The cell counting kit-8 (CCK 8) method was used to determine the effect of the extract on the activities of the SKOV3, OVCAR3, and A2780 epithelial ovarian cancer cells, and flow cytometry was used to detect the apoptosis. The effects of the extract on the expressions of Beclin-1 and Bcl-2 mRNA in the epithelial ovarian cancer cells were detected by fluorescence quantitative polymerase chain reaction (PCR). Its effect on the expressions of Beclin-1 and Bcl-2 proteins in the epithelial ovarian cancer cells was detected by Western blot. The statistical softwares SPSS 22.0 and GraphPad Prism were used to analyze the experimental results. The one-way ANOVA was used to determine the cell 50% inhibiting concentration (IC 50) value. t test was applied. Results Three flavonoid glycosides were isolated and purified from Clinacanthus nutans (Burm.f.) Lindau, and they were identified as saponarin, schaftoside, and vitexin. The results of the CCK8 experiment showed that vitexin significantly inhibited the proliferation of the epithelial ovarian cancer cells ( P < 0.05). The IC 50 values (semi-inhibitory concentrations) of the SKOV3, OVCAR3, and A2780 epithelial ovarian cancer cells were 33.777 μg/μl, 34.114 μg/μl, and 31.968 μg/μl. The results of fluorescence quantitative PCR showed that compared with those in the blank group, the relative expression of Beclin-1 mRNA increased and the expression of Bcl-2 mRNA decreased in the SKOV3, A2780, and OVCAR3 epithelial ovarian cancer cell groups after vitexin treatment, with statistical differences (all P<0.01). The results of apoptosis test showed that the inhibitory effect of vitexin on the growth of the SKOV3 epithelial ovarian cancer cells significantly increased with the vitexin concentration ( P<0.01). Western bolt showed that after vitexin treatment, the expression of Beclin-1 protein increased significantly ( P<0.01), and the expression of Bcl-2 protein decreased significantly ( P<0.01). Conclusions Vitexin shows significant anticancer activity by inhibiting the proliferation and inducing the apoptosis of epithelial ovarian cancer cells. The anticancer activity may be related to regulating the interaction between Bcl-2 and Beclin-1, controlling the autophagy level of tumor cells, and promoting autophagy-dependent cell death. Reference | Related Articles | Metrics

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Randomized controlled study of amantadine combined with dalingfu in the treatment of patients with Parkinson's disease Shao Keke, Ru Wenwen International Medicine and Health Guidance News    2021, 27 (6): 881-884.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.024 Abstract （939）      PDF （1057KB）（663）       Knowledge map    Save Objective To analyze the effect of amantadine combined with dalingfu on mental state and cognitive function of patients with Parkinson's disease. Methods A total of 122 patients with Parkinson's disease who were treated in our hospital from January 2017 to July 2019 were selected and were divided into the observation group (oral amantadine and dalingfu) and the control group (oral amantadine and levodopaand benserazide hydrochloride) by the random number table method. The clinical efficacy, mental status, cognitive function, symptom score, serum index, and adverse reactions of the two groups were observed. Results The effective rate of the observation group was 93.44% (57/61), which was higher than 78.69% (48/61) of the control group ( P<0.05). After treatment, the MMSE score and MoCA score of the observation group were higher than those before treatment and those of the control group, and the UPDRS score was lower than that before treatment and that of the control group (all P<0.05). After treatment, serum levels of GSH-Px, SOD, DA, 5-HT, NE, and BDNF in the observation group were higher than those before treatment and those in the control group, and serum levels of MDA, IL-6, and IL-1β were lower than those before treatment and those in the control group (all P<0.05). During the treatment period, the total incidence of complications in the observation group was 11.48% (7/61), and 8.20% (5/61) in the control group, without statistically significant difference ( P>0.05). Conclusion Amantadine combined with Dalingfu can effectively improve the cognitive function and mental state of patients with Parkinson's disease, and its effect may be related to the restoration of serum neurotransmitter levels. Reference | Related Articles | Metrics

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Application value of composite echocardiography technique in detecting cardiotoxicity caused by lymphoma chemotherapy Xue Jing, Zhang Zhoulong, Chen Shengjiang, Yuan Xiaozhi, Duan Like, Wang Huifen International Medicine and Health Guidance News    2022, 28 (16): 2236-2240.   DOI: 10.3760/cma.j.issn.1007-1245.2022.16.004 Abstract （938）            Knowledge map    Save Objective To investigate the application value of composite echocardiography technique in dynamically monitoring cardiotoxicity caused by lymphoma chemotherapy. Methods A total of 28 non-Hodgkin lymphoma patients underwent chemotherapy in The First Affiliated Hospital of Henan University of Science and Technology, including 12 males and 16 females, aged (51.22±10.17) years; 30 healthy volunteers were selected as controls during the same period, including 12 males and 18 females, aged (50.19±12.06) years. Real-time two-dimensional echocardiography (RT-2DE), tissue Doppler imaging (TDI), and two-dimensional speck-tracking imaging (2D-STI) were used to detect the cardiac function indexes in all patients after 2, 4, and 6 cycles of chemotherapy. The left ventricular ejection fraction (LVEF), left ventricular anterior diameter (LV), left atrial anterior diameter (LA), peak E, peak A, E/A, mitral peak E deceleration time (DT), the ratio of early diastolic velocity of blood flow spectrum (E) to early diastolic peak velocity of mitral annulus (e'), left ventricular global circumferential strain (LVGCS), left ventricular global radial strain (LVGRS), left ventricular global longitudinal strain (LVGLS), and peak left ventricular twist angle (LVPtw) were observed and compared in both groups. Independent sample t test or one-way ANOVA was used for the measurement data, and Chi-square test was used for the count data. Results There were no statistically significant differences in the LVEF, LV, LA, peak E, peak A, and E/A between the chemotherapy group and the control group after 2 and 4 cycles of chemotherapy (all P>0.05). There was no statistically significant difference in the DT between the chemotherapy group and the control group after 2 cycles of chemotherapy ( P>0.05), but there was a statistically significant difference after 4 cycles of chemotherapy [(213.16±21.23) ms vs. (181.26±20.23) ms] ( P<0.05). After 6 cycles of chemotherapy, the LVEF, LV, LA, peak E, peak A, E/A, and DT in the chemotherapy group were (49.01±4.12)%, (56.68±4.32) mm, (43.64±4.02) mm, (78.36±12.20) cm/s, (90.96±12.61) cm/s, (0.76±0.21), and (256.23±32.14) ms, with statistically significant differences compared with those in the control group (all P<0.05). There were no statistically significant differences in the e' and E/e' between the chemotherapy group and the control group after 2 cycles of chemotherapy (both P>0.05). In the chemotherapy group, the e' was (8.22±1.27) cm/s and the E/e' was (18.17±3.12) after 4 cycles of chemotherapy, the e' was (4.29±2.17) cm/s and the E/e' was (20.17±4.06) after 6 cycles of chemotherapy, with statistically significant differences compared with those in the control group (all P<0.05). There were statistically significant differences in the LVGRS, LVGCS, LVGLS, and LVPtw between the chemotherapy group and the control group after 2, 4, and 6 cycles of chemotherapy (all P<0.05). Conclusion Chemotherapy with anthracycline for tumor patients can lead to cardiotoxicity, and RT-2DE combined with TDI and 2D-STI can detect the cardiotoxicity caused by chemotherapy earlier and more sensitively, which is of great significance for guiding clinical practice. Reference | Related Articles | Metrics

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Correlations between changes of serum related cytokines and clinical stage in patients with primary glaucoma Wang Yali International Medicine and Health Guidance News    2022, 28 (6): 850-854.   DOI: 10.3760/cma.j.issn.1007-1245.2022.06.029 Abstract （921）            Knowledge map    Save Objective To analyze the correlations between changes of serum related cytokines and clinical stage in patients with primary glaucoma. Methods A total of 85 patients with primary glaucoma treated in Zhengzhou Second People's Hospital from July 2019 to March 2021 were selected as a study group [40 males and 45 females, aged (56.67±2.12) years], and 50 healthy subjects who underwent physical examination in the hospital during the same period were selected as a control group [23 males and 27 females, aged (57.17±2.33) years]. The levels of interleukin-4 (IL-4), IL-6, and IL-12 were compared between the two groups. According to the clinical symptoms and visual field examination results, the patients in the study group were divided into a mild stage group (29 cases), a moderate stage group (33 cases), and a severe stage group (23 cases). The levels of IL-4, IL-6, and IL-12 in patients with mild stage, moderate stage, and severe stage were compared and analyzed. Logistic regression analysis was used to explore the correlations between the levels of IL-4, IL-6, and IL-12 and the clinical stage in patients with primary glaucoma, and Pearson correlation analysis was used to analyze the correlations between the changes of serum related cytokines and the clinical stage in patients with primary glaucoma. Independent sample t test was used for comparison of the measurement data between two groups, F test was used for comparison of the measurement data among multiple groups, and χ 2 test was used for the count data. Results The level of IL-4 in the study group was (236.89±45.36) pg/ml, which was significantly higher than that in the control group [(191.65±50.34) pg/ml], and the levels of IL-6 and IL-12 were (35.42±28.46) pg/ml and (96.94±51.23) pg/ml, respectively, which were significantly lower than those in the control group [(61.18±30.21) pg/ml and (130.21±56.55) pg/ml], with statistically significant differences (all P<0.05). There were no statistically significant differences in the gender, age, blood pressure, and blood glucose among patients with mild stage, moderate stage, and severe stage (all P>0.05); the intraocular pressure (IOP) in the three groups became higher and higher from mild to severe stage, with a statistically significant difference among the three groups ( P<0.05). The serum levels of IL-6 and IL-12 in the three groups decreased significantly from mild to severe stage, and the levels of IL-6 and IL-12 in patients with severe stage were significantly lower than those in patients with mild stage (both P<0.05); the serum level of IL-4 in the three groups increased gradually from mild to severe stage, but there was no statistically significant difference among the three groups ( P>0.05). Logistic regression analysis showed that IL-6 and IL-12 levels were significantly correlated with the clinical stage of primary glaucoma (both P<0.05); Pearson analysis showed that the changes of serum IL-6 and IL-12 levels were negatively correlated with the clinical stage of primary glaucoma patients ( r=-0.450, -0.430). Conclusion The changes of serum related cytokines have a certain correlation with the clinical stage of primary glaucoma, which can be used to evaluate the severity of primary glaucoma and provide scientific basis for clinical treatment. Reference | Related Articles | Metrics

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Research progress of semaglutide in treatment of obesity Xing Guoqing, Yu Suguo International Medicine and Health Guidance News    2022, 28 (7): 898-901.   DOI: 10.3760/cma.j.issn.1007-1245.2022.07.003 Abstract （900）            Knowledge map    Save Obesity has become a serious public health crisis in the whole world, and its incidence is increasing. Obesity and a series of concurrent diseases bring huge burden to the health care system. How to lose weight more effectively has become a hot spot in today's society, and it is difficult to control body weight only by life intervention. Therefore, anti-obesity drugs as an auxiliary means have received widespread attention, but relatively few drugs have been approved for weight loss. Semaglutide, a new glucagon-like peptide-1 receptor agonist (GLP-1RA), has the advantages of long half-life and high stability as compared with traditional GLP-1RA. This article focuses on the research progress of semaglutide in the treatment of obesity, which provides a new choice for reducing obesity. Reference | Related Articles | Metrics

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Application of video electroencephalogram combined with peripheral blood inflammation indexes in the diagnosis of brain injury in premature infants Deng Shiyue, Lyu Xiang, Jiang Lijun International Medicine and Health Guidance News    2022, 28 (6): 832-836.   DOI: 10.3760/cma.j.issn.1007-1245.2022.06.025 Abstract （888）            Knowledge map    Save Objective To investigate the value of video electroencephalogram (VEEG) combined with peripheral blood inflammation indicators [total number of white blood cells (WBC), hypersensitive C-reactive protein (hs-CRP), and procalcitonin (PCT)] in the diagnosis of brain injury in premature infants, and to provide new clinical ideas for the evaluation of brain injury and its short-term prognosis in premature infants. Methods The premature infants who were admitted to Affiliated Hospital of Yangzhou University from October 2020 to July 2021 and premature infants who were born in the obstetric department of other hospitals in the city with high risk factors of brain injury and transferred to neonatal intensive care unit of Affiliated Hospital of Yangzhou University within 24 hours were selected. According to the results of head magnetic resonance imaging (MRI) at 40 weeks of corrected gestational age, the premature infants were divided into a brain injury group and a non-brain injury group, with 28 cases in each group. In the brain injury group, there were 16 males and 12 females, with a gestational age of (32.83±2.09) weeks; there were 13 males and 15 females in the non-brain injury group, with a gestational age of (32.79±2.14) weeks. All preterm infants were examined by bedside VEEG within 1 week after birth and 2 ml of venous blood was collected on the 1st, 3rd, and 7th day after birth to detect the levels of WBC, hs-CRP, and PCT. The sensitivity and specificity of VEEG in the diagnosis of brain injury in premature infants were analyzed by four-grid table of diagnostic test, and the differences of WBC, hs-CRP, and PCT levels between the two groups at different time points were analyzed by ANOVA for repeated measurement. Results The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and accuracy of VEEG in the diagnosis of brain injury in premature infants were 78.6% (22/28), 82.1% (23/28), 81.5% (22/27), 79.3% (23/29), 4.4, 3.8, and 80.4% respectively, and the Kappa value was 0.607. On the 1st day after birth, there was no statistically significant difference in the hs-CRP level between the two groups ( P>0.05), the WBC and PCT levels in the brain injury group were higher than those in the non-brain injury group (both P<0.05). On the 3rd day after birth, the WBC, hs-CRP, and PCT levels in the brain injury group were higher than those in the non-brain injury group (all P<0.05). On the 7th day after birth, there were no statistically significant differences in the WBC and PCT levels between the two groups (both P>0.05), while the hs-CRP level was higher in the brain injury group ( P<0.05). Conclusions VEEG can be used as a reliable basis for the early diagnosis of brain injury in premature infants. The simultaneous increase of WBC, hs-CRP, and PCT levels on the 3rd day after birth often indicates the risk of brain injury in premature infants. Reference | Related Articles | Metrics

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Prevalence and treatment of amblyopia among primary and secondary school students in urban Chayu County, Tibet Yao Na, Chen Dongcui, Cai Yue, Xie Liqiong, Chen Linxing, Liu Bin International Medicine and Health Guidance News    2022, 28 (14): 2015-2017.   DOI: 10.3760/cma.j.issn.1007-1245.2022.14.020 Abstract （885）            Knowledge map    Save Objective To investigate the prevalence and risk factors of amblyopia among primary and secondary school students in urban Chayu County, Nyingchi City, Tibet Autonomous Region. Methods A cross-sectional study was conducted. In May 2018, eye and vision screening were carried out for primary and secondary school students in urban Chayu County, including visual acuity and refraction, anterior segment examination, fundus examination, eye position examination, etc. Cycloplegia was performed for those whose visual acuity was less than 6 /12. A questionnaire survey was carried out for students diagnosed with amblyopia and the causes were analyzed. Paired t test was used for the measurement data. Logistic regression analysis was used to analyze the relationship between age and gender and prevalence of amblyopia. Results A total of 1 795 students from primary and secondary schools participated in the survey, including 888 males and 907 females. Among them, 77 cases were diagnosed with amblyopia, with a prevalence rate of 4.3%. There were no statistically significant differences in the prevalence rate among different age and genders (both P>0.05). The main causes of amblyopia among the primary and secondary school students were anisometropia in 15 cases (19.5%), ametropia in 60 cases (77.9%), and strabismus in 2 cases (2.6%). Conclusions Ametropic amblyopia and anisometropic amblyopia are the main causes of amblyopia among primary and secondary school students in urban Chayu county. Wearing clinically prescribed glasses in time helps to reduce the prevalence of amblyopia. Reference | Related Articles | Metrics

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Normative application of nursing information system in the management of patients and their families entering and leaving the ward Ren Qiuhua, Gao Qiaoyan, Cong Bo International Medicine and Health Guidance News    2022, 28 (14): 1977-1981.   DOI: 10.3760/cma.j.issn.1007-1245.2022.14.012 Abstract （884）            Knowledge map    Save Objective To explore the normative application and effect of nursing information system in the management of patients and their families entering and leaving the ward. Methods From January 2020 to December 2021, 3 492 patients admitted to the department of medical oncology in Weihai Central Hospital were selected as the research subjects for a prospective study. Among them, 1 668 patients from January to December 2020 received routine management of patients and their families entering and leaving the ward, as a control group; 1 824 patients from January to December 2021 received management of patients and their families entering and leaving the ward based on the mobile nursing information system, as an observation group. The control group included 936 males and 732 females, aged (68.43±2.49) years; the observation group included 1 008 males and 816 females, aged (68.58±2.55) years. Before and after management of entering and leaving the ward based on the mobile nursing information system, the standard management rate of entering and leaving the ward, nursing work efficiency, daily visits, per capita time out of ward, patient satisfaction, and nurse job satisfaction were statistically analyzed. Independent sample t test was used for the measurement data and χ 2 test was used for the count data. Results The standard management rate of one patient and one companion entering and leaving the ward in the observation group was 98.85% (3 606/3 648), which was higher than that in the control group [96.04% (3 204/3 336)], with a statistically significant difference ( χ 2=56.457, P<0.001). In the observation group, the time consuming of temperature monitoring, ultraviolet disinfection, and recording the time of patients and their families in and out of the ward were (24.25±1.17) s, (7.25±0.79) s, and (61.47±3.63) s, respectively, which were shorter than those in with control group [(50.36±10.24) s, (19.36±2.14) s, and (83.45±8.40) s], with statistically significant differences ( t=108.130, 225.467, and 101.839; all P<0.001). The daily visits, per capita time out of ward in the observation group were (103.25±8.03) person/d and (30.21±3.20) min, respectively, which were lower than those in the control group [(140.24±11.26) person/d and (43.53±6.37) min], with statistically significant differences ( t=159.056 and 111.809; both P<0.001). The patient satisfaction in the observation group was 98.03% (1 788/1 824), which was higher than that in the control group [94.60% (1 578/1 668)], with a statistically significant difference ( χ 2=29.334, P<0.001). The nurse job satisfaction in the observation group was (143.17±2.48) points, which was higher than that in the control group [(130.79±2.91) points], with a statistically significant difference ( t=9.714, P<0.001). Conclusions The management of patients and their families entering and leaving the ward based on the mobile nursing information system can improve the efficiency of nursing work, and effectively improve the standard rate of ward management, reduce the daily number of people entering and leaving the ward, and shorten the per capita time out of ward. The satisfactions of both nurses and patients are improved, and the quality of nursing service is improved. Reference | Related Articles | Metrics

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Study on the effect of combined application of pain and psychological care on patients with advanced cancer pain Tang Zhenzhen, Wang Manman, Li Yanwei International Medicine and Health Guidance News    2022, 28 (2): 185-189.   DOI: 10.3760/cma.j.issn.1007-1245.2022.02.009 Abstract （850）            Knowledge map    Save Objective To explore the effect of combined application of pain and psychological care on patients with advanced cancer pain. Methods A total of 80 patients with advanced cancer pain admitted to Affiliated Cancer Hospital of Zhengzhou University from March 2019 to March 2020 were selected. By the simple randomization, they were divided into a control group and an observation group with 40 cases in each group. In the control group, the ratio of male: female was 19:21, aged (59.22±7.36) years, including 9 cases of lung cancer, 13 cases of colon cancer, 12 cases of gastric cancer, and 6 cases of others. In the observation group, the ratio of male: female was 18: 22, aged (58.37±7.24) years, including 8 cases of lung cancer, 11 cases of colon cancer, 14 cases of gastric cancer, and 7 cases of others. The control group received psychological care, and the observation group received standardized pain nursing and psychological care. The nursing effects of the two groups were compared, including pain degree [Visual Analogue Scale (VAS)], negative moods [Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS)], sleep quality [Pittsburgh Sleep Quality Index (PSQI)], and quality of life [Functional Assessment of Cancer Therapy-Generic Scale (FACT-G)]. Independent sample t test was used for inter-group comparison of measurement data, paired t test was used for intra-group comparison of measurement data, and χ2 test was used for count data. Results After nursing, the VAS score in both groups decreased compared with those before nursing (both P<0.05), and the VAS score of the observation group [(1.87±0.21) points] was lower than that of the control group [(2.15±0.27) points] (P<0.05). After nursing, the SDS and SAS scores of the two groups decreased compared with those before nursing (all P<0.05), and the SDS and SAS scores of the observation group [(46.64± 4.19) and (42.38±4.05) points] were lower than those of the control group [(49.42±5.90) and (45.71±4.96) points] (both P<0.05). After nursing, the scores of sleep latency, sleep duration, sleep quality, sleep efficiency, daytime function, sleep disorder, and hypnotic drugs of PSQI in the observation group were (1.28±0.30), (1.39±0.33), (1.56±0.37), (1.41±0.27), (1.31±0.26), (1.44± 0.31), and (1.38±0.34) points, which were significantly lower than those in the control group [(1.51± 0.32), (1.58±0.36), (1.77±0.41), (1.66±0.35), (1.49±0.29), (1.68±0.39), and (1.65±0.41) points] (all P<0.05). After nursing, the scores of social/family status, physiological status, emotional status, and functional status of FACT-G in both groups increased compared with those before nursing (all P< 0.05), and the scores of the observation group were (25.08±6.21), (24.11±6.34), (22.67±6.18), and (24.18±6.19) points, which were higher than those in the control group [(21.74±5.63), (20.27±4.98), (19.81±5.32), and (20.51±5.52) points] (all P<0.05). Conclusion For patients with advanced cancer pain, standardized pain nursing combined with psychological nursing intervention can significantly reduce patients' pain course and negative emotions, improve their quality of sleep and life, with a high application value. Reference | Related Articles | Metrics

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Investigation on the knowledge and skills about nosocomial infection prevention of support staff in medical institutions of Guangzhou Yang Li, Wang Yanfang, Tao Shu, Zeng Huazhi, Zi Qinglan, Lin Xiujuan, Gu Liping International Medicine and Health Guidance News    2021, 27 (6): 935-940.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.039 Abstract （841）      PDF （991KB）（405）       Knowledge map    Save Objective To investigate and analyze the status of training and implementation about nosocomial infection prevention knowledge and skills of support staff in medical institutions, so as to make effective measures to reduce the incidence of nosocomial infection. Methods Totally 497 support staff in medical institutions of Guangzhou were selected by convenient sampling and were investigated with the self-designed nosocomial infection prevention knowledge and skills questionnaire from April to May 2019 to assess their trained rate, mastering rate, carrying out rate of nosocomial infection prevention knowledge and skills, and adequate supplying rate of supporting facility. Results In the total of 497 support staff, there were 76.66% (381/497) older than forty, 85.11% (423/497) were female, 87.73% (436/497) had education degree equal to or below senior middle school, 48.09% (239/497) had working experience shorter than 5 years; 73.24% (364/497) had received standardized training, 37.02% (184/497) considered that the training by nurses was better; the cumulative person-time that didn't know well about hand hygiene, cleaning disinfection, medical waste classification, and pricking wound management were 11.86% (59/497), 31.79% (158/497), 11.67% (58/497), 4.42% (22/497); the cumulative person-time that didn't do well about hand hygiene, tool hygiene, medical waste classification, and work-clothes hygiene were 6.24% (31/497), 11.47% (57/497), 10.26% (51/497), 51.11% (254/497); the rates of persons that could not get convenient wash facilities, enough hand-disinfection solution, gloves were 14.28% (71/497), 9.06% (45/497), 14.49% (72/497); 95.5% (42/44) of recommendations were about more training. Conclusion The hospital support staff personnel structure need to be optimized, more systematic and standardized training about nosocomial infection prevention knowledge and skills should be provided, more convenient hygiene facilities and enough hygiene appliances in their working also should be provided. Reference | Related Articles | Metrics

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Relationship between midline structure deviation degree and prognosis in patients with massive cerebral infarction after surgery You Huichao, Sun Dengjiang, Ouyang Heping, Li Wenqi International Medicine and Health Guidance News    2022, 28 (15): 2108-2112.   DOI: 10.3760/cma.j.issn.1007-1245.2022.15.009 Abstract （838）            Knowledge map    Save Objective To analyze the relationship between midline deviation degree before surgery and the prognosis after decompression for massive cerebral infarction and provide clinical references. Methods A retrospective case-control study was conducted. According to the inclusion and exclusion criteria, the data of the patients with massive cerebral infarction treated at Hubei No.3 People's Hospital from October 2014 to October 2020 were collected to analyze the risk factors of death after decompressive craniectomy for massive cerebral infarction, and to study the relationship between the preoperative midline deviation degree and short-term death and long-term functional prognosis. SPSS 26.0 was used for the statistical analysis. t and χ 2 tests and Fisher's exact test were applied. The influencing factors of long-term Barthel index (BI) were analyzed. Multiple linear regression analysis was applied. Results A total of 77 patients with massive cerebral infarction who underwent standard decompressive craniectomy were collected, and 39 patients were included at last, including 27 males and 12 females who were 39-86 years old, with an average of 58.7. The patients with a preoperative linear structure deviation less than 10 mm had an increased risk of death after decompression as compared with the patients with a preoperative linear structure deviation ≥ 10 mm [odds ratio ( OR)=11.48, 95% confidence interval ( CI) 1.12-118.14]. The patients whose Glasgow Coma Scale (GCS) score ≤7 had an increased risk of death after decompression as compared with the patients whose GCS score >7 ( OR=13.12, 95% CI 1.41-122.43). Preoperative coma, GCS score, and the deviation degree of cerebral linear structure did not affect the long-term BI of the patients who survived after surgery. Age was one of the factors affecting the long-term prognosis of the survived patients after surgery. With the increase of age, the patients' BI decreased. Conclusions Preoperative cerebral linear structure deviation <10 mm and GCS score ≤7 points are the risk factors of death after decompression for massive cerebral infarction. The preoperative deviation degree of cerebral linear structure does not affect the long-term functional recovery of survived patients after decompression. Reference | Related Articles | Metrics

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Analysis of humanistic care needs and influencing factors of elderly patients with primary liver cancer undergoing interventional therapy Ma Weiwei International Medicine and Health Guidance News    2021, 27 (6): 901-904.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.030 Abstract （832）      PDF （1000KB）（476）       Knowledge map    Save Objective To observe the current situation of humanistic care needs of elderly patients with primary liver cancer undergoing interventional therapy, and to analyze the influencing factors. Methods Eighty-six elderly patients with primary liver cancer who received interventional therapy in our hospital from January 2018 to August 2019 were selected as the research objects. The self-made humanistic care demand questionnaire was used to investigate the current situation of humanistic care needs of all the selected patients. According to the survey results, the selected patients were divided into high humanistic care demand group and low humanistic care demand group. All patients were investigated with self-made baseline data questionnaire. The baseline data of patients with primary liver cancer were collected, and all factors that may affect the demand for humanistic care were included. The single factor and multi factor analysis were carried out to analyze the factors leading to the high demand for humanistic care in elderly patients with primary liver cancer undergoing interventional therapy. Results According to the survey, 23 cases (26.74%) had high demand for humanistic care. The results of single factor and multiple logistic regression analysis showed that women, more hospitalization times, children as the main caregivers, poor awareness of primary liver cancer knowledge, and poor family support function were all influencing factors of higher demand for humanistic care in patients with primary liver cancer (all OR>1, P<0.05). Conclusion Women, more hospitalization times, children as the main caregivers, poor awareness of primary liver cancer knowledge, and poor family support function may be the important factors leading to the increase of humanistic care needs of elderly patients with primary liver cancer during interventional treatment, and early intervention should be given. Reference | Related Articles | Metrics

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Comparative study on clinical symptoms and ultrasonic image features of benign and malignant non-mass-like breast lesions  Zhuang Shulian, Yang Shuang, Lai Danhui, Ye Siting, Lin Xian, Chen Miao, Zhang Jianxing International Medicine and Health Guidance News    2022, 28 (8): 1138-1142.   DOI: 10.3760/cma.j.issn.1007-1245.2022.08.024 Abstract （829）            Knowledge map    Save Objective To analyze the differences of clinical symptoms and ultrasonic image features between benign and malignant non-mass-like breast lesions and to investigate their diagnostic values. Methods A total of 229 non-mass-like breast lesions detected by ultrasound in 210 female patients aged (44.3±11.1) years were retrospectively analyzed in The Second Affiliated Hospital, Guangzhou University of Chinese Medicine from June 2017 to July 2019. The differences of clinical symptoms and ultrasonic image features were compared between the benign and malignant groups. The ultrasonic image features included size, orientation, cord-shaped hypoecho in the lesion, echo pattern, posterior features, calcification, associated features, and blood flow signal. Independent sample t test was used to compare the measurement data, and χ 2 test or Fisher's exact probability method was used to compare the count data. Results A total of 71 malignant lesions and 158 benign lesions were confirmed by surgery or biopsy. There were statistically significant differences in clinical symptoms, cord-shaped hypoecho in the lesion, echo pattern of lesions, calcification, associated features, and blood flow between the benign group and the malignant group (all P<0.05); in the benign group, the echo pattern of lesions was mainly type Ⅱa and Ⅴ, while in the malignant group, it was mainly type Ⅰb and Ⅱb; there were no statistically significant differences in the size, orientation, and posterior features (all P>0.05). Conclusion There are some differences in the clinical symptoms and ultrasonic image features between benign and malignant non-mass-like breast lesions, which may be helpful to the differential diagnosis for non-mass-like breast lesions. Reference | Related Articles | Metrics

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Clinical analysis of cotton absorption combined with budesonide suspension in type Ⅰ tympanoplasty Fei Yongguang, Cen Ruixiang International Medicine and Health Guidance News    2022, 28 (14): 1959-1964.   DOI: 10.3760/cma.j.issn.1007-1245.2022.14.008 Abstract （827）            Knowledge map    Save Objective To explore the difference in curative effects of cotton absorption combined with budesonide suspension in type Ⅰ tympanoplasty under dry and wet ear conditions. Methods A total of 66 patients with chronic suppurative otitis media at rest from Wuhan Xinzhou District People's Hospital and Huangshi Central Hospital from January 2018 to December 2020 were prospectively included. They were divided into four groups with the random number table method, including 17 cases in the dry ear observation group [11 males and 6 females, aged (36.23±7.39) years], 19 cases in the dry ear control group [12 males and 7 females, aged (37.28±7.29) years], 16 cases in the wet ear observation group [10 males and 6 females, aged (37.12±7.26) years], and 14 cases in the wet ear control group [9 males and 5 females, aged (37.75±7.17) years]. All patients underwent type Ⅰ tympanoplasty under otoendoscope, and the dry and wet ear observation groups were given cotton absorption combined with budesonide suspension to fix the tympanum and external auditory canal at the end of the operation. The preoperative eustachian function and levels of inflammatory factors [serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP)] and air-bone gaps before operation and 1 month and 3 months after operation in the four groups were counted and compared, and the dry ear rate, dry ear time, eardrum healing rate, and hearing improvement rate 6 months after operation were counted. t test or ANOVA was used for the measurement data, and Chi-square test or Fisher's exact probability method was used for the count data. Results There was no statistically significant difference in the preoperative eustachian function among the four groups before operation ( P>0.05). The serum levels of IL-6, TNF-α, and hs-CRP in the four groups 1 month and 3 months after operation were higher than those before operation, and the air-bone gap was lower than that before operation; the serum levels of IL-6, TNF-α, and hs-CRP and air-bone gap 3 months after operation were lower than those 1 month after operation; 1 month and 3 months after operation, the serum levels of IL-6, TNF-α, and hs-CRP and air-bone gaps in the dry ear observation group and wet ear observation group were lower than those in the other two groups, with statistically significant differences (all P<0.05). Six months after operation, the dry ear rate was 16/17 (94.12%) in the dry ear observation group, 17/19 (89.47%) in the dry ear control group, 15/16 (93.75%) in the wet ear observation group, and 13/14 (92.86%) in the wet ear control group, without statistically significant difference among the four groups ( P=1.000). The postoperative dry ear duration was (9.24±3.26) weeks in the dry ear observation group, (13.37±3.75) weeks in the dry ear control group, (9.11±3.17) weeks in the wet ear observation group, and (14.21±3.65) weeks in the wet ear control group; the postoperative dry ear durations in the dry ear observation group and wet ear observation group were shorter than those in the other two groups, with statistically significant differences (all P<0.05). Six months after operation, the healing rate of eardrum was 17/17 (100.00%) in the dry ear observation group, 18/19 (94.73%) in the dry ear control group, 15/16 (93.75%) in the wet ear observation group, and 14/14 (100.00%) in the wet ear control group, without statistically significant difference among the four groups ( P=0.849). Six months after operation, the hearing improvement rate was 12/17 (70.59%) in the dry ear observation group, 7/19 (36.84%) in the dry ear control group, 13/16 (81.25%) in the wet ear observation group, and 6/14 (42.86%) in the wet ear control group; the hearing improvement rates in the dry ear observation group and the wet ear observation group were better than those in the other two groups, with a statistically significant difference ( P<0.05). Conclusions For chronic suppurative otitis media at rest without ossicular chain lesions, there is no significant difference in the eardrum healing rate or dry ear rate of type Ⅰ tympanoplasty under otoendoscope under dry and wet ear conditions. The application of cotton absorption combined with budesonide suspension can speed up the improvement of inflammatory factors in the patients' body, shorten the dry ear time, and improve the degree of hearing improvement. Reference | Related Articles | Metrics

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Correlation between alcoholic osteoporosis and alcoholic liver disease Wei Haitao, Liu Rui, Xun Wei, Wang Min, Liu Zhongyang, Zhang Wenlong, Wang Jing International Medicine and Health Guidance News    2022, 28 (15): 2113-2117.   DOI: 10.3760/cma.j.issn.1007-1245.2022.15.010 Abstract （816）            Knowledge map    Save Objective To investigate the relationship between alcoholic osteoporosis and alcoholic liver disease and the pathogenesis. Methods One hundred and twenty-two patients who had been drinking for over 5 years and who were treated at First Hospital and Second Hospital of Baotao Medical College, Inner Mongolia University of Science and Technology were retrospectively studied, and they were (40.0±14.6) years old. There were 82 males, who drank alcohol ≥ 40 g/d, and 40 females, who drank alcohol ≥ 20 g/d. The bone mineral density (BMD), liver function, osteocalcin, 25-hydroxyvitamin D [25(OH)D3], tumor necrosis factor α (TNF-α) were detected and liver color ultrasound examination was performed in all the patients. According to the BMD, liver function, and abdominal color ultrasound results, the patients were divided into an alcoholic osteoporosis group (35 cases), an alcoholic liver disease group (45 cases), and an alcoholic osteoporosis complicated with alcoholic liver disease group (42 cases). Forty-five healthy examinees of an age during the same period were selected as a healthy control group. SPSS 24.0 was used to analyze the data. t test was used for the measurement data. Results The levels of osteocalcin in the alcoholic osteoporosis group, the alcoholic liver disease group, and the alcoholic osteoporosis complicated with alcoholic liver disease group were (24.73±3.66) μg/L, (27.34±2.94) μg/L, and (17.44±3.09) μg/L, and the levels of 25(OH)D3 were (22.47±2.82) μg/L, (25.63±3.84) μg/L, and (16.87±4.33) μg/L, which were lower than those in the healthy control group [(32.65±3.27) μg/L and (30.21±4.22) μg/L], and the levels of osteocalcin and 25(OH)D3 in the alcoholic osteoporosis complicated with alcoholic liver disease group were lower than those in the alcoholic osteoporosis group and the alcoholic liver disease group, with statistical differences (all P<0.05). The levels of osteocalcin and 25(OH)D3 in the alcoholic osteoporosis group were lower than those in the alcoholic liver disease group, but with no statistical differences (both P>0.05). The levels of TNF-α in the alcoholic osteoporosis group, the alcoholic liver disease group, and the alcoholic osteoporosis complicated with alcoholic liver disease group were (10.33±3.41) pg/ml, (13.23±4.02) pg/ml, and (16.94±3.92) pg/ml, which were higher than that in the healthy control group [(5.54±2.39) pg/ml], and the level in the alcoholic osteoporosis complicated with alcoholic liver disease group was higher than those in the alcoholic osteoporosis group and the alcoholic liver disease group, and the level in the alcoholic osteoporosis group was higher than that in the alcoholic liver disease group, with statistical differences (all P<0.05). Conclusions We consider that alcoholic liver disease and alcoholic osteoporosis play a complementary role in the pathogenesis. Osteocalcin, 25(OH)D3, and TNF-α may be the common pathogenesis, which is not only the initial factor of the disease, but also the results. Reference | Related Articles | Metrics

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Application value of B-type natriuretic peptide, D-dimer, and homocysteine in clinical diagnosis and risk classification of acute pulmonary embolism Liu Xiaoyi, Yang Wei, Chen Yongquan International Medicine and Health Guidance News    2021, 27 (6): 875-877.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.022 Abstract （797）      PDF （1072KB）（527）       Knowledge map    Save Objective To explore the application value of B-type natriuretic peptide (BNP), D-dimer (DD), and homocysteine (Hcy) in the clinical diagnosis and risk classification of acute pulmonary embolism (APE). Methods A total of 89 APE patients admitted to the intensive care unit (ICU) of our hospital and 30 healthy physical examination people from July 2018 to June 2020 were selected as the research objects. According to the severity of APE, the patients were divided into high-risk group (36 cases), medium-risk group (31 cases), low-risk group (22 cases). The levels of BNP, DD, and Hcy in the three groups were detected and analyzed. Results Through one-way analysis of variance, the levels of BNP, DD, and Hcy in different risk grade APE patient groups and healthy control group were not exactly the same (all P<0.001), the BNP and Hcy levels of the high-risk group, medium-risk group, and low-risk group were higher than those of the healthy control group (all P<0.05), and the DD levels of the high-risk group and the medium-risk group were higher than those of the low-risk group and the healthy control group (all P<0.05). ROC curve analysis showed that the areas under the curves (AUC) of BNP, DD, and Hcy were 0.762, 0.583, and 0.644, respectively. When BNP, DD, and Hcy took 153.62 μg/L, 1.13 μg/L, and 15.24 μmol/L, they achieved the maximum diagnostic efficiency, with the sensitivity and specificity of 88.7% and 82.4% for BNP, 72.5% and 79.3% for DD, and 63.6% and 90.8% for Hcy. Spearman correlation analysis showed that the levels of BNP, DD, and Hcy were positively correlated with the risk classification of APE patients ( r=0.736, 0.715, 0.628), with statistically significant differences (all P<0.05). Conclusion The levels of BNP, DD, and Hcy have important guiding significance in the clinical diagnosis and risk classification of APE. It is clinically recommended to perform these three tests at the same time for patients with suspected APE to obtain the best diagnostic accuracy. Reference | Related Articles | Metrics

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Salmonella infection and its drug resistance at a hospital in Xiamen from 2019 to 2021 Wu Wenhui, Chen Yongquan, Wu Jianning International Medicine and Health Guidance News    2022, 28 (13): 1872-1875.   DOI: 10.3760/cma.j.issn.1007-1245.2022.13.019 Abstract （796）            Knowledge map    Save Objective To analyze the epidemiological characteristics and drug resistance of Salmonella infection at a hospital in Xiamen. Methods Bacterial culture, identification, and drug susceptibility tests were performed on the stool samples of the 761 patients with suspected foodborne pathogen infection who visited Xiamen Humanity Hospital, Fujian Medical University from January 2019 to December 2021. There were 447 males and 314 females, and they were 0-95 years old.The patients were grouped according to gender, age, and sampling time. The detection results and drug resistance characteristics of Salmonella were cross-sectionally studied and analyzed. The χ 2 test was applied. Results According to VITEK-MS mass spectrometry analysis and serum agglutination test, a total of 69 cases of Salmonella infection were found in the 761 patients, with a total detection rate of 9.07% (69/761). The 69 strains of Salmonella were distributed in 6 serogroups and 16 serotypes, mainly group B and group D. Salmonella typhimurium and Salmonella enteritidis accounted for 42.03% (29/69) and 23.19% (16 /69), the highest. According to chi-square test, there was no statistical difference in the infection rate of Salmonella between the patients of different genders ( χ 2=0.142, P=0.706), and was between the patients of different age groups ( χ 2=65.005, P<0.001); the infection rate of the 0-18 years old group was significantly higher than that of the adults. There were certain differences in the infection rate of Salmonella between different months, showing a certain change trend with the month, and the infection rate was higher from May to October. The drug sensitivity results showed that the Salmonella had the highest resistance rates to ampicillin and ampicillin/sulbactam, 74.55% (41/55) and 61.82% (34/55); the resistance rate to compound sulfamethoxazole was 38.18% (21/55); it was not resistant to imipenem. Conclusions The serotypes of Salmonella infection in Xiamen City are complex, mainly Salmonella typhimurium and Salmonella enteritidis. Juvenile infection accounts for the main part, with obvious seasonal and regional characteristics, and summer and autumn are the high incidence seasons. Salmonella in this area have high resistance rates to ampicillin and ampicillin/sulbactam. Reference | Related Articles | Metrics

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Single hole laparoscopic radical resection for patients with colorectal cancer Li Feng, Xuan Jinfeng, Gong Chao, Li jiongxian International Medicine and Health Guidance News    2022, 28 (13): 1829-1833.   DOI: 10.3760/cma.j.issn.1007-1245.2022.13.011 Abstract （795）            Knowledge map    Save Objective To investigate the curative effects of single hole laparoscopic radical resection and traditional laparoscopic radical resection for colorectal cancer. Methods This was a random control trial. Sixty patients with colorectal cancer treated in Department of Gastrointestinal Surgery, Wuzhou Red Cross Hospital from January 2020 to December 2021 were randomly selected, and were divided into an observation group and a control group by lottery, with 30 cases in each group. There were 19 males and 11 females in the observation group, and they were (59.00±6.00) years old. There were 18 males and 12 females in the control group, and they were (59.00±7.00) years old. The observation group were treated with single hole laparoscopic radical resection of colorectal cancer, and the control group with traditional laparoscopic radical resection of colorectal cancer. The short-term curative effects, operation and postoperative conditions, pain degrees, inflammatory reaction, oxidative stress indicators, and incidences of complications were compared between these two groups. Independent-sample t test and χ 2 test were applied. Results The total effective rate of the observation group was significantly higher than that of the control group [96.67% (29/30) vs. 73.33% (22/30)], with a statistical difference ( χ 2=4.705, P=0.030). Compared with the control group, the observation group had less bleeding, less drainage on the 4th day after the operation, more lymph node dissection, shorter times for postoperative anal exhaust, early activity, and recovery of gastrointestinal function, shorter hospital stay, and lower pain degree, with statistical differences (all P<0.05). Before the operation, there were no statistical differences in the levels of inflammatory response and oxidative stress indicators between the two groups (all P>0.05). After the operation, the levels of C reaction protein, interleukin-6 (IL-6), and superoxide dismutase (SOD) were (13.57±5.34) mg/L, (16.28±5.64) ng/L, and (85.63±11.84) kU/L in the observation group, and were (26.84±5.12) mg/L, (33.54±7.50) ng/L, and (74.25±12.35) kU/L in the control group, with statistical differences between these two groups (all P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group [6.67% (2/30) vs. 30.00% (9/30)], with a statistical difference ( χ 2=5.454, P=0.019). Conclusion Compared with traditional laparoscopic radical resection of colorectal cancer, single hole laparoscopic radical resection of colorectal cancer has better curative effect and high safety, and can improve inflammatory reaction and oxidative stress reaction and reduce pain. Reference | Related Articles | Metrics

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The effect of hydrocortisone succinate combined with ademetionine on liver function and pregnancy outcomes of patients with intrahepatic cholestasis of pregnancy Feng Yunqian, Huo Yan, Wang Shuang International Medicine and Health Guidance News    2021, 27 (6): 799-801.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.003 Abstract （795）      PDF （1030KB）（496）       Knowledge map    Save Reference | Related Articles | Metrics

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Two cases of severe adverse reactions caused by somatostatin for injection Cui Hongxia, Zhao Zhanwei International Medicine and Health Guidance News    2022, 28 (9): 1305-1306.   DOI: 10.3760/cma.j.issn.1007-1245.2022.09.028 Abstract （785）            Knowledge map    Save Somatostatin for injection is widely used in clinic, and its common adverse reactions include sickness, vomiting, diarrhea, lip numbness, allergy, arrhythmia, and so on. In this paper, two cases of drug adverse reactions induced by somatostatin, myocardial ischemia and severe hypoglycemia, were reported, so as to provide references for clinical application. Reference | Related Articles | Metrics

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Effects of Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture method on TCM syndrome score of patients with posterior circulation ischemic vertigo (turbid phlegm disturbing orifices type) Feng Zhen International Medicine and Health Guidance News    2021, 27 (6): 878-880.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.023 Abstract （782）      PDF （1062KB）（667）       Knowledge map    Save Objective To investigate the effects of Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture method on TCM syndrome score of patients with posterior circulation ischemic vertigo (turbid phlegm disturbing orifices type). Methods From June 2017 to August 2019, 122 patients with posterior circulatory ischemic vertigo (turbid phlegm disturbing orifices type) were selected in our hospital. They were divided into observation group ( n=61) and control group ( n=61) according to simple randomization method. The control group was given betahistine hydrochloride sodium chloride injection, and the observation group was given Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture on the basis of the control group. The efficacy, TCM syndrome score, peak blood flow velocity (Vs) of the vertebrobasilar artery during systole, vasoactive substance [thromboxane B2 (TXB2), 6-keto-PGF1α] before and 2 weeks after treatment were compared between the two groups. Results The total effective rate of the observation group was 91.80% (56/61), higher than that of the control group [77.05% (47/61)], with statistically significant difference ( P<0.05). After 2 weeks of treatment, the TCM syndrome score of the observation group was lower than that of the control group, the Vs of the vertebrobasilar artery in the observation group was higher than that in the control group, with statistically significant differences (both P<0.05). After 2 weeks of treatment, the level of plasma 6-keto-PGF1α of the observation group was higher than that of the control group, the level of plasma TXB2 was lower than that of the control group, with statistically significant differences (both P<0.05). Conclusion Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture has a significant effect on posterior circulation ischemic vertigo (turbid phlegm disturbing orifices type), which can effectively improve the symptoms of patients and increase the blood flow velocity of the vertebrobasilar artery. Reference | Related Articles | Metrics

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Application of clinical pathway teaching method with "standardized medical order" as the core in obstetric clinical teaching Liu Rongxin, Bao Zhimin, Qu Shouhui, Yuan Xuelian, Li Sha International Medicine and Health Guidance News    2022, 28 (2): 189-192.   DOI: 10.3760/cma.j.issn.1007-1245.2022.02.010 Abstract （771）            Knowledge map    Save Objective To explore the application effect of clinical pathway teaching method with "standardized medical order" as the core in obstetric clinical teaching. Methods A total of 100 clinical obstetric interns in Zhengzhou First People's Hospital from November 2020 to April 2021 were selected, and were simply randomly divided into a traditional teaching group and an standardized medical order teaching group, with 50 interns in each group. There were 30 males and 20 females in the traditional teaching group, and there were 32 males and 18 females in the standardized medical order teaching group. The traditional teaching method was used in the traditional teaching group, and the clinical pathway teaching method with "standardized medical order" as the core was used in the standardized medical order teaching group. According to the unified arrangement of the hospital, the interns were trained for 8 weeks, and the interns were assessed according to the requirements of the syllabus. The scores of theoretical knowledge, case analysis ability, and skill operation of the two groups were compared, as well as their satisfaction on obstetric teaching. Independent sample t test was used for measurement data, and χ2 test was used for count data. Results The scores of theoretical knowledge, case analysis ability, and skill operation of the standardized medical order teaching group [(90.10±2.61) points, (91.34±3.60) points, and (91.50±3.18) points] were higher than those of the traditional teaching group [(87.26±4.33) points, (88.90±3.26) points, and (89.20±3.47) points], with statistically significant differences (all P<0.05). The satisfaction of the standardized medical order teaching group on obstetric teaching methods, teaching contents, teaching interaction, and self-improvement [88% (44/50), 92% (46/50), 96% (48/50), and 90% (45/50)] were higher than those of the traditional teaching group [70% (35/50), 76% (38/50), 76% (38/50), and 74% (37/50)], with statistically significant differences (all P<0.05). Conclusion The application of clinical pathway teaching method with "standardized medical order" as the core in obstetric clinical teaching can not only improve the interns' performance in all aspects, improve their satisfaction degree, which is worthy of promotion in clinical teaching. Reference | Related Articles | Metrics

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Randomized controlled study of Shaofu Zhuyu granule combined with ceftazidime in treatment of chronic pelvic inflammatory disease  Lin Shipeng, Chen Furong, Zheng Saimei International Medicine and Health Guidance News    2022, 28 (11): 1574-1578.   DOI: 10.3760/cma.j.issn.1007-1245.2022.11.022 Abstract （763）            Knowledge map    Save Objective To observe the effect of Shaofu Zhuyu granule combined with ceftazidime in the treatment of chronic pelvic inflammatory disease (CPID) and to provide references for the selection of a disease treatment scheme. Methods One hundred and twelve patients with CPID admitted to Maternal and Child Health Center of Haifeng County from June 2019 to June 2021 were selected for the prospective study. They were divided into a combined group and a reference group by the random number table method, with 56 cases in each group. The combined group was (38.58 ± 8.03) years old, with a disease course of (5.05±1.66) years. The reference group was (36.89 ± 7.34) years old, with a disease course of (4.67±1.72) years. The reference group was treated with ceftazidime, and the combined group with Shaofu Zhuyu granule and ceftazidime, for 2 weeks. The curative effects, adverse reactions, and recurrence rates 3 and 6 months after the treatment were compared between the two groups by the χ 2 test, and the pelvic mass diameters, pelvic effusion depths, and hemorheological indexes (high shear whole blood specific viscosity, plasma specific viscosity, low shear whole blood specific viscosity, and hematocrit) before and after the treatment by the paired t test and independent-sample t test. Results The total effective rate of the combined group was higher than that of the reference group [89.29% (50/56) vs. 71.43% (40/56); χ 2=5.657, P=0.017). There was no statistical difference in the total incidence of adverse reactions between the combined group and the reference group [12.50% (7/56) vs. 16.07% (9/56); χ 2=0.292, P=0.589]. After 2 weeks' treatment, the diameter of pelvic mass, depth of pelvic effusion, high shear whole blood specific viscosity, plasma specific viscosity, low shear whole blood specific viscosity, and hematocrit in the combined group were (1.06±0.38) cm, (1.42±0.48) cm, (2.86±0.49) mPa·s, (1.28±0.35) mPa·s, (6.41 ± 1.56) mPa·s, and (42.38 ± 3.45)%, which were lower than those in the reference group [(2.88±0.57) cm, (1.96±0.55) cm, (3.95±0.53) mPa·s, (1.77±0.38) mPa·s, (9.79±1.97) mPa·s, and (45.07±4.02)%] ( t=19.881, 5.536, 11.301, 7.098, 10.066, and 3.800; all P<0.001). Three and six months after the treatment, the recurrence rates in the combined group were lower than those in the reference group [1.82% (1/55) vs. 14.55% (8/55) and 7.41% (4/54) vs. 25.93% (14/54); χ 2=4.356 and 6.667, P=0.037 and 0.010]. Conclusion Shaofu Zhuyu granule combined with ceftazidime in the treatment of patients with CPID can improve hemorheology, promote the regression of pelvic mass and pelvic effusion, enhance curative effect, reduce recurrence, and obtain good safety. Reference | Related Articles | Metrics

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Efficacy of infrared physiotherapy combined with external application of Glauber's salt on postoperative gastrointestinal dysfunction after surgery for acute appendicitis Xu Ruihua International Medicine and Health Guidance News    2022, 28 (3): 429-434.   DOI: 10.3760/cma.j.issn.1007-1245.2022.03.032 Abstract （758）            Knowledge map    Save Objective To explore the efficacy of infrared physiotherapy combined with the external application of Glauber's salt on postoperative gastrointestinal dysfunction (PGD) after surgery for acute appendicitis. Methods One hundred and seventeen patients with PGD after surgery for acute appendicitis admitted to The People's Hospital of Linyi City from June 2020 to May 2021 were divided into a control group A, a control group B, and a study group by the random number table method, with 39 cases in each group. In the control group A, there were 23 males and 16 females, and they were (35.72±6.16) years old. In control group B, there were 26 males and 13 females, and they were (36.86±6.55) years old. There were 25 males and 14 females in the study group, and they were (37.37±6.73) years old. The control group A were treated with infrared physiotherapy, the control group B with the external application of Glauber's salt, and the study group with infrared physiotherapy and the external application of Glauber's salt. The curative effects, the recovery times of bowel sounds, the first postoperative exhaustion times, and the first postoperative defecation times, and the traditional Chinese medicine (TCM) syndrome scores and the levels of motilin (MTL) and gastrin (GAS) before and after treatment were compared between these 3 groups. The measurement data were compared between the groups by independent-sample t test, and the enumeration data by χ2 test. Results On day 1, 2, and 3 after the treatment, the TCM syndrome scores of the study group were lower than those of the control group A and the control group B, with statistical differences (all P<0.01). The total effective rate of the study group was higher than those of the control group A and the control group B [94.87% (37/39) vs. 76.92% (30/39) and 79.49% (31/39)], with statistical differences (both P<0.05). The recovery time of bowel sounds, the first postoperative exhaustion time, and the first postoperative defecation time in the study group were shorter than those in the control group A and the control group B [(20.37±5.70) h vs. (26.58±6.89) h vs. (27.60±7.25) h, (21.33±6.02) h vs. (27.18±6.75) h vs. (29.35±7.68) h, and (35.74±7.79) h vs. (44.33±8.84) h vs. (48.45±9.28) h], with statistical differences (all P<0.001). The levels of MTL and GAS on day 3 after the treatment in the study group were higher than those in the control group A and the control group B [(254.27±42.35) ng/L vs. (220.35±39.10) ng/L and(212.60±38.32) ng/L; (168.42±28.73) ng/L vs. (143.15±27.64) ng/L and (135.60±25.89) ng/L], with statistical differences (all P<0.05). Conclusions Infrared physiotherapy combined with the external application of Glauber's salt can better alleviate PGD-related symptoms in patients after surgery for acute appendicitis, accelerate gastrointestinal peristalsis, and shorten the recovery time of bowel sounds, the first postoperative exhaustion time, and the first postoperative defecation time. Reference | Related Articles | Metrics

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Application of Jinsang Sanjie capsules in patients with reflux pharyngitis Fan Xiaxia International Medicine and Health Guidance News    2022, 28 (8): 1154-1158.   DOI: 10.3760/cma.j.issn.1007-1245.2022.08.028 Abstract （755）            Knowledge map    Save Objective To explore the effect of Jinsang Sanjie capsules in patients with reflux pharyngitis. Methods A total of 94 patients with reflux pharyngitis in Qingyang Hospital of Traditional Chinese Medicine from August 2020 to July 2021 were selected for retrospective study. According to different treatment plans, they were divided into a control group and an observation group, with 47 cases in each group. There were 22 males and 25 females in the control group, aged (46.51±8.79) years; there were 19 males and 28 females in the observation group, aged (45.51±7.79) years. The control group was treated with rabeprazole and mosapride, and the observation group was additionally treated with Jinsang Sanjie capsules on the basis of the control group. The total effective rates, clinical symptom scores, serum inflammatory factors levels [interleukin-2 (IL-2), IL-8, and tumor necrosis factor-α (TNF-α)], plasma gastrointestinal hormones levels [vasoactive intestinal peptide (VIP), motilin (MTL), and gastrin (GAS)], and adverse reactions of the two groups were observed. The measurement data were tested by independent sample t test or paired t test and the count data by χ2 test. Results The total effective rate of the observation group was 95.74% (45/47), higher than that of the control group [82.98% (39/47)] (P<0.05). After treatment, the scores of cough, dysphagia, sticky throat, heartburn and acid reflux, and heating in the observation group were (0.51±0.14) points, (0.32±0.17) points, (0.31±0.12) points, (0.42±0.14) points, and (0.61±0.28) points, respectively, lower than those in the control group [(0.66±0.23) points, (0.41±0.22) points, (0.49±0.17) points, (0.71±0.29) points, and (0.81±0.31) points] (all P<0.05). After treatment, the levels of IL-8, TNF-α, and VIP in the observation group were (12.17±1.21) ng/L, (8.31±1.07) ng/L, and (16.88±2.19) ng/L, respectively, lower than those in the control group [(19.31±2.75) ng/L, (13.10±1.26) ng/L, and (20.86±2.31) ng/L], and the levels of IL-2, MTL, and GAS were (8.43±1.96) μg/L, (320.25±46.14) ng/L, and (162.96±23.15) ng/L, respectively, higher than those in the control group [(6.31±1.05) μg/L, (281.29±42.56) ng/L, and (133.57±18.46) ng/L] (all P<0.05). The rate of adverse reactions in the observation group was 4.26% (2/47), and there was no statistically significant difference compared with 8.51% (4/47) in the control group (P>0.05). Conclusion Jinsang Sanjie capsules combined with rabeprazole and mosapride has a significant effect in the treatment of reflux pharyngitis, which can effectively improve the patients' symptoms and reduce the levels of inflammatory factors. Reference | Related Articles | Metrics