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Effect of edaravone dexcamphenol injection with concentrated solution combined with butylphthalide on acute cerebral infarction Qian Xuanchen, Li Qingjie, Nie Er International Medicine and Health Guidance News    2023, 29 (13): 1813-1816.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.009 Abstract （374）            Knowledge map    Save Objective To investigate the effect of edaravone dexcamphenol injection with concentrated solution combined with butylphthalide in the treatment of acute cerebral infarction. Methods This was a retrospective study. A total of 76 cases of acute cerebral infarction in Affiliated Hospital of Xuzhou Medical University from January 2020 to October 2022 were selected and were divided into a conventional group and a treatment group according to different treatment methods with 38 cases in each group. In the conventional group, there were 20 males and 18 females; the age ranged from 39 to 81 years old, with a mean of (59.36±9.25) years old. In the treatment group, there were 21 males and 17 females; the age ranged from 38 to 80 years old, with a mean of (58.69±9.96) years old. The conventional group was treated with butylphthalide, and the treatment group was treated with edaravone dexcamphenol injection with concentrated solution combined with butylphthalide. The efficacy and neurological function indexes [National Institutes of Health Stroke Scale (NIHSS) score], Barthel indexes (BI), and Ability of Daily Living Scale (ADL) scores before treatment and 2 weeks after treatment were compared between the two groups. The statistical methods used were independent sample t test, paired t test, χ2 test, and rank sum test. Results The total effective rate of the treatment group was higher than that of the conventional group [94.74% (36/38) vs. 78.95% (30/38)], with a statistically significant difference (χ2=4.145, P=0.042). There was no statistically significant difference in the NIHSS score between the two groups before treatment (t=0.194, P=0.847). After 2 weeks of treatment, the NIHSS scores of both groups were decreased (both P<0.05), and the NIHSS score of the treatment group was lower than that of the conventional group [(12.37±3.12) points vs. (19.36±2.96) points, t=10.019, P<0.001]. Before treatment, there were no statistically significant differences in the BI and ADL scores between the two groups (t=0.233, P=0.817; t=0.337, P=0.737). After 2 weeks of treatment, the BI and ADL scores in both groups were higher than those before treatment (all P<0.05), the BI score [(22.98±3.58) points vs. (18.25±3.01) points, t=6.234, P<0.001] and ADL score [(84.21±8.92) points vs. (77.69±7.69) points, t=3.413, P=0.001] in the treatment group were higher than those in the conventional group. Conclusion In the treatment of patients with acute cerebral infarction, edaravone dexcamphenol injection with concentrated solution combined with butylphthalide can effectively improve the therapeutic effect, neurological function, and daily living ability, which is worthy of popularization and application. Reference | Related Articles | Metrics

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Retrospective analysis on false positive results in HIV screening by chemiluminescence microparticle immunoassay Wang Songzi, Wang Yichong, Li Liubing, Liang Jiaying, Deng Jiankai, Cui yingpeng International Medicine and Health Guidance News    2023, 29 (14): 1962-1966.   DOI: 10.3760/cma.j.issn.1007-1245.2023.14.009 Abstract （368）            Knowledge map    Save Objective To explore the factors causing the high false-positive rate in human immunodeficiency virus (HIV) detection by chemiluminescence microparticle immunoassay (CMIA). Methods The medical records of 295 patients positive in HIV detection by CMIA in First Hospital Affiliated to Sun Yat-sen University from January 2018 to December 2020 were retrospectively analyzed. The patients were (47.4±16.7) years old. There were 185 males who were (47.5±17.4) years old and 110 females who were (47.2±15.5) years old. According to the results of HIV confirmatory test, the patients were divided into a true positive group (101 cases) and a false positive group (194 cases). The correlations of false positive results with detection time, gender, age, and S/CO value were analyzed. The case data of 155 patients positive in HIV detection by CMIA were collected, and were divided into a true positive group (77 cases), a false positive group (78 cases), and a negative group (78 cases). The relations of false positive with the patients' diagnosis and other laboratory indicators were analyzed. SPSS 24.0 was used for the statistical analysis. The ratios were compared by χ2 test. Results The false positive rates in 2018, 2019, and 2020 were 47.6% (39/82), 67.3% (66/98), and 77.4% (89/115), respectively, indicating that the false positive rate of HIV screening by CMIA increased year by year. The false positive rate in the patients under 20 or over 70 years old was relatively higher (P<0.05). The false positive rate in the female patients was higher than that in the male patients [87.3% (96/110) vs. 53.0% (98/185)], with a statistical difference (P<0.05). The S/CO value of the most patients with false positives was low; the false positive rates of the patients with diseases of the circulatory system, digestive system, urinary system, and reproductive system were higher. Conclusion Age, gender, S/CO value, and complications of circulatory system and digestive system may cause a higher false positive rate. Reference | Related Articles | Metrics

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Effect of alprazolam on preoperative anxiety level and postoperative stress response in patients undergoing radical operation of lung cancer Zhao Xiaoyan, Shang Pingping International Medicine and Health Guidance News    2023, 29 (11): 1565-1568.   DOI: 10.3760/cma.j.issn.1007-1245.2023.11.019 Abstract （340）            Knowledge map    Save Objective To observe the effect of alprazolam in radical operation of lung cancer and its effects on preoperative anxiety and postoperative stress response. Methods This was a prospective randomized controlled trial. A total of 125 patients with lung cancer who received radical resection in The First Affiliated Hospital of Henan University from October 2020 to December 2022 were selected as the subjects, and were divided into two groups by the lottery method. In the control group, there were 42 males and 20 females, aged (60.44±5.36) years. In the observation group, there were 40 males and 23 females, aged (61.25±5.41) years. The control group only received routine intervention, and the observation group received alprazolam tablets assisted surgical treatment before surgery. The preoperative psychological state, preoperative and postoperative stresses, postoperative recovery, and occurrence of adverse drug reactions were compared between the two groups. Independent sample t test, χ2 test, and Fisher exact probability method were used for statistical analysis.  Results The scores of preoperative Self-rating Anxiety Scale (SAS) and state anxiety and trait anxiety of the State-Trait Anxiety Inventory (STAI) in the observation group were lower than those in the control group [(41.22±5.76) points vs. (44.49±5.33) points, (40.36±5.33) points vs. (44.46±5.49) points, (41.35±5.46) points vs. (45.11±5.47) points], with statistically significant differences (t=3.293, 4.237, and 3.846; all P<0.05). Before surgery, there were no statistically significant differences in the stress indexes between the two groups (all P>0.05). After surgery, the levels of norepinephrine (NE), cortisol (Cor), and prolactin (PRL) in the observation group were lower than those in the control group [(4.32±1.06) mg/kg vs. (5.77±1.36) mg/kg, (376.45±50.61) nmol/L vs. (405.33±50.12) nmol/L, (14.23±5.16) mmol/L vs. (17.44±5.28) mmol/L], with statistically significant differences (t=6.655, 3.205, and 3.438; all P<0.05). After surgery, the Visual Analog Scale (VAS) score [(4.11±1.24) points vs. (5.63±1.27) points], intrathoracic drainage volume within 24 after surgery [(88.45±10.47) ml vs. (93.11±10.36) ml], extubation time [(3.61±1.22) d vs. (4.77±1.48) d], and length of hospital stay [(6.64±1.23) d vs. (7.88±1.46) d] in the observation group were all lower than those in the control group, with statistically significant differences (t=6.771, 2.501, 4.785, and 5.174; all P<0.05). The incidence of drug-related adverse reactions in the observation group was slightly higher than that in the control group [6.35% (4/63) vs. 4.84% (3/62)], but the difference was not statistically significant (P>0.05). Conclusion Alprazolam assisted radical resection of lung cancer can reduce the patients' preoperative anxiety level and postoperative stress response, which is conducive to the patients' postoperative rehabilitation and does not increase the incidence of adverse reactions. Reference | Related Articles | Metrics

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Epidemiological and genotype study of hand-foot-and-mouth disease during and after the COVID-19 pandemic from 2022 to 2023 Xiao Xue, Liang Yuting, Gu Rui, Li Li, Chen Juan, Zhong Jiayu International Medicine and Health Guidance News    2023, 29 (23): 3525-3528.   DOI: 10.3760/cma.j.issn.1007-1245.2023.23.045 Abstract （328）            Knowledge map    Save Objective To study the epidemiology of hand-foot-and-mouth disease (HFMD) and the spectrum of genotypes in the other enteroviruses (EVs) [non- enterovirus 71 (EV71) and non- Coxsaekievirus group A 16 (CA16)] in Guangzhou and Foshan area during and after the COVID-19 pandemic from 2022 to 2023. Methods EV universal type, EV71, and CA16 were detected by real time fluorescent reverse transcription polymerase chain reaction (RT-PCR) respectively for suspected HFMD samples from 2022 to 2023. The positive specimens of non-EV71 and non-CA16 were amplified and sequenced based on 5′ UTR primers. The spectrum of genotypes was analyzed with BLAST in NCBI on the basis of 5'-UTR primers. Results A total of 362 suspected HFMD specimens were collected in 2022, 47 (12.98%) of which were positive by real time simultaneous three virus detections. Among which, the positive rates of EV71, CA16, and non-EV71 and non-CA16 were 0, 1.38% (5/362), and 11.60% (42/362), respectively. A total of 297 suspected HFMD specimens were collected in 2023, 100 (33.67%) of which were positive by simultaneous three virus detections. Among which, the positive rates of EV71, CA16, and non-EV71 and non-CA16 were 0, 2.36% (7/297), and 31.31% (93/297), respectively. Sequence analysis of 51 non-EV71 non-CA16 positive samples showed that there were 9 genotypes of non-EV71 non-CA16 EVs detected from 2022 to 2023, which were CA6, CA10, CA4, CA2, CA8, CB5 (Coxsaekievirus group B 5), CB2, CB3, and E30 (echovirus 30), among which, CA6 accounted for 27.45% (14/51), followed by CA10, accounting for 15.69% (8/51). Conclusions The EV infection rate after the COVID-19 pandemic in 2023 was higher than that in 2022 during the COVID-19 pandemic. The non-EV71 and non-CA16 EVs were the main causative agent of HFMD during 2022-2023. The sequence analysis showed that CA6 and CA10 were the most prevalent pathogens of non-EV71 and non-CA16 EVs, so, more attention should be paid to CA6 and CA10 of other type EVs. Reference | Related Articles | Metrics

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Clinical efficacy and safety of Dapagliflozin combined with sacubitril valsartan in the treatment of heart failure patients with reduced ejection fraction Chen Yuan, Zhao Ziming, Cui Liuyi, Ma Xiangyu, Shen Lei International Medicine and Health Guidance News    2024, 30 (2): 301-305.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.025 Abstract （278）            Knowledge map    Save Objective To investigate the clinical efficacy and safety of Dapagliflozin combined with sacubitril valsartan in the treatment of heart failure patients with reduced ejection fraction. Methods A total of 86 heart failure patients with reduced ejection fraction admitted to Zhengzhou Seventh People's Hospital from January 2020 to June 2021 were selected as the study objects and were divided into two groups according to the envelope randomization method. In the experimental group, the ratio of male to female was 26/17, and the age was (65.08±5.52) years old. In the control group, the ratio of male to female was 27/16, and the age was (65.21±5.37) years old. Forty-three patients in the control group were treated with sacubitril valsartan, and 43 patients in the experimental group were treated with Dapagliflozin on this basis, continuous oral administration for 3 months. The therapeutic effect, cardiac function, 6-min walking distance (6MWD), N-terminal brain natriuretic peptide precursor (NT-proBNP), and inflammatory factors were compared between the two groups. t test and χ2 test were used. Results After 3 months of administration, the total effective rate of the heart failure patients with reduced ejection fraction in the experimental group was higher than that in the control group [95.35% (41/43) vs. 79.07% (34/43)], with a statistically significant difference (P<0.05). After 3 months of administration, the levels of left ventricular end-diastolic inner diameter (LVIDd), NT-proBNP, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor α (TNF-α) in both groups were decreased compared with those before administration, and those in the experimental group were lower than those in the control group; the left ventricular ejection fraction (LVEF) and 6MWD levels in both groups were significantly increased compared with those before administration, and those in the experimental group were higher than those in the control group, with statistically significant differences (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the experimental group and the control group [13.95% (6/43) vs. 11.63% (5/43)] (P>0.05). Conclusion In the treatment of heart failure patients with reduced ejection fraction, Dapagliflozin combined with sacubitril valsartan has significant efficacy, which can reduce the inflammation, improve the cardiac function, increase the cardiac ejection fraction, and is safe and worthy of application. Reference | Related Articles | Metrics

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Comparison of the efficacies and safety of sodium acetate succinyl gelatin electrolyte injection and succinyl gelatin injection in perioperative period  Chen Hai, Deng Haibo, Zhang Xing, Wang Lingzhi, Yang Hanyu International Medicine and Health Guidance News    2023, 29 (17): 2452-2459.   DOI: 10.3760/cma.j.issn.1007-1245.2023.17.019 Abstract （259）            Knowledge map    Save Reference | Related Articles | Metrics

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Application of comprehensive nursing intervention in treatment of androgenetic alopecia with nano-microneedles Wan Changlan, Yu Yong, Yang Kunxia, Shen Xiuling, Wu Hui, Li Runxiang, Li Zhenjie International Medicine and Health Guidance News    2023, 29 (12): 1756-1759.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.029 Abstract （238）            Knowledge map    Save Objective To observe and analyze the therapeutic effect and the changes of anxiety and depression in patients with androgenetic alopecia treated with 5% topical minoxidil introduced by nano-microneedles after strengthening comprehensive nursing intervention. Methods Eighty male patients with androgenetic alopecia admitted to Outpatient Department of Zhongshan Fourth Road, Guangzhou Institute of Dermatology from September 2021 to October 2022 were selected and divided into a control group and an observation group by the random number table method, with 40 cases in each group. The control group were (36.96±8.80) years old, and the observation group (37.05±9.69). Both groups were treated with 5% topical minoxidil by nano-microneedles. The control group were given routine nursing intervention, and the observation group comprehensive nursing intervention. The clinical efficacies, densities and thicknesses of new hair, and anxiety and depression scores were compared between the two groups after the treatment. t and χ2 tests were applied. Results The total effective rate of the observation group was significantly higher than that of the control group [87.5% (35/40) vs. 67.5% (27/40)], with a statistical difference (χ2=4.59, P<0.05). After comprehensive nursing intervention, the number of hair in the control group was significantly higher than that in the observation group (221.35±25.16) pieces/cm2 vs. (204.37±28.12) pieces/cm2, with a statistical difference (t=2.84, P<0.05). After the intervention, the scores of Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) in the observation group were lower than those in the control group [(45.55±3.43) vs. (48.20±4.71) and (46.43±1.57) vs. (49.33±4.23)], with statistical differences (t=2.88 and 4.07; both P<0.05). Conclusions Comprehensive nursing intervention can effectively alleviate the anxiety and depression of patients with androgenetic alopecia treated with nano-microneedles, and improve the therapeutic effect. Reference | Related Articles | Metrics

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Nursing care for patients with electrical storm after cardiac surgery Liu Zhichang, Ling Yun, Lin Qiongyu, Zhu Sumin International Medicine and Health Guidance News    2023, 29 (13): 1896-1899.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.028 Abstract （232）            Knowledge map    Save Objective To summarize the nursing experiences for patients with electrical storm after cardiac surgery. Methods A total of 7 patients with electrical storm after cardiac surgery admitted to Guangdong Provincial People's Hospital from April 2020 to February 2022 were selected as the study objects, including 6 males and 1 female, aged (51.10±18.67) years. The nursing process for patients with electrical storm after cardiac surgery was retrospectively analyzed, including identification of electrical storm risk factors, hemodynamic monitoring and life support, paying close attention to electrolytes, nursing of antiarrhythmic drug use, moderate sedation and environmental management, skin care, psychological care, and extracorporeal membrane oxygen and supportive treatment to patients with difficult circulation stability. Results After active treatment and nursing, electrical storm was corrected in 5 patients; 1 patient was treated with extracorporeal membrane oxygenation and returned to sinus rhythm due to recurrent ventricular fibrillation; 1 patient died after rescue. Conclusions Electrical storm can occur at any time after cardiac surgery. Careful observation on rhythm changes, timely detection, active treatment, and effective nursing measures are the keys to stabilize the patients' illness. Reference | Related Articles | Metrics

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Effect of ginkgo biloba dropping pills combined with valsartan capsules in treatment of elderly patients with hypertension  Liu Ning, Zheng Xueyan, Dong Min, Sun Baolian International Medicine and Health Guidance News    2023, 29 (12): 1674-1677.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.011 Abstract （216）            Knowledge map    Save Objective To observe the effect of ginkgo biloba dropping pills combined with valsartan capsules in the treatment of elderly patients with hypertension. Methods A total of 116 elderly patients with hypertension admitted to Jinan Second People's Hospital from January 2020 to December 2021 were selected for the randomized controlled trial. The patients were divided into a combined treatment group and a basic treatment group by the random number table method, with 58 cases in each group. There were 38 males and 20 females in the basic treatment group; they were (70.23±3.51) years old. There were 39 males and 19 females in the combined treatment group; they were (70.92±3.67) years old. The basic treatment group were treated with ginkgo biloba dropping pills, and the combined treatment group with ginkgo biloba dropping pills and valsartan capsules. The blood pressures before and after the treatment, clinical efficacies, and incidences of adverse reactions during the treatment were compared between the two groups. t, Z, and χ2 tests were applied. Results The diastolic blood pressures and systolic blood pressures in the 2 groups were lower after than before the treatment (all P<0.05); after the treatment, the diastolic blood pressure and systolic blood pressure in the combined treatment group were lower than those in the basic treatment group (both P<0.05). The total effective rate of the combined treatment group was significantly higher than that of the basic treatment group [96.55% (56/58) vs. 72.41% (42/58); P<0.05]. There was no statistical difference in the incidence of adverse reactions during the treatment between the combined treatment group and the basic treatment group (P>0.05). Conclusion Ginkgo biloba dripping pills combined with valsartan capsules in the treatment of elderly patients with hypertension can effectively improve the clinical efficacy and reduce their diastolic and systolic blood pressures, and is safe, so it is worthy of promotion. Reference | Related Articles | Metrics

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Application of sacubitril/valsartan in patients with heart failure taking dialysis  Xi Zhefan, Yang Jia, Zou Haozhen, Dong Hua International Medicine and Health Guidance News    2023, 29 (18): 2522-2525.   DOI: 10.3760/cma.j.issn.1007-1245.2023.18.002 Abstract （205）            Knowledge map    Save Sacubitril/valsartan is an angiotensin receptor neprilysin inhibitor. It can inhibit the breakdown of endogenous natriuretic peptides and block angiotensin receptors, thereby reducing the activation of the renin-angiotensin-aldosterone system. It can also promote myocardial remodeling, inhibit myocardial fibrosis, increase the glomerular filtration rate, and delay the deterioration of renal function. Sacubitril/valsartan is beneficial to patients with chronic kidney disease by reducing cardiovascular risk and delaying the progression of chronic kidney disease. As a result, sacubitril/valsartan is one of the important drugs for heart failure, hypertension, and uremia. However, its long-term use may also cause some adverse reactions, especially kidney damage. There are few reports on the application of sacubitril/valsartan in patients with end-stage of renal disease and heart failure. The purpose of this study is to observe the application of sacubitril/valsartan in maintenance dialysis patients with heart failure, to investigate its safety, and to provide references for researches in relevant fields. Reference | Related Articles | Metrics

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Research progress on influencing factors and clinical treatment of adolescent scoliosis Wang Aiying, Ji Zhonglei, Chen Haipeng, Yang Qing, Yang Qi International Medicine and Health Guidance News    2023, 29 (22): 3176-3180.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.006 Abstract （202）            Knowledge map    Save The incidence of adolescent scoliosis is increasing year by year. It has adverse effects on adolescents' physiological and psychological growth. In this paper, the relationship between the time beginning to stand, body weight, amount of exercise, school bag, writing posture, and flat foot and the formation of scoliosis is described. According to the risk factors of scoliosis and adolescents' behaviors and developmental characteristics, regular screening and prevention strategies were implemented. The treatment plan is elaborated from the aspects of exercise therapy, respiratory training, suspension, massage, electrical stimulation, traction, braces, surgery, etc., so as to provide references and direction for the clinical treatment of scoliosis. Reference | Related Articles | Metrics

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Clinical study of dioscorea glue in the treatment of stable chronic obstructive pulmonary disease Liang Binghui, Jian Xiaoyun, Lin Zehui, Zou Peng, Jiang Rongbin, Li Jiachun, Wang Jingmin, Zhan Weijie International Medicine and Health Guidance News    2023, 29 (13): 1837-1840.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.014 Abstract （189）            Knowledge map    Save Objective To evaluate the clinical efficacy of dioscorea glue in the treatment of stable chronic obstructive pulmonary disease (COPD). Methods This was a prospective randomized controlled trial. From November 2020 to March 2022, a total of 120 patients with stable COPD and qi deficiency of lung and spleen in Department of Respiratory Medicine of Foshan Hospital of Traditional Chinese Medicine were divided into a treatment group (60 cases) and a control group (60 cases) by the random number table method. In the treatment group, there were 42 males and 18 females, aged (65.77±5.59) years. In the control group, there were 40 males and 20 females, aged (64.68±4.92) years. The control group was given conventional western medicine treatment, and the treatment group was given dioscorea glue on the basis of conventional western medicine treatment for 6 months. The changes of tumor necrosis faction-α (TNF-α), CD3+, CD4+, albumin (ALB), BODE index, and number of acute exacerbations before treatment and 3 and 6 months after treatment were observed in the two groups. t test and χ2 test were used. Results Three and six months after treatment, the TNF-α indexes [(5.89±1.14) ng/L and (5.55±1.21) ng/L] in the treatment group were lower than those in the control group [(6.79±1.11) ng/L and (6.66±1.19) ng/L], and the CD3+ [(56.61±5.49)% and (59.89±5.01)%] and CD4+ indexes [(34.56±4.49)% and (35.50±4.29)%] were higher than those in the control group [(53.64±5.68)%, (53.28±5.05)%, (30.82±4.20)%, and (30.79±4.20)%], with statistically significant differences (all P<0.05). Six months after treatment, the ALB index [(35.89±0.64) g/L] in the treatment group was higher than that in the control group [(29.14±0.64) g/L], and the BODE index [(1.63±0.95) points] and the number of acute exacerbations [(1.30±0.17) times] were lower than those of the control group [(2.18±1.12) points and (1.62±0.21) times], with statistically significant differences (all P<0.05). Conclusion Dioscorea glue combined with bronchodilator inhalant is effective in the treatment of stable COPD patients with qi deficiency of lung and spleen, which can eliminate the inflammation, regulate the immune function, improve the clinical symptoms and nutritional status, reduce the number of acute exacerbations, and improve the quality of life. Reference | Related Articles | Metrics

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Clinical effect of Miya cupping combined with conventional symptomatic treatment on children with exogenous fever Zhang Xiaochun, Chen Li, Zheng Shanzhen, Chen Feng, Wang Haiyan, Li Zhiya International Medicine and Health Guidance News    2023, 29 (19): 2697-2701.   DOI: 10.3760/cma.j.issn.1007-1245.2023.19.008 Abstract （183）            Knowledge map    Save Objective To investigate the clinical effect of Miya cupping combined with conventional symptomatic treatment in children with exogenous fever. Methods This study was a randomized controlled trial. A total of 208 children with exogenous fever admitted to the fever clinic of the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from September 2021 to June 2022 were selected, including 120 boys and 88 girls, aged 1.5-8.0 years. The children were divided into an experimental group and a control group using a simple random method, with 104 cases in each group. The control group adopted conventional symptomatic treatment, and the experimental group was given Miya cupping on the basis of conventional symptomatic treatment. The cooling efficacy and traditional Chinese Medicine (TCM) syndrome score of the two groups were compared. χ2 test, independent sample t test, paired t test, repeated measure ANOVA, and rank sum test were used. Results One case was withdrawn from each of the experimental group and the control group, and 103 cases were finally included in each group for analysis. Before treatment, the body temperatures of the two groups were higher than normal, and there were no statistically significant differences in the body temperature and TCM syndrome score between the two groups (all P>0.05). At 30 min, 1 h, 2 h, 4 h, and 6 h after treatment, the body temperatures of the experimental groups were (37.91±0.68) ℃, (37.64±0.58) ℃, (37.30±0.44) ℃, (36.97±0.32) ℃, and (36.89±0.30) ℃, respectively, those of the control group were (38.38±0.54) ℃, (38.15±0.45) ℃, (37.72±0.38) ℃, (37.39±0.28) ℃, and (37.20±0.23) ℃, respectively, and repeated measurement ANOVA showed that there was a statistically significant difference in the body temperature between the two groups (F=289.244, P<0.001). At 6 h after treatment, the effective rate of cooling was 99.0% (102/103) in the experimental group and 92.2% (95/103) in the control group, with a statistically significant difference between the two groups (χ2=5.693, P=0.017). The scores of fever, chills, red pharynx, nasal congestion, runny nose, cough, headache, and thirst in the experimental group were lower than those in the control group (all P<0.05). Conclusion Conventional symptomatic treatment combined with Miya cupping in the treatment of children with exogenous fever can effectively improve the clinical symptoms of fever, chills, red pharynx, nasal congestion, runny nose, cough, headache, and thirst, which has good efficacy and safety. Reference | Related Articles | Metrics

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Research progress of PI3K/AKT signaling pathway in cardiovascular disease Zhao Jiahao, Shang Xue, Zhu Hui, Li Xinxi, Xu Huipu International Medicine and Health Guidance News    2023, 29 (15): 2077-2080.   DOI: 10.3760/cma.j.issn.1007-1245.2023.15.002 Abstract （178）            Knowledge map    Save Cardiovascular disease refers to various lesions of the cardiovascular system, mainly including coronary heart disease, heart failure, hypertension, etc., and has become the first major death disease in China. The phosphatidyl inositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway is one of the important metabolic pathways and plays an important role in the cardiovascular system. This article reviews the research progress of PI3K/AKT signaling pathway in cardiovascular disease. Reference | Related Articles | Metrics

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Effect of fishbone diagram analysis combined with PDCA in improving the nurses' ability to prevent the pressure injury Jiang Qiaoxia, Li Liuying, Zuo Man, Zeng Xueling International Medicine and Health Guidance News    2023, 29 (11): 1595-1598.   DOI: 10.3760/cma.j.issn.1007-1245.2023.11.027 Abstract （175）            Knowledge map    Save Objective To explore the effect of fishbone diagram analysis combined with PDCA in improving the nurses' ability to prevent the pressure injury. Methods This study was a quasi-experimental study. A total of 31 nurses were selected as the research subjects from Heyuan Hospital of Guangdong Provincial People's Hospital in December 2021, with working life of 4-30 years, aged (31.32±7.27) years. Since January 2022, we analyzed the factors that affected nurses' pressure injury risk assessment ability by drawing a fishbone diagram. Then we carried out the PDCA activities: (1)defining the work responsibilities and assessment system of the members of the specialist team; (2)refining the workflow to enhance the high-risk assessment of pressure injury; (3)developing pictorial health education manual and video for pressure injury prevention. The scores of nurses' pressure injury related knowledge and the implementation rate of pressure injury prevention measures for high-risk patients were compared before the implementation (December 2021) and after the implementation (June 2022). Paired t test and χ2 test were used for statistical analysis. Results After the implementation of PDCA activities, the score of nurses' stress injury related knowledge examination was higher than that before the implementation [(87.27±15.53) points vs. (60.45±8.18) points], and the implementation rate of pressure injury prevention measures for high-risk patients was higher than that before the implementation [88.83% (152/172) vs. 77.69% (101/130)], with statistically significant differences (t=-8.74, P=0.02; χ2=6.21, P=0.01). Conclusion Fishbone diagram analysis and PDCA can improve the nurses' ability to prevent the pressure injury. Reference | Related Articles | Metrics

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Semaglutide combined with clomiphene for obese patients with polycystic ovary syndrome and insulin resistance Yang Qiaofen, Li Xingmei, Zhang Xuan International Medicine and Health Guidance News    2024, 30 (11): 1802-1807.   DOI: 10.3760/cma.j.issn.1007-1245.2024.11.009 Abstract （171）            Knowledge map    Save Objective To evaluate the effect of semaglutide combined with clomiphene for obese patients with polycystic ovary syndrome (PCOS) and insulin resistance. Methods A total of 102 obese patients with PCOS and insulin resistance who were treated at Yulin Hospital, First Hospital, Xi 'an Jiaotong University from January 2022 to December 2023 were selected for the randomized controlled trial. They were divided into a control group and a study group by the random number table method, with 51 cases in each group. The control group were (28.45±3.21) years old; their disease course was (5.36±0.76) years. The study group were (28.38±3.19) years old; their disease course was (5.41±0.77) years. The control group took clomiphene, and the study group clomiphene and semaglutide, for 12 weeks. The body mass indexes (BMI), glycemic and lipid metabolism indicators [homeostatic model assessment of beta-cell function (HOMA-β), homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides (TG), and total cholesterol (TC)], endometrial and ovulation conditions (endometrial thickness, cervical mucus score, and number of mature follicles), serological indicators [protein tyrosine phosphatase 1B (PTP1B), fibroblast growth factor 21 (FGF21), and insulin-like growth factor (IGF)], changes in intestinal floras (Enterococcus, Enterobacteriaceae, Bifidobacterium, and Lactobacillus), and adverse reactions (nausea and vomiting, hypoglycemia, fatigue, and dizziness and headache) were compared between the two groups. t and χ2 tests were used for the statistical analysis. Results After the treatment, the BMI and levels of HOMA-IR, TG, TC, and HOMA-β in the study group were better than those in the control group (t=2.433, 6.282, 3.749, 9.145, and 7.105; all P<0.05); the endometrial thickness, cervical mucus score, and number of mature follicles in the study group were higher than those in the control group (t=27.240, 10.097, and 6.883; all P<0.05); the levels of PTP1B, FGF21, and IGF in the study group were lower than those in the control group (t=4.558, 14.640, all 5.001; P<0.05); the numbers of Enterococcus and Enterobacteriaceae in the study group were lower than those in the control group [(7.01±0.33) vs. (7.98±0.39) and (7.24±0.47) vs. (7.85±0.51)], while the numbers of Bifidobacterium and Lactobacillus in the study group were higher than those in the control group [(9.88±0.71) vs. (9.13±0.67) and (9.89±0.36) vs. (9.73±0.34)] (t=13.559, 6.281, 5.487, and 2.308; all P<0.05). The incidence of adverse reactions in the study group was lower than that in the control group [3.92% (2/51) vs. 11.76% (6/51)], but the difference was not statistically significant (χ2=2.170, P=0.141). Conclusion Semaglutide combined with clomiphene for obese patients with PCOS can effectively reduce their BMI, improve their glucose and lipid metabolism indicators, promote the development of their uterine endometrium and ovulation, adjust their serological indicators, and improve the composition of intestinal floras. Reference | Related Articles | Metrics

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Effects of acetylcysteine combined with budesonide atomization on lung function and airway inflammation in patients with AECOPD Xin Yanan, Lyu Xin, Liang Fang, Li Wei, Yang Qiaofeng International Medicine and Health Guidance News    2023, 29 (24): 3556-3561.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.007 Abstract （161）            Knowledge map    Save Objective To study the effects of acetylcysteine combined with budesonide atomization on lung function and airway inflammation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 89 patients with AECOPD admitted to Liaocheng Third People's Hospital from February 2020 to February 2023 were selected and divided into an observation group (45 cases) and a control group (44 cases) by the envelope method. There were 24 males and 20 females in the control group; they were (58.69±3.64) years old. There were 25 males and 20 females in the observation group; they were (58.74±3.62) years old. The control group received conventional treatment; in addition, the observation group took acetylcysteine and budesonide atomization. The therapeutic effects, lung function [the forced expiratory volume in first second (FEV1), peak rate of expiration flow (PEF), forced vital capacity (FVC), and FEV1/FVC], blood gas indicators [oxygen partial pressure (PaO2), blood oxygen saturation (SpO2), and CO2 partial pressure (PaCO2)], serum levels of fetuin-A, retinol binding protein 4 (RBP4), and adiponection (APN), and incidences of adverse reactions were compared between the two groups. t and χ2 tests were applied. Results After the treatment, the total effective rate of the observation group was higher than that of the control group [97.78% (44/45) vs. 81.82% (36/44)], with a statistical difference (P<0.05). After the treatment, the FEV1, PEF, FVC, FEV1/FVC increased in both groups; those in the observation group were higher than those in the control group [(1.42±0.15)L vs. (1.26±0.13)L, (3.06±0.75)L/s vs. (2.60±0.78)L/s, (1.43±0.21)L vs. (1.26±0.19)L, and (64.52±3.64)% vs.(62.37±3.67)%; all P<0.05]. After the treatment, the PaO2 and SpO2 increased and PaCO2 decreased in both group, and those in the observation group were better than those in the control group (all P<0.05). After the treatment, the level of fetuin-A increased in both groups; the level in the observation group was higher than that in the control group [(408.54±40.83) mg/L vs. (390.44±37.39) mg/L; P<0.05]. After the treatment, the levels of RBP4 and APN of the two groups decreased; the levels in the observation group were lower than those in the control group [(54.63±14.24) mg/L vs. (61.43±14.63) mg/L and (8.44±2.07) μg/L vs. (9.45±2.16) μg/L; both P<0.05]. There was no statistical difference in the total incidence of rash, laryngeal irritation, nausea and vomiting, and headache between the two groups (P>0.05). Conclusion The combination of acetylcysteine and budesonide atomization for patients with AECOPD is effective, and can significantly improve their pulmonary function and blood gas indicators, and better control their airway inflammation. Reference | Related Articles | Metrics

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Effect applying remazolam in painless gastroenteroscopy in elderly patients Song Zhiyong, Zhang Xiaohua, Li Quan, Wang Zhao'an, Ren Gaoyan International Medicine and Health Guidance News    2023, 29 (24): 3625-3628.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.020 Abstract （155）            Knowledge map    Save Objective To investigate the effect of remazolam on cognitive function and hemodynamics in elderly patients undergoing painless gastroenteroscopy. Methods One hundred and two elderly patients undergoing painless gastroenteroscopy at Shouguang Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected for the randomized controlled trial, and were divided into an observation group and a routine group by the random number table method, with 51 cases in each group. There were 31 males and 20 females in the observation group; they were (9.63±6.25) years old. There were 20 males and 31 females in the routine group; they were (79.06±6.93) years old. The observation group took tsyloremazolam and afentanil for anesthesia, and the routine group took propofol and afentanil for anesthesia. The times to come to and times to leave the room, the scores of Mini-Mental State Examination before and 2 and 5 d after the operation, and the blood pressures and oxygen saturations before (T1) and 3 (T2), 6 (T3), and 9 min (T4) after administration were compared between the two groups. t and χ2 tests were applied. Results The time to come to and the time to leave the room in the observation group were shorter than those in the routine group [(7.25±1.15) min vs. (9.69±1.68) min and (28.74±4.25) min vs. (37.85±6.23) min], with statistical differences (t=14.195 and 7.852; both P<0.05). There were statistical differences in the scores of MMSE of group, time, and interaction between the two groups (Fbetween groups=17.358; Ftime=19.652; Finteraction=13.745; all P<0.05). The scores of MMSE 2 and 5 d after the operation in the observation group were higher than those in the routine group. The systolic and diastolic blood pressures and oxygen saturation at T2 in the observation group were higher than those in the routine group (Fbetween groups=9.580, 9.541, and 19.520; all P<0.05). The systolic and diastolic blood pressures and oxygen saturation at T3 and T4 were higher than those at T2 in the routine group (F时间=8.852, 9.580, and 8.520; all P<0.05). Conclusion Applying remazolam in painless gastroenteroscopy in elderly patients can shorten their time to come to, improve their cognitive function, and reduce the impact on their hemodynamics, which is worthy of clinical application. Reference | Related Articles | Metrics

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Research progress of platelets in liver cirrhosis Zhou Zhaonian, Zheng Weiqiang International Medicine and Health Guidance News    2023, 29 (12): 1640-1643.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.003 Abstract （155）            Knowledge map    Save Platelets, the main effector cells in hemostasis, undergo dynamic changes in their structure and function and are involved in complex pathophysiological processes through granule release, associated signaling receptors, and platelet aggregation and activation. Significant thrombocytopenia is present in patients with cirrhosis, and increasing evidences suggest that platelets play important roles in processes such as immune inflammation, host defense, angiogenesis, tissue repair, regeneration, etc. The potential role of platelets in cirrhosis is reviewed in the hope of improving the survival quality of patients with cirrhosis. Reference | Related Articles | Metrics

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Efficacy of daglipzin combined with insulin degludec and liraglutide injection in treatment of patients with diabetic nephropathy and poor blood glucose control Chen Ying, Duan Shuangli, Li Li International Medicine and Health Guidance News    2024, 30 (23): 4009-4014.   DOI: 10.3760/cma.j.issn.1007-1245.2024.23.026 Abstract （153）            Knowledge map    Save Objective To observe the effect of dagliprazin combined with insulin degludec and liraglutide injection in the treatment of patients with diabetic nephropathy (DN) and poor blood glucose control. Methods A total of 167 patients with DN and poor blood glucose control treated at Hanzhong Nanzheng District People's Hospital from February 2022 to February 2024 were selected for the randomized controlled trial, and were divided into a study group (83 cases) and a control group (84 cases) by the random number table method. There were 47 males and 36 females in the study group; they were (57.39±8.16) years old; their disease course was (12.51±2.23) years; there were 48 cases of DN stage Ⅱ and stage 35 cases of stageⅢ. There were 50 males and 34 females in the control group; they were (56.47±8.23) years old; their disease course was (12.36±2.19) years; there were 51 cases of DN stage Ⅱ and 33 cases of stage Ⅲ. The study group were treated with dagliprazin and insulin degludec and liraglutide injection, and the control group with dagaglizin and insulin glargine, for 3 months. The clinical efficacies, renal function, blood glucose, markers of renal injury, peripheral blood cytokines, and the incidence rates of adverse drug reactions were compared between the two groups by t and χ2 tests. Results Before the treatment, there were no statistical differences in the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) and urine albumin-to-creatinine ratio (UACR) between the two groups (all P>0.05). After the treatment, the levels of Scr and BUN and UACR in the study group were lower than those in the control group [(65.24±8.93) μmol/L vs. (76.12±10.43) μmol/L, (6.23±1.12) mmol/L vs. (8.04±1.41) mmol/L, and (92.32±14.26) mg/g vs. (106.21±18.35) mg/g], with statistical differences (all P<0.05). Before the treatment, there were no statistical differences in the levels of fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPBG), and glycosylated hemoglobin (HbA1c) between the two groups (all P>0.05). After the treatment, the levels of FBG, 2hPBG, and HbA1c in the study group were lower than those in the control group [(6.14±0.76) mmoL/L vs. (7.01±0.89) mmoL/L, (8.16±1.49) mmol/L vs. (9.32±1.73) mmol/L, and (5.21±0.59)% vs. (5.82±0.68)%], with statistical differences (all P<0.05). Before the treatment, there were no statistical differences in the levels of N-acetyl-β-D-glucosidase (NAG), retinol-binding protein (RBP), and neutrophil gelatinase-associated lipocalin (NGAL) between the two groups (all P>0.05). After the treatment, the levels of NAG, RBP, and NGAL in the study group were lower than those in the control group [(15.12±2.54) U/L vs. (18.84±3.01) U/L, (1.08±0.21) mg/L vs. (1.37±0.26) mg/L, and (51.26±8.13) μg/L vs. (62.13±10.28) μg/L], with statistical differences (all P<0.05). Before the treatment, there were no statistical differences in the levels of free fatty acid (FFA) and peroxisome surge activator receptor γ (PPARγ) between the two groups (both P>0.05). After the treatment, the levels of FFA and PPARγ in the study group were lower than those in the control group [(9.03±1.76) μg/L vs. (11.26±2.51) μg/L and (1 306.49±201.43) ng/L vs. (1 148.52±159.47) ng/L], with statistical differences (both P<0.05). The total effective rate of the study group was higher than that of the control group [85.54% (71/83) vs. 70.24% (59/84); P<0.05]. The incidence rates of adverse drug reactions in the study group and the control group were 6.02% (5/83) and 4.76% (4/84), respectively, with no statistical difference (P>0.05). Conclusion Dagliprazin combined with insulin degludec and liraglutide injection in the treatment of patients with DN and poor blood glucose control is effective, can improve their renal function, blood glucose, markers of kidney injury, and peripheral blood cytokines, and does not increase adverse drug reactions. Reference | Related Articles | Metrics

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Electromyographic biofeedback in treatment of patients suffering from hemiplegia during acute stage of cerebral infarction Lin Wenjun, Lin Xiaoting, Huang Gengbing, Lin Yuwei, Yu Zixi International Medicine and Health Guidance News    2023, 29 (24): 3649-3652.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.026 Abstract （152）            Knowledge map    Save Objective To explore the effect of electromyographic biofeedback in the treatment of patients suffering from hemiplegia during acute stage of cerebral infarction. Methods One hundred patients suffering from hemiplegia during acute stage of cerebral infarction treated at Jieyang People's Hospital from July 2021 to June 2023 were selected for the randomized controlled trial, and were divided into an observation group and a control group by the random number table method, with 50 cases in each group. At last, there were 47 cases in the observation group, including 26 males and 21 females who were (65.40±10.45) years old; there were 50 cases in the control group, including 29 males and 21 females who were (68.40±13.78) years old. Both groups routinely took neurological drugs and early rehabilitation; in addition, the observation group took electromyographic biofeedback treatment. The scores of Munual Muscle Testing (MMT), Brunnstrom's neurophysiological assessment, and Barthel index were compared between the two groups before and after the treatment. Wilcoxon non-parameter test was applied. Results The scores of MMT and Brunnstrom's neurophysiological assessment of the upper and lower limbs and Barthel index were higher after than before the treatment in both groups (all P<0.05); after the treatment, the scores of MMT of the lower limbs [3.00 (2.00, 4.00) vs. 2.00 (2.00, 3.00)], Brunnstrom's neurophysiological assessment [upper limbs: 2.00 (2.00, 3.00) vs. 2.00 (1.00, 2.00); lower limbs: 3.00 (2.00, 4.00) vs. 2.00 (2.00, 3.00)], and Barthel index [55.00 (50.00, 65.00) vs. 35.00 (15.00, 55.00)] in the observation group were better than those in the control group (all P<0.05). Conclusion Electromyographic biofeedback for patients suffering from hemiplegia during acute stage of cerebral infarction can promote their recovery of the hemiplegic limbs' function, so it is worth being clinically generalized. Reference | Related Articles | Metrics

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Review of near-infrared spectroscopy for sports injuries and functionality Zhang Hao, Cao Zhijie, Li Xuemei, Xu Gongcheng, Li Min, Qi Hongkai, Li Zengyong, Li Wei International Medicine and Health Guidance News    2024, 30 (2): 182-186.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.002 Abstract （149）            Knowledge map    Save With the rise of national sports, the occurrence of sports injuries increases year by year, and at the same time, with the improvement of people's economic life, more attention is paid to the rehabilitation after sports injuries. Most of the current sports injury rehabilitation treatments mainly focus on limb function rehabilitation, but the changes in the brain function after sports injuries have also begun to receive attention from the researchers. Functional near-infrared spectroscopy (fNIRS) can be better applied in the detection of brain function in patients with sports injuries due to its anti-interference and portability. This paper summarizes the research results of sports injury rehabilitation and fNIRS, discusses the current situation and research progress of sports injury rehabilitation, and analyzes fNIRS and its application value in the study of the neural control mechanism of injured limbs after sports injuries, which puts forward new ideas to further enhance the rehabilitation effect of sports injuries. Reference | Related Articles | Metrics

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Advances in the application of machine learning in hemodialysis treatment Zhou Hongming, Li Yunyi, Li Weilong, Song Zhuoheng, Chen Yu, Cao Rui, Hu Bo, Luan Shaodong, Yin Lianghong International Medicine and Health Guidance News    2023, 29 (13): 1777-1781.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.001 Abstract （148）            Knowledge map    Save Hemodialysis centers are mostly for patients with chronic kidney disease, and most patients choose hemodialysis for treatment. But hemodialysis also imposes a burden of expensive medical costs and adverse reactions on patients. With the development of machine learning, machine learning has shown satisfactory results in vascular access, complications, and prognosis of hemodialysis. Therefore, grasping machine learning and using this tool are beneficial to doctors and nurses in hemodialysis room, which can ultimately improve the quality of life in hemodialysis patients. Reference | Related Articles | Metrics

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Mechanism of radix trichosanthis in the treatment of lung cancer based on network pharmacology and molecular docking Cui Qidi, Sun Shanshan, Lu Mei, Huang Yanying, Lyu Wenwen International Medicine and Health Guidance News    2024, 30 (6): 881-889.   DOI: 10.3760/cma.j.issn.1007-1245.2024.06.001 Abstract （147）            Knowledge map    Save Objective To investigate the target and mechanism of radix trichosanthis in the treatment of lung cancer based on network pharmacology and molecular docking. Methods The search period was up to July 2022. The active ingredients of radix trichosanthis were selected using the TCMSP and TCMID databases combined with the PubChem database. The potential targets of active ingredients were obtained using the TCMSP, TCMID, and SwissTargetPrediction databases. The GeneCards, OMIM, TTD, and DrugBank databases were searched to collect the targets of lung cancer. The drugs were intersected with disease targets and a Venn diagram was drawn using the online web site Venny 2.1. The common target protein-protein interaction network was drawn using the String database. The "drug-active ingredient-disease-target" network diagram was constructed through Cytoscape 3.8.2 software. Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of common targets were performed using Metascape database. Molecular docking verification was performed using Autodock software. Results Through screening, 28 active ingredients and 201 action targets were obtained from radix trichosanthis. A total of 1 645 lung cancer targets were retrieved from the four major disease databases. There were 37 intersecting targets between the drug and disease. According to the Degree value, estrogen receptor 1 (ER1), signal transduction and transcriptional activator 3 (STAT3), and epidermal growth factor receptor (EGFR) were determined as the core targets. GO enrichment analysis found that radix trichosanthis might treat lung cancer by regulating gland development, cell proliferation, cell adhesion, receptors, enzymes, and activities of proteins. The KEGG pathway enrichment analysis revealed that radix trichosanthis might act on chemical oncogenic receptor activation, pathways in cancer, hypoxia-inducing factor 1 (HIF-1) signaling pathway, and microRNAs and proteoglycans in cancer. Molecular docking results showed that the binding activity of key small molecule compounds to the core target was significant. Conclusion Radix trichosanthis plays a role in the treatment of lung cancer through multi-target and multi-pathway mechanisms, laying a foundation for subsequent experiments and clinical applications. Reference | Related Articles | Metrics

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Meta-analysis of stellate ganglion block in treatment of migraine Yan Wanhong, Xue Jianjun, Jia Yu, Wang Shitai International Medicine and Health Guidance News    2023, 29 (12): 1629-1635.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.001 Abstract （146）            Knowledge map    Save Objective To systematically evaluate the clinical efficacy and safety of stellate ganglion block for migraine. Methods The PubMed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, China Science and Technology Journal Database, and WanFang Data were searched for randomized controlled trials on stellate ganglion block in the treatment of migraine from their establishment to September 2022. A risk of bias assessment tool recommended by the Cochrane Handbook was used to evaluate the inherent bias of the included studies. The data were statistically analyzed by the RevMan 5.4 software. Results In the final meta-analysis, 26 studies with a total of 2 074 patients were included. The results showed that the effective rate in treating migraine in the stellate ganglion block group was higher than that in the control group (RR=1.21, 95%CI 1.15-1.29, P<0.001). The duration of headache attacks (MD=-2.80, 95%CI -4.32-1.28, P<0.001) and the headache score of Visual Analogue Scale (MD=-1.02, 95%CI -1.35-0.68, P<0.001) after the treatment in the stellate ganglion block group were lower than those in the control group. There was no statistical difference in the incidence of adverse reactions between the two groups (RR=0.98, 95%CI 0.46-2.09, P=0.95). Conclusion The stellate ganglion block, an effective treatment for migraine, has obvious advantages in terms of reducing headache severity and improving headache duration, and does not increase its related adverse reactions. Reference | Related Articles | Metrics

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Research progress on new immunosuppressive agents in treatment of idiopathic membranous nephropathy Yang Jia, Xi Zhefan, Zou Haozhen, Xu Qiang, Dong Hua International Medicine and Health Guidance News    2023, 29 (18): 2517-2521.   DOI: 10.3760/cma.j.issn.1007-1245.2023.18.001 Abstract （145）            Knowledge map    Save Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in adults. Although conventional immunosuppressive drugs can improve the remission rate, there are serious adverse effects and some patients can progress to end-stage renal disease within a few years. This article mainly introduces the progress on new immunosuppressive agents in the treatment of idiopathic membranous nephropathy. Reference | Related Articles | Metrics

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Relationship between intestinal floras and metabolic diseases Fang Jianfeng International Medicine and Health Guidance News    2023, 29 (16): 2225-2229.   DOI: 10.3760/cma.j.issn.1007-1245.2023.16.002 Abstract （145）            Knowledge map    Save Metabolic diseases refer to the general name for metabolic disorders, including obesity, diabetes, non-alcoholic liver disease, etc. There are tens of billions of bacteria in human gut; their metabolites can interact with the human hosts and affect human health. The gut microbiotas are closely related to the human hosts' metabolic health; in abnormal situations, they may lead to a variety of common metabolic diseases, such as obesity, type 2 diabetes, non-alcoholic liver disease, cardio-pulmonary metabolic diseases, malnutrition, etc. In this review, we discuss the relationship of gut microbiotas with common metabolic diseases, the pathogenic mechanisms leading to these diseases, and the treatment and prevention methods of metabolic diseases from the perspectives of gut microbiotas, so as to provide new directions for the treatment of metabolic diseases. Reference | Related Articles | Metrics

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One case of epileptiform seizures caused by cefmetazole sodium for injection  Zhang Na, Gao Yue International Medicine and Health Guidance News    2023, 29 (16): 2319-2321.   DOI: 10.3760/cma.j.issn.1007-1245.2023.16.023 Abstract （144）            Knowledge map    Save Cefmetazole is a semi-synthetic antibiotic of cephalosporins, and is widely used in clinical practice. Its common adverse reactions mainly include glutamic oxaloacetic transaminase and glutamic-pyruvic transaminase elevation, rash, nausea, vomiting, allergic reaction, etc. This paper reports a patient with epileptic seizures during intravenous infusion of cefmetazole sodium at Songjiang District Central Hospital. According to the evaluation method of adverse drug reactions, the epileptic seizures in the patient might be caused by the use of cefmetazole sodium. Through the report of this case, we hope that the clinical staff pay attention to epileptic seizures possibly caused by cefmetazole and hope to provide clinical references. Reference | Related Articles | Metrics

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Tropisetron and esomeprazole in prevention and treatment of chemotherapy related gastrointestinal adverse reactions in patients with colorectal cancer Li Shanshan, Liang Bing, Liu Qiwei International Medicine and Health Guidance News    2023, 29 (18): 2592-2596.   DOI: 10.3760/cma.j.issn.1007-1245.2023.18.018 Abstract （144）            Knowledge map    Save Objective To explore the preventive and therapeutic effects of tropisetron versus esomeprazole for chemotherapy related gastrointestinal adverse reactions in patients with colorectal cancer. Methods One hundred and twenty-four patients with colorectal cancer taking chemotherapy at Nanyang First People's Hospital from January 2020 to January 2022 were selected for the randomized controlled trial. They were divided into groups A and B by lottery, with 62 cases in each group. There were 32 males and 30 females in group A; they were (55.25±5.37) years old. There were 31 males and 31 females in group B; they were (56.07±5.22) years old. Group A took tropisetron and chemotherapy, and group B esomeprazole and chemotherapy. Both groups were followed up for one year. The incidence of gastrointestinal adverse reactions during chemotherapy, the scores of Index of Nausea, Vomiting, and Retching (INVR) on day 1, 7 and 14 of chemotherapy and after one chemotherapy cycle, and the long-term quality of life were compared between the two groups. χ2 and t tests were applied. Results After the treatment with different drugs, the incidence of gastrointestinal adverse reactions during chemotherapy, the acid reflux frequency, the nausea frequency, and the vomiting frequency in group A were lower than those in group B [12.90% (8/62) vs. 30.65% (19/62), (1.16±0.23) times/d vs. (3.44±1.22) times/d, (2.14±0.45) times/d vs. (4.41±1.23) times/d, and (1.27±0.33) times/d vs. (3.11±1.25) times/d; χ2=5.729; t=14.461, 13.647, and 11.207; all P<0.05]. There was no statistical difference in the score of INVR between groups A and B on day 1 of chemotherapy [(20.33±5.41) vs. (21.24±5.18); t=1.272, P>0.05]. The scores of INVR on day 7 and 14 of chemotherapy and after one cycle of chemotherapy in group A were lower than those in group B [(15.11±3.46) vs. (18.61±3.12), (12.33±2.46) vs. (14.24±3.36), and (10.19±1.47) vs. (12.25±2.72); t=5.915, 5.156, and 5.246; all P<0.05]. During the follow-up period, the scores of physiological status, social/family status, emotional status, functional status, sleep status, and compliance status of Functional Assessment of Cancer Therapy of Colorectal (FACT-C) in group A were higher than those in group B [(22.45±5.33) vs. (19.35±5.31), (23.36±5.27) vs. (20.18±5.32), (20.31±5.24) vs. (17.25±5.33), (21.25±5.16) vs. (18.44±5.28), (23.11±5.17) vs. (20.21±5.22), and (23.35±5.25) vs. (20.22±5.32); t=3.244, 3.344, 3.244, 2.997, 3.108, and 3.297; all P<0.05]. Conclusion Tropisetron is better than esomeprazole in the prevention and treatment of gastrointestinal adverse reactions. Reference | Related Articles | Metrics

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Clinicopathological significance of expression level of tumor-infiltrating lymphocytes in patients with HER2 positive breast cancer Man Qirong, Zhao Tiantian, Duan Chao, Li Ling International Medicine and Health Guidance News    2023, 29 (22): 3231-3235.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.021 Abstract （143）            Knowledge map    Save Objective To investigate the relationship between the expression of tumor-infiltrating lymphocytes (TILs) and clinicopathological characteristics, and the effect of TILs on prognosis in patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer. Methods A total of 94 female patients with HER2 positive breast cancer treated at Tengzhou Central People's Hospital from October 2016 to October 2018 were collected, with a median age of 51 years (32-73 years). Among them, 49 patients took trastuzumab and chemotherapy, and 45 chemotherapy. The degree of TILs in the tumor area of each patient's HE section was evaluated. χ² test was used to analyze the category data. The Kaplan Meier survival curve and Cox proportional hazard regression model were used to analyze the prognostic factors. The relationship between the degree of TILs and the clinicopathological characteristics and the effect of TILs on the patients' recurrence free survival (RFS) were analyzed. Results Among the 94 patients, 61 had low infiltration, and 33 high infiltration. There were no significant correlations between the degree of TILs and clinical pathological parameters (all P>0.05). In the targeted therapy group, 32 cases had low infiltration, and 17 cases high infiltration. The RFS of the patients with high TILs was longer than that of the patients with with low TILs (P=0.036); TNM stage and the degree of TILs were independent factors for the patients' prognosis (P=0.003 and 0.029). In the general chemotherapy group, 29 cases had low infiltration, and 16 cases high infiltration. The RFS of the patients with high TILs was longer than that of the patients with with low TILs (P=0.049); TNM stage and TILs were independent factors related to the patients' prognosis (P=0.001 and 0.028). Conclusions TILs can be used as tumor markers in predicting the prognosis and therapeutic effect of patients with HER2 positive breast cancer, and may become new therapeutic targets for tumors. Reference | Related Articles | Metrics

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Role of PP1A in cancer and research progress Si Hang, Wang Nana, Liu Susu, Zhang Qian International Medicine and Health Guidance News    2023, 29 (23): 3336-3340.   DOI: 10.3760/cma.j.issn.1007-1245.2023.23.004 Abstract （143）            Knowledge map    Save Protein phosphatases are a group of proteins that widely exist in human cells and catalyze protein dephosphorylation. The phosphoprotein phosphatase catalytic subunits (PPPCs) superfamily is a group of protein phosphatases that primarily dephosphorylate serine/threonine residues. The protein phosphatase-1 (PP1) is involved in most eukaryotic phosphorylation reaction and participates in regulating a variety of biological activities. The catalytic subunit α of PP1 (PP1A) is the most important subtype of the PP1 catalytic subunit encoded by PPP1CA, which plays an important role in the survival and metastasis of a variety of tumors, but it also exhibits inhibitory effect in tumors, which makes it a possible new target for tumor treatment. Therefore, this article aims to review the key role of PP1A in a variety of tumors and evaluate its potential as a novel target for tumor therapy. Reference | Related Articles | Metrics

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Efficacy evaluation of lenvatinib combined with atezolizumab sequential TACE in the treatment of patients with hepatitis B complicated with advanced liver cancer Liu Chunhua, Liu Ling, Tao Changming, He Yukai International Medicine and Health Guidance News    2023, 29 (11): 1573-1578.   DOI: 10.3760/cma.j.issn.1007-1245.2023.11.021 Abstract （142）            Knowledge map    Save Objective To investigate the value of lenvatinib combined with atezolizumab sequential transhepatic arterial chemoembolization (TACE) in the treatment of patients with hepatitis B complicated with advanced liver cancer. Methods This study was a randomized controlled trial. A total of 96 patients with hepatitis B complicated with advanced liver cancer admitted to Liaocheng People's Hospital from January 10, 2019 to September 10, 2022 were selected for the study, and were divided into an observation group and a control group according to the random number table method. In the control group, there were 25 males and 23 females, aged (54.52±7.13) years; in the observation group, there were 28 males and 20 females, aged (53.74±6.55) years. The control group was given conventional TACE treatment, and the observation group was given lenvatinib combined with atezolizumab sequential TACE treatment. The disease remission rate, disease control rate, liver function indexes [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL)], cellular immune function indexes [lymphocytes (CD3+, CD4+, and CD8+) and CD4+/CD8+], and infiltrative metastasis indexes [vascular endothelial growth factor (VEGF) and glypican-3 (GPC-3)] before and after treatment, and occurrence of adverse events were compared between the two groups. t test, χ2 test, and Ridit test were used for statistical analysis. Results The disease remission rate and disease control rate of the observation group were higher than those of the control group [72.92% (35/48) vs. 52.08% (25/48), 85.42% (41/48) vs. 62.50% (30/48)] (χ2=4.444, P=0.035; χ2=6.544, P=0.010). After treatment, the CD3+, CD4+, CD4+/CD8+ in the observation group were (64.28±5.35)%, (33.52±2.81)%, and (1.28±0.23), which were higher than those in the control group [(58.92±5.13)%, (28.75±2.63)%, and (1.03±0.19)]; the AST, ALT, TBIL, VEGF, GPC-3, and CD8+ were (38.73±8.41) U/L, (47.62±10.39) U/L, (17.95±2.35) µmol/L, (312.58±33.45) ng/L, (10.75±1.98) µg/L, and (26.19±2.04)%, which were lower than those in the control group [(55.62±7.85) U/L,(67.88±11.55) U/L,  (22.46±2.71) µmol/L, (338.74±35.76) ng/L, (12.46±2.05) µg/L, and (27.91±2.13)%]; the differences were statistically significant (t=15.010, 8.587, 5.806, 10.172, 9.035, 8.711, 3.701, 4.156, and 4.040; all P<0.001). There was no statistically significant difference in the total incidence of adverse events between the observation group and the control group [31.25% (15/48) vs. 25.00% (12/48)] (P>0.05). Conclusion Lenvatinib combined with atezolizumab sequential TACE has better clinical effect in the treatment of patients with hepatitis B complicated with advanced liver cancer, which can effectively reduce the immune suppression, improve the liver function, and alleviate the disease. Reference | Related Articles | Metrics

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Progress and feasibility analysis of clinical application of hyperbaric oxygen chamber rehabilitation therapy Zan Xingchun, Xu Jixiang, Zhou Xiaomei International Medicine and Health Guidance News    2023, 29 (11): 1489-1493.   DOI: 10.3760/cma.j.issn.1007-1245.2023.11.003 Abstract （142）            Knowledge map    Save This paper aimed to summarize the clinical application research progress, feasibility analysis, and mechanism research contents of hyperbaric oxygen chamber therapy synchronous rehabilitation therapy, discuss the existing research results, analyze the feasibility, and determine the next research direction. Literatures on rehabilitation in hyperbaric oxygen chamber was retrieved from CNKI and PubMed databases from January 2006 to December 2022, and the included literatures were analyzed from the aspects of research contents and research methods (experimental design, rehabilitation therapy techniques, research mechanisms, and evaluation methods). According to the research contents of the included literatures, they were roughly divided into 5 different directions according to the function: sports rehabilitation, cognitive rehabilitation, respiratory rehabilitation, musculoskeletal rehabilitation, and rehabilitation nursing. The hyperbaric oxygen in-cabin rehabilitation techniques involved in this study included comprehensive rehabilitation exercise training, motor ideation therapy, occupational cognitive therapy, neuromuscular electrical stimulation, bionic electrical stimulation, right median nerve electrical stimulation, acupuncture, artificial nose, and traction therapy, among which in-cabin physical therapy, occupational therapy, and traditional rehabilitation were the most common. In recent 10 years, the number of such studies had been increasing, and the experimental designs were diverse, including randomized controlled trials and paired trials. The subjects of the studies were mainly common patients in the rehabilitation department, and the curative effect evaluation methods were mainly various rehabilitation evaluation scales. The main mechanisms involved were: ① significantly improving the hemorheological indicators; ② promoting the repair of neurovascular units; ③ enhancing the central nerve plasticity; ④ activating related protease enzymes, growth factors, and triphosadenine (ATP). At present, the quantity and quality of clinical application researches of hyperbaric oxygen chamber rehabilitation therapy need to be improved, the clinical research contents are relatively simple, and the research methods are still in the exploratory stage. Most of the results of these studies focus on the clinical efficacy of dysfunction in the early post-traumatic brain injury and sequelae stage, and it is urgent to reveal the exact mechanism of action of hyperbaric chamber rehabilitation therapy through these studies. The effect of rehabilitation therapy in hyperbaric oxygen chamber still needs to be verified by further clinical mechanism research. Reference | Related Articles | Metrics

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Effect of acupoint massage combined with sitting Baduanjin in improving constipation after cerebrovascular disease operation Zeng Aiqing, Sun Chi, Yu Lu, Xia Rui International Medicine and Health Guidance News    2023, 29 (23): 3466-3470.   DOI: 10.3760/cma.j.issn.1007-1245.2023.23.032 Abstract （140）            Knowledge map    Save Objective To study the effect of acupoint massage combined with sitting Baduanjin in improving constipation after cerebrovascular disease operation. Methods This study was a randomized controlled trial. One hundred patients with constipation after cerebrovascular disease operation who were hospitalized in the Second Affiliated Hospital of Nanchang University between July 2021 and January 2023 were divided into two groups with 50 cases in each group according to the random number table method. In the control group, 28 males and 22 females, aged (61.25±3.25) years, were given conventional care; in the experimental group, 30 males and 20 females, aged (62.03±3.31) years, were given acupoint massage combined with sitting Baduanjin on the basis of the control group for 4 consecutive weeks. The quality of life, defecation score, and stool trait typing were compared between the two groups. χ2 test, rank sum test, and t test were used. Results After 2 and 4 weeks of treatment, the PAC-QOL scores in the experimental group were (46.38±4.85) points and (35.17±2.46) points, which were lower than those in the control group [(54.25±5.35) points and (41.05±4.23) points], with statistically significant differences (t=7.706 and 8.497, both P<0.001). After 2 and 4 weeks of treatment, the defecation scores in the experimental group were (1.42±0.38) points and (1.02±0.18) points, which were lower than those in the control group [(1.64±0.46) points and (1.26±0.27) points], with statistically significant differences (t=2.67 and 5.230, both P<0.05). After 2 and 4 weeks of treatment, Bristol's stool characteristics were classified as type Ⅰ (10 cases, 0), type Ⅱ (16 cases, 2 cases), type Ⅲ (16 cases, 10 cases), type Ⅳ (8 cases, 22 cases), and type Ⅴ (0, 16 cases) in the experimental group, which were better than those in the control group [type Ⅰ (13 cases, 0 cases), type Ⅱ (23 cases, 10 cases), type Ⅲ (12 cases, 15 cases), type Ⅳ (2 cases, 15 cases), and type Ⅴ (0, 10 cases)], with statistically significant differences (Z=2.221 and 2.667, P=0.026 and 0.008). Conclusion Acupoint massage combined with sitting Baduanjin can effectively change the stool characteristics after cerebrovascular disease operation, promote the defecation, and improve the constipation and quality of life. Reference | Related Articles | Metrics

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Clinical analysis of 62 cases of mycoplasma pneumoniae pneumonia mutated by A2063G gene of 23Sr RNA Jia Jinrong, Chen Buxin, Yu Weijun, Long Xiaohui, Jiang Weiyi International Medicine and Health Guidance News    2023, 29 (23): 3439-3442.   DOI: 10.3760/cma.j.issn.1007-1245.2023.23.026 Abstract （139）            Knowledge map    Save Reference | Related Articles | Metrics

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Research progress of intestinal flora and intestinal diseases Fu Xinnian, Zheng Sheng, Yang Juan International Medicine and Health Guidance News    2023, 29 (22): 3162-3165.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.003 Abstract （139）            Knowledge map    Save Intestinal flora is closely related to the occurrence and development of intestinal diseases and plays an important role in maintaining intestinal homeostasis. In this paper, the research progress of intestinal flora and intestinal diseases, including colorectal polyps, colorectal cancer, inflammatory bowel disease, and irritable bowel syndrome, is reviewed, so as to provide references for the prevention, diagnosis, and treatment of intestinal diseases. Reference | Related Articles | Metrics

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Research progress of NLRP3 inflammasome in pathogenesis of diabetic nephropathy Li Mengjie, Liang Dong, Xing Wenhua, Lin Qianyu, Zhang Hui, Zhang Xiaomin International Medicine and Health Guidance News    2023, 29 (24): 3532-3537.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.002 Abstract （137）            Knowledge map    Save Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes and is associated with increased mortality in patients with diabetes. Inflammation is an important part of the development of DN. Nucleotide-binding oligomerizing domain-like receptor protein 3 (NLRP3) inflammasome is the most deeply studied inflammasome in recent years, and its abnormal activation has also been shown to be positively correlated with the progression of DN. This article mainly reviews the pathogenesis and research progress of NLRP3 inflammasome in DN. Reference | Related Articles | Metrics

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Efficacy and safety of belizumab in treatment of patients with systemic lupus erythematosus: a meta-analysis Li Hao, Li Jiangtao, Liu Dan, Li Shunhua International Medicine and Health Guidance News    2023, 29 (22): 3217-3224.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.019 Abstract （135）            Knowledge map    Save Objective To analyze the clinical efficacy and safety of belizumab in the treatment of patients with systemic lupus erythematosus and conduct a meta-analysis. Methods The PubMed, Web of Science, Cochrane Library, EMBASE, China National Knowledge Internet (CNKI), China Biomedical Literature Database (CBM), VIP database, and Wanfang database were searched for all the randomized controlled trials related to belizumab and systemic lupus erythematosus from their establishment to February 2023. According to the including and excluding criteria, the literatures were screened, and the data were obtained. The RevMan5.4.1 software and Sata16 software were used for the meta-analysis of the obtained data. Relative risk and weighted mean difference were used to represent the effect indicators. The efficacies and safety of the two groups were compared. The sensitivity and publication bias were analyzed. Results A total of 9 randomized controlled trials were included, with a total of 2 657 patients, including 1 522 cases in the belizumab group and 1 135 cases in the placebo group. Clinical efficacy: compared with the placebo group, the qualified rate of the systemic lupus erythematosus responder index (SRI4) (RR=1.29, 95%CI 1.17-1.42, P<0.001; I2=0,P=0.91) of belizumab continuous treatment for 52 weeks significantly increased; the patients' clinical symptoms were effectively improved; the severe flare (SF) was reduced (RR=0.68, 95%CI 0.58-0.79, P<0.001; I2=0, P=0.48); the disease activity was effectively reduced; the patients' quality of life was improved; the decrease of the SELENA-SLEDAI score ≥4 points (RR=1.28, 95%CI 1.17-1.40, P<0.001; I2=0%, P=0.95); the systemic lupus erythematosus disease activity index (SLEDAI) score (WMD=-4.77, 95%CI -8.67--0.86, P=0.02; I2=97%, P<0.001). Safety: there were no statistical differences in the total incidence of adverse events (RR=0.99, 95%CI 0.96-1.02, P=0.54; I2=0, P=0.90) and the incidence of serious adverse events (RR=0.85, 95%CI 0.64-1.12, P=0.25; I2=57%, P=0.05) between the two groups. Conclusion Belizumab as an additional treatment for patients with systemic lupus erythematosus has good efficacy and does not increase the incidence of adverse reactions after medication. Reference | Related Articles | Metrics

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Roles of epigenetics and miRNA in depression Chen Guanhong, Yu Mingzi, Fang Yuhan, Cheng Xuefeng, Li Qi, Li Chen International Medicine and Health Guidance News    2023, 29 (13): 1782-1786.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.002 Abstract （135）            Knowledge map    Save Depression, one of the most important types of modern mental illness, is a common emotional disorder with continuous and long-term depression as its main clinical feature. Recent studies have shown that dysexpression of miRNA is associated with a variety of human diseases, including cancer and psychology-related diseases, and miRNA plays an important role in the pathogenesis of depression and antidepressant treatment. Epigenetics refers to the biological phenomenon of long-term heritable gene function changes without changes in DNA sequence, including histone modification, DNA methylation, and miRNA regulation. Many studies have shown that dysregulation of epigenetic modification is the key to elucidating the pathogenesis of depression. This paper reviews the recent progress in epigenetic pathogenesis of depression and the role of miRNA in depression, in order to provide reference for the pathogenesis study and treatment of depression. Reference | Related Articles | Metrics

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P16/Ki-67 double staining in screening cervical cancer Gao Yali, Wu Kunying International Medicine and Health Guidance News    2023, 29 (14): 1986-1990.   DOI: 10.3760/cma.j.issn.1007-1245.2023.14.014 Abstract （135）            Knowledge map    Save Objective To investigate the application value of double staining of suppressor gene protein 16 (P16)/proto-oncogene cell proliferation nuclear antigen (Ki-67) in screening cervical cancer. Methods The clinical data of 100 patients with cervical lesions who were treated at Zhengzhou Maternal and Child Health Hospital from October 2020 to May 2022 were retrospectively analyzed. The patients were (55.65±2.14) years old. All the patients received P16/Ki-67 double staining test, liquid based cytology (TCT) examination, and high-risk human papillomavirus (HR-HPV) detection. The biopsy results under colposcopy were used as the gold standard. The measurement data were analyzed by t test, and the enumeration data by χ2 test. The value of HR-HPV, TCT, and P16/Ki-67 double staining in the diagnosis of cervical lesions was analyzed by the receiver operating characteristic curve (ROC). Results Among the 100 patients with cervical lesions, 14 cases (14.00%) were found with inflammatory lesions by colposcopy, 26 cases (26.00%) cervical intraepithelial neoplasia (CIN) Ⅰ, 26 cases (26.00%) CIN Ⅱ, 28 cases (28.00%) CIN Ⅲ, and 6 cases (6.00%) cervical squamous cell carcinoma (SCC). The sensitivity, specificity, and accuracy of HR-HPV in the diagnosis of cervical lesions were 97.6%(84/86), 85.71(12/14), and 96.00%(96/100), respectively; the sensitivity, specificity, and accuracy of TCT in the diagnosis of cervical lesions were 88.37%(76/86), 78.57%(11/14), and 87.00%(87/100), respectively; the sensitivity, specificity, and accuracy of P16/Ki-67 double staining in the diagnosis of cervical lesions were 91.86%(79/86), 85.71%(12/14), and 91.00%(91/100), respectively; there were no statistical differences between HR-HPV, TCT, and P16/Ki-67 double staining (all P>0.05). The areas under the curves (AUC) of HR-HPV, TCT, and P16/Ki-67 double staining in the diagnosis of cervical lesions were 0.917, 0.835, and 0.888, respectively. There were no statistical differences in AUC between P16/Ki-67 double staining on one hand and TCT and HR-HPV examination on the other hand (both P>0.05). Conclusion P16/Ki-67 double staining in screening cervical cancer and precancerous lesions is as effective as TCT and HR-HPV. It has the advantages of high efficiency, objectivity, simplicity, and repeatability, and can be used as a new choice for screening cervical cancer and precancerous lesions. Reference | Related Articles | Metrics