Abstract:

Objective　To observe and analyze the therapeutic effect and the changes of anxiety and depression in patients with androgenetic alopecia treated with 5% topical minoxidil introduced by nano-microneedles after strengthening comprehensive nursing intervention. Methods　Eighty male patients with androgenetic alopecia admitted to Outpatient Department of Zhongshan Fourth Road, Guangzhou Institute of Dermatology from September 2021 to October 2022 were selected and divided into a control group and an observation group by the random number table method, with 40 cases in each group. The control group were (36.96±8.80) years old, and the observation group (37.05±9.69). Both groups were treated with 5% topical minoxidil by nano-microneedles. The control group were given routine nursing intervention, and the observation group comprehensive nursing intervention. The clinical efficacies, densities and thicknesses of new hair, and anxiety and depression scores were compared between the two groups after the treatment. t and χ² tests were applied. Results　The total effective rate of the observation group was significantly higher than that of the control group [87.5% (35/40) vs. 67.5% (27/40)], with a statistical difference (χ²=4.59, P<0.05). After comprehensive nursing intervention, the number of hair in the control group was significantly higher than that in the observation group (221.35±25.16) pieces/cm² vs. (204.37±28.12) pieces/cm², with a statistical difference (t=2.84, P<0.05). After the intervention, the scores of Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) in the observation group were lower than those in the control group [(45.55±3.43) vs. (48.20±4.71) and (46.43±1.57) vs. (49.33±4.23)], with statistical differences (t=2.88 and 4.07; both P<0.05). Conclusions　Comprehensive nursing intervention can effectively alleviate the anxiety and depression of patients with androgenetic alopecia treated with nano-microneedles, and improve the therapeutic effect.

Key words:

Androgenetic alopecia, Comprehensive nursing intervention, Nano-microneedles, Anxiety, Depression

摘要：

目的　观察分析使用纳米微针导入5%米诺地尔酊治疗雄激素性脱发（AGA）患者时加强综合护理干预，患者治疗效果及焦虑抑郁情绪变化的情况。方法　选择2021年9月至2022年10月期间广州市皮肤病防治所中四门诊部收治的80例男性AGA患者，用随机数字表法将患者分为两组。对照组40例，年龄19～54（36.96±8.80）岁；观察组40例，年龄18～53（37.05±9.69）岁。两组均给予纳米微针导入5%米诺地尔酊治疗，对照组应用常规护理干预，观察组应用综合护理干预，对比两组患者治疗后临床疗效、新生毛发密度及粗度、焦虑抑郁评分，统计学方法采用t检验、χ²检验。结果　观察组总有效率为87.5%（35/40），高于对照组［67.5%（27/40）］，差异有统计学意义（χ²=4.59，P<0.05）；综合护理干预后，观察组头发数量高于对照组［（221.35±25.16）根/cm²比（204.38±28.12）根/cm²］，差异有统计学意义（t=2.84，P<0.05）；干预后，观察组焦虑自评量表（SAS）、抑郁自评量表（SDS）评分均低于对照组［（45.55±3.43）分比（48.20±4.71）分、（46.43±1.57）分比（49.33±4.23）分］，差异均有统计学意义（t=2.88、4.07，均P<0.05）。结论　综合护理干预能够有效缓解纳米微针治疗AGA患者的焦虑抑郁情绪，提升治疗效果。

关键词:

雄激素性脱发, 纳米微针, 综合护理干预, 焦虑, 抑郁