Relationships between protein phosphatase 1 and its dephosphorylation
and depression

doi:10.3760/cma.j.issn.1007-1245.2022.06.001

Abstract

Abstract: In recent years, it has been found that the biological regulation of protein phosphatase family in different brain regions has attracted much attention in depression research. Serine / Threonine protein phosphatase 1 (PP1) controls synaptic plasticity by catalyzing the dephosphorylation of most phosphoserine and phosphothreonine in cells at synapses. Although PP1 and its dephosphorylation are involved in many key biological processes, there is a relative paucity of studies on their relationships with depression. This paper reviews various evidences to support that PP1 and its dephosphorylation may play an important role in the pathogenesis and disease progression of depression.

Key words: Serine / Threonine protein phosphatase 1, Dephosphorylation, Depression, Synaptic plasticity

摘要： 近年来发现蛋白磷酸酶家族在不同的脑区进行的生物调控在抑郁症研究中一直很受重视，其中丝氨酸/苏氨酸蛋白磷酸酶1（protein phosphatase 1，PP1）可通过其在突触处催化细胞中大部分磷酸丝氨酸和磷酸苏氨酸的去磷酸化来控制突触可塑性。尽管PP1及其去磷酸化参与了许多关键的生物过程，但与抑郁症的相关性研究较少。本文通过综述各种证据，支持PP1及其去磷酸化在抑郁症的发病机制与疾病进展中可能发挥重要的作用。

关键词: 丝氨酸/苏氨酸蛋白磷酸酶1, 去磷酸化, 抑郁症, 突触可塑性

Ma Xiangxian, Jiang Yuting, Wang Sanwang, Cui Minghu. Relationships between protein phosphatase 1 and its dephosphorylation and depression[J]. International Medicine and Health Guidance News, 2022, 28(6): 741-744.

马相贤, 蒋宇婷, 王三旺, 崔明湖. 蛋白磷酸酶1及其去磷酸化与抑郁症的关联研究[J]. 国际医药卫生导报, 2022, 28(6): 741-744.

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Relationships between protein phosphatase 1 and its dephosphorylation and depression

蛋白磷酸酶1及其去磷酸化与抑郁症的关联研究

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