International Medicine and Health Guidance News ›› 2023, Vol. 29 ›› Issue (18): 2517-2521.DOI: 10.3760/cma.j.issn.1007-1245.2023.18.001
• New Medical Advances • Next Articles
Research progress on new immunosuppressive agents in treatment of idiopathic membranous nephropathy
Yang Jia1, Xi Zhefan1, Zou Haozhen1, Xu Qiang2, Dong Hua1
1 Department of Nephrology, Binzhou Medical University Hospital, Binzhou 256603, China; 2 Department of Critical Care Medicine, Binzhou People's Hospital, Binzhou 256601, China
Received:
2023-04-01
Online:
2023-09-15
Published:
2023-09-21
Contact:
Dong Hua, Email: donghua197704@sina.com
新型免疫抑制剂在特发性膜性肾病治疗中的研究进展
杨佳1 席哲帆1 邹皓珍1 徐强2 董华1
1滨州医学院附属医院肾内科,滨州 256603;2滨州市人民医院重症医学科,滨州 256601
通讯作者:
董华,Email:donghua197704@sina.com
Yang Jia, Xi Zhefan, Zou Haozhen, Xu Qiang, Dong Hua.
Research progress on new immunosuppressive agents in treatment of idiopathic membranous nephropathy [J]. International Medicine and Health Guidance News, 2023, 29(18): 2517-2521.
杨佳 席哲帆 邹皓珍 徐强 董华.
新型免疫抑制剂在特发性膜性肾病治疗中的研究进展 [J]. 国际医药卫生导报, 2023, 29(18): 2517-2521.
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URL: http://www.imhgn.com/EN/10.3760/cma.j.issn.1007-1245.2023.18.001
[1] Ronco P, Beck L, Debiec H, et al. Membranous nephropathy[J]. Nat Rev Dis Primers, 2021,7(1):69. DOI: 10.1038/s41572-021-00303-z. [2] Cai Q, Hendricks AR. Membranous nephropathy: a ten-year journey of discoveries[J]. Semin Diagn Pathol, 2020,37(3):116-120. DOI: 10.1053/j.semdp.2020.01.001. [3] Gauckler P, Shin JI, Alberici F, et al. Rituximab in membranous nephropathy[J]. Kidney Int Rep, 2021,6(4):881-893. DOI: 10.1016/j.ekir.2020.12.035. [4] van den Brand JA, van Dijk PR, Hofstra JM, et al. Long-term outcomes in idiopathic membranous nephropathy using a restrictive treatment strategy[J]. J Am Soc Nephrol, 2014,25(1):150-158. DOI: 10.1681/ASN.2013020185. [5] Brglez V, Boyer-Suavet S, Seitz-Polski B. Complement pathways in membranous nephropathy: complex and multifactorial[J]. Kidney Int Rep, 2020,5(5):572-574. DOI: 10.1016/j.ekir.2020.02.1033. [6] Lutz J. Pathophysiology, diagnosis, and treatment of membranous nephropathy[J]. Nephrol Ther, 2021,17S:S1-S10. DOI: 10.1016/j.nephro.2021.03.001. [7] Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases[J]. Kidney Int, 2021,100(4S):S1-S276. DOI: 10.1016/j.kint.2021.05.021. [8] van den Brand JAJG, Ruggenenti P, Chianca A, et al. Safety of rituximab compared with steroids and cyclophosphamide for idiopathic membranous nephropathy[J]. J Am Soc Nephrol, 2017,28(9):2729-2737. DOI: 10.1681/ASN.2016091022. [9] Ponticelli C, Escoli R, Moroni G. Does cyclophosphamide still play a role in glomerular diseases?[J]. Autoimmun Rev, 2018,17(10):1022-1027. DOI: 10.1016/j.autrev.2018.04.007. [10] Bomback AS, Fervenza FC. Membranous nephropathy: approaches to treatment[J]. Am J Nephrol, 2018,47 Suppl 1:30-42. DOI: 10.1159/000481635. [11] Tian Z, Li Y, Xie Y, et al. Efficacy and safety of tacrolimus combined with corticosteroids in patients with idiopathic membranous nephropathy: a systematic review and meta-analysis of randomized controlled trials[J]. Int Urol Nephrol, 2022,54(10):2555-2566. DOI: 10.1007/s11255-022-03169-6. [12] Salvadori M, Tsalouchos A. New antigens involved in membranous nephropathy beyond phospholipase A2 receptor[J]. World J Nephrol, 2022,11(4):115-126. DOI: 10.5527/wjn.v11.i4.115. [13] Del Vecchio L, Allinovi M, Rocco P, et al. Rituximab therapy for adults with nephrotic syndromes: standard schedules or B cell-targeted therapy?[J]. J Clin Med, 2021,10(24):5847. DOI: 10.3390/jcm10245847. [14] Dahan K, Debiec H, Plaisier E, et al. Rituximab for severe membranous nephropathy: a 6-month trial with extended follow-up[J]. J Am Soc Nephrol, 2017,28(1):348-358. DOI: 10.1681/ASN.2016040449. [15] 韩蜜,潘勇,伍奕.抗肿瘤药物医嘱审核及不合理情况分析[J].临床合理用药杂志,2020,13(17):11-12,17.DOI:10.15887/j.cnki.13-1389/r.2020.17.006. [16] Fernández-Juárez G, Rojas-Rivera J, Logt AV, et al. The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy[J]. Kidney Int, 2021, 99(4):986-998. DOI: 10.1016/j.kint.2020.10.014. [17] Scolari F, Delbarba E, Santoro D, et al. Rituximab or cyclophosphamide in the treatment of membranous nephropathy: the RI-CYCLO randomized trial[J]. J Am Soc Nephrol, 2021,32(4):972-982. DOI: 10.1681/ASN.2020071091. [18] Kidoguchi K, Kubota Y, Kusaba K, et al. Severe infusion reaction, anti-rituximab antibodies and lymphoma[J]. QJM, 2020,113(4):273-274. DOI: 10.1093/qjmed/hcz296. [19] Huang L, Dong QR, Zhao YJ, et al. Rituximab for the management of idiopathic membranous nephropathy: a meta-analysis[J]. Int Urol Nephrol, 2021,53(1):111-119. DOI: 10.1007/s11255-020-02633-5. [20] Ruggenenti P, Cravedi P, Chianca A, et al. Rituximab in idiopathic membranous nephropathy[J]. J Am Soc Nephrol, 2012,;23(8):1416-1425. DOI: 10.1681/ASN.2012020181. [21] Teisseyre M, Cremoni M, Boyer-Suavet S, et al. Advances in the management of primary membranous nephropathy and rituximab-refractory membranous nephropathy[J]. Front Immunol, 2022,13:859419. DOI: 10.3389/fimmu.2022.859419. [22] Casan JML, Wong J, Northcott MJ, et al. Anti-CD20 monoclonal antibodies: reviewing a revolution[J]. Hum Vaccin Immunother, 2018,14(12):2820-2841. DOI: 10.1080/21645515.2018.1508624. [23] Podestà MA, Ruggiero B, Remuzzi G, et al. Ofatumumab for multirelapsing membranous nephropathy complicated by rituximab-induced serum-sickness[J]. BMJ Case Rep, 2020,13(1):e232896. DOI: 10.1136/bcr-2019-232896. [24] Podestà MA, Gennarini A, Portalupi V, et al. Accelerating the depletion of circulating anti-phospholipase A2 receptor antibodies in patients with severe membranous nephropathy: preliminary findings with double filtration plasmapheresis and ofatumumab[J]. Nephron, 2020,144(1):30-35. DOI: 10.1159/000501858. [25] Boyer-Suavet S, Andreani M, Lateb M, et al. Neutralizing anti-rituximab antibodies and relapse in membranous nephropathy treated with rituximab[J]. Front Immunol, 2020,10:3069. DOI: 10.3389/fimmu.2019.03069. [26] Pierpont TM, Limper CB, Richards KL. Past, Present, and future of rituximab-the world's first oncology monoclonal antibody therapy[J]. Front Oncol, 2018,8:163. DOI: 10.3389/fonc.2018.00163. [27] Klomjit N, Fervenza FC, Zand L. Successful treatment of patients with refractory pla2r-associated membranous nephropathy with obinutuzumab: a report of 3 cases[J]. Am J Kidney Dis, 2020,76(6):883-888. DOI: 10.1053/j.ajkd.2020.02.444. [28] Sethi S, Kumar S, Lim K, et al. Obinutuzumab is effective for the treatment of refractory membranous nephropathy[J]. Kidney Int Rep. 2020 Jul 3;5(9):1515-1518. DOI: 10.1016/j.ekir.2020.06.030. [29] Baert L, Manfroi B, Casez O, et al. The role of APRIL - a proliferation inducing ligand - in autoimmune diseases and expectations from its targeting[J]. J Autoimmun, 2018,95:179-190. DOI: 10.1016/j.jaut.2018.10.016. [30] Dörner T, Kinnman N, Tak PP. Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers[J]. Pharmacol Ther, 2010,125(3):464-475. DOI: 10.1016/j.pharmthera. 2010.01.001. [31] Shabgah AG, Shariati-Sarabi Z, Tavakkol-Afshari J, et al. The role of BAFF and APRIL in rheumatoid arthritis[J]. J Cell Physiol, 2019,234(10):17050-17063. DOI: 10.1002/jcp.28445. [32] 杨佳,高洁,赵文静,等.泰它西普在IgA肾病和狼疮性肾炎中的研究进展[J].中国现代医学杂志,2022,32(19):51-56.DOI:10.3969/j.issn.1005-8982.2022.19.009. [33] Jackson SW, Davidson A. BAFF inhibition in SLE-Is tolerance restored?[J]. Immunol Rev, 2019,292(1):102-119. DOI: 10.1111/imr.12810. [34] Angioi A, Lepori N, López AC, et al. Treatment of primary membranous nephropathy: where are we now?[J]. J Nephrol, 2018,31(4):489-502. DOI: 10.1007/s40620- 017-0427-5. [35] Barrett C, Willcocks LC, Jones RB, et al. Effect of belimumab on proteinuria and anti-phospholipase A2 receptor autoantibody in primary membranous nephropathy[J]. Nephrol Dial Transplant, 2020,35(4):599-606. DOI: 10.1093/ndt/gfz086. [36] Netti GS, Infante B, Spadaccino F, et al. Serum levels of BAFF and APRIL predict clinical response in anti-PLA2R-positive primary membranous nephropathy[J]. J Immunol Res, 2019,2019:8483650. DOI: 10.1155/2019/8483650. [37] van de Donk NWCJ, Usmani SZ. CD38 antibodies in multiple myeloma: mechanisms of action and modes of resistance[J]. Front Immunol, 2018,9:2134. DOI: 10.3389/fimmu.2018.02134. [38] Vink CH, van Cranenbroek B, van der Heijden JW, et al. Daratumumab for multidrug-resistant phospholipase-A2 receptor-related membranous nephropathy[J]. Kidney Int, 2022,101(3):646-647. DOI: 10.1016/j.kint.2021. 12.019. [39] 齐焰,贾俊亚,顾秋华,等.低剂量利妥昔单抗对原发性膜性肾病的长期疗效观察[J].中华医学杂志,2022,102(40):3201-3206.DOI:10.3760/cma.j.cn112137-20220716- 01555. [40] Chen W, Liu Q, Liao Y, et al. Outcomes of tacrolimus therapy in adults with refractory membranous nephrotic syndrome: a prospective, multicenter clinical trial[J]. Am J Med Sci, 2013,345(2):81-87. DOI: 10.1097/MAJ.0b013e31824ce676. [41] Lateb M, Ouahmi H, Payré C, et al. Anti-PLA2R1 antibodies containing sera induce in vitro cytotoxicity mediated by complement activation[J]. J Immunol Res, 2019,2019:1324804. DOI: 10.1155/2019/1324804. [42] Gao S, Cui Z, Zhao MH. Complement C3a and C3a receptor activation mediates podocyte injuries in the mechanism of primary membranous nephropathy[J]. J Am Soc Nephrol, 2022,33(9):1742-1756. DOI: 10.1681/ASN.2021101384. [43] Perry DK, Burns JM, Pollinger HS, et al. Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production[J]. Am J Transplant, 2009,9(1):201-209. DOI: 10.1111/j.1600-6143. 2008.02461.x. [44] Salhi S, Ribes D, Colombat M, et al. Bortezomib plus dexamethasone for rituximab-resistant PLA2R+ membranous nephropathy[J]. Kidney Int, 2021,100(3):708-709. DOI: 10.1016/j.kint.2021.04.011. [45] Hartono C, Chung M, Kuo SF, et al. Bortezomib therapy for nephrotic syndrome due to idiopathic membranous nephropathy[J]. J Nephrol, 2014,27(1):103-106. DOI: 10.1007/s40620-013-0028-x. |
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