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Research progress on autophagy and ischemic cerebrovascular diseases Jiang Meng, Zhao Jingru, Liu Hui, Liu Qingxin International Medicine and Health Guidance News    2025, 31 (8): 1265-1269.   DOI: 10.3760/cma.j.cn441417-20240621-08008 Abstract （226）            Knowledge map    Save Ischemic cerebrovascular disease (ICVD) is a disease that seriously endangers human health, and it has the characteristics of acute onset, disability, and high mortality rate. In recent years, the incidence rate has been increasing year by year, and the age of onset is getting younger and younger. Autophagy is a life phenomenon unique to eukaryotes in self-repairing processes, and is a physiological process in which lysosomes in cells degrade phagocytoses. Studies have found that autophagy can be activated after ischemic brain injury, which affects protein expression and internal environment, thereby accelerating or stopping the progression of ICVD. The two-sided nature of autophagy is still unclear, and moderate regulation of autophagy activation may be the key to the protective role of autophagy. This article discusses the related contents of ICVD, autophagy, and the possible protective and damaging effects of autophagy in ICVD, in order to provide new solutions and targets for the diagnosis and treatment of ICVD. Reference | Related Articles | Metrics

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Effect of multidisciplinary team psychological support combined with mindfulness-based cognitive therapy on negative emotions of elderly patients with uterine prolapse  Liu Yaqi, Gong Xiaofan, Li Chenyang, Bai Xue International Medicine and Health Guidance News    2025, 31 (10): 1610-1614.   DOI: 10.3760/cma.j.cn441417-20241022-10005 Abstract （225）            Knowledge map    Save Objective To evaluate the effect of multidisciplinary team psychological support combined with mindfulness-based cognitive therapy on negative emotional stress in elderly patients with uterine prolapse. Methods Eighty-nine patients with uterine prolapse treated at Henan Provincial People's Hospital from January 2023 to January 2024 were selected for the randomized controlled trial, and were divided into an experimental group (45 cases) who were (68.55±6.25) years old and a control group (44 cases) who were (69.01±6.79) years old by the random number table method. In the experimental group, there were 12 cases of POP-Q stage Ⅱ, 22 cases of stage Ⅲ, and 11 cases of stage Ⅳ. In the control group, there were 14 cases of POP-Q stage Ⅱ, 20 cases of stage Ⅲ, and 10 cases of stage. The experimental group were intervened by multidisciplinary team psychological support and mindfulness-based cognitive therapy, while the control group received routine care, for 12 weeks. The scores of Pelvic Floor Distress Inventory-20 (PFDI-20), Geriatric Depression Scale-Short Form (GDS-15), Hospital Anxiety and Depression Scale Depression subscale (HADS-A), SF-36 Health Survey (SF-36), and Social Dysfunction Screening Schedule (SDSS) were compared between the two groups before and after the intervention. χ2 test and t test were used for the statistical comparisons. Results After 12 weeks' intervention, the scores of PFDI-20, GDS-15, HADS-A, SDSS, and SF-36 in the experimental group were better than those in the control group (32.83±8.72 vs. 41.92±9.02, 7.14±1.92 vs. 9.63±2.27, 8.23±2.47 vs. 10.76±2.63, 8.04±3.58 vs. 10.12±3.61, and 72.45±6.78 vs. 65.41±7.12), with statistical differences (all P<0.05). Conclusion Application of multidisciplinary team psychological support and mindfulness-based cognitive therapy in negative emotion stress nursing for elderly patients with uterine prolapse can alleviate their symptoms of pelvic floor dysfunction, depression, and anxiety, and improve their quality of life and social function. Reference | Related Articles | Metrics

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Analysis of influencing factors of prolonged length of hospital stay in patients with acute intracerebral hemorrhage  Ren Changqing, Li Huiping, Du Zhenping, Wang Lixin, Wu Shibiao International Medicine and Health Guidance News    2025, 31 (7): 1157-1161.   DOI: 10.3760/cma.j.cn441417-20240912-07021 Abstract （223）            Knowledge map    Save Objective To investigate the influencing factors of prolonged length of hospital stay (LOS) in patients with acute intracerebral hemorrhage (ICH). Methods This retrospective study included 310 patients with ICH in three branches of Guangdong Hospital of Traditional Chinese Medicine from May 2019 to May 2021. We recorded baseline data and laboratory data within 24 hours after admission. According to the LOS, the patients were divided into a prolonged group (>14 days) and a non-prolonged group (≤14 days). Among the 211 cases in the non-prolonged group, there were 142 males, aged (61.62±15.51) years. Among the 99 patients in the prolonged group, there were 64 males, aged (63.39±15.12) years. Independent sample t test, Mann-Whitney U test, χ2 test, and multivariate logistic regression analysis were used to analyze the independent influencing factors of prolonged LOS in ICH patients. Results Among the 310 ICH patients enrolled, the average LOS was 12 days. The hospitalization cost in the prolonged group was higher than that in the non-prolonged group [22 613.48 (15 343.92, 38 598.77) yuan vs. 98 618.66 (60 511.49, 152 027.37) yuan, Z=-11.194, P<0.001], accounting for 63.1% of the total hospitalization medical cost. Multivariate logistic regression analysis showed that surgery (OR=2.477, 95%CI 1.286-4.770), stroke-associated pneumonia (SAP) (OR=2.189, 95%CI 1.033-4.641), in-hospital death (OR=0.073, 95%CI 0.021-0.249), and discharge from hospital with non-severe disability [modified Rankin scale (mRS) score ≤2 points] (OR=0.244, 95%CI 0.110-0.539) were independent influencing factors for prolonged LOS in ICH patients (all P<0.05). Conclusions Surgery, in-hospital death, SAP, and discharge from hospital with non-severe disability are closely related to prolonged LOS in patients with ICH. To achieve the purpose of reducing invalid LOS, reducing the waste of medical resources, and reducing the burden on patients and society, we suggest optimizing the surgical procedure, preventing and treating SAP at an early stage, and using antibacterial drugs rationally. In addition, we should pay attention to early rehabilitation management and establish a stable two-way referral channel with rehabilitation hospitals. Reference | Related Articles | Metrics

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Amlodipine induced severe gingival hyperplasia in a child with Alport syndrome Liu Yujie, Wang Xiangli, Zhao Gongping, Cao Guanghai, Zhang Shufeng, Tian Ming, Liu Cuihua International Medicine and Health Guidance News    2025, 31 (7): 1209-1211.   DOI: 10.3760/cma.j.cn441417-20240914-07031 Abstract （219）            Knowledge map    Save This article analyzed a boy with Alport syndrome who has been taking amlodipine besylate for a long time . The 15-year-old boy was diagnosed with Alport syndrome at 7 years and 7 months old (May 2016), and progressed to chronic kidney disease stage 5 at 10 years and 4 months old (February 2019). He started peritoneal dialysis in March 2019, and had been taking various antihypertensive drugs for many years due to the existence of malignant hypertension. However, his blood pressure was not well controlled, mostly in the 130-150/90-110 mmHg (1 mmHg= 0.133 kPa) range. Gingival hyperplasia occurred in February 2023 and gradually worsened. CT examination, bone marrow cell blood examination, physical examination, and medication history were performed to diagnose the gingival hyperplasia associated with calcium channel blockers (CCB). Gingival hyperplasia improved significantly after amlodipine reduction. The exact mechanism of drug-induced gingival hyperplasia is not fully understood. Whether the severe gingival hyperplasia manifestation is related to the gene mutation causing collagen synthesis abnormality or increased drug susceptibility in the patient's underlying disease of Alport syndrome needs further research. Reference | Related Articles | Metrics

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Research progress of ultrasound-guided radiofrequency ablation in treatment of thyroid micropapillary carcinoma Li Qiang International Medicine and Health Guidance News    2025, 31 (8): 1258-1260.   DOI: 10.3760/cma.j.cn441417-20241114-08006 Abstract （217）            Knowledge map    Save The incidence rate of papillary thyroid carcinoma (PTC) has been rising annually, with a notable increase in the detection rate of papillary thyroid microcarcinoma (PTMC) due to advancements in medical detection technology. PTMC is characterized by low aggressiveness and a high survival rate, but there is controversy regarding the optimal treatment approach. Traditional thyroidectomy may lead to complications. Radiofrequency ablation (RFA) has garnered significant attention as a novel therapeutic method. RFA utilizes high temperatures to destroy cancerous tissue, with minimal invasion and a low complication rate. Studies have confirmed the efficacy and safety of RFA for treating PTMC, and the long-term follow-up results demonstrated a high rate of complete disappearance and no local tumor progression. Additionally, RFA has some advantages in the treatment of recurrent thyroid cancer. Therefore, RFA has emerged as an effective alternative to traditional surgery for the treatment of PTMC Reference | Related Articles | Metrics

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Perioperative care for 4 patients with infectious endocarditis associated superior mesenteric artery aneurysm Qin Wenfeng, Wang Wei, Ma Danying, Qing Hongkun, Li Li International Medicine and Health Guidance News    2025, 31 (7): 1212-1216.   DOI: 10.3760/cma.j.cn441417-20240926-07032 Abstract （215）            Knowledge map    Save Objective To explore the perioperative nursing experiences for superior mesenteric artery aneurysm (SMAA) associated with infective endocarditis (IE). Methods Four patients diagnosed with SMAA associated with IE were admitted to Guangdong Provincial People's Hospital from March 2022 to June 2024. There were 2 males and 2 females, aged 27-53 (37.25±11.27) years, with a body mass index of 14.18-18.14 (16.75±1.76) kg/m2, preoperative cardiac function classification of the New York Heart Association (NYHA): 1 case of grade Ⅱ, 1 case of grade Ⅲ, and 2 cases of grade Ⅳ. The key aspects and measures of perioperative nursing were analyzed, including pre-procedural observation prior to SMAA endovascular treatment, post-embolization nursing care for the mesentery, parenteral nutrition support, anti-infective medication nursing, maintenance of cardiac function, pain nursing, and monitoring for bleeding complications after cardiac surgery. Paired t test was used for statistical analysis. Results All four patients successfully completed both cardiac surgery and mesenteric embolization procedures. The duration of mechanical ventilation was 6-19 (13.25±6.29) h, the ICU stay was 1-4 (2.50±1.30) d, and the total hospital stay was 9-31 (16.75±9.81) d. Complications included one case each of perioperative SMAA rupture with local hematoma formation, distal occlusion of the superior mesenteric artery, mural thrombosis, arrhythmia, and postoperative hemorrhage. All four patients were discharged after comprehensive nursing care; notably, their albumin and hemoglobin levels improved compared to admission values [(37.30±5.96) g/L vs. (28.80±3.90) g/L, (104.50±10.08) g/L vs. (86.50±14.93) g/L] (both P>0.05). The nursing satisfaction score ranged from 96 to 99 (97.75±1.26) points, all of which were satisfactory. No recurrence of IE or SMAA was observed during 3-12 months of follow-up. Conclusion The proactive implementation of preventive measures alongside individualized nursing strategies during the perioperative period can significantly reduce complication rate while promoting early recovery in patients and enhancing overall patient satisfaction on nursing care. Reference | Related Articles | Metrics

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Enteral nutrition support combined with swallowing training for stroke patients with swallowing disorders and psychological anxiety Ma Yuan, Wu Bingli, Zhang Shike, Li Cancan, Wang Ziliang International Medicine and Health Guidance News    2025, 31 (8): 1306-1310.   DOI: 10.3760/cma.j.cn441417-20240701-08016 Abstract （215）            Knowledge map    Save Objective To explore the value of enteral nutrition support combined with swallowing training for stroke patients with dysphagia and psychological anxiety. Methods A retrospective study was conducted to select 130 stroke patients with swallowing disorder combined with anxiety in Henan Provincial People's Hospital from June 2020 to December 2023, and divided them into control group and study group according to different treatment methods, with 65 cases in each group. There were 37 males and 28 females in the control group; they were (62.00±11.05) years old; there were 27 mild cases, 25 moderate cases, and 13 severe cases; there were 38 cases of mild anxiety, 15 cases of moderate anxiety, and 12 cases of severe anxiety. there were 35 males and 30 females in the study group; they were (65.00±11.05) years old; there were 38 mild cases, 25 moderate cases, and 12 severe cases; There were 35 cases of mild anxiety, 18 cases of moderate anxiety, and 12 cases of severe anxiety. The control group did swallowing training; in addition, the study group took enteral nutrition support. The clinical efficacies, nutritional indicators, prognostic effects, immune function indicators, anxiety, and incidence rates of complications were compared between the two groups by t and χ2 tests. Results After the treatment, the total effective rate of the study group was 95.38% (62/65), which was higher than that of the control group [81.54% (53/65)], and the difference was statistically significant (P<0.05). After the treatment, the nutritional indicators [hemoglobin (Hb), albumin (ALB), total protein (TP), and prealbumin (PA)], Brathel score, Fugl Meyer motor function score, and immune function indicators (IgA, IgG, and IgM) in the study group were higher than those in the control group; the scores of NIHSS, SAS, and SDS and incidence rate of complications in the study group were lower than those in the control group (all P<0.05). Conclusion Enteral nutrition support combined with swallowing training for stroke patients with swallowing disorders and psychological anxiety can improve their nutritional status and alleviate their anxiety, have fewer complications, and is safe. Reference | Related Articles | Metrics

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Research progress of dietary inflammatory index and colorectal cancer and its precancerous lesions  Qin Zhenkun, Deng Dongyan, Feng Xiaoling International Medicine and Health Guidance News    2025, 31 (10): 1624-1627.   DOI: 10.3760/cma.j.cn441417-20241218-10008 Abstract （214）            Knowledge map    Save Colorectal cancer (CRC) is a prevalent malignant tumor of the digestive system and the second leading cause of cancer-related mortality worldwide. Colorectal adenomatous polyps (CAP) serve as precursors to this malignancy. Chronic inflammation significantly contributes to the onset and progression of CRC and CAP inducing DNA damage and gene mutations, as well as disrupting the homeostasis of gut microbiota. Dietary patterns are closely linked to this process; pro-inflammatory diets elevate levels of chronic inflammation, while anti-inflammatory diets mitigate them. Researches conducted both domestically and internationally have demonstrated that a high dietary inflammatory index (DII) correlates with increased risk of CRC; however, the relationship between DII and CAP remains inconsistent. This article reviews the current state of researches on the association between colorectal cancer, its precursors, and DII, with the aim of providing theoretical foundation for simplifying DII to develop personalized dietary intervention strategies, thereby enhancing the prevention and treatment of CRC and its precursors. Reference | Related Articles | Metrics

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Value of ultrasound imaging features combined with TgAb and TSH for differentiating benign and malignant thyroid nodules Yang Jinyan, Ma Zhe, Xu Hua International Medicine and Health Guidance News    2025, 31 (8): 1311-1315.   DOI: 10.3760/cma.j.cn441417-20240919-08017 Abstract （212）            Knowledge map    Save Reference | Related Articles | Metrics

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Prediction model of effect of interventional ablation for early breast cancer based on ultrasonic elastography and MRI Luo Ting, Yan Ting, He Rui International Medicine and Health Guidance News    2025, 31 (8): 1234-1239.   DOI: 10.3760/cma.j.cn441417-20241101-08001 Abstract （212）            Knowledge map    Save Objective To explore the prediction model of the effect of interventional ablation for early breast cancer based on magnetic resonance imaging (MRI) and ultrasonic elastography. Methods Retrospective analysis was made on 126 female patients with breast cancer admitted to First Affiliated Hospital of Xi'an Medical University from January 2021 to January 2024. They were (49.46±5.17) years old. All the patients were treated with ultrasound guided radiofrequency ablation. Six months after the surgery, the patients were divided into a pathological complete remission (pCR) group and a non-pCR group according to the pathological results. The ultrasonic elastic imaging indicator [shear wave velocity (SWV)] and MRI indicators [T1 weighted (T1WI) signal, T2WI low fat suppression signal, enhanced signal, and apparent diffusion coefficient (ADC)] were compared between the two groups. The influencing factors of the effect of interventional ablation for early breast cancer were analyzed to build a prediction model for evaluating the effect of interventional ablation for early breast cancer. The data were compared between the two groups by t and χ2 tests.The influencing factors were analyzed by the logistic regression model. The fitting degree was evaluated by the Hosmer-Lemeshow test. The predictive efficacy was evaluated by the receiver operating characteristic curve (ROC). Results Among the 126 patients, 114 had pCR, and 12 had non-pCR. The maximum tumor diameter, SWV ratio of diseased side to opposite side (SWVr), T1WI low/equal signal, T2WI fat suppression high signal, and enhanced signal were the risk factors of non-pCR in interventional ablation for early breast cancer, and ADC was the protective factor (all P<0.05). The sensitivity, specificity, and area under the curve of the nomogram model for predicting non-pCR in interventional ablation for early breast cancer were 0.862, 0.874, and 0.879, respectively. Conclusion Maximum tumor diameter, SWVr, T1WI signal, T2WI low fat suppression signal, enhanced signal, and ADC can evaluate the effect of interventional ablation for early breast cancer, and building a prediction model is helpful to identify the effect of interventional ablation for early breast cancer. Reference | Related Articles | Metrics

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Construction of early warning model for mechanical ventilation weaning failure in neonatal respiratory distress syndrome Deng Qiaoni, Chang Ya'na, Zhou Xiaoyu, Kang Hua International Medicine and Health Guidance News    2025, 31 (9): 1499-1505.   DOI: 10.3760/cma.j.cn441417-20241120-09018 Abstract （211）            Knowledge map    Save  Objective To explore the influencing factors of mechanical ventilation weaning failure in neonatal respiratory distress syndrome and constructing a risk prediction model. Methods A total of 185 children with respiratory distress syndrome admitted to Baoji High-Tech Hospital from December 2021 to July 2024, who underwent mechanical ventilation within 72 hours after birth, were selected as the study objects, including 79 boys and 106 girls. The children were randomly divided into a training set (148 cases) and a validation set (37 cases) in a ratio of 4∶1. The children were categorized into a weaning failure group (22 cases) and a weaning success group (126 cases) according to whether they required reintubation within 72 hours after the initial weaning, the success rate of weaning was 85.14% (126/148).In the weaning failure group, there were 8 boys and 14 girls, gestation aged (29.41±0.63) weeks. In the weaning success group, there were 51 boys and 75 girls, gestation aged (30.15±0.48) weeks. Clinical data of the patients was collected, including gestational age, gender, weight, birth weight, 5-minute Apgar score after birth, intubation in the delivery room, etc. Independent sample t test and χ2 test were used for statistical analysis. Multivariate logistic regression analysis was used to analyze the influencing factors of ventilation weaning failure in neonatal respiratory distress syndrome. A Nomogram model was established, and C-index was used to evaluate the discrimination. The predictive efficacy of the model for the failure of weaning from mechanical ventilation in children with respiratory distress syndrome was analyzed by using the receiver operating characteristic curve (ROC). Results The gestational age of the weaning failed group was lower than that of the weaning success group, the FiO2 and PCO2 before weaning were higher than that of the weaning success group, the proportion of using high-dose caffeine was lower than that of the weaning success group, and the proportions of patent ductus arteriosus and ventilator-associated pneumonia were higher than that of the weaning success group (all P<0.05). Logistic regression analysis revealed that gestational age (OR=0.223, 95%CI: 0.067-0.737), high-dose caffeine use (OR=0.249, 95%CI: 0.075-0.825), FiO2 before weaning (OR=3.766, 95%CI: 1.135-12.487), PCO2 before weaning (OR=3.473, 95%CI: 1.047-11.516), patent ductus arteriosus (OR=3.951, 95%CI: 1.192-13.101), and ventilator-associated pneumonia (OR=5.038, 95%CI: 1.519-16.705) were independent risk factors for weaning failure in children with respiratory distress syndrome (all P<0.05). The nomogram model demonstrated a sensitivity of 0.784 and specificity of 0.877 in predicting weaning failure in the training set, with an area under the curve (AUC) of 0.851. In the validation set, the model achieved a sensitivity of 0.759 and specificity of 0.867, with an AUC of 0.844. Conclusions Gestational age, caffeine dosage, FiO2 and PCO2 before weaning, patent ductus arteriosus, and ventilator-associated pneumonia are significantly associated with weaning failure in children with respiratory distress syndrome. The nomogram model developed in this study provides a valuable tool for early assessment of weaning failure risk in this population. Reference | Related Articles | Metrics

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Impact of multi-track specialized nursing mode based on motivation-behavior transformation on postoperative scar treatment with mesenchymal stem cells  Zhang Shixin, Li Gang, Li Yinghui, Cheng Ding, Ren Yongyuan, Zhao Yujia, Bai Yang, Wang Kun International Medicine and Health Guidance News    2025, 31 (10): 1737-1742.   DOI: 10.3760/cma.j.cn441417-20241208-100032 Abstract （211）            Knowledge map    Save Objective To analyze the effect of the multi-track specialized nursing mode based on motivation-behavior transformation for scar patients treated with mesenchymal stem cells. Methods This was a random, prospective, and single-center clinical study. Eighty patients with scar treated at The Second Hospital of Tianjin Medical University from May 2021 to April 2024 were selected for this study. All the patients were treated with mesenchymal stem cells. The patients were divided into a control group and an observation group by lottery, with 40 cases in each group. There were 23 males and 17 females in the control group; they were  (57.78±5.45) years old. There were 21 males and 19 females in the observation group; they were  (57.56±5.39) years old. The control group took conventional nursing, and the observation group were intervened by the multi-track specialized nursing mode based on motivation-behavior transformation. The scores of psychological status, life quality, and hope level before and after the intervention were compared between the two groups. χ2 test and t test were used for statistical analysis . Results After 2 months of intervention, the observation group showed significantly lower negative emotion score compared to the control group (11.31±2.12 vs. 16.18±3.18, P<0.001, and significantly higher positive emotion score (25.34±5.12 vs. 20.23±5.03, P<0.001. Additionally, the observation group demonstrated significantly higher score across all quality-of-life dimensions, including physical function (86.45±8.1 vs. 80.34±8.45), psychological function (87.58±8.07 vs. 80.13±7.45), social function (85.21±8.18 vs. 80.23±7.34)], and material living conditions (75.82±7.36 vs. 70.57±7.26) (all P<0.001). Furthermore, the observation group exhibited significantly higher hope levels than the control group (38.32±5.12 vs. 30.18±5.18, P<0.001). Conclusion The effect of the multi-track specialized nursing mode based on motivation-behavior transformation for scar patients treated with mesenchymal stem cells can not only regulate their psychological status, but also improve their hope level and life quality. Reference | Related Articles | Metrics

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Effect of escitalopram combined with Shugan Jieyu capsule on senile depression with insomnia Yang Yufeng, Lu Lijun, Deng Qian, Chen Shidong, Wang Huiying International Medicine and Health Guidance News    2025, 31 (9): 1549-1553.   DOI: 10.3760/cma.j.cn441417-20241125-09027 Abstract （210）            Knowledge map    Save Objective To analyze the efficacy of escitalopram combined with Shugan Jieyu capsule in the treatment of senile depression with insomnia. Methods A total of 58 outpatients with senile depression and insomnia admitted to the First Affiliated Hospital of Nanyang Medical College from May 2021 to May 2023 were retrospectively selected and divided into control group and observation group according to different treatment methods, with 29 cases in each group. In the control group, there were 12 males and 17 females, aged (68.79±3.26) years old, and the course of disease was (12.57±2.45) months. The patients were treated with escitalopram orally, with an initial dose of 10 mg/d, and the dose was adjusted to 20 mg/d within 2 weeks. There were 14 males and 15 females in the observation group, aged (69.52±3.35) years old, and the course of disease was (12.82±2.34) months. Patients in the control group were po administered with Shugan Jieyu Capsules on the basis of the control group, 0.72 g/d, 2 times/d. All patients were treated continuously for 2 months.Clinical efficacy, psychological status [Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) scores], sleep indicators (sleep onset time, total sleep time), Montreal Cognitive Assessment (MoCA) scores, neurochemical indicators [serotonin (5-HT), dopamine (DA), norepinephrine (NE)], Pittsburgh Sleep Quality Index (PSQI) scores, General Quality of Life Inventory (GQOLI-74) scores, and adverse reactions were compared between the two groups. Statistical analyses were performed using Fisher's exact test and t tests. Results The total effective rate in the observation group was higher than that in the control group [96.55% (28/29) vs. 72.41% (21/29)], with a statistically significant difference (P=0.025). After 2 months of treatment, the SDS and SAS scores in the observation group were lower than those in the control group [(32.45±2.12) points vs. (38.26±2.43) points, (31.64±1.93) points vs. (37.58±2.12) points]. The observation group had a shorter sleep onset time compared to the control group [(30.58±3.24) min vs. (54.62±4.35) min] and a longer total sleep time [(6.71±1.35) h vs. (5.26±1.21) h]. The MoCA score in the observation group was higher than that in the control group [(28.23±1.04) points vs. (25.76±1.15) points]. The levels of 5-HT, DA, and NE in the observation group were (108.51±6.35) µg/L, (78.26±4.18) ng/L, and (10.12±0.64) mg/L, respectively, compared to (98.76±5.02) µg/L, (66.58±3.75) ng/L, and (9.35±0.58) mg/L in the control group. The PSQI score in the observation group was lower than that in the control group [(4.72±0.53) points vs. (7.25±0.62) points], while the GQOLI-74 score was higher in the observation group [(78.29±4.38) points vs. (70.35±4.12) points], with all differences being statistically significant (all P<0.05). The overall incidence of adverse reactions between the two groups was not statistically significant (P=1.000). Conclusion Escitalopram combined with Shugan Jieyu capsule in the treatment of senile depression with insomnia can improve the clinical efficacy and reduce depression, Prolong sleep time, improve cognitive function, regulate neurotransmitter levels, Improve sleep quality, improve quality of life, and better safety. Reference | Related Articles | Metrics

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Effect of acupotomy under the guidance of meridian tendon theory combined with scalp acupuncture on lower limb spasm after stroke  Liu Bin, Li Jintao, Wu Peng International Medicine and Health Guidance News    2025, 31 (7): 1084-1088.   DOI: 10.3760/cma.j.cn441417-20241113-07007 Abstract （210）            Knowledge map    Save Objective To analyze the effect of acupotomy under the guidance of meridian tendon theory combined with scalp acupuncture in the treatment of lower limb spasm after stroke and its influences on spasm degree and balance function. Methods A total of 80 patients with lower limb spasm after stroke admitted to Xi'an International Medical Center Hospital from February 2021 to June 2024 were prospectively selected, and were divided into 2 groups with 40 cases in each group according to the random number table method. There were 20 males and 20 females in the control group, aged (49.20±4.17) years, the spasticity time of lower limb was (10.21±2.63) d, and the hemiplegia site was on the left side in 18 cases and right side in 22 cases. There were 23 males and 17 females in the observation group, aged (49.81±4.37) years, the spasticity time of lower limb was (10.65±3.02) d, and the hemiplegia site was on the left side in 20 cases and right side 20 cases. The control group was treated with scalp acupuncture (once a day, 6 times a week), and the observation group was treated with scalp acupuncture combined with acupotomy under the guidance of meridian tendon theory (3 times a week). Both groups were treated for 4 weeks. The therapeutic effect, adverse reactions, spasticity, balance function, activities of daily living, lower limb motor function, and three-dimensional gait analysis were compared between the two groups. χ2 test, rank sum test, and t test were used for statistical analysis. Results The effective rate of the observation group was 95.00% (38/40), which was higher than that of the control group [77.50% (31/40)] (χ2=5.165, P=0.023). After 4 weeks of treatment, the grade of spasticity in the observation group was better than that in the control group (P<0.05); the modified Barthel index (MBI) [(52.63±3.78) points], Fugl-Meyer Lower Limb Motor Function Rating Scale (FMA-LE) score [(23.20±2.98) points], and Berg Balance Scale (BBS) score [(46.25±5.04) points] in the observation group were higher than those in the control group [(46.21±3.42) points, (20.45±2.68) points, and (41.08±4.59) points] (t=7.965, 4.340, and 4.797, all P<0.05); the step frequency [(73.20±4.99) steps/min] and step speed [(0.61±0.07) m/s] in the observation group were higher than those in the control group [(70.02±4.24) steps/min and (0.52±0.06) m/s] (t=3.071 and 6.174, both P<0.05); the maximum dorsiflexion angle of the affected ankle [(14.02±1.62)°] and the maximum plantar flexion angle of the affected ankle [(20.02±2.74)°] in the observation group were higher than those in the control group [(11.84±1.27)° and (17.21±2.27)°] (t=6.698 and 4.995, both P<0.05). No aggravation occurred in both groups during treatment, and no adverse reactions such as needle fainting, subcutaneous hematoma, or congestion occurred. Conclusion Acupotomy under the guidance of meridian tendon theory combined with scalp acupuncture has significant therapeutic effect in the treatment of lower limb spasm after stroke, which can reduce the degree of spasm, and improve the gait kinematics parameters, step frequency and pace, and lower limb motor function. Reference | Related Articles | Metrics

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Platelet-derived values in diagnosis and treatment of children with common thrombocytopenia Fan Chunhui, Yan Bin, Hu Tianxi, Ye Yaping, Tao Linjing, Du Weipeng, Wang Ruijuan International Medicine and Health Guidance News    2025, 31 (8): 1348-1353.   DOI: 10.3760/cma.j.cn441417-20240407-08024 Abstract （210）            Knowledge map    Save Objective To explore the clinical value of platelet count (PLT), platelet pressure product (PCT), platelet volume distribution width (PDW), platelet mean volume (MPV), and large platelet ratio (P-LCR) in the diagnosis and treatment of common thrombocytopenia in children. Methods This was a retrospective study. Seventy-six children with immune thrombocytopenia (ITP) treated at Nanyang Central Hospital from December 2021 to January 2024 were selected, including 47 boys and 29 girls; they were 2 (7, 11) years old. Eighty children with leukemia and 75 with aplastic anemia were selected as a case group, including 95 boys and 60 girls; they were 9 (5, 13) years old. In the same period, 182 healthy children with normal physical examination were selected as a control group, including 103 boys and 79 girls; they were 8 (4, 14) years old. The blood routine was detected by the Mindray BC-7500 hematology analyzer. The results of PLT, PCT, PDW, MPV, and P-LCR were collected. The differences in platelet-derived values between the ITP group, the case group, and the control group were analyzed by the t test and Mann-Whitney U test. The Spearman rank correlation was used to analyze the correlation between different platelet-derived values. The diagnostic efficacy of the platelet-derived values for ITP was assessed using the receiver operating characteristic curve (ROC). Results The PLT and PCT in the ITP group were lower than those in the control group [14.00 (4.25, 41.75)×109/L vs. 308.00 (276.50, 347.25)×109/L and 0.02 (0.01, 0.07)% vs. 0.27(0.24, 0.30)%]; the MPV and P-LCR in the ITP group were higher than those in the control group [11.00 (9.50, 12.70) fl vs. 8.70 (8.20, 9.33) fl and 40.00 (31.00, 50.00)% vs. 16.80 (13.50, 21.50)%]; there were statistical differences (all P<0.001). The PLT, MPV, and PCT in the ITP group were lower than those in the leukemia group or the aplastic anemia group, while the P-LCR was higher (all P<0.001). In the children with ITP, MPV was positively correlated with PCT and P-LCR (r=0.50 and 0.83; both P<0.001), but PCT was not correlated with P-LCR (P>0.05). MPV had high differential diagnostic value for ITP, with an area under the curve of 0.87, a sensitivity of 99.99%, and a specificity of 81.30%; when the maximum of the Jordon index was taken, its cutoff value was 14.05 fl. The combined detection of MPV, PCT, and P-LCR could further improve the differential diagnostic value of ITP (AUC=0.96). After the treatment, the PLT and PCT were higher than those after the treatment [189.00 (118.00, 320.50)×109/L vs. 12.50 (4.00, 34.00)×109/L and 0.20 (0.15, 0.31)% vs. 0.02(0.01, 0.06)%], while the PDW and P-LCR were lower [16.00 (14.65, 16.40) fl vs. 16.50 (15.95, 17.60) fl and 29.85 (22.33, 38.78)% vs. 40.00 (30.85, 50.40)%]; there were statistical differences (all P<0.001). After the treatment, the PDW, MPV, and P-LCR in the ITP group were higher than those in the control group, while the PLT and PCT were lower (all P<0.05). Conclusions PCT, MPV, and P-LCR differ between children with ITP and bone marrow-associated thrombocytopenia. The combination of the three helps differentially diagnose ITP. Reference | Related Articles | Metrics

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Clinical effect of targeted therapy with rituximab for patients with locally advanced nasopharyngeal carcinoma Zhang Yu, Zhang Kaishuo, Cao Hongyou, Gao Shan International Medicine and Health Guidance News    2025, 31 (4): 669-673.   DOI: 10.3760/cma.j.cn441417-20240727-04028 Abstract （208）            Knowledge map    Save Objective To explore the clinical effect of targeted therapy with rituximab combined with nedaplatin chemotherapy and concurrent radiotherapy for patients with locally advanced nasopharyngeal carcinoma. Methods Sixty-five patients with locally advanced nasopharyngeal carcinoma treated at Hanzhong Central Hospital and Ankang People's Hospital from August 2016 to December 2020 were selected for the randomized controlled trial, and were divided into a control group (33 cases) and an observation group (32 cases) by the random number table method. Three cases in the control group and 2 in the observation group lost to the follow up, with 30 cases in each group. There were 16 males and 14 females in the control group; they were (45.54±5.43) years old. There were 17 males and 13 females in the observation group; they were (46.02±5.47) years old. The control group took radiotherapy and nedaplatin chemotherapy. The observation group took radiotherapy, nedaplatin chemotherapy, and targeted treatment with nituzumab. The clinical efficacies, levels of biochemical indicators [white blood cell count (WBC), platelet count (PLT), and alanine transaminase (ALT)], serum epidermal growth factor like domain 7 (EGFL7), vascular endothelial growth factor (VEGF), and transforming growth factor β 1 (TGF - β 1) before the treatment and after 3 months' follow-up, adverse reactions during the follow-up period, recurrence rates, and survival status (3 years' follow-up) were compared between the two groups. χ2 and t tests were used for the statistical analysis. Results The total effective rate in the observation group was higher than that in the control group [70.0%(21/30) vs. 43.3%(13/30)], with a statistical difference (χ2=4.344; P=0.037). Before the treatment, there were no statistical differences in the levels of biochemical indicators and serum EGFL7, VEGF, and TGF-β1 between the two groups (all P>0.05). After 3 months' follow up, the levels of ALT, EGFL7, VEGF, and TGF-β1 in the observation group were lower than those in the control group [(44.65±6.54) U/L vs. (73.87±6.87) U/L, (48.65±7.54) μg/L vs. (60.98±1.98) μg/L, (188.65±18.54) ng/L vs. (209.09±27.65) ng/L, and (18.65±1.43) mg/L vs. (35.76±4.32) mg/L], with statistical differences (t=16.873, 8.663, 3.363, and 20.594; all P<0.05). During the follow up, the incidence rates of WBC decrease and nausea and vomiting in the observation group were lower than those in the control group [10.0% (3/30) vs. 63.3% (19/30) and 6.7% (2/30) vs. 30.0% (9/30)], with statistical differences (χ2=18.373 and 5.455; both P<0.05). There were no statistical differences in the recurrence rate and survival rate during the 3-year follow-up between the two groups (both P>0.05). Conclusion Targeted therapy with rituximab combined with nedaplatin chemotherapy and concurrent radiotherapy for patients with locally advanced nasopharyngeal carcinoma can effectively regulate their serum levels of EGFL7, VEGF, and TGF-β1, control disease progress, improve treatment effect, and decrease the incidence of adverse reactions, and has minimal impact on their liver function. Reference | Related Articles | Metrics

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Analysis of risk factors of delayed encephalopathy caused by acute carbon monoxide poisoning Wu Yanfang, Zhang Yu, Fu Yongwang International Medicine and Health Guidance News    2025, 31 (4): 596-602.   DOI: 10.3760/cma.j.cn441417-20240924-04015 Abstract （204）            Knowledge map    Save Objective To study the risk factors associated with delayed encephalopathy in patients with acute carbon monoxide poisoning (ACOP). Methods A retrospective analysis was performed on 365 patients with moderate to severe ACOP treated at Inner Mongolia Autonomous Region People's Hospital from October 2020 to October 2023. There were 154 females and 211 males. They were 18-80 years old. Their clinical data were collected. They were followed up for more than 60 days. According to whether delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) occurred, the patients were divided into a DEACMP group (80 cases) and a non-DEACMP group (285 cases). The univariate analysis was used to compare the general clinical data and the first emergency laboratory indicators between the two groups, and the indicators with statistical differences were selected for the multivariate logistic regression analysis to analyze the risk factors of DEACMP. According to their age, the patients were divided into a 18-45 years old group (92 cases), a >45-60 years old group (142 cases), and a >60-80 years old group (131 cases); the clinical data and the first emergency laboratory indicators were compared between the 3 groups. χ2 test and Fisher's precision probability test were used to compared the data between the groups. Results The results of univariate analysis showed that there were statistical differences between the DEACMP group and the non-DEACMP group in age, previous history (diabetes and hypertension), duration of coma, toxicity degree, myocardial injury, rhabdomyolysis, lung infection, and first hyperbaric oxygen therapy (HBOT) time (all P<0.05). The early abnormal rates of white blood cell count (WBC), C-reaction protein (CRP), D-dimer (D-D), troponin I (cTnI), and creatine kinase (CK) in the DEACMP group were higher than those in the non-DEACMP group [73.8% (59/80) vs. 42.8% (122/285), 47.5% (38/80) vs. 27.1% (77/285), 61.3% (49/80) vs. 20.7% (59/285), 67.5% (54/80) vs. 27.7% (79/285), and 78.8% (63/80) vs. 35.1% (100/285)], with statistical differences (all P<0.05). The results of multivariate logistic regression analysis showed that age increase, long duration of coma, myocardial injury, long first HBOT time, and early abnormal CRP, D-D, cTnI, and CK were independent risk factors for DEACMP (all P<0.05). The elder the patients with ACOP were, the longer the duration of coma, the easier to have rhabdomyolysis, the higher the rates of early abnormal CRP and cTnI, and the more likely they had DEACMP. Conclusion Age increase, long duration of coma, myocardial injury, long first HBOT time, and early abnormal CRP, D-D, cTnI, and CK may be the independent risk factors for DEACMP. Reference | Related Articles | Metrics

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Mechanism of total peony glycosides for inhibiting malignant behaviors of thyroid cancer cells Cao Madi, Wang Ke, Yang Aimin International Medicine and Health Guidance News    2025, 31 (8): 1275-1282.   DOI: 10.3760/cma.j.cn441417-20241114-08010 Abstract （204）            Knowledge map    Save Objective To investigate the effect and mechanism of total peony glycosides (TPG) on the malignant behaviors of thyroid cancer cells (SW579). Methods The cancer tissue and their adjacent tissue of 90 patients with thyroid cancer who were diagnosed and received surgical treatment in Xi'an Workers Hospital from June 2016 to December 2019 were collected. The circ_HOMER1 expression level in the thyroid cancer tissue was detected by the real-time fluorescent quantitative reverse transcription PCR (RT-qPCR); the relationship between circ_HOMER1 expression and clinicopathological characteristics of the patients was explored. The SW579 cells were divided into a control (con) group, a TPG 50 mg/L group, a TPG 100 mg/L group, a TPG 200 mg/L group, an si-NC group, an si-circ_HOMER1 group, a TPG + anti-miR-23a-3p group, and a TPG + pcDNA-circ_HOMER1 group. The RT-qPCR was performed to detect the expressions of circ_HOMER1 and miR-23a-3p; the Transwell method was employed to detect the cell migration and invasion; the plate cloning and CCK-8 assays were used to detect the cell proliferation. The targeting relationship between circ_HOMER1 and miR-23a-3p was determined by the dual luciferase reporter assay. The correlation between circ_HOMER1 expression and clinicopathological features was evaluated. χ2 test and one-way analysis of variance were used for the statistical analysis. Results The expression of circ_HOMER1 was up-regulated in the thyroid cancer tissue. The circ_HOMER1 expression was correlated with TNM stage, lymph node metastasis, and envelope infiltration (all P<0.05). The expression levels of circ_HOMER1 in the TPG 50 mg/L group, the TPG 100 mg/L group, and the TPG 200 mg/L group were lower than that in the control group (0.78±0.04, 0.47±0.03, and 0.23±0.02 vs. 1.00±0), while the levels of miR-23a-3p were higher (1.49±0.03, 2.11±0.06, and 2.89±0.09 vs. 1.00±0), with statistical differences (F=1 425.931 and 1 904.071; both P<0.05). The numbers of migration, clone, and invasion in in the TPG 50 mg/L group, the TPG 100 mg/L group, and the TPG 200 mg/L group were lower than those in the control group, while the cell inhibition rates were higher (all P<0.05). The migration, proliferation, and invasion behaviors of the SW579 cells in the si-circ_HOMER1 group were lower than those in the si-NC group (all P<0.05). The proliferation, migration, and invasion behaviors in the TPG+pcDNA-circ_HOMER1 group and the TPG+anti-miR-23a-3p group were higher than those in the TPG group (all P<0.05). MiR-23a-3p was a target gene of circ_HOMER1. Conclusion TPG may inhibit the malignant proliferation, migration, and invasion of thyroid cancer cells down-regulating the circ_HOMER1/miR-23a-3p axis. Reference | Related Articles | Metrics

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Changes of TCB, ALB, and B/A levels in neonates with hyperbilirubinemia and their correlations with long-term neurodevelopmental outcomes Yang Dong, Yang Yunfan, Mu Qing, Luo Liqian International Medicine and Health Guidance News    2025, 31 (7): 1194-1198.   DOI: 10.3760/cma.j.cn441417-20240806-07028 Abstract （204）            Knowledge map    Save Objective To investigate the changes of transcutaneous bilirubin (TCB), albumin (ALB), and total bilirubin/albumin (B/A) levels in neonates with hyperbilirubinemia and their correlations with long-term neurodevelopmental outcomes. Methods Ninety-eight neonates with hyperbilirubinemia admitted to Northwest Women and Children's Hospital from January 2021 to January 2023 were selected as an observation group, and 90 normal neonates born in our hospital during the same period were selected as a control group. There were 53 boys and 45 girls in the observation group, with gestational age of (40.04±1.32) weeks, age of (3.57±0.36) d, and birth weight of (3.40±0.53) kg, and the delivery methods were cesarean section in 17 cases and vaginal delivery in 81 cases. In the control group, there were 55 boys and 35 girls, with gestational age of (39.99±1.41) weeks, age of (3.63±0.34) d, and birth weight of (3.47±0.51) kg, and the delivery methods were cesarean section in 18 cases and vaginal delivery in 72 cases. The TCB and ALB levels were detected in the observation group (before treatment and after 7 days of treatment) and the control group (the next day after inclusion in the study), and the B/A level was calculated. After 12 months of follow-up, the children were divided into a poor outcome group (12 cases) and a good outcome group (86 cases) according to the neurodevelopmental outcomes. Multivariate logistic regression analysis was used to analyze the influencing factors of adverse neurodevelopmental outcomes of neonatal hyperbilirubinemia. The receiver operating characteristic curve (ROC) was used to analyze the predictive efficacies of TCB, ALB, and B/A for adverse neurodevelopmental outcomes of neonatal hyperbilirubinemia. Independent sample t test, paired t test, and χ2 test were used for statistical analysis. Results The TCB and B/A levels in the observation group before treatment were higher than those in the control group [(360.23±35.82) μmol/L vs. (202.38±21.45) μmol/L, 9.87±1.90 vs. 4.60±1.84], but the ALB was lower than that in the control group [(30.48±4.23) g/L vs. (35.04±2.42) g/L] (all P<0.05). Before and after 7 days of treatment, the TCB and B/A levels in the poor outcome group were higher than those in the good outcome group [(383.23±39.74) μmol/L vs. (342.31±23.86) μmol/L, (182.23±22.10) μmol/L vs. (172.34±9.84) μmol/L, 11.92±2.11 vs. 8.78±1.49, 9.20±1.56 vs. 4.84±1.17], but the ALB was lower than that in the good outcome group [(27.92±2.19) g/L vs. (32.84±2.78) g/L, (31.80±1.62) g/L vs. (35.13±2.12) g/L] (all P<0.05). Multivariate logistic regression analysis showed that pre-treatment TCB, ALB, and B/A levels were independent risk factors for adverse neurodevelopmental outcomes of neonatal hyperbilirubinemia (all P<0.05). ROC results showed that the area under the curve of pre-treatment TCB, ALB, and B/A combined detection was larger than that predicted by TCB, ALB, or B/A alone (all P<0.05). Conclusions The TCB and B/A levels of neonatal hyperbilirubinemia increased significantly, and the ALB level decreased. The combined detection of TCB, ALB, and B/A had high predictive value for adverse neurodevelopmental outcomes, which should be paid close attention to clinically. Reference | Related Articles | Metrics

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Pathogenesis of diabetic foot complicated with osteoporosis  Feng Deping, Zhang Kaige, Li Ruonan International Medicine and Health Guidance News    2025, 31 (10): 1628-1631.   DOI: 10.3760/cma.j.cn441417-20241114-10009 Abstract （204）            Knowledge map    Save Diabetes is a systemic disease. With the progression of the disease, it will lead to a variety of serious complications, and bone metabolism will also be affected. The onset of diabetic bone changes is insidious, so it is often ignored. Patients with diabetes have higher risk of osteoporosis than ordinary people. Patients with diabetic foot are more likely to suffer from osteoporosis than patients with simple diabetes due to poor blood glucose control, vascular neuropathy, chronic inflammation, and other reasons, resulting in pathological fracture, which increases the difficulty of treatment and treatment cost, and causes heavy family and social burden. This article aims to explore the pathogenesis of osteoporosis in diabetic foot patients and to provide evidences for the early prevention and treatment of osteoporosis in diabetic foot patients. Reference | Related Articles | Metrics

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Short-term efficacy of PD-1 inhibitor combined with SOX chemotherapy regimen for patients with locally advanced gastric adenocarcinoma and its influencing factors  Li Fei, Du Jing, Sun Li, Cai Cheng International Medicine and Health Guidance News    2025, 31 (10): 1660-1664.   DOI: 10.3760/cma.j.cn441417-20241118-10016 Abstract （204）            Knowledge map    Save Objective To investigate the short-term efficacy of programmed death protein-1 (PD-1) inhibitor combined with oxaliplatin + tiggio (SOX) chemotherapy regimen in the neoadjuvant treatment of patients with locally advanced gastric adenocarcinoma and its influencing factors. Methods One hundred and twenty-eight patients with locally advanced gastric adenocarcinoma treated at Xi'an Third Hospital from May 2022 to May 2024 were selected for the randomized controlled trial, and were divided into a control group and a study group by the random number table method, with 64 cases in each group. The control group took the SOX chemotherapy regimen, while the study group PD-1 inhibitor and the SOX chemotherapy regimen; both groups completed three cycles of chemotherapy. The short-term clinical efficacies, age, gender, maximum tumor diameters, tumor sites, TNM stages, pathological types, degrees of differentiation, bile acid levels, neutrophil to lymphocyte count ratios (NLR), and expressions of programmed death receptor ligand 1 (PD-L1) were compared between the two groups. The occurrences of adverse reactions during the treatment in the two groups were analyzed. The logistic regression analysis was used to assess the factors influencing the short-term efficacy of PD-1 inhibitor combined with the SOX chemotherapy regimen for the patients with locally advanced gastric adenocarcinoma. χ2 and t tests were used for the statistical analysis. Results The short-term efficacy in the study group was higher than that in the control group [75.00% (48/64) vs. 57.81% (37/64)], with a statistical difference (P<0.05); There were no statistical differences in age, gender, tumor site, pathological type, and differentiation degree between the two groups (all P>0.05). The proportions of the patients with a maximum tumor diameter <6 cm, TNM stage Ⅱ, and PD-L1 expression ≥1% in the study group were higher than those in the control group [78.13% (50/64) vs. 51.56% (33/64), 68.75% (44/64) vs. 28.13% (18/64), and 76.56% (49/64) vs. 48.44% (31/64)], and the bile acid level and proportion of the patients with NLR≥3.7 were lower [(4.64±1.42) μmol/L vs. (5.87±1.78) μmol/L and 23.44% (15/64) vs. 68.75% (44/64)], with statistical differences (all P<0.05). During the treatment, there were 4 cases of nausea, 5 cases of vomiting, and 7 cases of anorexia in the study group; there were 6 cases of nausea, 4 cases of vomiting, and 8 cases of anorexia in the control group; there was no statistical differences (χ2=0.160, P>0.05). The logistic regression analysis showed that maximum tumor diameter <6 cm, TNM stage Ⅱ, low bile acid level, NLR≥3.7, and PD-L1 expression ≥1% were all protective factors for the short-term efficacy of PD-1 inhibitor combined with SOX chemotherapy regimen for the patients with locally advanced gastric adenocarcinoma (all P<0.05). Conclusions PD-1 inhibitor combined with SOX chemotherapy regimen for patients with locally advanced gastric adenocarcinoma has good short-term efficacy. PD-L1 expression ≥1%, the maximum tumor diameter < 6 cm, and TNM stage Ⅱ are protective factors of clinical efficacy. The appropriate treatment regimen should be selected clinically based on these factors. Reference | Related Articles | Metrics

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Value of Doppler ultrasound and inflammatory markers in diagnosis of lower limb vascular lesions in patients with type 2 diabetes mellitus Liu Xueni, Hui Rongrong, Deng Qing International Medicine and Health Guidance News    2025, 31 (8): 1337-1342.   DOI: 10.3760/cma.j.cn441417-20240829-08022 Abstract （203）            Knowledge map    Save Objective To explore the value of color Doppler ultrasound combined with inflammatory markers in the diagnosis of lower limb vascular lesions in patients with type 2 diabetes mellitus (T2DM). Methods From January 2019 to January 2024, 185 patients with T2DM and lower limb vascular lesions treated at Yan'an City Traditional Chinese Medicine Hospital were selected as an observation group, and 50 T2DM patients without lower limb vascular lesions a control group. There were 26 males (52.00%) and 24 females (48.00%) in the control group; they were (65.24±3.64) years old; their disease course was (8.53±1.64) years. There were 102 males (55.14%) and 83 females (44.86%) in the observation group; they were (65.57±3.57) years old; their disease course was (8.64±1.35) years. Both groups underwent color Doppler ultrasound examination. The lower limb hemodynamic parameters, the rates of lower limber atherosclerotic plaque formation, plaque locations, and dorsalis pedis arterial stenosis were compared between the two groups. The blood samples from both groups were detected for serum biochemical and inflammatory marker levels. The diagnostic value of Doppler ultrasound parameters and levels of inflammatory markers for lower limb vascular lesions in the patients was assessed using the receiver operating characteristic curve (ROC). χ2 and t tests were used for the statistical analysis. Results The peak flow velocities of the femoral, popliteal, and dorsalis pedis arteries in the observation group were lower than those in the control group [(120.88±0.95) cm/s vs. (135.15±0.88) cm/s, (71.93±0.45) cm/s vs. (79.65±0.31) cm/s, and (33.64±1.11) cm/s vs. (42.42±1.35) cm/s], with statistical differences (t=95.679, 114.122, and 47.300; all P<0.05). The pulsatility indices of the femoral, popliteal, and dorsalis pedis arteries in the observation group were higher than those in the control group (5.56±1.22 vs. 4.59±1.12, 6.31±1.12 vs. 5.54±1.23, and 8.21±1.14 vs. 7.52±1.05), with statistical differences (t=5.073, 4.223, and 3.860; all P<0.05). The stenotic segments of anterior tibial artery, posterior tibial artery, dorsal artery of foot, femoral artery, and femoral artery in the control group was fewer than that in the observation group, and the stenotic degree of dorsal artery of foot was lower, with statistical differences (χ2=44.023 and 165.489; both P<0.05). The levels of low-density lipoprotein cholesterol and glycated hemoglobin in the observation group were higher than those in the control group [(3.55±0.51) mmol/L vs. (2.78±0.47) mmol/L and (8.78±1.12)% vs. (7.57±0.85)%], with statistical differences (t=9.626 and 7.102; both P<0.05). The serum levels of albumin and 25(OH)D in the observation group were lower than those in the control group [(33.21±4.38) g/L vs. (39.34±5.31) g/L and (19.37±3.65) μg/L vs. (25.12±4.38) μg/L], with statistical differences (t=8.377 and 9.456; both P<0.05). The serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), C-reactive protein (CRP), and immunoglobulin (IgA) in the observation group were higher than those in the control group [(140.63±20.14) mg/L vs. (118.65±16.65) mg/L, (25.64±5.11) ng/L vs. (18.32±4.41) ng/L, (9.63±3.65) mg/L vs. (5.97±2.10) mg/L, and (1.12±0.29) g/L vs. (0.55±0.20) g/L], with statistical differences (t=7.087, 9.239, 6.787, and 16.110; all P<0.05). The area under the ROC (AUC) for the diagnosis of lower limb vascular lesions in the patients using color Doppler ultrasound parameters combined with serum levels of low-density lipoprotein cholesterol, albumin, glycated hemoglobin, 25(OH)D, IL-6, (TNFα), (CRP), and IgA was 0.980, with a sensitivity of 99.50%, a specificity of 98.00%, and a Youden index of 0.975. Conclusion Color Doppler ultrasound combined with inflammatory markers can improve the diagnostic accuracy for lower limb vascular lesions in patients with T2DM, which helps in the early identification and intervention of high-risk patients, improving clinical treatment strategies and their outcomes. Reference | Related Articles | Metrics

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Daochi San combined with narrow-spectrum intense pulsed light for patients with acne vulgaris of heart meridian heat accumulation syndrome Wang Shaobo, Li Wei, Zhao Chan, Liu Yan International Medicine and Health Guidance News    2025, 31 (10): 1713-1718.   DOI: 10.3760/cma.j.cn441417-20241220-10027 Abstract （202）            Knowledge map    Save Objective To explore the effect of Daochi San combined with narrow-spectrum intense pulsed light for patients with acne vulgaris of heart meridian heat accumulation syndrome. Method A total of 126 patients with acne vulgaris admitted to Chang 'an Hospital from January 2022 to July 2024 were selected as the prospective research subjects, and  were divided into a Daochi San group, narrow-spectrum intense pulsed light group, and a combination group by  lottery, with 42 patients in each group. There were 15 males and 27 females in the Daochi San group, with an age of (23.67±4.66) years and a disease course of (1.48±0.31) years. There were 18 males and 24 females in the narrow-spectrum intense pulsed light group, with an age of (22.19±3.52) years and a disease course of (1.43±0.36) years. There were 16 males and 26 females in the combination group, with an age of (22.52±3.49) years and a disease course of (1.57±0.38) years. The Daochi San group were treated with the Daochi San, the narrow-spectrum intense pulsed light group narrow-spectrum intense pulsed light, and the combination group with Daochi San and narrow-spectrum intense pulsed light, for 3 months. The study evaluated traditional Chinese medicine symptom scores, skin lesion severity, serum inflammatory factor levels [tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12), and interleukin-17 (IL-17)] before and after treatment, clinical efficacy, and adverse reaction incidence.One-way analysis of variance, t test, and χ2 test were used for the statistical analysis. Results Before the treatment, there were no statistical differences in the scores of traditional Chinese medicine symptoms and skin lesions and levels of TNF-α, IL-12, and IL-17 between the 3 groups (all P>0.05). After the treatment, the scores of traditional Chinese medicine symptoms (7.88±1.57,      7.36±1.44, and 4.81±0.98) and skin lesion (10.38±2.34, 9.52±2.08, and 6.05±0.98) and levels of TNF-α [(33.16±4.41) μg/L, (34.53±4.78) μg/L, and (27.84±3.66) μg/L], IL-12 [(30.34±3.85) μg/L, (29.22±3.34) μg/L, and (23.65±3.09) μg/L], and IL-17 [(1.42±0.26) μg/L, (1.37±0.25) μg/L, and (0.92±0.18) μg/L] decreased in the three groups (all P<0.001), and there were statistical differences between the 3 groups ( all P<0.001); those in the combination group were lower than those in the Daochi San group (all P<0.001) and those in the narrow-spectrum intense pulsed light group (all P<0.001). The total effective rates of the Daochi San group, the narrow-spectrum intense pulsed light group, and the combination group were 69.05% (29/42), 73.81% (31/42), and 92.86% (39/42), the combination group  was higher than those in the Daochi San group and the narrow-spectrum intense pulsed light group (χ2=7.919，P=0.0219). The incidence rates of adverse reactions in the Daochi San group, the narrow-spectrum intense pulsed light group, and the combination group were 2.38% (1/42), 7.14% (3/42), and 9.52% (4/42), respectively, with no statistical difference (χ2=1.869, P>0.05). Conclusion Daochi San combined with narrow-spectrum intense pulsed light for patients with acne vulgaris of heart meridian heat accumulation syndrome can promote symptom relief and skin lesion regression, inhibit inflammatory reactions, with high efficacy and good safety. Reference | Related Articles | Metrics

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Application of AI technology in preplanning of unicompartmental knee arthroplasty  Pan Xi'an, Zhang Yuanjin, Zhang Guofu, Li Jun, Sun Farui, Liu Bingxia International Medicine and Health Guidance News    2025, 31 (9): 1532-1537.   DOI: 10.3760/cma.j.cn441417-20241008-09024 Abstract （202）            Knowledge map    Save Objective To explore the clinical application value of Artificial Intelligence (AI) technology in preoperative planning of unicompartmental knee arthroplasty. Methods This study is a retrospective controlled analysis. A total of 35 patients who underwent unicompartmental knee arthroplasty at Huangshi Central Hospital from July 2021 to July 2023 were selected and divided into an experimental group and a control group based on the preoperative planning method used. Among the 14 patients in the experimental group, 6 were male and 8 were female, the age was (62.43±3.55) years old, AI technology was used for preoperative planning. In the control group, there were 7 males and 14 females in 21 patients, the age was (62.10±2.86) years old, Preoperative planning was performed according to the traditional X-ray method. The surgical time, intraoperative blood loss, postoperative drainage volume, prosthesis conformity rate (the preoperatively predicted sizes and models of the prosthesis and spacer matching exactly with those used intraoperatively), as well as the American Hospital Specialty (HHS) knee scores, Visual Analog Scale (VAS) scores, and improvement in knee range of motion at 3 months and 1 year postoperatively were recorded and compared. The χ2 test and t test were used for statistical analysis. Results The surgical time, intraoperative blood loss, and postoperative drainage volume in the experimental group were (59.07±3.36) minutes, (107.29±10.16) ml, and (78.93±10.95) ml, The control group were (69.57±2.11) minutes, (123.38±7.65) ml, and (95.19±12.49) ml, with all differences being statistically significant (t=11.378, 5.347,and 3.958, all P<0.001). At 3 months and 1 year postoperatively, the HHS knee scores and the range of motion of the knee was greater in the experimental group[(79.93±1.14) points vs. (76.81±1.54) points,(119.57±4.62)° vs. (111.76±6.25)°,(92.36±1.87) points vs. (90.48±1.25) points,(130.29±4.60)° vs. (120.57±4.98)°], and VAS scores in the experimental group were lower than those in the control group [(1.71±0.47) points vs. (2.43±0.68) points, (1.14±0.36) points vs. (1.86±0.48) points], with all differences being statistically significant (all P<0.05). The conformity rates for the femoral side, tibial side, and spacer in the experimental group were higher than those in the control group [92.86% (13/14) vs. 42.86% (9/21), 92.86% (13/14) vs. 38.10% (8/21), 85.71% (12/14) vs. 33.33% (7/21), all P<0.05]. Conclusion The application of AI technology in preoperative planning for unicompartmental knee arthroplasty can accurately predict the model of the femoral and tibial prostheses as well as the size of the spacer, improve prosthesis conformity rates, reduce intraoperative blood loss and postoperative drainage volume, alleviate postoperative knee pain symptoms, and enhance knee range of motion, demonstrating significant clinical guidance value. Reference | Related Articles | Metrics

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Operation room nursing guided by enhanced recovery after surgery concept for patients taking laparoscopic cholecystectomy  Sun Bei, Sun Fei, Wan Xinjian International Medicine and Health Guidance News    2025, 31 (10): 1742-1747.   DOI: 10.3760/cma.j.cn441417-20241104-10033 Abstract （201）            Knowledge map    Save Objective To evaluate the effect of operating room nursing guided by the enhanced recovery after surgery (ERAS) concept for patients undergoing laparoscopic cholecystectomy. Methods one hundred patients who underwent laparoscopic cholecystectomy at Hanzhong Central Hospital from January 2022 to January 2023 were selected for the randomized controlled trial, and were divided into an observation group and a control group by the random number table method, with 50 cases in each group. There 25 males and 25 females in the observation group; they were 35-65 (50.34±7.45) years old. There 25 males and 25 females in the control group; they were 34-66 (49.87±7.58) years old. The control group took routine nursing; in addition, the observation group took operation nursing guided by the ERAS concept. The body temperatures and scores of Visual Analogue Scale (VAS) at different time points, recovery indicators (time to tracheal extubation, anesthesia recovery room stay, time for first off-bed activity, time for first anal exhaust, time for recovery to oral intake, and hospital stay), social function [Social Disability Screening Schedule (SDSS)], psychological stress [Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD), and quality of life [World Health Organization Quality of Life Scale (WHO-QOL)] were compared between the two groups. χ2 and t tests were used for the statistical analysis. Results The body temperatures 1 h after anesthesia and when they entered and left the anesthesia recovery room in the observation group were higher than those in the control group [(36.23±0.18) ℃ vs. (35.21±0.23) ℃, (36.40±0.31) ℃ vs. (35.57±0.54) ℃, (36.62±0.18) ℃ vs. (36.12±0.14) ℃], with statistical differences (all P<0.05). The scores of VAS 6, 12, 24, and 72 h after the operation in the observation group were lower than those in the control group ( 7.76±1.56 vs  7.80±1.51 ., 4.48±0.71 vs. 6.57±0.87, 3.71±0.61 vs. 4.55±0.61, and 2.86±0.82 vs. 4.55±0.61), with statistical differences (all P<0.05). The time to tracheal extubation, anesthesia recovery room stay, time for first off-bed activity, time for first anal exhaust, time for recovery to oral intake, and hospital stay in the observation group were shorter than those in the control group [(55.48±7.93) min vs. (75.30±10.76) min,(115.37±16.48) min vs. (166.26±23.75) min, (14.68±2.13) h vs. (18.95±2.71) h, (23.28±3.33) h vs. (36.59±5.23) h, (18.50±2.64) h vs. (30.57±4.37) h, and (5.31±0.75) d vs. (6.58±0.96) d], with statistical differences (all P<0.05). After the intervention, the scores of SDSS, HAMA, and HAMD in the observation group were lower than those in the control group (6.96±0.99 vs. 11.17±0.09, 16.06±2.29 vs. 22.05±3.15, and 17.26±2.47 vs. 20.89±2.98), with statistical differences (all P<0.05). After the intervention, the total score of WHO-QOL in the observation group was higher than that in the control group (81.18±6.36 vs. 71.80±6.15), with a statistical difference (P<0.05). Conclusion ERAS-guided operating room nursing for patients undergoing laparoscopic cholecystectomy can reduce their perioperative temperature fluctuation and postoperative pain, shorten recovery time, and improve their social function, psychological stress, and quality of life. Reference | Related Articles | Metrics

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Efficacy of modified PVP in the treatment of senile patients with mid-thoracic OVCF complicated with degenerative spinal disease Zhang Bo, Zhang Bin International Medicine and Health Guidance News    2025, 31 (9): 1415-1420.   DOI: 10.3760/cma.j.cn441417-20240710-09002 Abstract （201）            Knowledge map    Save Objective To investigate the effect of CT-guided modified unilateral pedicle approach vertebroplasty (PVP) in the treatment of senile patients with osteoporotic vertebral compression fracture (OVCF) of mid-thoracic vertebra (T5-T9) and degenerative spinal disease. Methods A retrospective analysis was performed on 105 elderly patients with mid-thoracic vertebra (T5-T9) OVCF complicated with degenerative spinal disease admitted to Shaanxi Nuclear Industry 215 Hospital from February 2019 to May 2022. They were divided into a study group (63 cases) and a control group (42 cases) according to different approaches. In the control group, there were 6 males and 36 females, aged (76.81±5.74) years, and the course of disease was (12.51±4.72) d. In the study group, there were 8 males and 55 females, aged (76.27±5.93) years, and the course of disease was (12.93±4.30) d. The study group received modified CT-guided PVP, and the control group received bilateral transpedicle approach vertebroplasty. The perioperative conditions, pain, imaging parameters, biomechanical indexes, and complications were compared between the two groups. Repeated measure ANOVA, independent sample t test, and χ2 test were used for statistical analysis. Results The operation time of the study group was longer than that of the control group [(48.50±6.45) min vs. (37.13±5.32) min], and the intraoperative X-ray exposure times and hospitalization cost were lower than those of the control group [(17.35±2.59) times vs. (21.23±3.68) times, (1.91±0.28) million yuan vs. (2.45±0.37) million yuan] (all P<0.05). There was no statistically significant difference in the amount of blood loss, injection amount of bone cement, distribution of bone cement, postoperative ambulation time, or hospital stay between the two groups (all P>0.05). The Visual Analogue Scale (VAS) scores of the study group and the control group were (1.32±0.28) points and (1.39±0.31) points one year after surgery, which were lower than those before surgery and one month after surgery (all P<0.05); the anterior edge heights of the injured vertebra in the study group and the control group were (22.48±3.76) mm and (22.72±3.98) mm, and the posterior edge heights of the injured vertebra were (37.85±5.73) mm and (37.64±5.30) mm, which were higher than those before surgery and one month after surgery (all P<0.05); the local Cobb angles were (10.14±1.78)° and (10.38±1.70)°, which were lower than those before surgery and one month after surgery (all P<0.05). There was no statistically significant difference in the total incidence of complications between the control group and the study group [28.6% (12/42) vs. 22.2% (14/63)] (P>0.05). Conclusion In elderly patients with mid-thoracic vertebrae (T5-T9) OVCF complicated with degenerative spinal disease, CT-guided modified PVP can effectively improve the biomechanical function, reduce the degree of pain, and save the hospitalization costs, but it has a certain learning curve. Reference | Related Articles | Metrics

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Relationship of levels of SIRI, pro-ADM, and MDH1 with pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy Wang Yatao, Li Feng, Rao Zhouzhou International Medicine and Health Guidance News    2025, 31 (8): 1287-1291.   DOI: 10.3760/cma.j.cn441417-20241111-08012 Abstract （200）            Knowledge map    Save Objective To investigate the relationship of the levels of systemic inflammatory response index (SIRI), pro-adrenomedullin (pro‐ADM), and lactate dehydrogenase 1 (MDH1) with pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods This is a retrospective study. One hundred and twenty-four patients with ICP treated at Xi'an Third Hospital from July 2021 to June 2024 were selected, and were divided into an adverse outcome group (51 cases), who were (28.94±3.27) years old and (30.55±1.35) weeks pregnant, and a favorable outcome group (73 cases), who were (29.33±2.69) years old and (31.12±1.29) weeks pregnant. The onset weeks of pregnancy, disease severities, and levels of albumin (Alb), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acids, pro-ADM, MDH1, and SIRI were compared between the two groups. The logistic regression was used to analyze the factors affecting the patients' pregnancy outcomes. The predictive value of SIRI combined with pro-ADM and MDH1 for adverse pregnancy outcomes was assessed. t and χ2 tests were used for the statistical analysis. Results The adverse group had earlier onset of pregnancy, a higher proportions of severe case, and higher levels of Alb, ALT, AST, total bile acids, pro-ADM, MDH1, and SIRI than the favorable group (t=2.395; χ2=6.529; t=3.001, 2.345, 2.366, 2.628, 6.156, 4.319, and 8.007; all P<0.05). The logistic analysis indicated that the onset weeks of pregnancy, disease severity, and levels of Alb, ALT, AST, total bile acids, pro-ADM, MDH1, and SIRI were significant factors influencing pregnancy outcomes (all P<0.05). The receiver operating characteristic curve showed that the combination of pro-ADM, MDH1, and SIRI had a sensitivity of 82.4% and a specificity of 93.2%. Conclusions The levels of pro-ADM, MDH1, and SIRI are closely related to pregnancy outcomes in patients with ICP. Enhancing monitoring of these markers can improve clinical management and their prognosis. Reference | Related Articles | Metrics

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Clinical efficacy and safety observation of small-needle knife loosening combined with traditional Chinese medicine hot compress in the treatment of adhesive frozen shoulder syndrome  Yang Baohua, Dong Bo, Gou Wei International Medicine and Health Guidance News    2025, 31 (7): 1103-1107.   DOI: 10.3760/cma.j.cn441417-20240816-07011 Abstract （200）            Knowledge map    Save Objective To observe the clinical efficacy and safety of small-needle knife loosening combined with traditional Chinese medicine hot compress in the treatment of adhesive frozen shoulder syndrome. Methods A total of 80 patients with adhesive frozen shoulder syndrome admitted to Baoji Second Hospital of Traditional Chinese Medicine from August 2023 to May 2024 were prospectively selected and were divided into two groups with 40 cases in each group by drawing lots. Group A included 12 males and 28 females, aged (57.74±7.88) years, the course of disease was (5.25±1.33) months, and there were 24 cases on the left shoulder and 16 cases on the right shoulder. Group B included 14 males and 26 females, aged (58.01±7.16) years, the course of disease was (5.21±1.42) months, and there were 21 cases on the left shoulder and 19 cases on the right shoulder. Group A was treated with small-needle knife loosening alone, once every two weeks, twice in total. Group B was treated with small-needle knife loosening combined with hot compress of traditional Chinese medicine: hot compress of traditional Chinese medicine was started 1 day after small-needle knife loosening, once a day, 30 min each time, continuous treatment for 4 weeks, and hot compress was suspended once in case of small-needle knife treatment day. The McGill pain questionnaire score, interleukin-10 (IL-10), IL-6, periarticular shoulder muscle strength, shoulder range of motion, and total clinical effective rate were compared between the two groups. t test and χ2 test were used for statistical analysis. Results After treatment, The Present Pain Intensity (PPI) scores [(1.45±0.34) and (0.85±0.22) points], Visual Analogue Scale (VAS) scores [(2.45±0.74) and (1.60±0.48) points], Pain Rating Index (PRI) scores [(10.10±1.78) and (6.75±1.26) points] in group A and B were lower than those before treatment, and those in group B were lower than those in group A (all P<0.05). After treatment, the levels of IL-10 in group A and B were higher than those before treatment, and the levels of IL-6 were lower than those before treatment; the level of IL-10 in group B was higher than that in group A, and the level of IL-6 was lower than that in group A (all P<0.05). After treatment, the peak anterior flexion moments [(42.63±4.22) and (51.04±4.89) N/m], average power of anterior flexion [(45.52±5.11) and (56.65±6.02) W], peak abduction moments [(44.15±4.29) and (52.05±5.21) N/m], and average power of abduction [(44.12±5.27) and (51.77±4.82) W] in group A and B were higher than those before treatment, and those in group B were higher than those in group A (all P<0.05). After treatment, the ranges of motion of shoulder anterior flexion, posterior extension, internal rotation, external rotation, and abduction in group A and B were higher than those before treatment, and those in group B were higher than those in group A (all P<0.05). The total effective rate of group B [95.00% (38/40)] was higher than that of group A [80.00% (32/40)], with a statistically significant difference (P<0.05). Conclusion Small-needle knife loosening combined with traditional Chinese medicine hot compresses in the treatment of adhesive frozen shoulder syndrome can reduce the pain, improve the degree of shoulder joint restriction, regulate the expressions of inflammatory factors, and improve the treatment efficacy. Reference | Related Articles | Metrics

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Relationship of serum levels of nonestesterified fatty acid and adiponectin with diabetic retinopathy  Si Yanyan, Liu Shengxun International Medicine and Health Guidance News    2025, 31 (10): 1706-1708.   DOI: 10.3760/cma.j.cn441417-20240319-10025 Abstract （200）            Knowledge map    Save Objective To investigate the relationship of serum levels of adiponectin (ADPN) and nonestesterified fatty acid (NEFA) with diabetic retinopathy (DR). Methods Thirty-four patients with type 2 diabetes mellitus (T2DM) treated at Binzhou Medical University Hospital from November 2021 to May 2022 were selected as the study objects, including 18 males and 16 females who were 36-75 years old. According to whether they had DR, the patients were divided into a non-DR group (18 cases) and a DR group (16 cases). Sixteen healthy examinees taking physical examination at Binzhou Medical University Hospital during the same period were selected as a health control group, including 9 males and 7 females who were 33-74 years old. The levels of NEFA, ADPN, blood glucose, cholesterol (CHO), low-density lipoprotein (LDL), triglyceride (TG), and high-density lipoprotein (HDL) in all the subjects were detected. t test was used for the statistical analysis. Results The levels of NEFA and ADPN in the DR group were (1.03±0.38) mmol/L and (5.64±1.57) mg/L, the levels in the non-DR group (0.47±0.13) mmol/L and (7.99±1.98) mg/L, and the levels in the healthy control group （0.47±0.13） mmol/L and （7.99±1.98） mg/L， with statistical differences (both P<0.05). Conclusion Serum levels of SNEFA and ADPN are associated with DR in patients with T2DM. Reference | Related Articles | Metrics

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Value of transperineal ultrasound combined with shear wave elastography in diagnosis of pelvic floor dysfunction  Gao Xin, Gao Xiaoting, Chen Xin, Mu Liang, Xue Xiaomei, He Jing International Medicine and Health Guidance News    2025, 31 (10): 1615-1619.   DOI: 10.3760/cma.j.cn441417-20240805-10006 Abstract （199）            Knowledge map    Save Objective To explore the value of transperineal ultrasound combined with shear wave elastography (SWE) in the diagnosis of pelvic floor dysfunction (PFD). Methods This was a retrospective study. One hundred and twenty patients with PFD treated at Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University from October 2021 to October 2023 were selected as a study group; 82 healthy women who received physical examination during the same period were selected as a control group. All the subjects took transperineal ultrasound and SWE examinations. The general data (age, body mass index, parity, and education level) and parameters of transperineal ultrasound and SWE examinations under different conditions were collected in both groups. The accuracy rates of different examination methods in the diagnosis of PDF were compared. t and χ2 tests were use for the statistical comparisons. The receiver operating characteristic curve (ROC) was applied to evaluate the value of transperineal ultrasound combined with SWE in the diagnosis of PFD. Results There were no statistical differences in age, body mass index, parity, and education level between the two groups (all P>0.05). Under different conditions, the anteroposterior diameter, left-right diameter, and area of anal levator hiatus in the study group were larger than those in the control group, while the Young' s modulus of puborectal muscle (PR) was lower (all P<0.05). The accurate rates of transperineal ultrasound, SWE, and their combination in the detection of PDF were 86.67% (104/120), 90.83% (109/120) , and 97.50% (117/120), respectively; the accurate rate of the combination was higher than those of transperineal ultrasound and SWE (both P<0.05). The ROC results showed that the areas under the curves (AUC) of the anteroposterior diameter, left-right diameter, and area of anal levator hiatus and the Young' s modulus of PR for PFD were 0.622, 0.569, 0.676, 0.638, 0.643, 0.586, 0.680, and 0.694 (all P<0.05), respectively, and the AUC of the combined diagnosis was 0.846 (P<0.05). Conclusion Transperineal ultrasound combined with SWE has high diagnostic value fir PFD. Reference | Related Articles | Metrics

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Study on the effect of Chinese medicine meridian theory on the recovery of neurological function in patients with cerebral infarction  Yue Qiuxiang, Cui Xiaocan, Feng Guangda , Chen Tongyao International Medicine and Health Guidance News    2025, 31 (7): 1089-1093.   DOI: 10.3760/cma.j.cn441417-20240704-07008 Abstract （199）            Knowledge map    Save  Objective To investigate the effect of Chinese medicine meridian theory on the recovery of neurological function in patients with cerebral infarction. Methods Ninety-eight patients with cerebral infarction during the rehabilitation period from October 2022 to October 2023 in Xinxiang First People's Hospital were selected for a retrospective study, and they were divided into a control group and a study group according to the treatment time with 49 cases in each group. In the control group, there were 25 males and 24 females, aged 52-76 (61.2±2.4) years. In the study group, there were 23 males and 26 females, aged 54-75 (60.5±2.2) years. The control group was given routine nursing, and the study group was combined with comprehensive intervention measures based on Chinese medicine meridian theory. Both groups were intervened and followed up for 6 months. The neurological function recovery, psychological state, quality of life, and nursing satisfaction were compared between the two groups after intervention. χ2 test and t test were used for statistical analysis. Results Compared to those before intervention, the National Institutes of Health Stroke Scale (NIHSS) scores [(4.65±1.39) and (8.84±1.12) points], Barthel indexes [(74.63±3.36) and (58.86±1.08) points], Fugl-Meyer Motor Function Assessment (FMA) scores [(38.59±3.10) and (31.90±6.15) points], optimism scores [(27.06±9.54) and (23.55±7.15) points], toughness scores [(24.84±8.46) and (21.39±6.74) points], self-strengthening scores [(25.69±8.29) and (21.73±7.00) points], physiological function scores [(65.73±12.51) and (60.82±9.30) points], vitality scores [(58.84±9.44) and (53.20±7.37) points], emotional function scores [(58.41±9.20) and (53.04±7.11) points], general health scores [(64.71±11.59) and (58.33±9.14) points], body function scores [(60.84±10.38) and (54.98±8.04) points], somatic pain scores [(52.51±7.16) and (46.71±6.26) points], social function scores [(62.45±8.76) and (56.71±8.87) points], and mental health scores [(64.14±10.15) and (60.35±7.70) points] in the study group and the control group were improved after intervention, and those in the study group were better than those in the control group, with statistically significant differences (all P<0.05). The satisfaction rate of the study group was 87.76% (43/49), which was higher than that of the control group [61.22% (30/49)], with a statistically significant difference (P<0.05). Conclusion Chinese medicine meridian theory can significantly improve the neurological deficits and the ability of daily life, reduce depression, anxiety, and other emotional disorders, and further improve patient satisfaction through various means such as acupuncture, tui-na massage, traditional Chinese medicine treatment, and functional exercises in patients with cerebral infarction during the rehabilitation period. Reference | Related Articles | Metrics

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Application of serum homocysteine and coagulation function in short-term outcome assessment of patients with acute cerebral infarction Du Haigang, Cui Han International Medicine and Health Guidance News    2025, 31 (8): 1369-1372.   DOI: 10.3760/cma.j.cn441417-20240622-08028 Abstract （199）            Knowledge map    Save Objective To evaluate the value of serum homocysteine (Hcy) level and coagulation function indicators in the assessment of short-term outcomes in patients with acute cerebral infarction. Methods Seventy-eight patients with acute cerebral infarction treated at Laboratory Department, 987th Hospital of Joint Logistics Support Force, People's Liberation Army of China were selected as the study objects. According to the scores of the modified Rankin Scale (mRS) one month after follow-up, the fifty-three patients with mRS scores of ≤2 were including into the good prognosis group, while the 25 patients with mRS scores of >2 the poor prognosis group. The levels of homocysteine (Hcy) and coagulation function [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and plasma fibrinogen (FIB)] were compared between the two groups. The value of serum Hcy level and coagulation function indicators in the short-term outcome assessment of patients with acute cerebral infarction was analyzed using the receiver operating characteristic curve (ROC). Results There were no statistical differences in gender, age, weight, time from onset to visit, and severity between the good prognosis group and the poor prognosis group (all P>0.05). The Hcy level in the good prognosis group was lower than that in the poor prognosis group [(12.75±1.47) μmol/L vs. (16.96±1.39) μmol/L], with a statistical difference (t=12.009, P<0.001). The PT, APTT, and TT in the good prognosis group were shorter than those in the poor prognosis group [(12.31±1.86) s vs. (10.07±1.71) s, (36.32±4.71) s vs. (28.73±3.09) s, and (18.48±1.95) s vs. (11.27±1.26)s], with statistical differences (t=5.247, 8.483, and 19.605; all P<0.001). The FIB level in the good prognosis group was lower than that in the poor prognosis group [(2.99±0.34) g/L vs. (4.31±0.48) g/L], with a statistical difference (t=12.364; P<0.001). The sensitivity and specificity of serum Hcy and coagulation function in the short-term outcome assessment of acute cerebral infarction were 92.0% and 94.3%, respectively, both higher than any single test. The area under ROC (AUC) was 0.977, higher than the AUC's of Hcy (0.880), PT (0.802), APTT (0.863), TT (0.908), and FIB (0.889). Conclusion In patients with acute cerebral infarction, the levels of Hcy and coagulation function indicators are closely related to their short-term prognosis and can be used as effective predictive factors. The combined testing shows higher sensitivity and specificity in the assessment of their short-term outcomes. Reference | Related Articles | Metrics

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Research status of hypertensive rat model  Zhao Zhou, Liu Weipeng, Li Zongrui, Wang Ruizhi, Hu Baoguang International Medicine and Health Guidance News    2025, 31 (9): 1465-1470.   DOI: 10.3760/cma.j.cn441417-20241010-09012 Abstract （198）            Knowledge map    Save The study of hypertension in rat models is currently active. Rats have a similar genome, cardiovascular system structure, and physiological characteristics to humans, making them a preferred animal model for studying hypertension. In order to gain a deep understanding of the pathogenesis of this disease and to explore new treatment methods, various experimental models of hypertension have been constructed. These models can be mainly divided into spontaneous and secondary hypertension models. The former includes spontaneously hypertensive rats (SHR), N-nitro-L-arginine methyl ester (L-NAME) model, Dahl salt-sensitive model, Milan hypertensive strain (MHS) model, and Sabra hypertension-prone (SBH) model, and the latter includes renal hypertension model, endocrine hypertension model, arterial hypertension model, and other secondary hypertension model (such as hypertension model induced by sleep apnea syndrome, hypertension model induced by diabetes, etc). This article provides a comprehensive overview of the different model production methods, advantages, and disadvantages, aiming to provide a more convenient and accurate solution for the clinical treatment of hypertension. Reference | Related Articles | Metrics

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The current application status of central venous catheters in intravenous therapy for inpatients in the hospital wards  Chen Juanjuan International Medicine and Health Guidance News    2025, 31 (9): 1565-1568.   DOI: 10.3760/cma.j.cn441417-20241008-09030 Abstract （197）            Knowledge map    Save This article reviews the definition, placement method, tip position, indications, application in special population and complications of midline catheter, so as to provide help for the placement and clinical use of midline catheter. Reference | Related Articles | Metrics

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Personalized skin care management in a cachectic peritoneal dialysis patient with chronic diarrhea: a clinical case study  Yang pei, Wang Yuquan, Wang Qi International Medicine and Health Guidance News    2025, 31 (10): 1753-1756.   DOI: 10.3760/cma.j.cn441417-20240924-10035 Abstract （197）            Knowledge map    Save Objective  To summarize the skin care measures and experience of patients with long hospitalization periods, high risk of pressure injuries, and susceptibility to pressure ulcers by a case study. Methods  One long-term bedridden patient with impaired active nutrient intake, diarrhea, and intraperitoneal infection who took peritoneal dialysis received pressure ulcer prevention and personalized perianal skin care interventions. Results  During the 15-day hospitalization, there was no perianal skin damage during episodes of diarrhea. The patient's skin remained intact until        discharge. Conclusions  Timely personalized nursing interventions, such as the use of                     foam dressings for pressure ulcer prevention and management, should be implemented for patients at high risk of pressure injuries. For patients with diarrhea, rectal tampon insertion can keep the skin around the anus and buttocks dry, preventing stool contamination from irritating the skin and pressure ulcers and improving their comfort and satisfaction with the care. Reference | Related Articles | Metrics

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The effect of Xiangdan injection combined with metoprolol tartrate on clinical symptoms and oxidative stress response in patients with coronary heart disease and angina pectoris Zang Keliang, Ban Fang, Zhang Qiumei, Zhang Hengliang International Medicine and Health Guidance News    2025, 31 (9): 1520-1524.   DOI: 10.3760/cma.j.cn441417-20240808-09022 Abstract （196）            Knowledge map    Save Objective To analyze the efficacy of Xiangdan injection combined with metoprolol tartrate in patients with coronary heart disease and angina pectoris, as well as its impact on clinical symptoms and oxidative stress response. Methods A total of 92 patients with angina pectoris of coronary heart disease who were admitted to Shangqiu Municipal Hospital from April 2021 to April 2024 were selected as the research subjects. The patients were divided into the control group (46 cases) and the research group (46 cases) by using the random number table method. There were 25 males and 21 females in the control group, aged 51-78(64.29±7.08) years, course of coronary heart disease 2-10(6.24±1.66) years. There were 22 males and 24 females in the research group, aged 52-79(65.36±7.17) years, course of coronary heart disease 2-11(6.51±1.84) years. The control group was treated with metoprolol tartrate, and the research group was treated with Xiangdan injection combined with metoprolol tartrate. Compare the clinical efficacy of the two groups; clinical symptoms (frequency and duration of angina pectoris attacks), levels of myocardial injury markers [creatine kinase MB (CK-MB), brain natriuretic peptide (BNP), cardiac troponin Ⅰ (cTnⅠ)], and oxidative stress indicators [superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA)] before and after treatment; and adverse reactions (vertigo, nausea, fatigue, etc.). Independent sample t test, paired t test, and χ2 test were used for statistical analysis. Results The total effective rate of treatment in the research group was higher than that in the control group[89.13% (41/46) vs. 71.74% (33/46)](P<0.05). After the treatment, the frequency of angina pectoris attacks in the research group was lower than that in the control group[(2.49±0.62) times/week vs. (3.25±0.68) times/week] and the duration of angina pectoris was shorter than that of the control group[(5.05±0.97) min vs. (6.54±0.39) min] (both P<0.05); the levels of BNP, CK-MB and cTnⅠ in the research group were lower than those in the control group [(114.72±16.87) ng/L vs. (143.59±18.04) ng/L, (15.27±2.21) U/L vs. (18.67±2.16) U/L, (1.21±0.27) μg/L vs. (1.46±0.26) μg/L] (all P<0.05); the MDA level in the research group was lower than that in the control group [(6.24±1.29) mol/L vs. (8.27±1.46) mol/L] and the levels of CAT and SOD were higher than those of the control group [(34.97±4.38) U/ml vs. (30.67±4.21) U/ml, (98.46±7.64) U/L vs. (90.37±7.92) U/L](all P<0.05). There were no statistically significant difference in the total incidence rate of adverse reactions between the two groups (P>0.05). Conclusion Xiangdan injection combined with metoprolol tartrate has significant effect in treating angina pectoris in coronary heart disease, which helps to improve the symptoms of angina pectoris, reduce oxidative stress damage, improve myocardial damage, and has high safety. Reference | Related Articles | Metrics

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Automated breast volume imaging combined with miR-22-3p and PDGF levels in evaluation of relationship between lymph node metastasis and prognosis in patients with breast cancer Shao Yuan, Wang Zhibin, Kan Binghua International Medicine and Health Guidance News    2025, 31 (8): 1244-1249.   DOI: 10.3760/cma.j.cn441417-20241031-08003 Abstract （196）            Knowledge map    Save Objective To analyze the relationship between axillary lymph node metastasis (ALN) and prognosis of patients with breast cancer by automated breast volume imaging (ABVS) combined with miR-22-3p and platelet endothelium-derived factor (PDGF). Methods This was a retrospective study. Ninety-seven patients with breast cancer treated at Hanzhong Central Hospital from January 2021 to September 2023 were selected, including 25 menopausal patients. They were 19-75 years old. The level of PDGF was detected by the enzyme linked immunosorbent assay before the surgery; the ABVS technique was used for the examination. The real-time fluorescence quantitative PCR was used to detect serum miR-22-3p. All the patients were treated with the modified radical operation. According to postoperative pathological results whether they had ALN, the patients were divided into an occurrence group (20 cases) and a non-occurrence group (77 cases). The Pearson correlation was used to analyze the relationship between ABVS technology combined with miR-22-3p and PDGF levels and the occurrence of ALN in the patients. The patients were followed up for 1 year by outpatient recheck or telephone. The recurrence, death, and survival were counted, and the patients were divided into a poor prognosis group (17 cases) and a good prognosis group (cases) according to their prognosis. The basic data were compared between the poor prognosis group and the good prognosis group. The binary logistic stepwise regression model was used to analyze the factors affecting the patients' prognosis. The receiver operating characteristic curve (ROC) was used to analyze the diagnostic efficacy. t and χ2 tests were used for the statistical analysis. Results The level of miR-22-3p in the occurrence group was lower than that in the non-occurrence group (0.81±0.23 vs. 1.14±0.28); the proportions of the patients with lesion size ≥2 cm and distance between lesion and nipple and level of PDGF in the occurrence group was higher than those in the non-occurrence group [60.00% (12/20) vs. 29.87% (23/77), 65.00% (13/20) vs. 32.47% (25/77), and (602.30±52.56) ng/L vs. (543.85±49.74) ng/L]; there were statistical differences (all P<0.05). The results of Pearson correlation analysis showed that miR-22-3p was negatively correlated with the occurrence of ALN in the patients (r=-0.592; P<0.001); the lesion size ≥2 cm, distance between lesion and nipple ≥2 cm, and level of PDGF were positively correlated with the occurrence of ALN in the patients (r=0.612, 0.601, and 0.584; all P<0.001). The level of miR-22-3p in the poor prognosis group was lower than that in the good prognosis group (0.86±0.27 vs. 1.22±0.36); the level of PDGF and the proportions of the patients with TNM stage Ⅲ-Ⅳ, irregular edge, and micro-calcification foci in the poor prognosis group were higher than those in the good prognosis group [(586.32±56.41) ng/L vs. (521.31±54.02) ng/L, 58.82% (10/17) vs. 26.25% (21/80), 64.71% (11/17) vs. 30.00% (24/80), and 70.59% (12/17) vs. 36.25% (29/80)]; there were statistical differences (all P<0.05). The binary logistic regression analysis showed that the levels of miR-22-3p and PDGF, TNM stage Ⅲ-Ⅳ, micro-calcification foci, and irregular edge were the factors affecting the patients' poor prognosis (all P<0.05). The ROC analysis showed that the combination of miR-22-3p, PDGF, TNM stage Ⅲ-Ⅳ, micro-calcification foci, and irregular edge had high value in the prediction of the patients' poor prognosis (area under the curve=0.896). Conclusions ABVS technology combined with miR-22-3p and PDGF has good efficacy in the evaluation of poor prognosis in patients with breast cancer. The ABVS technology combined with miR-22-3p and PDGF is correlated with the occurrence of ALN in patients with breast cancer. Reference | Related Articles | Metrics

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Clinical effect of ultrasound-guided acupotomy combined with Qinxitong in the treatment of rheumatoid shoulder arthritis  Zhang Tingting, Niu Xiaoqing, Li Juan, Li Rui, Song Jia International Medicine and Health Guidance News    2025, 31 (7): 1108-1113.   DOI: 10.3760/cma.j.cn441417-20240806-07012 Abstract （195）            Knowledge map    Save Objective To analyze the clinical effect of ultrasound-guided acupotomy combined with Qinxitong in the treatment of rheumatoid shoulder arthritis. Methods This study was a randomized controlled trial. A total of 120 patients with rheumatoid shoulder arthritis treated in Xi'an Fifth Hospital from September 2021 to March 2023 were selected and were divided into group A, B, and C by the random number table method, with 40 cases in each group. Group A included 8 males and 32 females, aged (52.43±11.77) years, with a course of disease of (55.40±33.89） months. Group B included 11 males and 29 females， aged （51.48±11.91） years， with a course of disease of (56.25±40.41) months. Group C included 10 males and 30 females, aged (53.18±10.47) years, with a course of disease of (55.88±41.52) months. All the three groups took methotrexate tablet 10.0-12.5 mg/time, once a week, and leflunomide tablet 10-20 mg/time, once a day. Group A was treated with ultrasound-guided acupotomy once a week for 3 consecutive weeks. Group B took Qinxitong orally, 1.08-1.80 g/time, twice a day. Group C was treated with ultrasound-guided acupotomy combined with Qinxitong, and the treatment plan was consistent with group A and B. All the three groups were treated for 12 weeks. The Visual Analogue Scale (VAS) score, Constant-Murley Shoulder Joint Function Score (CMS), erythrocyte sedimentation rate (ESR), C reactive protein (CRP), 28 joint disease activity score-erythrocyte sedimentation rate (DAS28-ESR), and 28 joint disease activity score-C reactive protein (DAS28-CRP) were compared among the three groups before treatment, 4 weeks after treatment, and 12 weeks after treatment, as well as clinical efficacy and adverse effects. χ2 test, analysis of variance, and generalized estimation equation were used for statistical analysis. Results The effective rate of group C was 97.50% (39/40), higher than those of group A [77.50% (31/40)] and B [77.50% (31/40)], with a statistically significant difference (χ2=8.004, P=0.018). After 4 weeks and 12 weeks of treatment, the VAS, ESR, CRP, DAS28-ESR, and DAS28-CRP of the three groups showed a decreasing trend compared to before treatment, and those in group C were lower than those in group A and B; the CMS showed an upward trend, and that in group C was higher than those in group A and B (all P<0.05). The incidences of adverse reactions in group A, B, and C were 12.50% (5/40), 17.50% (7/40), and 20.00% (8/40), respectively, with no statistically significant difference (P>0.05). Conclusion The combination of ultrasound-guided acupotomy and Qinxitong in the treatment of rheumatoid arthritis can relieve shoulder joint pain, improve shoulder joint function, reduce inflammation level and disease activity, and improve clinical efficacy, with relatively high safety in clinical application. Reference | Related Articles | Metrics

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Establishment and verification of re-examination rules for ORIENTER FA280S fully automatic feces analyzer  Ou Caiwen, Ke Peifeng, Zhong Yusheng, Yu Jinqi, Su Si'En, Lin Fujia International Medicine and Health Guidance News    2025, 31 (10): 1696-1701.   DOI: 10.3760/cma.j.cn441417-20241218-10023 Abstract （195）            Knowledge map    Save Objective To establish and validate the re-examination rules for the ORIENTER FA280S fully automatic feces analyzer at the Dadelu Main Hospital of The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, and to improve the efficacy of routine and occult blood testing in feces samples. Methods A total of 500 routine feces samples were randomly collected from the Dadelu Main Hospital of The Second Affiliated Hospital of Guangzhou University of Chinese Medicine between March 1 and May 31, 2024. These samples were tested using the ORIENTER FA280S fully automatic feces analyzer, with manual microscopic examination as the gold standard. χ2 test was conducted to compare the results of instrumental analysis and manual smear microscopic examination, allowing for the screening of re-examination rules for the fully automatic feces analyzer. To validate the re-examination rules, 248 true-positive feces samples for any test item were collected between June 1 and August 31, 2024, and the missed detection rate was calculated. The re-examination rules were evaluated against internationally accepted criteria (false negative rate <5%). Results For the group used to establish re-examination rules, the positive rates for red blood cells, white blood cells, fungi, parasite eggs, and occult blood test were 5.6% (28/500) , 5.6% (28/500), 4.4% (22/500), 7.2% (36/500), and 24.8% (124/500), respectively. For the validation group, the positive rates for red blood cells, white blood cells, fungi, parasite eggs, and occult blood test were 18.55% (46/248), 29.03% (72/248), 9.27% (23/248), 22.18% (55/248), and 67.34% (167/248), respectively. Five re-examination rules formulated were as below: ⑴ microscopic examination was taken when feces were loose/watery, and red/white blood cells or fungi were negative; ⑵ high-power microscopic review was done when parasites or eggs were reported by the instrument and confirmed by the analyzer's high power field and if the analyzer's field was blur; ⑶ microscopic examination for suspected red/white blood cells or fungi; ⑷ chemical re-test for occult blood was done when feces were dark, brown, or black, and the occult blood test was negative; ⑸ gold standard re-test for occult blood was done when red blood cells were positive, but the occult blood test was negative. The false negative rate for the validated re-examination rules was 4.03% (10/248), lower than 5.00%. Conclusion These rules effectively control the false negative rate, meet international standards, and satisfy testing requirements. Reference | Related Articles | Metrics

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Effects of paroxetine combined with aniracetam on glycolipid metabolism in elderly patients with depression Li Yan, Zhao Limin, Qu Shanshan International Medicine and Health Guidance News    2025, 31 (9): 1544-1548.   DOI: 10.3760/cma.j.cn441417-20241025-09026 Abstract （195）            Knowledge map    Save Objective To observe the effects of paroxetine combined with aniracetam on cognitive function and glucose and lipid metabolism disorders in elderly patients with depression. Methods A retrospective analysis was conducted on the clinical data of 85 elderly patients with depression treated at Ankang Central Hospital from March 2020 to February 2024. Patients were divided into a control group (41 cases) and an observation group (44 cases) based on different treatment methods. The control group included 23 males and 18 females, the age was (71.43±4.26) years old; they received paroxetine orally, starting at a dose of 10 mg/d, which was increased to 20 mg/d after 3 days, with optional dosage adjustments up to a maximum of 40 mg/d. The observation group included 27 males and 17 females, the age was (72.58±4.87) years old; they received aniracetam orally at a dose of 100 mg once daily, in addition to paroxetine treatment. Both groups were treated for 8 weeks. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale, depression severity was evaluated using the Hamilton Depression Scale (HAMD), and clinical efficacy, serological indicators, glucose-lipid metabolism indicators, and adverse reactions were compared. Statistical methods included t tests and χ² tests. Results After 8 weeks of treatment, the MoCA and HAMD scores in the observation group were (27.10±0.45) and (6.37±1.02) points, respectively, compared to (25.51±0.83) and (12.18±2.54) points in the control group, with statistically significant differences (t=11.082, and 14.013, both P<0.001). Serum levels of glial cell-derived neurotrophic factor, serotonin, and norepinephrine were (631.49±65.87, 135.84±17.20, 141.29±15.94) ng/L in the observation group, compared to (527.86±58.30, 118.25±13.76, 128.46±13.52) ng/L in the control group, with statistically significant differences (t=7.659, 5.182, and 3.987, all P<0.05). There were no statistically significant differences between the two groups in terms of hemoglobin A1c, low-density lipoprotein cholesterol, postprandial 2-hour blood glucose, and triglyceride levels (all P>0.05). The total effective rate in the observation group was 93.18% (41/44), higher than the control group's 75.61% (31/41), with a statistically significant difference (χ²=5.059, P=0.025). The overall incidence of adverse reactions was not statistically significant between the two groups (P>0.05). Conclusion The combination of paroxetine and aniracetam is effective in treating elderly depression, improving cognitive function, regulating glucose-lipid metabolism disorders and neurotransmitter levels, and demonstrating reliable safety. Reference | Related Articles | Metrics