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Effect of edaravone dexcamphenol injection with concentrated solution combined with butylphthalide on acute cerebral infarction Qian Xuanchen, Li Qingjie, Nie Er International Medicine and Health Guidance News    2023, 29 (13): 1813-1816.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.009 Abstract （300）            Knowledge map    Save Objective To investigate the effect of edaravone dexcamphenol injection with concentrated solution combined with butylphthalide in the treatment of acute cerebral infarction. Methods This was a retrospective study. A total of 76 cases of acute cerebral infarction in Affiliated Hospital of Xuzhou Medical University from January 2020 to October 2022 were selected and were divided into a conventional group and a treatment group according to different treatment methods with 38 cases in each group. In the conventional group, there were 20 males and 18 females; the age ranged from 39 to 81 years old, with a mean of (59.36±9.25) years old. In the treatment group, there were 21 males and 17 females; the age ranged from 38 to 80 years old, with a mean of (58.69±9.96) years old. The conventional group was treated with butylphthalide, and the treatment group was treated with edaravone dexcamphenol injection with concentrated solution combined with butylphthalide. The efficacy and neurological function indexes [National Institutes of Health Stroke Scale (NIHSS) score], Barthel indexes (BI), and Ability of Daily Living Scale (ADL) scores before treatment and 2 weeks after treatment were compared between the two groups. The statistical methods used were independent sample t test, paired t test, χ2 test, and rank sum test. Results The total effective rate of the treatment group was higher than that of the conventional group [94.74% (36/38) vs. 78.95% (30/38)], with a statistically significant difference (χ2=4.145, P=0.042). There was no statistically significant difference in the NIHSS score between the two groups before treatment (t=0.194, P=0.847). After 2 weeks of treatment, the NIHSS scores of both groups were decreased (both P<0.05), and the NIHSS score of the treatment group was lower than that of the conventional group [(12.37±3.12) points vs. (19.36±2.96) points, t=10.019, P<0.001]. Before treatment, there were no statistically significant differences in the BI and ADL scores between the two groups (t=0.233, P=0.817; t=0.337, P=0.737). After 2 weeks of treatment, the BI and ADL scores in both groups were higher than those before treatment (all P<0.05), the BI score [(22.98±3.58) points vs. (18.25±3.01) points, t=6.234, P<0.001] and ADL score [(84.21±8.92) points vs. (77.69±7.69) points, t=3.413, P=0.001] in the treatment group were higher than those in the conventional group. Conclusion In the treatment of patients with acute cerebral infarction, edaravone dexcamphenol injection with concentrated solution combined with butylphthalide can effectively improve the therapeutic effect, neurological function, and daily living ability, which is worthy of popularization and application. Reference | Related Articles | Metrics

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Retrospective analysis on false positive results in HIV screening by chemiluminescence microparticle immunoassay Wang Songzi, Wang Yichong, Li Liubing, Liang Jiaying, Deng Jiankai, Cui yingpeng International Medicine and Health Guidance News    2023, 29 (14): 1962-1966.   DOI: 10.3760/cma.j.issn.1007-1245.2023.14.009 Abstract （240）            Knowledge map    Save Objective To explore the factors causing the high false-positive rate in human immunodeficiency virus (HIV) detection by chemiluminescence microparticle immunoassay (CMIA). Methods The medical records of 295 patients positive in HIV detection by CMIA in First Hospital Affiliated to Sun Yat-sen University from January 2018 to December 2020 were retrospectively analyzed. The patients were (47.4±16.7) years old. There were 185 males who were (47.5±17.4) years old and 110 females who were (47.2±15.5) years old. According to the results of HIV confirmatory test, the patients were divided into a true positive group (101 cases) and a false positive group (194 cases). The correlations of false positive results with detection time, gender, age, and S/CO value were analyzed. The case data of 155 patients positive in HIV detection by CMIA were collected, and were divided into a true positive group (77 cases), a false positive group (78 cases), and a negative group (78 cases). The relations of false positive with the patients' diagnosis and other laboratory indicators were analyzed. SPSS 24.0 was used for the statistical analysis. The ratios were compared by χ2 test. Results The false positive rates in 2018, 2019, and 2020 were 47.6% (39/82), 67.3% (66/98), and 77.4% (89/115), respectively, indicating that the false positive rate of HIV screening by CMIA increased year by year. The false positive rate in the patients under 20 or over 70 years old was relatively higher (P<0.05). The false positive rate in the female patients was higher than that in the male patients [87.3% (96/110) vs. 53.0% (98/185)], with a statistical difference (P<0.05). The S/CO value of the most patients with false positives was low; the false positive rates of the patients with diseases of the circulatory system, digestive system, urinary system, and reproductive system were higher. Conclusion Age, gender, S/CO value, and complications of circulatory system and digestive system may cause a higher false positive rate. Reference | Related Articles | Metrics

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Nursing care for patients with electrical storm after cardiac surgery Liu Zhichang, Ling Yun, Lin Qiongyu, Zhu Sumin International Medicine and Health Guidance News    2023, 29 (13): 1896-1899.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.028 Abstract （183）            Knowledge map    Save Objective To summarize the nursing experiences for patients with electrical storm after cardiac surgery. Methods A total of 7 patients with electrical storm after cardiac surgery admitted to Guangdong Provincial People's Hospital from April 2020 to February 2022 were selected as the study objects, including 6 males and 1 female, aged (51.10±18.67) years. The nursing process for patients with electrical storm after cardiac surgery was retrospectively analyzed, including identification of electrical storm risk factors, hemodynamic monitoring and life support, paying close attention to electrolytes, nursing of antiarrhythmic drug use, moderate sedation and environmental management, skin care, psychological care, and extracorporeal membrane oxygen and supportive treatment to patients with difficult circulation stability. Results After active treatment and nursing, electrical storm was corrected in 5 patients; 1 patient was treated with extracorporeal membrane oxygenation and returned to sinus rhythm due to recurrent ventricular fibrillation; 1 patient died after rescue. Conclusions Electrical storm can occur at any time after cardiac surgery. Careful observation on rhythm changes, timely detection, active treatment, and effective nursing measures are the keys to stabilize the patients' illness. Reference | Related Articles | Metrics

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Application of comprehensive nursing intervention in treatment of androgenetic alopecia with nano-microneedles Wan Changlan, Yu Yong, Yang Kunxia, Shen Xiuling, Wu Hui, Li Runxiang, Li Zhenjie International Medicine and Health Guidance News    2023, 29 (12): 1756-1759.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.029 Abstract （175）            Knowledge map    Save Objective To observe and analyze the therapeutic effect and the changes of anxiety and depression in patients with androgenetic alopecia treated with 5% topical minoxidil introduced by nano-microneedles after strengthening comprehensive nursing intervention. Methods Eighty male patients with androgenetic alopecia admitted to Outpatient Department of Zhongshan Fourth Road, Guangzhou Institute of Dermatology from September 2021 to October 2022 were selected and divided into a control group and an observation group by the random number table method, with 40 cases in each group. The control group were (36.96±8.80) years old, and the observation group (37.05±9.69). Both groups were treated with 5% topical minoxidil by nano-microneedles. The control group were given routine nursing intervention, and the observation group comprehensive nursing intervention. The clinical efficacies, densities and thicknesses of new hair, and anxiety and depression scores were compared between the two groups after the treatment. t and χ2 tests were applied. Results The total effective rate of the observation group was significantly higher than that of the control group [87.5% (35/40) vs. 67.5% (27/40)], with a statistical difference (χ2=4.59, P<0.05). After comprehensive nursing intervention, the number of hair in the control group was significantly higher than that in the observation group (221.35±25.16) pieces/cm2 vs. (204.37±28.12) pieces/cm2, with a statistical difference (t=2.84, P<0.05). After the intervention, the scores of Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) in the observation group were lower than those in the control group [(45.55±3.43) vs. (48.20±4.71) and (46.43±1.57) vs. (49.33±4.23)], with statistical differences (t=2.88 and 4.07; both P<0.05). Conclusions Comprehensive nursing intervention can effectively alleviate the anxiety and depression of patients with androgenetic alopecia treated with nano-microneedles, and improve the therapeutic effect. Reference | Related Articles | Metrics

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Application of sacubitril/valsartan in patients with heart failure taking dialysis  Xi Zhefan, Yang Jia, Zou Haozhen, Dong Hua International Medicine and Health Guidance News    2023, 29 (18): 2522-2525.   DOI: 10.3760/cma.j.issn.1007-1245.2023.18.002 Abstract （145）            Knowledge map    Save Sacubitril/valsartan is an angiotensin receptor neprilysin inhibitor. It can inhibit the breakdown of endogenous natriuretic peptides and block angiotensin receptors, thereby reducing the activation of the renin-angiotensin-aldosterone system. It can also promote myocardial remodeling, inhibit myocardial fibrosis, increase the glomerular filtration rate, and delay the deterioration of renal function. Sacubitril/valsartan is beneficial to patients with chronic kidney disease by reducing cardiovascular risk and delaying the progression of chronic kidney disease. As a result, sacubitril/valsartan is one of the important drugs for heart failure, hypertension, and uremia. However, its long-term use may also cause some adverse reactions, especially kidney damage. There are few reports on the application of sacubitril/valsartan in patients with end-stage of renal disease and heart failure. The purpose of this study is to observe the application of sacubitril/valsartan in maintenance dialysis patients with heart failure, to investigate its safety, and to provide references for researches in relevant fields. Reference | Related Articles | Metrics

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Clinical study of dioscorea glue in the treatment of stable chronic obstructive pulmonary disease Liang Binghui, Jian Xiaoyun, Lin Zehui, Zou Peng, Jiang Rongbin, Li Jiachun, Wang Jingmin, Zhan Weijie International Medicine and Health Guidance News    2023, 29 (13): 1837-1840.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.014 Abstract （133）            Knowledge map    Save Objective To evaluate the clinical efficacy of dioscorea glue in the treatment of stable chronic obstructive pulmonary disease (COPD). Methods This was a prospective randomized controlled trial. From November 2020 to March 2022, a total of 120 patients with stable COPD and qi deficiency of lung and spleen in Department of Respiratory Medicine of Foshan Hospital of Traditional Chinese Medicine were divided into a treatment group (60 cases) and a control group (60 cases) by the random number table method. In the treatment group, there were 42 males and 18 females, aged (65.77±5.59) years. In the control group, there were 40 males and 20 females, aged (64.68±4.92) years. The control group was given conventional western medicine treatment, and the treatment group was given dioscorea glue on the basis of conventional western medicine treatment for 6 months. The changes of tumor necrosis faction-α (TNF-α), CD3+, CD4+, albumin (ALB), BODE index, and number of acute exacerbations before treatment and 3 and 6 months after treatment were observed in the two groups. t test and χ2 test were used. Results Three and six months after treatment, the TNF-α indexes [(5.89±1.14) ng/L and (5.55±1.21) ng/L] in the treatment group were lower than those in the control group [(6.79±1.11) ng/L and (6.66±1.19) ng/L], and the CD3+ [(56.61±5.49)% and (59.89±5.01)%] and CD4+ indexes [(34.56±4.49)% and (35.50±4.29)%] were higher than those in the control group [(53.64±5.68)%, (53.28±5.05)%, (30.82±4.20)%, and (30.79±4.20)%], with statistically significant differences (all P<0.05). Six months after treatment, the ALB index [(35.89±0.64) g/L] in the treatment group was higher than that in the control group [(29.14±0.64) g/L], and the BODE index [(1.63±0.95) points] and the number of acute exacerbations [(1.30±0.17) times] were lower than those of the control group [(2.18±1.12) points and (1.62±0.21) times], with statistically significant differences (all P<0.05). Conclusion Dioscorea glue combined with bronchodilator inhalant is effective in the treatment of stable COPD patients with qi deficiency of lung and spleen, which can eliminate the inflammation, regulate the immune function, improve the clinical symptoms and nutritional status, reduce the number of acute exacerbations, and improve the quality of life. Reference | Related Articles | Metrics

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Effect of ginkgo biloba dropping pills combined with valsartan capsules in treatment of elderly patients with hypertension  Liu Ning, Zheng Xueyan, Dong Min, Sun Baolian International Medicine and Health Guidance News    2023, 29 (12): 1674-1677.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.011 Abstract （128）            Knowledge map    Save Objective To observe the effect of ginkgo biloba dropping pills combined with valsartan capsules in the treatment of elderly patients with hypertension. Methods A total of 116 elderly patients with hypertension admitted to Jinan Second People's Hospital from January 2020 to December 2021 were selected for the randomized controlled trial. The patients were divided into a combined treatment group and a basic treatment group by the random number table method, with 58 cases in each group. There were 38 males and 20 females in the basic treatment group; they were (70.23±3.51) years old. There were 39 males and 19 females in the combined treatment group; they were (70.92±3.67) years old. The basic treatment group were treated with ginkgo biloba dropping pills, and the combined treatment group with ginkgo biloba dropping pills and valsartan capsules. The blood pressures before and after the treatment, clinical efficacies, and incidences of adverse reactions during the treatment were compared between the two groups. t, Z, and χ2 tests were applied. Results The diastolic blood pressures and systolic blood pressures in the 2 groups were lower after than before the treatment (all P<0.05); after the treatment, the diastolic blood pressure and systolic blood pressure in the combined treatment group were lower than those in the basic treatment group (both P<0.05). The total effective rate of the combined treatment group was significantly higher than that of the basic treatment group [96.55% (56/58) vs. 72.41% (42/58); P<0.05]. There was no statistical difference in the incidence of adverse reactions during the treatment between the combined treatment group and the basic treatment group (P>0.05). Conclusion Ginkgo biloba dripping pills combined with valsartan capsules in the treatment of elderly patients with hypertension can effectively improve the clinical efficacy and reduce their diastolic and systolic blood pressures, and is safe, so it is worthy of promotion. Reference | Related Articles | Metrics

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Effects of acetylcysteine combined with budesonide atomization on lung function and airway inflammation in patients with AECOPD Xin Yanan, Lyu Xin, Liang Fang, Li Wei, Yang Qiaofeng International Medicine and Health Guidance News    2023, 29 (24): 3556-3561.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.007 Abstract （123）            Knowledge map    Save Objective To study the effects of acetylcysteine combined with budesonide atomization on lung function and airway inflammation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 89 patients with AECOPD admitted to Liaocheng Third People's Hospital from February 2020 to February 2023 were selected and divided into an observation group (45 cases) and a control group (44 cases) by the envelope method. There were 24 males and 20 females in the control group; they were (58.69±3.64) years old. There were 25 males and 20 females in the observation group; they were (58.74±3.62) years old. The control group received conventional treatment; in addition, the observation group took acetylcysteine and budesonide atomization. The therapeutic effects, lung function [the forced expiratory volume in first second (FEV1), peak rate of expiration flow (PEF), forced vital capacity (FVC), and FEV1/FVC], blood gas indicators [oxygen partial pressure (PaO2), blood oxygen saturation (SpO2), and CO2 partial pressure (PaCO2)], serum levels of fetuin-A, retinol binding protein 4 (RBP4), and adiponection (APN), and incidences of adverse reactions were compared between the two groups. t and χ2 tests were applied. Results After the treatment, the total effective rate of the observation group was higher than that of the control group [97.78% (44/45) vs. 81.82% (36/44)], with a statistical difference (P<0.05). After the treatment, the FEV1, PEF, FVC, FEV1/FVC increased in both groups; those in the observation group were higher than those in the control group [(1.42±0.15)L vs. (1.26±0.13)L, (3.06±0.75)L/s vs. (2.60±0.78)L/s, (1.43±0.21)L vs. (1.26±0.19)L, and (64.52±3.64)% vs.(62.37±3.67)%; all P<0.05]. After the treatment, the PaO2 and SpO2 increased and PaCO2 decreased in both group, and those in the observation group were better than those in the control group (all P<0.05). After the treatment, the level of fetuin-A increased in both groups; the level in the observation group was higher than that in the control group [(408.54±40.83) mg/L vs. (390.44±37.39) mg/L; P<0.05]. After the treatment, the levels of RBP4 and APN of the two groups decreased; the levels in the observation group were lower than those in the control group [(54.63±14.24) mg/L vs. (61.43±14.63) mg/L and (8.44±2.07) μg/L vs. (9.45±2.16) μg/L; both P<0.05]. There was no statistical difference in the total incidence of rash, laryngeal irritation, nausea and vomiting, and headache between the two groups (P>0.05). Conclusion The combination of acetylcysteine and budesonide atomization for patients with AECOPD is effective, and can significantly improve their pulmonary function and blood gas indicators, and better control their airway inflammation. Reference | Related Articles | Metrics

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Clinical efficacy and safety of Dapagliflozin combined with sacubitril valsartan in the treatment of heart failure patients with reduced ejection fraction Chen Yuan, Zhao Ziming, Cui Liuyi, Ma Xiangyu, Shen Lei International Medicine and Health Guidance News    2024, 30 (2): 301-305.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.025 Abstract （117）            Knowledge map    Save Objective To investigate the clinical efficacy and safety of Dapagliflozin combined with sacubitril valsartan in the treatment of heart failure patients with reduced ejection fraction. Methods A total of 86 heart failure patients with reduced ejection fraction admitted to Zhengzhou Seventh People's Hospital from January 2020 to June 2021 were selected as the study objects and were divided into two groups according to the envelope randomization method. In the experimental group, the ratio of male to female was 26/17, and the age was (65.08±5.52) years old. In the control group, the ratio of male to female was 27/16, and the age was (65.21±5.37) years old. Forty-three patients in the control group were treated with sacubitril valsartan, and 43 patients in the experimental group were treated with Dapagliflozin on this basis, continuous oral administration for 3 months. The therapeutic effect, cardiac function, 6-min walking distance (6MWD), N-terminal brain natriuretic peptide precursor (NT-proBNP), and inflammatory factors were compared between the two groups. t test and χ2 test were used. Results After 3 months of administration, the total effective rate of the heart failure patients with reduced ejection fraction in the experimental group was higher than that in the control group [95.35% (41/43) vs. 79.07% (34/43)], with a statistically significant difference (P<0.05). After 3 months of administration, the levels of left ventricular end-diastolic inner diameter (LVIDd), NT-proBNP, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor α (TNF-α) in both groups were decreased compared with those before administration, and those in the experimental group were lower than those in the control group; the left ventricular ejection fraction (LVEF) and 6MWD levels in both groups were significantly increased compared with those before administration, and those in the experimental group were higher than those in the control group, with statistically significant differences (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the experimental group and the control group [13.95% (6/43) vs. 11.63% (5/43)] (P>0.05). Conclusion In the treatment of heart failure patients with reduced ejection fraction, Dapagliflozin combined with sacubitril valsartan has significant efficacy, which can reduce the inflammation, improve the cardiac function, increase the cardiac ejection fraction, and is safe and worthy of application. Reference | Related Articles | Metrics

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Comparison of the efficacies and safety of sodium acetate succinyl gelatin electrolyte injection and succinyl gelatin injection in perioperative period  Chen Hai, Deng Haibo, Zhang Xing, Wang Lingzhi, Yang Hanyu International Medicine and Health Guidance News    2023, 29 (17): 2452-2459.   DOI: 10.3760/cma.j.issn.1007-1245.2023.17.019 Abstract （116）            Knowledge map    Save Reference | Related Articles | Metrics

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Clinical effect of Miya cupping combined with conventional symptomatic treatment on children with exogenous fever Zhang Xiaochun, Chen Li, Zheng Shanzhen, Chen Feng, Wang Haiyan, Li Zhiya International Medicine and Health Guidance News    2023, 29 (19): 2697-2701.   DOI: 10.3760/cma.j.issn.1007-1245.2023.19.008 Abstract （94）            Knowledge map    Save Objective To investigate the clinical effect of Miya cupping combined with conventional symptomatic treatment in children with exogenous fever. Methods This study was a randomized controlled trial. A total of 208 children with exogenous fever admitted to the fever clinic of the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from September 2021 to June 2022 were selected, including 120 boys and 88 girls, aged 1.5-8.0 years. The children were divided into an experimental group and a control group using a simple random method, with 104 cases in each group. The control group adopted conventional symptomatic treatment, and the experimental group was given Miya cupping on the basis of conventional symptomatic treatment. The cooling efficacy and traditional Chinese Medicine (TCM) syndrome score of the two groups were compared. χ2 test, independent sample t test, paired t test, repeated measure ANOVA, and rank sum test were used. Results One case was withdrawn from each of the experimental group and the control group, and 103 cases were finally included in each group for analysis. Before treatment, the body temperatures of the two groups were higher than normal, and there were no statistically significant differences in the body temperature and TCM syndrome score between the two groups (all P>0.05). At 30 min, 1 h, 2 h, 4 h, and 6 h after treatment, the body temperatures of the experimental groups were (37.91±0.68) ℃, (37.64±0.58) ℃, (37.30±0.44) ℃, (36.97±0.32) ℃, and (36.89±0.30) ℃, respectively, those of the control group were (38.38±0.54) ℃, (38.15±0.45) ℃, (37.72±0.38) ℃, (37.39±0.28) ℃, and (37.20±0.23) ℃, respectively, and repeated measurement ANOVA showed that there was a statistically significant difference in the body temperature between the two groups (F=289.244, P<0.001). At 6 h after treatment, the effective rate of cooling was 99.0% (102/103) in the experimental group and 92.2% (95/103) in the control group, with a statistically significant difference between the two groups (χ2=5.693, P=0.017). The scores of fever, chills, red pharynx, nasal congestion, runny nose, cough, headache, and thirst in the experimental group were lower than those in the control group (all P<0.05). Conclusion Conventional symptomatic treatment combined with Miya cupping in the treatment of children with exogenous fever can effectively improve the clinical symptoms of fever, chills, red pharynx, nasal congestion, runny nose, cough, headache, and thirst, which has good efficacy and safety. Reference | Related Articles | Metrics

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Electromyographic biofeedback in treatment of patients suffering from hemiplegia during acute stage of cerebral infarction Lin Wenjun, Lin Xiaoting, Huang Gengbing, Lin Yuwei, Yu Zixi International Medicine and Health Guidance News    2023, 29 (24): 3649-3652.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.026 Abstract （93）            Knowledge map    Save Objective To explore the effect of electromyographic biofeedback in the treatment of patients suffering from hemiplegia during acute stage of cerebral infarction. Methods One hundred patients suffering from hemiplegia during acute stage of cerebral infarction treated at Jieyang People's Hospital from July 2021 to June 2023 were selected for the randomized controlled trial, and were divided into an observation group and a control group by the random number table method, with 50 cases in each group. At last, there were 47 cases in the observation group, including 26 males and 21 females who were (65.40±10.45) years old; there were 50 cases in the control group, including 29 males and 21 females who were (68.40±13.78) years old. Both groups routinely took neurological drugs and early rehabilitation; in addition, the observation group took electromyographic biofeedback treatment. The scores of Munual Muscle Testing (MMT), Brunnstrom's neurophysiological assessment, and Barthel index were compared between the two groups before and after the treatment. Wilcoxon non-parameter test was applied. Results The scores of MMT and Brunnstrom's neurophysiological assessment of the upper and lower limbs and Barthel index were higher after than before the treatment in both groups (all P<0.05); after the treatment, the scores of MMT of the lower limbs [3.00 (2.00, 4.00) vs. 2.00 (2.00, 3.00)], Brunnstrom's neurophysiological assessment [upper limbs: 2.00 (2.00, 3.00) vs. 2.00 (1.00, 2.00); lower limbs: 3.00 (2.00, 4.00) vs. 2.00 (2.00, 3.00)], and Barthel index [55.00 (50.00, 65.00) vs. 35.00 (15.00, 55.00)] in the observation group were better than those in the control group (all P<0.05). Conclusion Electromyographic biofeedback for patients suffering from hemiplegia during acute stage of cerebral infarction can promote their recovery of the hemiplegic limbs' function, so it is worth being clinically generalized. Reference | Related Articles | Metrics

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Advances in the application of machine learning in hemodialysis treatment Zhou Hongming, Li Yunyi, Li Weilong, Song Zhuoheng, Chen Yu, Cao Rui, Hu Bo, Luan Shaodong, Yin Lianghong International Medicine and Health Guidance News    2023, 29 (13): 1777-1781.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.001 Abstract （91）            Knowledge map    Save Hemodialysis centers are mostly for patients with chronic kidney disease, and most patients choose hemodialysis for treatment. But hemodialysis also imposes a burden of expensive medical costs and adverse reactions on patients. With the development of machine learning, machine learning has shown satisfactory results in vascular access, complications, and prognosis of hemodialysis. Therefore, grasping machine learning and using this tool are beneficial to doctors and nurses in hemodialysis room, which can ultimately improve the quality of life in hemodialysis patients. Reference | Related Articles | Metrics

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Effect applying remazolam in painless gastroenteroscopy in elderly patients Song Zhiyong, Zhang Xiaohua, Li Quan, Wang Zhao'an, Ren Gaoyan International Medicine and Health Guidance News    2023, 29 (24): 3625-3628.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.020 Abstract （89）            Knowledge map    Save Objective To investigate the effect of remazolam on cognitive function and hemodynamics in elderly patients undergoing painless gastroenteroscopy. Methods One hundred and two elderly patients undergoing painless gastroenteroscopy at Shouguang Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were selected for the randomized controlled trial, and were divided into an observation group and a routine group by the random number table method, with 51 cases in each group. There were 31 males and 20 females in the observation group; they were (9.63±6.25) years old. There were 20 males and 31 females in the routine group; they were (79.06±6.93) years old. The observation group took tsyloremazolam and afentanil for anesthesia, and the routine group took propofol and afentanil for anesthesia. The times to come to and times to leave the room, the scores of Mini-Mental State Examination before and 2 and 5 d after the operation, and the blood pressures and oxygen saturations before (T1) and 3 (T2), 6 (T3), and 9 min (T4) after administration were compared between the two groups. t and χ2 tests were applied. Results The time to come to and the time to leave the room in the observation group were shorter than those in the routine group [(7.25±1.15) min vs. (9.69±1.68) min and (28.74±4.25) min vs. (37.85±6.23) min], with statistical differences (t=14.195 and 7.852; both P<0.05). There were statistical differences in the scores of MMSE of group, time, and interaction between the two groups (Fbetween groups=17.358; Ftime=19.652; Finteraction=13.745; all P<0.05). The scores of MMSE 2 and 5 d after the operation in the observation group were higher than those in the routine group. The systolic and diastolic blood pressures and oxygen saturation at T2 in the observation group were higher than those in the routine group (Fbetween groups=9.580, 9.541, and 19.520; all P<0.05). The systolic and diastolic blood pressures and oxygen saturation at T3 and T4 were higher than those at T2 in the routine group (F时间=8.852, 9.580, and 8.520; all P<0.05). Conclusion Applying remazolam in painless gastroenteroscopy in elderly patients can shorten their time to come to, improve their cognitive function, and reduce the impact on their hemodynamics, which is worthy of clinical application. Reference | Related Articles | Metrics

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Effect of acupoint massage combined with sitting Baduanjin in improving constipation after cerebrovascular disease operation Zeng Aiqing, Sun Chi, Yu Lu, Xia Rui International Medicine and Health Guidance News    2023, 29 (23): 3466-3470.   DOI: 10.3760/cma.j.issn.1007-1245.2023.23.032 Abstract （88）            Knowledge map    Save Objective To study the effect of acupoint massage combined with sitting Baduanjin in improving constipation after cerebrovascular disease operation. Methods This study was a randomized controlled trial. One hundred patients with constipation after cerebrovascular disease operation who were hospitalized in the Second Affiliated Hospital of Nanchang University between July 2021 and January 2023 were divided into two groups with 50 cases in each group according to the random number table method. In the control group, 28 males and 22 females, aged (61.25±3.25) years, were given conventional care; in the experimental group, 30 males and 20 females, aged (62.03±3.31) years, were given acupoint massage combined with sitting Baduanjin on the basis of the control group for 4 consecutive weeks. The quality of life, defecation score, and stool trait typing were compared between the two groups. χ2 test, rank sum test, and t test were used. Results After 2 and 4 weeks of treatment, the PAC-QOL scores in the experimental group were (46.38±4.85) points and (35.17±2.46) points, which were lower than those in the control group [(54.25±5.35) points and (41.05±4.23) points], with statistically significant differences (t=7.706 and 8.497, both P<0.001). After 2 and 4 weeks of treatment, the defecation scores in the experimental group were (1.42±0.38) points and (1.02±0.18) points, which were lower than those in the control group [(1.64±0.46) points and (1.26±0.27) points], with statistically significant differences (t=2.67 and 5.230, both P<0.05). After 2 and 4 weeks of treatment, Bristol's stool characteristics were classified as type Ⅰ (10 cases, 0), type Ⅱ (16 cases, 2 cases), type Ⅲ (16 cases, 10 cases), type Ⅳ (8 cases, 22 cases), and type Ⅴ (0, 16 cases) in the experimental group, which were better than those in the control group [type Ⅰ (13 cases, 0 cases), type Ⅱ (23 cases, 10 cases), type Ⅲ (12 cases, 15 cases), type Ⅳ (2 cases, 15 cases), and type Ⅴ (0, 10 cases)], with statistically significant differences (Z=2.221 and 2.667, P=0.026 and 0.008). Conclusion Acupoint massage combined with sitting Baduanjin can effectively change the stool characteristics after cerebrovascular disease operation, promote the defecation, and improve the constipation and quality of life. Reference | Related Articles | Metrics

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A case of acute severe liver injury caused by Puyuanhewei capsules He Xiangqin, Zhang Junhua, Yang Fang, Ding Guofeng International Medicine and Health Guidance News    2023, 29 (22): 3205-3208.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.015 Abstract （85）            Knowledge map    Save The clinical data of a patient with severe liver injury caused by Puyuanhewei capsules for chronic atrophic gastritis in Binzhou Medical University Hospital were retrospectively analyzed. The causal relationship between Puyuanhewei capsules and liver injury was evaluated according to the Roussel Uclaf assessment method (RUCAM). Through document retrieval, the components that may cause liver injury in Puyuanhewei capsules were analyzed, and it was found that the possible pathogenic components were corydalis Yanhusuo and Taraxacum. The purpose is to remind clinicians to closely monitor the patients' liver function when using Puyuanhewei capsules and traditional Chinese patent medicines and simple preparations containing corydalis Yanhusuo, and to stop using the drug in time after serious liver damage occurs. Reference | Related Articles | Metrics

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Hyperthermia occurred after intravenous infusion of pantoprazole sodium for injection in a patient Zhao Zhanwei, Cong Ying, Cui Hongxia International Medicine and Health Guidance News    2023, 29 (12): 1713-1716.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.019 Abstract （85）            Knowledge map    Save This article reports an elderly diabetic patients at Weihai Central Hospital, Qingdao University. The patient had a fever after taking pantoprazole sodium for injection after stent placement in the left subclavian artery. After having a fever, the patient took anti-infection and anti-fever treatment, but had no ideal effect. The lung CT showed no pulmonary infection and the 2 cultures were negative, so the pharmacist doubted that it was drug fever, and recommended the patient stopped the suspicious drugs, and the patient's body temperature returned to normal. The case analysis showed that the patient could have a fever after intravenous infusion of pantoprazole sodium for injection. Therefore, the clinical occurrence of unexplained fever should be considered the possibility of drug fever. Reference | Related Articles | Metrics

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Research progress on new immunosuppressive agents in treatment of idiopathic membranous nephropathy Yang Jia, Xi Zhefan, Zou Haozhen, Xu Qiang, Dong Hua International Medicine and Health Guidance News    2023, 29 (18): 2517-2521.   DOI: 10.3760/cma.j.issn.1007-1245.2023.18.001 Abstract （83）            Knowledge map    Save Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in adults. Although conventional immunosuppressive drugs can improve the remission rate, there are serious adverse effects and some patients can progress to end-stage renal disease within a few years. This article mainly introduces the progress on new immunosuppressive agents in the treatment of idiopathic membranous nephropathy. Reference | Related Articles | Metrics

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One case of epileptiform seizures caused by cefmetazole sodium for injection  Zhang Na, Gao Yue International Medicine and Health Guidance News    2023, 29 (16): 2319-2321.   DOI: 10.3760/cma.j.issn.1007-1245.2023.16.023 Abstract （80）            Knowledge map    Save Cefmetazole is a semi-synthetic antibiotic of cephalosporins, and is widely used in clinical practice. Its common adverse reactions mainly include glutamic oxaloacetic transaminase and glutamic-pyruvic transaminase elevation, rash, nausea, vomiting, allergic reaction, etc. This paper reports a patient with epileptic seizures during intravenous infusion of cefmetazole sodium at Songjiang District Central Hospital. According to the evaluation method of adverse drug reactions, the epileptic seizures in the patient might be caused by the use of cefmetazole sodium. Through the report of this case, we hope that the clinical staff pay attention to epileptic seizures possibly caused by cefmetazole and hope to provide clinical references. Reference | Related Articles | Metrics

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Research progress of platelets in liver cirrhosis Zhou Zhaonian, Zheng Weiqiang International Medicine and Health Guidance News    2023, 29 (12): 1640-1643.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.003 Abstract （77）            Knowledge map    Save Platelets, the main effector cells in hemostasis, undergo dynamic changes in their structure and function and are involved in complex pathophysiological processes through granule release, associated signaling receptors, and platelet aggregation and activation. Significant thrombocytopenia is present in patients with cirrhosis, and increasing evidences suggest that platelets play important roles in processes such as immune inflammation, host defense, angiogenesis, tissue repair, regeneration, etc. The potential role of platelets in cirrhosis is reviewed in the hope of improving the survival quality of patients with cirrhosis. Reference | Related Articles | Metrics

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One case of lumbar intervertebral infection and intracranial infection caused by staphylococcus aureus Yin Xiaoling, Sun Shuangxi, Wang Yumei, Kang Junyang International Medicine and Health Guidance News    2023, 29 (18): 2628-2630.   DOI: 10.3760/cma.j.issn.1007-1245.2023.18.026 Abstract （73）            Knowledge map    Save Primary lumbar intervertebral infection caused by Staphylococcus aureus is rare, and the combination with intracranial infection is rarer. A 64-year-old male patient was admitted to Weihai Central Hospital with nervous system symptoms. The diagnosis was confirmed after physical examination and related auxiliary examinations. After multidisciplinary treatment, the patient achieved good prognosis. Reference | Related Articles | Metrics

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Clinicopathological significance of expression level of tumor-infiltrating lymphocytes in patients with HER2 positive breast cancer Man Qirong, Zhao Tiantian, Duan Chao, Li Ling International Medicine and Health Guidance News    2023, 29 (22): 3231-3235.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.021 Abstract （73）            Knowledge map    Save Objective To investigate the relationship between the expression of tumor-infiltrating lymphocytes (TILs) and clinicopathological characteristics, and the effect of TILs on prognosis in patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer. Methods A total of 94 female patients with HER2 positive breast cancer treated at Tengzhou Central People's Hospital from October 2016 to October 2018 were collected, with a median age of 51 years (32-73 years). Among them, 49 patients took trastuzumab and chemotherapy, and 45 chemotherapy. The degree of TILs in the tumor area of each patient's HE section was evaluated. χ² test was used to analyze the category data. The Kaplan Meier survival curve and Cox proportional hazard regression model were used to analyze the prognostic factors. The relationship between the degree of TILs and the clinicopathological characteristics and the effect of TILs on the patients' recurrence free survival (RFS) were analyzed. Results Among the 94 patients, 61 had low infiltration, and 33 high infiltration. There were no significant correlations between the degree of TILs and clinical pathological parameters (all P>0.05). In the targeted therapy group, 32 cases had low infiltration, and 17 cases high infiltration. The RFS of the patients with high TILs was longer than that of the patients with with low TILs (P=0.036); TNM stage and the degree of TILs were independent factors for the patients' prognosis (P=0.003 and 0.029). In the general chemotherapy group, 29 cases had low infiltration, and 16 cases high infiltration. The RFS of the patients with high TILs was longer than that of the patients with with low TILs (P=0.049); TNM stage and TILs were independent factors related to the patients' prognosis (P=0.001 and 0.028). Conclusions TILs can be used as tumor markers in predicting the prognosis and therapeutic effect of patients with HER2 positive breast cancer, and may become new therapeutic targets for tumors. Reference | Related Articles | Metrics

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Role of gut microbiota imbalance in alpha-synuclein induced microglia activation in patients with Parkinson's disease Cai Jinfeng, Wang Hongcai, Ge Ruli International Medicine and Health Guidance News    2023, 29 (22): 3153-3157.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.001 Abstract （71）            Knowledge map    Save More and more evidences show that gut microbiota is closely related to the development and progression of Parkinson's disease (PD). Recent studies have shown that gut microbiota can activate microglia in the brain by regulating alpha-synuclein (α-syn), aggravate neuroinflammation, and lead to dopamine neuron loss in patients with PD. In this paper, we review how the imbalance of gut microbiota leads to neuroinflammation through α-syn activation of microglia in the pathogenesis of PD. Reference | Related Articles | Metrics

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High frequency ultrasound characteristics of postpartum diastasis recti abdominis and its correlation with delivery mode Luo Si, He Junchu, Liang Yinru, Li Zhenzhou International Medicine and Health Guidance News    2023, 29 (24): 3529-3532.   DOI: 10.3760/cma.j.issn.1007-1245.2023.24.001 Abstract （70）            Knowledge map    Save In this paper, we reviewed the current research status of the high-frequency ultrasound features of postpartum diastasis recti abdominis and its correlation with delivery methods. It focuses on exploring the relationship between delivery methods and high-frequency ultrasound features of postpartum diastasis recti abdominis. We have discovered the widespread application of the high-frequency ultrasound technology in the evaluation of postpartum diastasis recti abdominis. Its high-frequency ultrasound features are of great significance for accurate evaluation and monitoring of postpartum diastasis recti abdominis. We have summarized that delivery methods have impact on the high-frequency ultrasound features of postpartum diastasis recti abdominis. Reference | Related Articles | Metrics

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Clinical efficacy of vincamine sustained-release capsules combined with brimonidine tartrate eye drops in treatment of anterior ischemic optic neuropathy Gu Chen, Ding Youshu, Bi Chao International Medicine and Health Guidance News    2023, 29 (12): 1693-1697.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.015 Abstract （68）            Knowledge map    Save Objective To observe the clinical efficacy of vinblastine sustained-release capsules combined with brimonidine tartrate eye drops in the treatment of anterior ischemic optic neuropathy. Methods A prospective study was conducted on 118 patients with anterior ischemic optic neuropathy admitted to Jining Puming Eye Hospital and Jinan Second People's Hospital from March 2020 to March 2022. They were randomly divided into a conventional group (59 cases with 64 eyes) and a combined group (59 cases with 64 eyes) by the red blue bicolor method. The routine group [31 men (35 eyes) and 28 women (29 eyes); 51-60 (55.78±4.20) years old; disease course 5-10 (7.28±2.11) days] were treated with brimonidine tartrate eye drops, and the combined group [30 men (34 eyes) and 29 women (30 eyes); 51-61 (55.82±4.31) years old; disease course 5-10 (7.30±2.15) days] with vinblastine sustained-release capsules and brimonidine tartrate eye drops. The clinical efficacies and incidences of adverse reactions of the two groups were compared. t and χ2 tests were applied. Results The total effective rate of the combined group was higher than that in the conventional group [96.88% (62/64) vs. 79.69% (51/64)], with a statistical difference (χ2=9.14, P<0.05). After the treatment, the thicknesses of peripheral nerve fiber layer and retinal ganglion cell complex in the combined group were lower than those in the conventional group [(66.15±11.19) μm vs. (83.06±14.23)μm and (61.37±6.27) μm vs. (74.11±7.82) μm], with statistical differences (t=7.473 and 10.17, both P<0.05). After the treatment, the 60'P100 and 15'P100 latencies in the combined group were lower than those in the conventional group [(108.21±2.34) ms vs. (110.78±2.74) ms and (110.25±3.12) ms vs. (113.58±3.68) ms], with statistical differences (t=5.71 and 5.52, both P<0.05). After the treatment, the amplitudes of 60'P100 and 15'P100 waves in the combined group were higher than those in the conventional group [(5.21±1.07)μV vs. (4.23±1.02) μV and (6.79±1.26) μV vs. (5.38±1.14) μV], with statistical differences (t=4.82 and 6.64, both P<0.05). After the treatment, the standard deviation of corrected visual field shape and the mean deviation of visual field in the combined group were significantly lower than those in the conventional group [(3.34±0.38) vs. (3.72±0.42) and (-5.01±1.42) vs. (-6.54±1.59)], with statistical differences (t=5.37 and 5.74, P<0.05). After the treatment, the light sensitivity and visual acuity of the combined group were significantly higher than those of the conventional group [(17.51±2.30) dB vs. (14.52±2.27) dB and (0.73±0.25) vs. (0.48±0.16)], with statistical differences (t=7.40 and 6.74, P<0.05). Conclusion Vinblastine sustained-release capsules combined with brimonidine tartrate eye drops has obvious effect in the treatment of patients with anterior ischemic optic neuropathy, and can significantly improve their visual field, visual acuity, light sensitivity, and amplitude and latency of P100 wave of visual evoked potential and reduce the thickness of peripheral nerve fiber layer and retinal ganglion cell complex, with high safety. Reference | Related Articles | Metrics

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Meta-analysis of stellate ganglion block in treatment of migraine Yan Wanhong, Xue Jianjun, Jia Yu, Wang Shitai International Medicine and Health Guidance News    2023, 29 (12): 1629-1635.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.001 Abstract （67）            Knowledge map    Save Objective To systematically evaluate the clinical efficacy and safety of stellate ganglion block for migraine. Methods The PubMed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, China Science and Technology Journal Database, and WanFang Data were searched for randomized controlled trials on stellate ganglion block in the treatment of migraine from their establishment to September 2022. A risk of bias assessment tool recommended by the Cochrane Handbook was used to evaluate the inherent bias of the included studies. The data were statistically analyzed by the RevMan 5.4 software. Results In the final meta-analysis, 26 studies with a total of 2 074 patients were included. The results showed that the effective rate in treating migraine in the stellate ganglion block group was higher than that in the control group (RR=1.21, 95%CI 1.15-1.29, P<0.001). The duration of headache attacks (MD=-2.80, 95%CI -4.32-1.28, P<0.001) and the headache score of Visual Analogue Scale (MD=-1.02, 95%CI -1.35-0.68, P<0.001) after the treatment in the stellate ganglion block group were lower than those in the control group. There was no statistical difference in the incidence of adverse reactions between the two groups (RR=0.98, 95%CI 0.46-2.09, P=0.95). Conclusion The stellate ganglion block, an effective treatment for migraine, has obvious advantages in terms of reducing headache severity and improving headache duration, and does not increase its related adverse reactions. Reference | Related Articles | Metrics

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Relationship between intestinal floras and metabolic diseases Fang Jianfeng International Medicine and Health Guidance News    2023, 29 (16): 2225-2229.   DOI: 10.3760/cma.j.issn.1007-1245.2023.16.002 Abstract （66）            Knowledge map    Save Metabolic diseases refer to the general name for metabolic disorders, including obesity, diabetes, non-alcoholic liver disease, etc. There are tens of billions of bacteria in human gut; their metabolites can interact with the human hosts and affect human health. The gut microbiotas are closely related to the human hosts' metabolic health; in abnormal situations, they may lead to a variety of common metabolic diseases, such as obesity, type 2 diabetes, non-alcoholic liver disease, cardio-pulmonary metabolic diseases, malnutrition, etc. In this review, we discuss the relationship of gut microbiotas with common metabolic diseases, the pathogenic mechanisms leading to these diseases, and the treatment and prevention methods of metabolic diseases from the perspectives of gut microbiotas, so as to provide new directions for the treatment of metabolic diseases. Reference | Related Articles | Metrics

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Tropisetron and esomeprazole in prevention and treatment of chemotherapy related gastrointestinal adverse reactions in patients with colorectal cancer Li Shanshan, Liang Bing, Liu Qiwei International Medicine and Health Guidance News    2023, 29 (18): 2592-2596.   DOI: 10.3760/cma.j.issn.1007-1245.2023.18.018 Abstract （66）            Knowledge map    Save Objective To explore the preventive and therapeutic effects of tropisetron versus esomeprazole for chemotherapy related gastrointestinal adverse reactions in patients with colorectal cancer. Methods One hundred and twenty-four patients with colorectal cancer taking chemotherapy at Nanyang First People's Hospital from January 2020 to January 2022 were selected for the randomized controlled trial. They were divided into groups A and B by lottery, with 62 cases in each group. There were 32 males and 30 females in group A; they were (55.25±5.37) years old. There were 31 males and 31 females in group B; they were (56.07±5.22) years old. Group A took tropisetron and chemotherapy, and group B esomeprazole and chemotherapy. Both groups were followed up for one year. The incidence of gastrointestinal adverse reactions during chemotherapy, the scores of Index of Nausea, Vomiting, and Retching (INVR) on day 1, 7 and 14 of chemotherapy and after one chemotherapy cycle, and the long-term quality of life were compared between the two groups. χ2 and t tests were applied. Results After the treatment with different drugs, the incidence of gastrointestinal adverse reactions during chemotherapy, the acid reflux frequency, the nausea frequency, and the vomiting frequency in group A were lower than those in group B [12.90% (8/62) vs. 30.65% (19/62), (1.16±0.23) times/d vs. (3.44±1.22) times/d, (2.14±0.45) times/d vs. (4.41±1.23) times/d, and (1.27±0.33) times/d vs. (3.11±1.25) times/d; χ2=5.729; t=14.461, 13.647, and 11.207; all P<0.05]. There was no statistical difference in the score of INVR between groups A and B on day 1 of chemotherapy [(20.33±5.41) vs. (21.24±5.18); t=1.272, P>0.05]. The scores of INVR on day 7 and 14 of chemotherapy and after one cycle of chemotherapy in group A were lower than those in group B [(15.11±3.46) vs. (18.61±3.12), (12.33±2.46) vs. (14.24±3.36), and (10.19±1.47) vs. (12.25±2.72); t=5.915, 5.156, and 5.246; all P<0.05]. During the follow-up period, the scores of physiological status, social/family status, emotional status, functional status, sleep status, and compliance status of Functional Assessment of Cancer Therapy of Colorectal (FACT-C) in group A were higher than those in group B [(22.45±5.33) vs. (19.35±5.31), (23.36±5.27) vs. (20.18±5.32), (20.31±5.24) vs. (17.25±5.33), (21.25±5.16) vs. (18.44±5.28), (23.11±5.17) vs. (20.21±5.22), and (23.35±5.25) vs. (20.22±5.32); t=3.244, 3.344, 3.244, 2.997, 3.108, and 3.297; all P<0.05]. Conclusion Tropisetron is better than esomeprazole in the prevention and treatment of gastrointestinal adverse reactions. Reference | Related Articles | Metrics

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Roles of epigenetics and miRNA in depression Chen Guanhong, Yu Mingzi, Fang Yuhan, Cheng Xuefeng, Li Qi, Li Chen International Medicine and Health Guidance News    2023, 29 (13): 1782-1786.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.002 Abstract （64）            Knowledge map    Save Depression, one of the most important types of modern mental illness, is a common emotional disorder with continuous and long-term depression as its main clinical feature. Recent studies have shown that dysexpression of miRNA is associated with a variety of human diseases, including cancer and psychology-related diseases, and miRNA plays an important role in the pathogenesis of depression and antidepressant treatment. Epigenetics refers to the biological phenomenon of long-term heritable gene function changes without changes in DNA sequence, including histone modification, DNA methylation, and miRNA regulation. Many studies have shown that dysregulation of epigenetic modification is the key to elucidating the pathogenesis of depression. This paper reviews the recent progress in epigenetic pathogenesis of depression and the role of miRNA in depression, in order to provide reference for the pathogenesis study and treatment of depression. Reference | Related Articles | Metrics

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Progress in treatment techniques for femoral shaft fractures in children Sun Hongshuo, Zhang Zhibo, Li Peng, Du Gangqiang, Jiang Jianhao, Yang Shuye International Medicine and Health Guidance News    2024, 30 (2): 177-181.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.001 Abstract （64）            Knowledge map    Save Femoral shaft fractures during childhood are a frequent type of fractures, comprising 1.4%-1.7% of all childhood fractures. The children's age, weight, type of fractures, and mode of injuries all need to be taken into consideration when deciding on the best treatment. Generally, non-invasive fixation methods, such as Pavlik sling or hip herringbone cast, are used for preschool children, while internal fixation methods, such as plates, flexible intramedullary nails, and locked intramedullary nails, are preferred for school-age children. External fixation, on the other hand, is typically reserved for special cases, such as complex trauma. This article reviews the progress of research on treatment techniques for childhood femoral shaft fractures, including conservative treatment, external fixation, and closed reduction. Reference | Related Articles | Metrics

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Research progress of GSDMD-mediated pyrodeath in atrial fibrillation Shang Xue, Zhao Jiahao, Li Xinxi, Zhu Hui, Zhao Ke, Liu Zhenxing, Xu Huipu International Medicine and Health Guidance News    2023, 29 (20): 2825-2828.   DOI: 10.3760/cma.j.issn.1007-1245.2023.20.001 Abstract （63）            Knowledge map    Save Pyroptosis is a programmed death mode recently discovered. Its pathways include the classical pyroptosis pathway, non-classical pyroptosis pathway, other caspase-mediated pyroptosis pathway, and granulozyme mediated pathway. Gasdermin protein (GSDM) is the final efficient protein. GSDMD is one of the Gasdermin pore-forming proteins that have been studied extensively and deeply. Pyrodeath is associated with chronic inflammatory diseases, tumors, atherosclerotic diseases, metabolic diseases, and neurodegenerative diseases. In recent years, it is found that pyrodeath involves in the cardiovascular field, but the research on atrial fibrillation is still in its infancy. Further research on the mechanism of pyrodeath in atrial fibrillation may become one of the effective strategies for atrial fibrillation in the future. Reference | Related Articles | Metrics

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Secondary Pneumocystis jirovecii pneumonia in one non-HIV patient during recovery period of COVID-19 Li Fei, Guo Lijuan, Wu Jingbo, Shi Xinjie International Medicine and Health Guidance News    2023, 29 (20): 2937-2940.   DOI: 10.3760/cma.j.issn.1007-1245.2023.20.024 Abstract （62）            Knowledge map    Save Pneumocystis jirovecii (PJ) is an opportunistic pathogen that can cause PJ pneumonia (PJP), which is common in human immunodeficiency virus (HIV) infected individuals. This paper reports a patient with COVID-19 and without underlying disease of HIV admitted to Department of Respiratory and Critical Care Medicine, Weihai Central Hospital, Qingdao University. The patient was improved after treatment but deteriorated during follow-up and was clearly diagnosed with PJP by the next-generation sequencing (NGS). This paper reviews the relevant literatures so as to provide some help for diagnosis and treatment of PJP. Reference | Related Articles | Metrics

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Treatment of 30 cases of kidney stones with combined traditional Chinese medicine stone expulsion after ultramicro-percutaneous nephrolithotripsy Liang Jianfeng, Xu Beixun, Xu Jinfeng, Pan Jie, Chen Jufeng, Wu Yuanshun, Ao Dawen, Ye Yinglin, Ruan Yongtong International Medicine and Health Guidance News    2023, 29 (13): 1841-1844.   DOI: 10.3760/cma.j.issn.1007-1245.2023.13.015 Abstract （62）            Knowledge map    Save Objective To evaluate the effect of combined traditional Chinese medicine stone expulsion after ultramicro-percutaneous nephrolithotripsy in the treatment of kidney stones below 2 cm. Methods This study was a randomized controlled trial. From October 2020 to December 2021, 60 patients with kidney stones who underwent ultramicro-percutaneous nephrolithotripsy in Department of Urology, Yangjiang Hospital of Traditional Chinese Medicine were enrolled. They were grouped according to the random numbering method, with 30 patients in each group. In the treatment group, 12 males and 18 females, with an average age of 37.43 years old, were treated with minimally invasive surgery combined with traditional Chinese medicine stone expulsion. In the control group, 15 males and 15 females, with an average age of 46.20 years old, were not given traditional Chinese medicine stone expulsion. The stone clearance rate and stone expulsion time after surgery were compared between the two groups. χ2 test was used. Results All 60 surgeries were successfully performed. Among them, the effective rate of the treatment group reached to 96.7% (29/30), which was higher than that of the control group [83.3% (25/30)], with a statistically significant difference (P<0.05). Conclusion In the treatment of kidney stones, the combination of minimally invasive surgery and traditional Chinese medicine stone expulsion is minimally invasive and efficient, and has few complications, which significantly reduces the damage to the body. Reference | Related Articles | Metrics

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Effect of modified Fangji Huangqi Decoction on drainage volume and inflammation in patients after laparoscopic tension-free inguinal hernia repair You Lixiang, Wu Xinjun, Du Shengwang, Shi Chunqiang International Medicine and Health Guidance News    2023, 29 (16): 2285-2288.   DOI: 10.3760/cma.j.issn.1007-1245.2023.16.015 Abstract （62）            Knowledge map    Save Objective To explore the effect of modified Fangji Huangqi Decoction on drainage volume and inflammation in patients after laparoscopic tension-free inguinal hernia repair. Methods A total of 102 patients after taking laparoscopic tension-free inguinal hernia repair at Lianyungang Hospital of Traditional Chinese Hospital from March 2020 to March 2021 were selected for the randomized controlled trial, and were divided into an observation group and a conventional group by the random number table method, with 51 cases in each group. In the observation group, there were 31 males and 20 females; they were (65.98±5.02) years old; their bleeding volume was (60.38±6.36) ml. In the conventional group, there were 30 males and 21 females; they were (64.38±5.48) years old; their bleeding volume was (59.38±6.10) ml. The conventional group were treated with Huangqi Jianzhong Decoction, and the observation group with modified Fangji Huangqi Decoction, for 3 d. The clinical efficacies, levels of interleukin-4 (IL-4) and C-reactive protein (CRP), drainage volumes, and drug safety were compared between the 2 groups. t and χ2 tests were applied. Results There was no statistical difference in the total effective rate between the two groups (P > 0.05). After the treatment, the levels of IL-4 and CRP and the drainage volume in the observation group were lower than those in the conventional group [(92.15±12.76) ng/L vs. (99.13±12.24) ng/L, (7.89±1.98) mg/L vs. (9.53±1.21) mg/L, and (71.36±13.58) ml vs. (89.63±15.36) ml; all P<0.05]. There was no statistical difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Modified Fangji Huangqi Decoction can reduce the drainage volume and inflammation in patients after laparoscopic tension-free inguinal hernia repair. Reference | Related Articles | Metrics

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NLRP3 inflammasome and diabetic cardiomyopathy Zhang Cui, Liu Zhen, Liu Jingyang, Shi Xinye, Liu Zhiqiang, Sun Jingwu International Medicine and Health Guidance News    2023, 29 (16): 2221-2225.   DOI: 10.3760/cma.j.issn.1007-1245.2023.16.001 Abstract （61）            Knowledge map    Save Diabetic cardiomyopathy (DCM) is a specific heart disease caused by diabetes, and is independent from other cardiovascular diseases. The pathogenesis of DCM is not very clear. Studies have found that inflammation plays an important role in the occurrence and development of DCM. With the discovery of NLRs family, more and more studies have been conducted on NLRP3 inflammasome and DCM. A large amount of evidence suggests that NLRP3 is involved in the pathophysiological process of DCM by mediating the release of pro-inflammatory factors and pyrodeath of cells. In this article, we systematically review the basic knowledge of NLRP3 inflammatories, the relationship between NLRP3 and DCM, and the therapeutic drugs targeting NLRP3 in DCM. Reference | Related Articles | Metrics

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Application of hydromorphone combined with ketorolac tromethamine in analgesia for patients undergoing laparoscopic cholecystectomy Weng Hongliang, Li Yujian, Li Zhibing, Li Xingda, Chen Benfa, Ma Yufeng International Medicine and Health Guidance News    2023, 29 (12): 1670-1673.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.010 Abstract （61）            Knowledge map    Save Objective To explore the value applying hydromorphone combined with ketorolac tromethamine in analgesia for patients undergoing laparoscopic cholecystectomy. Methods One hundred and twelve patients who took laparoscopic cholecystectomy in Linyi Central Hospital from July 2020 to June 2022 were selected for the randomized controlled trial. They were divided into a study group and a conventional group by the random number table method, with 56 cases in each group. There were 34 males and 22 females in the study group; they were (59.36±12.36) years old. There were 33 males and 23 females in the conventional group; they were (59.96±13.52) years old. The study group were anesthetized with hydromorphone and ketorolac tromethamine, and the conventional group with ketorolac tromethamine. The hospital stays, operation times, postoperative pain degrees [score of Visual Analog Scale (VAS)], and adverse reactions of the two groups were observed. t and χ2 tests were applied. Results The hospital stay in the study group was shorter than that in the conventional group [(5.58±3.01) d vs. (8.52±3.14) d; t=5.058, P<0.001]. The VAS scores in both group were lower 9 than 6 h after the operation; the VAS scores 6 and 9 h after the operation in the study group were lower than those in the conventional group (t=37.133 and 26.641, both P<0.001). The incidence of adverse reactions in the study group was lower than that in the conventional group [5.36% (3/56) vs. 17.86% (10/56); χ2=4.264, P=0.039]. Conclusion For patients undergoing laparoscopic cholecystectomy, 0.04 mg/kg hydromorphone combined with 0.5 mg/kg ketorolac tromethamine can promote their recovery and reduce the incidence of adverse reactions, and has significant sedative effect, so it is worthy of promotion. Reference | Related Articles | Metrics

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Therapeutic effect of blocking entrapment fixation with three Kirschner wires in the treatment of bone mallet finger Yuan Yunhua, Yu Tao, Tan Fang, Zhang Xingpeng, Wang Jian, Li Kai International Medicine and Health Guidance News    2023, 29 (17): 2463-2466.   DOI: 10.3760/cma.j.issn.1007-1245.2023.17.021 Abstract （61）            Knowledge map    Save Objective To introduce a method and its effect of blocking entrapment fixation with three Kirschner wires in the treatment of bone mallet finger. Methods From June 2019 to June 2022, 23 patients with bone mallet finger and avulsion fracture at the base of phalangeal phalanges in Shanghai Pudong New Area People's Hospital were retrospectively analyzed, including 16 males and 7 females, aged (32.17±7.99) years. After closed reduction, one Kirschner wire was used to fix the distal interphalangeal joint in overextension position, and two Kirschner wires were used to block the avulsion block with continuous entrapment. The three Kirschner wires were removed 6 weeks after surgery, and the activity of distal interphalangeal joint and fracture healing were observed and recorded during follow-up. Results The average follow-up was (11.22±5.72) months, and the operative time was (46.91±11.78) minutes. One patient was cured satisfactorily after dressing change due to local skin necrosis caused by the compression of the finger dorsal side by blocking Kirschner wire. No needle tract infection or skin necrosis was found in the other patients. All patients had bone healing and good finger movement. At the last follow-up, according to the Grawford functional evaluation criteria, 13 cases were excellent, 9 cases were good, and 1 case was fair, with an excellent and good rate of 95.65%. Conclusion Blocking entrapment fixation with three Kirschner wires in the treatment of bone mallet finger is stable and reliable, with simple operation, satisfactory effect, and clinical significance. Reference | Related Articles | Metrics

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Nursing care for a patient with immunotherapy-associated myocarditis and myositis caused by tirelizumab Wu Jieyuan, Cao Yingchun, Zhang Yongjun International Medicine and Health Guidance News    2023, 29 (22): 3298-3300.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.035 Abstract （61）            Knowledge map    Save The nursing experience of a patient with immunotherapy-associated myocarditis and myositis caused by tirelizumab was summarized. The nursing key points were as below: the multidisciplinary specialist nursing team was established; a phased and individualized early rehabilitation exercise program was developed; the formulation of endurance exercise prescription, early cardiopulmonary rehabilitation exercise, and limb rehabilitation exercise combined with Borg classification; monitoring the conditions closely; cooperation with the treatment; psychological nursing; posture management; pressure ulcers prevention; early nutritional support. After multidisciplinary treatment and careful nursing, the patient was improved and discharged from the hospital. The follow-up after discharge showed that the patient basically resumed self-care. Reference | Related Articles | Metrics

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Secondary pulmonary tuberculosis in one patient with myelodysplastic syndrome during recovery period of Pneumocystis jirovecii pneumonia Li Fei, Guo Lijuan, Shi Xinjie International Medicine and Health Guidance News    2023, 29 (22): 3187-3190.   DOI: 10.3760/cma.j.issn.1007-1245.2023.22.009 Abstract （60）            Knowledge map    Save Myelodysplastic syndrome (MDS) is characterized by abnormal hematopoiesis of blood cells. Patients with MDS often have low immune function. This paper reports a case of MDS patient with chest tightness as the main symptom. The patient was admitted to Weihai Central Hospital, Qingdao University and diagnosed with Pneumocystis jirovecii pneumonia. After treatment, the conditions were improved. However, the patient was hospitalized again because of fever, and the application of conventional anti-infective drugs was ineffective. After the second-generation sequencing technology, the patient was finally diagnosed as pulmonary tuberculosis. The related literatures were reviewed in order to provide some help to clinical work. Reference | Related Articles | Metrics

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One case of primary mucoepidermoid carcinoma on anterior chest wall skin Hou Guoqi, Tang Yan, Li Yingming International Medicine and Health Guidance News    2023, 29 (12): 1716-1718.   DOI: 10.3760/cma.j.issn.1007-1245.2023.12.020 Abstract （58）            Knowledge map    Save Reference | Related Articles | Metrics