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Clinical efficacy and safety of Dapagliflozin combined with sacubitril valsartan in the treatment of heart failure patients with reduced ejection fraction Chen Yuan, Zhao Ziming, Cui Liuyi, Ma Xiangyu, Shen Lei International Medicine and Health Guidance News    2024, 30 (2): 301-305.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.025 Abstract （264）            Knowledge map    Save Objective To investigate the clinical efficacy and safety of Dapagliflozin combined with sacubitril valsartan in the treatment of heart failure patients with reduced ejection fraction. Methods A total of 86 heart failure patients with reduced ejection fraction admitted to Zhengzhou Seventh People's Hospital from January 2020 to June 2021 were selected as the study objects and were divided into two groups according to the envelope randomization method. In the experimental group, the ratio of male to female was 26/17, and the age was (65.08±5.52) years old. In the control group, the ratio of male to female was 27/16, and the age was (65.21±5.37) years old. Forty-three patients in the control group were treated with sacubitril valsartan, and 43 patients in the experimental group were treated with Dapagliflozin on this basis, continuous oral administration for 3 months. The therapeutic effect, cardiac function, 6-min walking distance (6MWD), N-terminal brain natriuretic peptide precursor (NT-proBNP), and inflammatory factors were compared between the two groups. t test and χ2 test were used. Results After 3 months of administration, the total effective rate of the heart failure patients with reduced ejection fraction in the experimental group was higher than that in the control group [95.35% (41/43) vs. 79.07% (34/43)], with a statistically significant difference (P<0.05). After 3 months of administration, the levels of left ventricular end-diastolic inner diameter (LVIDd), NT-proBNP, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor α (TNF-α) in both groups were decreased compared with those before administration, and those in the experimental group were lower than those in the control group; the left ventricular ejection fraction (LVEF) and 6MWD levels in both groups were significantly increased compared with those before administration, and those in the experimental group were higher than those in the control group, with statistically significant differences (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the experimental group and the control group [13.95% (6/43) vs. 11.63% (5/43)] (P>0.05). Conclusion In the treatment of heart failure patients with reduced ejection fraction, Dapagliflozin combined with sacubitril valsartan has significant efficacy, which can reduce the inflammation, improve the cardiac function, increase the cardiac ejection fraction, and is safe and worthy of application. Reference | Related Articles | Metrics

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Semaglutide combined with clomiphene for obese patients with polycystic ovary syndrome and insulin resistance Yang Qiaofen, Li Xingmei, Zhang Xuan International Medicine and Health Guidance News    2024, 30 (11): 1802-1807.   DOI: 10.3760/cma.j.issn.1007-1245.2024.11.009 Abstract （152）            Knowledge map    Save Objective To evaluate the effect of semaglutide combined with clomiphene for obese patients with polycystic ovary syndrome (PCOS) and insulin resistance. Methods A total of 102 obese patients with PCOS and insulin resistance who were treated at Yulin Hospital, First Hospital, Xi 'an Jiaotong University from January 2022 to December 2023 were selected for the randomized controlled trial. They were divided into a control group and a study group by the random number table method, with 51 cases in each group. The control group were (28.45±3.21) years old; their disease course was (5.36±0.76) years. The study group were (28.38±3.19) years old; their disease course was (5.41±0.77) years. The control group took clomiphene, and the study group clomiphene and semaglutide, for 12 weeks. The body mass indexes (BMI), glycemic and lipid metabolism indicators [homeostatic model assessment of beta-cell function (HOMA-β), homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides (TG), and total cholesterol (TC)], endometrial and ovulation conditions (endometrial thickness, cervical mucus score, and number of mature follicles), serological indicators [protein tyrosine phosphatase 1B (PTP1B), fibroblast growth factor 21 (FGF21), and insulin-like growth factor (IGF)], changes in intestinal floras (Enterococcus, Enterobacteriaceae, Bifidobacterium, and Lactobacillus), and adverse reactions (nausea and vomiting, hypoglycemia, fatigue, and dizziness and headache) were compared between the two groups. t and χ2 tests were used for the statistical analysis. Results After the treatment, the BMI and levels of HOMA-IR, TG, TC, and HOMA-β in the study group were better than those in the control group (t=2.433, 6.282, 3.749, 9.145, and 7.105; all P<0.05); the endometrial thickness, cervical mucus score, and number of mature follicles in the study group were higher than those in the control group (t=27.240, 10.097, and 6.883; all P<0.05); the levels of PTP1B, FGF21, and IGF in the study group were lower than those in the control group (t=4.558, 14.640, all 5.001; P<0.05); the numbers of Enterococcus and Enterobacteriaceae in the study group were lower than those in the control group [(7.01±0.33) vs. (7.98±0.39) and (7.24±0.47) vs. (7.85±0.51)], while the numbers of Bifidobacterium and Lactobacillus in the study group were higher than those in the control group [(9.88±0.71) vs. (9.13±0.67) and (9.89±0.36) vs. (9.73±0.34)] (t=13.559, 6.281, 5.487, and 2.308; all P<0.05). The incidence of adverse reactions in the study group was lower than that in the control group [3.92% (2/51) vs. 11.76% (6/51)], but the difference was not statistically significant (χ2=2.170, P=0.141). Conclusion Semaglutide combined with clomiphene for obese patients with PCOS can effectively reduce their BMI, improve their glucose and lipid metabolism indicators, promote the development of their uterine endometrium and ovulation, adjust their serological indicators, and improve the composition of intestinal floras. Reference | Related Articles | Metrics

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Mechanism of radix trichosanthis in the treatment of lung cancer based on network pharmacology and molecular docking Cui Qidi, Sun Shanshan, Lu Mei, Huang Yanying, Lyu Wenwen International Medicine and Health Guidance News    2024, 30 (6): 881-889.   DOI: 10.3760/cma.j.issn.1007-1245.2024.06.001 Abstract （139）            Knowledge map    Save Objective To investigate the target and mechanism of radix trichosanthis in the treatment of lung cancer based on network pharmacology and molecular docking. Methods The search period was up to July 2022. The active ingredients of radix trichosanthis were selected using the TCMSP and TCMID databases combined with the PubChem database. The potential targets of active ingredients were obtained using the TCMSP, TCMID, and SwissTargetPrediction databases. The GeneCards, OMIM, TTD, and DrugBank databases were searched to collect the targets of lung cancer. The drugs were intersected with disease targets and a Venn diagram was drawn using the online web site Venny 2.1. The common target protein-protein interaction network was drawn using the String database. The "drug-active ingredient-disease-target" network diagram was constructed through Cytoscape 3.8.2 software. Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of common targets were performed using Metascape database. Molecular docking verification was performed using Autodock software. Results Through screening, 28 active ingredients and 201 action targets were obtained from radix trichosanthis. A total of 1 645 lung cancer targets were retrieved from the four major disease databases. There were 37 intersecting targets between the drug and disease. According to the Degree value, estrogen receptor 1 (ER1), signal transduction and transcriptional activator 3 (STAT3), and epidermal growth factor receptor (EGFR) were determined as the core targets. GO enrichment analysis found that radix trichosanthis might treat lung cancer by regulating gland development, cell proliferation, cell adhesion, receptors, enzymes, and activities of proteins. The KEGG pathway enrichment analysis revealed that radix trichosanthis might act on chemical oncogenic receptor activation, pathways in cancer, hypoxia-inducing factor 1 (HIF-1) signaling pathway, and microRNAs and proteoglycans in cancer. Molecular docking results showed that the binding activity of key small molecule compounds to the core target was significant. Conclusion Radix trichosanthis plays a role in the treatment of lung cancer through multi-target and multi-pathway mechanisms, laying a foundation for subsequent experiments and clinical applications. Reference | Related Articles | Metrics

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Comprehensive evaluation of the efficacy, quality of survival, and safety of tacrolimus in the treatment of myasthenia gravis: a meta-analysis Li Zhenzhen, Zhang Chengjuan, Hao Huihui, Ding Chuanhua, Liu Wenshan International Medicine and Health Guidance News    2024, 30 (2): 192-199.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.004 Abstract （122）            Knowledge map    Save Objective To evaluate the efficacy, quality of survival, and safety of tacrolimus in the treatment of myasthenia gravis by meta-analysis. Methods We searched CNKI, Wanfang Database, Vip Database, Web of Science, OVID, and Cochrane Library Database, and extracted the control studies of tacrolimus in the treatment of myasthenia gravis from the establishment of databases to May 2023. According to the inclusion and exclusion criteria, two researchers independently screened the literatures, extracted the data, and evaluated the quality of included literatures by using the risk bias evaluation tool of Cochrane Collaboration Network. The data were analyzed by using RevMan 5.3 software. Results A total of 1 007 patients were included in 14 studies, including 521 patients in the experimental group and 486 patients in the control group. The results of meta-analysis showed that the effective rate of the experimental group was higher than that of the control group [OR=5.68, 95%CI (3.33, 9.67), P<0.000 01]; the score of activities of daily living (ADL) in the experimental group was higher than that in the control group [SMD=1.37, 95%CI (1.10, 1.64), P<0.000 01]; the Quantitative MG Scoring System (QMG) score of the experimental group was lower than that of the control group [SMD=-0.47, 95%CI (-0.86, -0.09), P=0.02]; the 6 indexes of Busch score (role function, physical function, cognitive function, 6 vital forces, social function, and emotional function) in the experimental group were lower than those in the control group [SMD=-1.17, 95%CI (-1.50, -0.85), P<0.000 01; SMD=-1.72, 95%CI (-2.07, -1.37), P<0.000 01; SMD=-0.69, 95%CI (-1.00, -0.39), P<0.000 01; SMD=-1.15, 95%CI (-1.47, -0.83), P<0.000 01; SMD=-1.98, 95%CI (-2.67, -1.29), P<0.000 01; SMD=-0.69, 95%CI (-1.00, -0.39), P<0.000 01; SMD=-1.14, 95%CI (-1.78, -0.49), P=0.000 5]; the Manual Muscle Test (MMT) score of the experimental group was lower than that of the control group [SMD=-2.09, 95%CI (-2.80, -1.39), P<0.000 01]; there was no statistically significant difference in the Xu's absolute score between the experimental group and the control group [SMD=-0.34, 95%CI (-0.87, 0.19), P=0.21]; there was no statistically significant difference in the incidence of adverse reactions between the experimental group and the control group [OR=0.93, 95%CI (0.48, -1.80), P=0.83]. Conclusion Tacrolimus can better improve the severity of myasthenia gravis patients and improve the patients' quality of life, with reliable safety. However, due to the quality limitation of the included studies, large-sample, multi-center, and high-quality randomized controlled trials are still needed to confirm its clinical efficacy and safety. Reference | Related Articles | Metrics

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Review of near-infrared spectroscopy for sports injuries and functionality Zhang Hao, Cao Zhijie, Li Xuemei, Xu Gongcheng, Li Min, Qi Hongkai, Li Zengyong, Li Wei International Medicine and Health Guidance News    2024, 30 (2): 182-186.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.002 Abstract （122）            Knowledge map    Save With the rise of national sports, the occurrence of sports injuries increases year by year, and at the same time, with the improvement of people's economic life, more attention is paid to the rehabilitation after sports injuries. Most of the current sports injury rehabilitation treatments mainly focus on limb function rehabilitation, but the changes in the brain function after sports injuries have also begun to receive attention from the researchers. Functional near-infrared spectroscopy (fNIRS) can be better applied in the detection of brain function in patients with sports injuries due to its anti-interference and portability. This paper summarizes the research results of sports injury rehabilitation and fNIRS, discusses the current situation and research progress of sports injury rehabilitation, and analyzes fNIRS and its application value in the study of the neural control mechanism of injured limbs after sports injuries, which puts forward new ideas to further enhance the rehabilitation effect of sports injuries. Reference | Related Articles | Metrics

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Research progress of perivascular adipose tissue inflammation involved in the occurrence and development of aortic dissection Wang Ao, Zou Mingrui, Han Yuexin, Wang Yujiu International Medicine and Health Guidance News    2024, 30 (10): 1590-1593.   DOI: 10.3760/cma.j.issn.1007-1245.2024.10.002 Abstract （120）            Knowledge map    Save Aortic dissection (AD), also referred to as aortic dissection aneurysm, is a perilous condition associated with high mortality rate. Recent studies investigating the alterations in inflammatory markers during the disease progression suggest that inflammation plays a crucial role in determining the clinical outcomes of AD. The initial manifestation of inflammatory response occurs within the aortic adventitia and surrounding adipose tissue. Perivascular adipose tissue (PVAT) orchestrates arterial wall inflammation through proinflammatory mechanisms, which are closely linked to the occurrence and progression of various cardiovascular diseases. Consequently, detecting and intervening in PVAT inflammation holds immense significance for comprehending early pathophysiological changes in AD and implementing timely preventive measures among individuals at high risk. Reference | Related Articles | Metrics

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Research progress of myocardial fibrosis and AMPK-mTOR-ULK1 signaling pathway Liu Zhiqiang, Zhang Cui, Dong Wenjing, Liu Zhen, Sun Jingwu International Medicine and Health Guidance News    2024, 30 (8): 1297-1300.   DOI: 10.3760/cma.j.issn.1007-1245.2024.08.014 Abstract （113）            Knowledge map    Save Myocardial fibrosis is an important pathological change in the occurrence and development of many cardiovascular diseases, and it is also the pathological basis of heart pump failure and adverse cardiovascular events, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and continuous proliferation of cardiac fibroblasts (CFs). Adenylate activated protein kinase (AMPK) signaling pathway is the main system to mediate phosphorylation. AMPK activates autophagy, inhibits mammalian target of rapamycin (mTOR), and phosphorylates Unc-51-like autophagy activated kinase 1(ULK1). AMPK signaling pathway plays an important role in the occurrence and development of myocardial fibrosis. This paper analyzes the role of AMPK-mTOR-ULK1 signaling pathway in myocardial fibrosis, hoping to provide guidance for the treatment of myocardial fibrosis. Reference | Related Articles | Metrics

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Effects of cognitive behavioral therapy on anxiety, depression, and quality of life in patients with lung cancer: a meta-analysis Li Jinping, Xiao Huan International Medicine and Health Guidance News    2024, 30 (6): 890-896.   DOI: 10.3760/cma.j.issn.1007-1245.2024.06.002 Abstract （111）            Knowledge map    Save Objective To investigate the effects of cognitive behavioral therapy (CBT) on anxiety, depression, and quality of life in patients with lung cancer. Methods The databases such as Web of Science, PubMed, Embase, CINAHL, MEDLINE, CNKI, Wanfang, and VIP were searched until April 1, 2023. Literatures related to CBT intervention in lung cancer patients were screened according to the inclusion and exclusion criteria, the literature quality was evaluated, and meta-analysis was performed using RevMan 5.4 software. Results A total of 9 studies were included, involving 800 patients with lung cancer. CBT improved the anxiety [SMD=-0.80, 95%CI (-0.97, -0.63), P<0.000 01], depression [SMD=-1.25, 95%CI (-1.99, -0.52), P=0.000 8], and quality of life [SMD=0.89, 95%CI (0.62, 1.16), P<0.000 01] in lung cancer patients. Conclusions Existing evidences show that CBT can improve the anxiety, depression, and quality of life in lung cancer patients, but existing studies have problems of publication bias, high heterogeneity, and low quality. It is necessary to conduct high-quality, multi-center, and large-sample homogenization studies to further explore the intervention effects of CBT on anxiety, depression, and quality of life in lung cancer patients. Reference | Related Articles | Metrics

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Research progress of enhanced external counterpulsation in cardiac rehabilitation Shen Guzhuo, Chen Yanli, Li Xiufen International Medicine and Health Guidance News    2024, 30 (12): 1937-1941.   DOI: 10.3760/cma.j.issn.1007-1245.2024.12.001 Abstract （111）            Knowledge map    Save Cardiac rehabilitation is a comprehensive treatment that helps to reduce the risk of myocardial ischemia and improve the patients' quality of life. In addition, cardiac rehabilitation can also relieve the patients' negative emotions, help the patients improve self-cognition and emotional regulation ability, and promote the mental health. As an important means of cardiac rehabilitation, external counterpulsation has a positive impact on patients' long-term survival and quality of life by increasing coronary artery perfusion pressure, improving the function of cardiovascular system, and reducing the risk of cardiovascular disease and the rate of re-hospitalization and other prognostic indicators. This article discusses the research progress of enhanced external counterpulsation in cardiac rehabilitation from several aspects of clinical application and mechanism. Reference | Related Articles | Metrics

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Research progress on ultrasound in evaluation of endometrial receptivity in female infertility patients Hu Yujuan, Hong Xiaofang, Zhang Shuyue, Zhong Jianxing, Song Chujun, Cui Xu, Liang Weixiang, Liu Tao International Medicine and Health Guidance News    2024, 30 (11): 1776-1780.   DOI: 10.3760/cma.j.issn.1007-1245.2024.11.004 Abstract （108）            Knowledge map    Save In recent years, more and more women have sought assisted reproductive technology to help them conceive due to fertility or reproduction problems. Infertility has become a major problem affecting human health. Good endometrial receptivity (ER) is a key factor for successful pregnancy, and accurate and efficient assessment of endometrial receptivity has become a research hotspot. Endometrial pathology biopsy techniques are generally considered the gold standard for the evaluation of ER. However, due to its invasiveness and lag in evaluation, it is difficult to reflect the immediate endometrial receptivity, so its clinical application is limited. As a non-invasive examination method, ultrasound can continuously monitor in real-time during the cycle, and has been widely used in the diagnosis and treatment of female infertility, and has become the preferred examination method for infertility. This review focuses on ER, and describes the research progress of ultrasound endometrial morphology, endometrial blood flow, endometrial peristalsis wave, endometriography, and endometrial elastography in detail. Reference | Related Articles | Metrics

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Summary of best evidence for thirst management in ICU adult patients receiving mechanical ventilation Bian Hong, Yu Ping, Zhou Zhiyin, He Ping, Sun Qin International Medicine and Health Guidance News    2024, 30 (10): 1730-1734.   DOI: 10.3760/cma.j.issn.1007-1245.2024.10.030 Abstract （108）            Knowledge map    Save Objective To summarize the evidence related to thirst management in ICU adult patients with mechanical ventilation, and to identify the best evidence. Methods A systematic search was conducted on domestic and foreign databases for relevant literatures on thirst management in ICU adult patients with mechanical ventilation, including guidelines, clinical decisions, systematic reviews, evidence summaries, original studies, recommended practices, and best clinical practice information books. The search period was from the establishment of the databases to June 30, 2023. Two researchers were responsible for evaluating the quality of the included medical literature databases, PubMed, International Guide Library, China Guide Network, and the British National Institute for Health and Care Excellence (NICE) clinical research literatures, and were responsible for extracting evidence consistent with quality standards. Results Finally, 10 pieces of evidences were included, including 4 systematic reviews, 3 randomized controlled trials (RCTs), 1 expert consensus, and 2 evidence summaries. A total of 16 best evidences were formed from six aspects: influencing factors, evaluation content, evaluation tools, intervention measures, effect evaluation, and personnel management of thirst in ICU adult patients with mechanical ventilation. Conclusions In terms of clinical application evidences, it is necessary to evaluate the clinical conditions/environment of the hospitals, the positive and negative factors of doctors and nurses in applying evidences, and patients' preferences to carry out targeted evidence selection. In addition, as the best evidence continues to be updated over time, users should also continuously update the evidences and effectively respond to the thirst management issues of adult critically ill patients through scientific nursing methods, thereby promoting the improvement of nursing quality. Reference | Related Articles | Metrics

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Risk factors and delay strategies for progression of chronic kidney disease Li Xinmeng, Liu Qianqian, Liu Yunqi International Medicine and Health Guidance News    2024, 30 (11): 1766-1770.   DOI: 10.3760/cma.j.issn.1007-1245.2024.11.002 Abstract （107）            Knowledge map    Save Chronic kidney disease (CKD) is a complex disease and is often asymptomatic in the early stages, and can lead to renal dysfunction and progression to end-stage renal disease (ESRD) with a variety of complications, such as cardiovascular disease (CVD) and other complications. Current susceptibility factors for CKD include sex hormones, thyroid hormones, and familial genetic factors, etc. Risk factors for the disease onset and progression include glomerulonephritis, hypertension, diabetes mellitus, proteinuria, hyperlipidemia, and accumulation of urinary toxins. Current CKD treatments aims at slowing the progression of CKD and preventing cardiovascular diseases, so new treatments need to be developed to stop disease progression. This article reviews the risk factors of the progression of CKD and strategies for slowing its progression. Reference | Related Articles | Metrics

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Progress in treatment techniques for femoral shaft fractures in children Sun Hongshuo, Zhang Zhibo, Li Peng, Du Gangqiang, Jiang Jianhao, Yang Shuye International Medicine and Health Guidance News    2024, 30 (2): 177-181.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.001 Abstract （107）            Knowledge map    Save Femoral shaft fractures during childhood are a frequent type of fractures, comprising 1.4%-1.7% of all childhood fractures. The children's age, weight, type of fractures, and mode of injuries all need to be taken into consideration when deciding on the best treatment. Generally, non-invasive fixation methods, such as Pavlik sling or hip herringbone cast, are used for preschool children, while internal fixation methods, such as plates, flexible intramedullary nails, and locked intramedullary nails, are preferred for school-age children. External fixation, on the other hand, is typically reserved for special cases, such as complex trauma. This article reviews the progress of research on treatment techniques for childhood femoral shaft fractures, including conservative treatment, external fixation, and closed reduction. Reference | Related Articles | Metrics

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Research progress on the relationship between obstructive sleep apnea hypopnea syndrome and gut microflora  Lu Manlu, Zhu Jiwei, Ding Honghong, Yu Yan, Pan Lei International Medicine and Health Guidance News    2024, 30 (10): 1585-1589.   DOI: 10.3760/cma.j.issn.1007-1245.2024.10.001 Abstract （106）            Knowledge map    Save Obstructive sleep apnea hypopnea syndrome (OSAHS) is a respiratory disorder characterized by intermittent hypoxia and impaired reoxygenation that manifests during sleep. Researches have demonstrated a significant association between OSAHS and gut well-being, as it has the potential to disrupt the gut microbiome, modify the gut metabolites, compromise the integrity of the intestinal barrier, and trigger the systemic inflammation. This article provides a comprehensive review of the current research advancements pertaining to the relationship between OSAHS and gut microflora, and highlighting the potential role of disturbances in gut microflora in the progression of OSAHS, albeit with an incomplete understanding of the underlying mechanisms. Reference | Related Articles | Metrics

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Advances in METS-IR and cardiovascular diseases Wang Xinyu, Guo Yishan, Liu Qian, Wang Dong International Medicine and Health Guidance News    2024, 30 (14): 2289-2293.   DOI: 10.3760/cma.j.issn.1007-1245.2024.14.001 Abstract （106）            Knowledge map    Save With the improvement of living standards, the incidence and mortality of cardiovascular diseases are increasing year by year and have become an important public health problem. Insulin resistance status is closely related to the pathophysiologic process in the occurrence and development of cardiovascular diseases. In-depth study of the intrinsic link between insulin resistance and cardiovascular diseases is essential for early prevention, treatment, and follow-up of cardiovascular diseases. Traditional insulin resistance testing methods are cumbersome, time-consuming, and expensive, making them unsuitable for hospitals, not to mention being unable to be generalized in large-scale populations. Metabolic Score for Insulin Resistance (METS-IR) is a new type of predictors of insulin resistance, and METS-IR reflects insulin resistance with high efficiency and simplicity. Moreover, elevated METS-IR is positively correlated with cardiovascular diseases and poor cardiovascular prognosis. Based on this, this article summarizes the diagnostic and clinical value of METS-IR in common cardiovascular diseases. Reference | Related Articles | Metrics

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Analysis of the effect of quality control circle activities on reducing the incidence of local pain of peripheral intravenous potassium supplementation Zhong Lei, Ye Xiaorong, Liu Fangyun, Su Lishan International Medicine and Health Guidance News    2024, 30 (10): 1746-1751.   DOI: 10.3760/cma.j.issn.1007-1245.2024.10.033 Abstract （105）            Knowledge map    Save Objective To explore the effect of quality control circle activities on reducing the incidence of local pain of peripheral intravenous potassium supplementation. Methods A quality control circle activity group was established in December 2021 in the Second Affiliated Hospital of Guangzhou Medical University, and 124 patients undergoing peripheral intravenous potassium supplementation in our department from January to July 2022 were selected as the control group. There were 52 males and 72 females, aged (48.03±17.96) years, with a body mass of (52.81±8.72) kg. The current situation of pain incidence was investigated and the causes were analyzed by using a single dimension pain scale (oral 5-point scoring method), and the key points for improvement were determined. The target value was set and the countermeasures were formulated. Ninety-four patients undergoing peripheral intravenous potassium supplementation in our department from January to June 2023 were selected as the observation group. There were 32 males and 62 females, aged (51.39±18.98) years, with a body mass of (54.17±6.99) kg. The quality control circle activities were carried out and continuous quality improvement was made. The incidences of pain in the two groups were compared and the causes were analyzed. Statistical methods used were χ2 test and t test. Result The incidence of local pain in the observation group was lower than that in the control group [17.02% (16/94) vs. 48.39% (60/124)], with a statistically significant difference (χ2=23.16, P<0.05). Conclusion Quality control circle activities can effectively reduce the incidence of local pain in patients undergoing peripheral intravenous potassium supplementation, and improve the patients' medical experience and satisfaction. Reference | Related Articles | Metrics

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Clinical efficacy of treatment to plantar wart by Paiteling Liu Yuanling, Chen Wenyi, Wu Xuelin, Hu Yanqing, Yaqoob Muhammad Danish, Liu Kangxing International Medicine and Health Guidance News    2024, 30 (6): 1028-1031.   DOI: 10.3760/cma.j.issn.1007-1245.2024.06.031 Abstract （104）            Knowledge map    Save Objective To observe the clinical effect of Pateling to cure plantar wart. Methods A total of 150 patients with plantar wart in the 3rd Affiliated Hospital of Southern Medical University from January 2019 to December 2022 were selected and were randomly assigned into three groups. Fifty patients were treated with Paiteling, 50 patients were treated with CO2 laser, and 50 patients were treated with liquid nitrogen cryotherapy. Follow-up was performed 4 weeks and 12 weeks after the end of treatment to observe the clinical efficacy and recurrence of the 3 groups. χ2 test and F test were used. Results In the Paiteling group, 50 patients were (30.25±10.52) years old, including 27 males and 23 females, 15 cases of single lesion and 35 cases of two or more lesions. In the CO2 laser group, 50 patients were (28.65±11.25) years old, including 30 males and 20 females, 20 cases of single lesion and 30 cases of two or more lesions. In the liquid nitrogen cryotherapy group, 50 patients were (25.15±9.65) years old, including 25 males and 25 females, 20 cases of single lesion and 30 cases of two or more lesions. Four weeks after treatment, the clinical effective rate was 94.0% (47/50) in the Paiteling group, 84.0% (42/50) in the CO2 laser group, and 80.0% (40/50) in the liquid nitrogen cryotherapy group, and the difference was statistically significant among the three groups (χ2=6.258, P=0.025), but there was no statistically significant difference between the CO2 laser group and the liquid nitrogen cryotherapy group (χ2=0.619, P=0.532). Twelfth weeks after treatment, the clinical effective rate was 88.0% (44/50) in the Paiteling group, 78.0% (39/50) in the CO2 laser group, and 72.0% (36/50) in the liquid nitrogen cryotherapy group, and the difference was statistically significant among the three groups (χ2=5.893, P=0.031), but there was no statistically significant difference between the CO2 laser group and the liquid nitrogen cryotherapy group (χ2=2.021, P=0.328). Conclusion Paiteling can cure plantar wart effectively, which can reduce recurrence rate and can be used for clinic as a new therapy to treat plantar wart. Reference | Related Articles | Metrics

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Research progress on relationship between iron death and chemotherapy resistance in patients with breast cancer Yu Xiaojie, Cheng Lihao, Zhang Hao, Zhang Haojie, Yang Zhenlin International Medicine and Health Guidance News    2024, 30 (3): 353-356.   DOI: 10.3760/cma.j.issn.1007-1245.2024.03.001 Abstract （103）            Knowledge map    Save As a common malignant tumor in women, breast cancer has risen to the top of female malignant tumors, and has serious impact on women's health. At present, although there are various treatment methods for breast cancer, due to the high degree of malignancy and chemotherapy resistance of patients, the clinical treatment effect is not good, which seriously affects the patients' prognosis and survival. Iron death is a novel form of cell death characterized by intracellular iron overexpression and lipid reactive oxygen species accumulation. Studies have found that iron death is related to the occurrence, development, and evolution of breast cancer, so inducing iron death can inhibit the proliferation and distant metastasis of breast cancer cells, enhance the efficacy of chemotherapy drugs, and reverse the chemotherapy resistance of breast cancer. Therefore, inducing iron death may become a new strategy for clinical treatment of patients with breast cancer. In this paper, the mechanism of chemotherapy resistance and iron death in breast cancer and the research progress in the treatment of patients with breast cancer are reviewed. Reference | Related Articles | Metrics

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Effect of standardized feeding procedures on enteral nutrition tolerance in patients with sepsis Li Lanxiang, Chen Huiyao International Medicine and Health Guidance News    2024, 30 (2): 343-347.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.034 Abstract （100）            Knowledge map    Save Reference | Related Articles | Metrics

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Magnetic resonance imaging analysis of knee bone marrow edema in children with juvenile idiopathic arthritis Cui Pengxiang, Yang Kaihua, Yang Xin International Medicine and Health Guidance News    2024, 30 (2): 218-222.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.009 Abstract （100）            Knowledge map    Save Objective To analyze the magnetic resonance imaging (MRI) manifestations of knee bone marrow edema in children with juvenile idiopathic arthritis. Methods Retrospective analysis was used to analyze the MRI images of knee joint bone marrow edema in 126 children with juvenile idiopathic arthritis in Henan Children's Hospital from June 2020 to June 2022. There were 98 males and 28 females, aged (7.85±2.11) years, with a course of disease of (8.65±1.05) months, all of which were unilateral knee joint lesions. The synovial thickening and pannus, effusion and fluid accumulation of joint capsule, bone abnormalities, joint cartilage lesions, popliteal lymph node enlargement, abnormal meniscus and ligaments, and vascular shadows in joint cartilage were analyzed. Results In the 126 children with juvenile idiopathic arthritis, multiple pannus covered the surface of the joint femur [66 cases (52.38%)], low signal was dominant on T1W [96 cases (76.19%)], and homogeneous equal signal was dominant on T2W [66 cases (52.38%)]. There was a small amount of synovial fluid in the 126 children with juvenile idiopathic arthritis, of whom 102 cases (80.95%) had suprapatellar bursa effusion. The main types of bone marrow edema in children with juvenile idiopathic arthritis were low signal on T1W [48 cases (38.10%)] and patchy fuzzy signal on T2W [41 cases (32.54%)], and multiple "flame" like bone marrow edema with epiphyseal cartilage as the base and facing back to the joint cavity were found in the metaphyseal end [81 cases (64.29%)]. The main joint cartilage lesions in children with juvenile idiopathic arthritis were superficial roughness [60 cases (47.62%)] and local thinning [36 cases (28.57%)]. Of the 126 children with juvenile idiopathic arthritis, 42 cases had enlarged lymph node shadows in the knee and popliteal fossa, with low signal on T1W, low signal/slightly low signal on T2W, and high signal on SPIR/3D/FFE. In children with juvenile idiopathic arthritis, the anterior and posterior corners of the meniscus were mainly deformed [45 cases (35.71%)], and collapsed and fragmented [15 cases (11.90%)], and there were multiple swelling/local wavy changes in the anterior and posterior cruciate ligaments of the knee joint [21 cases (16.67%)]. Of the 126 children with juvenile idiopathic arthritis, 72 cases showed radial enhanced vascular shadows arranged perpendicular to the cartilage surface of the femoral condyle in the knee joint cartilage. Conclusions In the MRI manifestations of knee joints in children with juvenile idiopathic arthritis, there are multiple synovial thickening, joint cavity effusion, and bone marrow edema. Some children are accompanied by cartilage destruction and subchondral bone invasion. Reference | Related Articles | Metrics

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Classification and treatment progress of dyslipidemia Wang Yuqin, Liu Shengxun, Peng Xinguo International Medicine and Health Guidance News    2024, 30 (1): 24-27.   DOI: 10.3760/cma.j.issn.1007-1245.2024.01.005 Abstract （100）            Knowledge map    Save In recent years, cardiovascular diseases are still an important cause of adult mortality and morbidity in China. Their occurrence is usually associated with unhealthy diet and dyslipidemia. The management of dyslipidemia is urgent. Dyslipidemia is a metabolic disease caused by a variety of complex causes. Understanding the classification of dyslipidemia and the treatment of dyslipidemia is particularly important for the prevention and treatment of cardiovascular diseases. This paper aims to summarize the concept, types, and treatment progress of dyslipidemia based on systematic literature review, so as to provide new ideas and methods for the prevention and treatment of hyperlipidemia. Reference | Related Articles | Metrics

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Insulin glargine combined with semaglutide for type 2 diabetes mellitus patients with poor glycemic control and hypertension Li Chuansong, Liu Jiajing, Liu Yanfeng International Medicine and Health Guidance News    2024, 30 (11): 1807-1811.   DOI: 10.3760/cma.j.issn.1007-1245.2024.11.010 Abstract （100）            Knowledge map    Save Objective To investigate the efficacy and safety of insulin glargine combined with semaglutide injection in the treatment of type 2 diabetes mellitus (T2DM) patients with poor blood glucose control and hypertension. Methods One hundred and four T2DM patients with poor blood glucose control and hypertension treated at Jinan Maternal and Child Health Hospital from July 2021 to February 2023 were selected for the randomized controlled trial, and were divided into a control group and a study group by the random number table method, with 52 cases in each group. There were 30 males and 22 females in the control group; they were (48.04±4.03) years old; their body mass index was (24.08±3.15) kg/m2; their duration of T2DM was (5.96±0.74) years; their duration of hypertension was (2.96±0.41) years. There were 28 males and 24 females in the study group; they were (47.13±4.48) years old; their body mass index was (24.14±2.86) kg/m2; their duration of T2DM was (6.13±0.85) years; their duration of hypertension was (3.03±0.38) years. The control group were treated with semaglutide injection, and the study group with insulin glargine and semaglutide injection, for 3 months. The glucose metabolism, islet function, lipid metabolism, and blood pressures before and after the treatment and incidences of adverse drug reactions were compared between the two groups by t and χ2 tests. Results The levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG), and glycosylated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR) were lower after than before the treatment in both groups; the levels of FPG, 2hPPG, and HbA1c and HOMA-IR after the treatment in the study group were lower than those in the control group [(5.91±0.76) mmol/L vs. (6.49±0.88) mmol/L, (8.47±0.96) mmol/L vs. (9.58±1.06) mmol/L, (5.27±0.73)% vs. (6.19±0.97)%, and (4.53±0.69) vs. (5.39±0.86); t=3.935, 5.774, 9.724, and 5.624; all P<0.05]. The levels of triglyceride (TG) and total cholesterol (TC) were lower after than before the treatment in both groups; the levels of TG and TC after the treatment in the study group were lower than those in the control group [(2.11±0.31) mmol/L vs. (2.49±0.39) mmol/L and (4.74±0.58) mmol/L vs. (5.29±0.75) mmol/L; t=5.500 and 4.183; both P<0.05]. The levels of low density lipoprotein cholesterol (LDL-C) in both groups after the treatment were lower than those before the treatment (both P<0.05); there was no statistical difference in the level of LDL-C after the treatment between the two groups (P>0.05). There were no statistical differences in the systolic and diastolic blood pressures after the treatment between the control group and the study group [(121.03±14.28) mmHg (1 mmHg=0.133 kPa) vs. (116.81±15.41) mmHg and (84.01±9.62) mmHg vs. (81.98±8.56) mmHg; both P>0.05]. There was no statistical difference in the incidence of adverse drug reactions between the control group and the study group [11.54% (6/52) vs. 13.46% (7/52); P>0.05]. Conclusion Insulin glargine combined with semaglutide injection for T2DM patients with poor blood glucose control and hypertension can effectively control their glucose and lipid metabolism and improve their function of pancreatic islets, and is safe. Reference | Related Articles | Metrics

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Palliative care cognition and hospice care attitude among undergraduate nursing interns and correlation analysis Gai Na, Lei Qingmei, Shi Shengwen, Yan Hongbo, Ou Lishan, He Yuxi, Guan Yuxian International Medicine and Health Guidance News    2024, 30 (9): 1543-1547.   DOI: 10.3760/cma.j.issn.1007-1245.2024.09.030 Abstract （100）            Knowledge map    Save Objective To investigate the current situation of palliative nursing cognition and hospice care attitude of undergraduate nursing interns in Guangzhou, and to provide references for the teaching and training of undergraduate nursing students. Methods Two hundred and five undergraduate nursing interns from Second Hospital, Guangzhou Medical University, First Hospital, Guangzhou Medical University, and First Hospital, Guangdong Pharmaceutical University in Guangzhou were selected by the convenient sampling for the investigation, including 82 males and 123 females. There were 75 ones <22 years old, 117 ones 22-23 years old, and 13 ones >23 years old. The questionnaire included general demographic data (gender, age, student origin, feeling for patients taking hospice care, understanding of palliative care and hospice care, understanding of nursing for patients taking hospice care, and attitude to the patients' family members), The Chinese version of Palliative Care Knowledge Questionnaire (PCQN), and Chinese version of Fromelt End-of-Life Care Attitude Scale (FATCOD-B). t test, analysis of variance, and Pearson correlation analysis were used. Results Among the 205 collected questionnaires, 62.0% (127/205) interns were from urban areas, and 38.0% (78/205) from countryside; 53.2% (109/205) were not from one-child families, and 46.8% (96/205) from one-child families; 60.5% (124/205) did not choose nursing by their own will; 55.1% (113/205) did not know palliative care, and only 44.9% (92/205) knew; 63.4% (130/205) did not know the differences between palliative care and hospice care; 43.4% (89/205) knew the connotation of palliative care; 42.0% (86/205) took care of end-of-life patients or their family members in practice or life ever; 52.7% (108/205) did not take care of end-of-life patients in their internship; only 39.5% (81/205) talked about death with the patients or their family members. The scores of palliative care cognition and hospice care attitude in the 205 interns were (36.62±3.98) and (99.38±8.93), respectively. There was a positive correlation between palliative care cognition and hospice care attitude (r=0.282, P<0.01). Conclusions Undergraduate nursing interns' knowledge about palliative care and clinical care should be improved. College teachers should pay attention to the cultivation and training of nursing students' professional knowledge and skills in these two aspects, and carry out the theoretical study and curriculum practice of relevant knowledge in undergraduate study. Reference | Related Articles | Metrics

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Effectiveness and safety of Levosimendan treatment in patients with acute heart failure Guo Zhen, Wang Taoli, Li Naijie International Medicine and Health Guidance News    2024, 30 (12): 2039-2043.   DOI: 10.3760/cma.j.issn.1007-1245.2024.12.021 Abstract （98）            Knowledge map    Save Objective This study aimed to evaluate the clinical application effect of Levosimendan in patients with acute heart failure (AHF). Methods A total of 98 patients with AHF admitted to Tongchuan People's Hospital from January 2021 to October 2023 were included in this study and were randomly divided into two groups, with 49 patients in each group. There were 27 males and 22 females in the control group, the age was (67.14±6.65) years old, and the New York Heart Association (NYHA) grading was grade Ⅱ in 20 cases, grade Ⅲ in 15 cases, and grade Ⅳ in 14 cases. There were 28 males and 21 females in the observation group, the age was (66.57±6.64) years old, and the NYHA grading was grade Ⅱ in 19 cases, grade Ⅲ in 16 cases, and grade Ⅳ in 14 cases. The control group received standard treatment, and the observation group received standard treatment plus Levosimendan (intravenous injection), with a treatment period of 4 weeks. The duration of clinical symptoms (chest tightness and shortness of breath), myocardial enzyme levels [myeloperoxidase (MPO), N-terminal pro B-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and matrix metalloproteinase 9 (MMP-9)], and cardiac function indicators [left ventricular diameter (LVD), left atrial diameter (LAD), Left ventricular short axis shortening fraction (LVFS), tricuspid annular plane systolic excursion (TAPSE), and heart rate (HR)] before and after treatment, as well as the occurrence of adverse reactions during treatment were compared between the two groups. Independent sample t test and χ2 test were used. Results After treatment, the duration of chest tightness [(1.82±0.37) min/time] and dyspnea [(1.68±0.39) min/time] in the observation group were shorter than those in the control group [(2.49±0.42) min/time and (2.59±0.41) min/time], with statistically significant differences (both P<0.05). The levels of MPO [(2.89±0.61) pg/L], NT-proBNP [(2.05±0.67) g/L], cTnI [(2.58±0.56) μg/L], and MMP-9 [(58.58±7.41) μg/L] in the observation group were lower than those in the control group [(4.36±0.83) pg/L, (4.69±1.54) g/L, (2.97±0.63) μg/L, and (90.64±8.84) μg/L], with statistically significant differences (all P<0.05). The levels of LVD [(40.44±4.84) mm] and LVFS [(31.41±2.54)%] in the observation group were higher than those in the control group [(32.65±4.64) mm and (22.63±3.68)%], while the levels of LAD [(29.89±3.38) mm], TAPSE [(15.85±3.03) mm], and HR [(69.85±8.23) beats/min] were lower than those in the control group [(37.65±4.65) mm, (17.59±3.13) mm, and (86.52±8.51) beats/min], with statistically significant differences (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Levosimendan shows good efficacy and safety in patients with AHF and can be considered an effective treatment option for this condition. Reference | Related Articles | Metrics

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Effect of eurecline and butylphthalein for patients with acute cerebral infarction Wang Lingzhi, Du Yuanyuan, Liu Yan International Medicine and Health Guidance News    2024, 30 (3): 409-413.   DOI: 10.3760/cma.j.issn.1007-1245.2024.03.012 Abstract （98）            Knowledge map    Save Objective To analyze the effects of eurecline and butylphthalein on cognitive function, vascular endothelial function, and daily living ability in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction treated in Bayannur City Hospital from March 2021 to March 2023 were selected for the randomized controlled trial, and were divided into an observation group and a control group by lottery, with 50 cases in each group. There were 24 males and 26 females in the control group; they were (60.17±8.92) years old. There were 27 males and 23 females in the control group; they were (59.45±8.42) years old. The control group took intravenous infusion of eurekline. The observation group took eurecline and butylphthalein. The clinical efficacies, cerebral blood flow parameters [plasma viscosity, whole blood viscosity, fibrinogen (FIB)], vascular endothelial function [vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and nitric oxide (NO)], and scores of Montreal Cognitive Assessment Scale (MoCA) and Modified Barthel Index (MBI) before and after the treatment, and incidences of adverse reactions were compared between the two groups. The independent-sample t test, paired t test, and χ2 test were used. Results The total effective rate of the observation group was significantly higher than that of the control group [92.00% (46/50) vs. 76.00% (38/50)], with a statistical difference (χ2=4.962; P=0.029). After the treatment, the plasma viscosity, whole blood viscosity, and level of FIB in the observation group were lower than those in the control group [(1.74±0.52) mPa·s vs. (2.05±0.60) mPa·s, (16.59±6.33) mPa·s vs. (21.37±6.54) mPa·s, and (2.34±0.78) g/L vs. (2.93±0.72) g/L], with statistical differences (t=2.761, 3.714, and 3.930; all P<0.05). After the treatment, the levels of ET-1, NO, and VEGF in the observation group were better than those in the control group [(48.53±5.49) ng/L vs. (54.61±6.52) ng/L, (45.54±6.80) μmol/L vs. (38.22±5.71) μmol/L, and (54.21±8.35) ng/L vs. (49.64±6.08) ng/L], with statistical differences (t=5.044, 5.829, and 3.129; all P<0.05). After the treatment, the scores of MBI, MoCA, and NIHSS in the observation group were better than those in the control group [(68.37±12.54) vs. (55.91±11.47), (24.67±3.21) vs. (21.13±3.95), and (7.65±1.13) vs. (10.21±1.84)], with statistical differences (t=5.184, 4.918, and 8.383; all P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group [14.00% (7/50) vs. 10.00% (5/50); χ2=0.379,P=0.538]. Conclusion Eurecline combined with butylphthalein for patients with acute cerebral infarction can significantly improve the therapeutic effect and their cerebral microcirculation and vascular endothelial function and promote their recovery of cognitive function and daily living ability, and has high safety, so it is worthy of clinical promotion. Reference | Related Articles | Metrics

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Research progress on mechanism of ferroptosis in Alzheimer's disease Zheng Mei, Lu Ying, Mu Dawei International Medicine and Health Guidance News    2024, 30 (5): 705-709.   DOI: 10.3760/cma.j.issn.1007-1245.2024.05.001 Abstract （98）            Knowledge map    Save Alzheimer's disease is a neurodegenerative disease characterized by chronic neuroinflammation, and poses a serious medical challenge and burden worldwide. As an iron-dependent form of cell death characterized by iron accumulation, lipid peroxidation, disturbance of amino acid metabolism, and irreversible disruption of the plasma membrane. Ferroptosis may be associated with neurological dysfunction in Alzheimer's disease. This article reviews the role of ferroptosis in the pathologic progression of Alzheimer's disease through iron, lipid, and amino acid metabolisms, and the potential therapeutic measures for inhibiting ferroptosis in Alzheimer's disease. It is expected that ferroptosis will provide new insights into the pathogenesis and preventive treatment of Alzheimer's disease. Reference | Related Articles | Metrics

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Value of three-dimensional ultrasound imaging in diagnosis of congenital uterine malformation Xu Yinhui, Zhang Hao International Medicine and Health Guidance News    2024, 30 (11): 1812-1816.   DOI: 10.3760/cma.j.issn.1007-1245.2024.11.011 Abstract （97）            Knowledge map    Save Objective To explore the value of three-dimensional ultrasound imaging in the diagnosis of congenital uterine malformation. Methods The clinical data of 80 patients with suspected congenital uterine malformation treated at Weihai Municipal Hospital from May 2021 to April 2023 were retrospectively analyzed. They were 22 to 38 years old, with a median age of 28.34. Among them, 32 cases were infertile, 28 cases had primary abortion, and 20 cases had recurrent abortion. All of them were examined by two-dimensional ultrasound and three-dimensional ultrasound, and the combined diagnosis results of hysteroscopy and laparoscopy were regarded as the gold standard. The diagnostic efficiencies of two-dimensional ultrasound and three-dimensional ultrasound were compared, and the classification accuracy of three-dimensional ultrasound was calculated. χ2 test was used. Results A total of 80 patients with suspected congenital uterine malformation were screened out. The gold standard (hysteroscopy combined with laparoscopy) showed that there were 60 cases of congenital uterine malformation and 20 cases of non-congenital uterine malformation. Two-dimensional ultrasound showed that there were 50 cases of congenital uterine malformation and 30 cases of non-congenital uterine malformation. Three-dimensional ultrasound showed that there were 58 cases of congenital uterine malformation and 22 cases of non-congenital uterine malformation. The accuracy and sensitivity of three-dimensional ultrasound in diagnosing congenital uterine malformation were higher than those of two-dimensional ultrasound, and the missed diagnosis rate was lower than that of two-dimensional ultrasound (χ2=4.80, 4.91, and 4.91; P<0.05), but there was no statistical difference in specificity and misdiagnosis rate between the two methods (both P>0.05). The accuracies of three-dimensional ultrasound in diagnosing complete mediastinal uterus and incomplete mediastinal uterus were 94.74% (18/19) and 96.67% (29/30), respectively, and the accuracies in diagnosing other different types of congenital uterine malformations were 100.00%. The accuracies of two-dimensional ultrasound in diagnosing complete mediastinal uterus and incomplete mediastinal uterus were 78.95% (15/19) and 86.67% (26/30), respectively, and the accuracy in diagnosing arcuate uterus and residual horn/single horn uterus was only 66.67%(2/3), while the accuracies in diagnosing other different types of congenital uterine malformations were 100.00%. Conclusions Three-dimensional ultrasound imaging is of great value in the diagnosis of congenital uterine malformation, with high sensitivity and accuracy. At the same time, it can accurately classify diseases and has good clinical diagnostic value. Reference | Related Articles | Metrics

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New progress in treatment of intestinal bacterial overgrowth Gao Wenwen, Zhang Xiang, Wang Hong, Yin Yanhui International Medicine and Health Guidance News    2024, 30 (9): 1418-1421.   DOI: 10.3760/cma.j.issn.1007-1245.2024.09.003 Abstract （97）            Knowledge map    Save Small intestinal bacterial overgrowth (SIBO) is defined as an increase in the bacterial content of the small intestine above the normal value and is associated with various diseases, such as irritable bowel syndrome, inflammatory diseases, etc. The treatment for SIBO is still controversial. Therefore, this article reviews treatments for SIBO, including antibiotic, probiotics, prokinetic, herbal therapy, dietary therapies, and other treatments. Reference | Related Articles | Metrics

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Construction of sensitive indicators for quality of nursing care in internal medicine treatment for liver failure Zhang Sisi, Jiang Shuxian, Fan Chenmeng, Chen Miaoxia, Li Lili International Medicine and Health Guidance News    2024, 30 (9): 1559-1564.   DOI: 10.3760/cma.j.issn.1007-1245.2024.09.034 Abstract （95）            Knowledge map    Save Objective To construct a sensitive indicator system for the quality of nursing care in internal medicine treatment for liver failure. Methods The researchers reviewed the literatures in March 2022. By combining evidence-based literatures with expert interviews, and based on the structure-process-outcome model, a preliminary construction of nursing quality sensitive indicators of internal medicine treatment for liver failure was carried out. Two rounds of expert inquiries using the Delphi method were conducted; the indicators were revised and evaluated based on the experts' opinions; the best quality evaluation index system was constructed. The SPSS 26.0 software was used for the statistical analysis. The experts' general data were statistically described by frequency, proportion, and (). The experts' positive coefficient was expressed by the questionnaire recover rate. The experts' authority coefficient and degree were expressed as authority coefficient. The importance degree was weighed by importance scoring. Results The response rates for expert consultations were all 100%, with the expert authority coefficients for the first round being 0.958 and the second round 0.943, both over 0.700. The Kendall coordination coefficient ranged from 0.089 to 0.237 (P<0.05). Finally, the sensitive indicators for the quality of nursing in internal medicine treatment for liver failure were constructed, including 3 primary indicators, 13 secondary indicators, and 29 tertiary indicators. Conclusion The sensitive indicators for the quality of nursing in internal medicine treatment for liver failure constructed in this study have good reliability, scientificity, and a certain degree of specialized sensitivity, which can provide certain basis for the evaluation of the quality of medical treatment and nursing for liver failure. Reference | Related Articles | Metrics

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Progress in endovenous treatment of thrombotic iliac vein compression syndrome  Ye Feiting, Yan Leilei, Zhang Chengde International Medicine and Health Guidance News    2024, 30 (12): 1950-1954.   DOI: 10.3760/cma.j.issn.1007-1245.2024.12.004 Abstract （95）            Knowledge map    Save Thrombotic iliac vein compression syndrome (TIVCS) is caused by iliac vein compression, resulting in iliac vein return obstruction and blood stasis, followed by ipsilateral lower extremity deep venous thrombosis (LEDVT). Without effective treatment, it can lead to pulmonary embolism in the acute stage, seriously endangering the life and health, and may develop into lower extremity post thrombotic syndrome (PTS) in the later stage, which seriously affect the quality of life. At present, endovenous treatment is the main therapy, including inferior vena cava filter (IVCF) implantation, catheter directed thrombolysis (CDT), percutaneous mechanical thrombectomy (PMT), balloon angioplasty, and stent implantation. However, there is still controversy about the timing of iliac vein stenosis treatment, and there is no unified standard. Therefore, this article reviews the progress of endovenous treatment for TIVCS. Reference | Related Articles | Metrics

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Observation of the sedative effects of different doses of dexmedetomidine combined with midazolam on children with mental disorders undergoing cranial magnetic resonance imaging  Lei Yangang, Zhao Ningxia, Qiao Cheng, Li Yu International Medicine and Health Guidance News    2024, 30 (12): 1999-2003.   DOI: 10.3760/cma.j.issn.1007-1245.2024.12.013 Abstract （94）            Knowledge map    Save Objective To evaluate the sedative effects of different doses of dexmedetomidine combined with midazolam on children with mental disorders undergoing cranial magnetic resonance imaging (MRI). Methods This study was a randomized controlled trial. From January 2021 to October 2023, 84 children with mental disorders requiring cranial MRI at Xi'an Traditional Chinese Medicine Brain Disease Hospital were enrolled in this study, and were divided into two groups according to the random number table method. In the low-dose group, there were 23 boys and 19 girls, aged (5.95±0.93) years, 9 cases of autism, 7 cases of hyperactivity disorders, 7 cases of depression, 5 cases of anxiety disorders, and 14 other cases. In the high-dose group, there were 25 boys and 17 girls, aged (5.84±0.97) years, 8 cases of autism, 7 cases of hyperactivity disorders, 11 cases of depression, 6 cases of anxiety disorders, and 10 other cases. At 30 min before MRI examination, the low-dose group was given 2 μg/kg of dexmedetomidine via nasal drip and 0.1 mg/kg of midazolam via intravenous injection, and the high-dose group was given 3 μg/kg of dexmedetomidine via nasal drip and 0.1 mg/kg of midazolam via intravenous injection. The coordination (completion rate and incidence of agitation), vital signs at different time points (heart rate, blood pressure, and pulse oxygen saturation), sedation effects (modified Ramsay sedation scale scores 10, 20, 30, 40, and 50 min after administration), and adverse events were observed in the two groups. χ2 test and t test were used. Results There were no statistically significant differences in the examination completion rate or incidence of agitation between the low dose group and the high dose group [85.71% (36/42) vs. 90.48% (38/42), 21.43% (9/42) vs. 19.05% (8/42)] (χ2=0.045, P=0.500; χ2=0.074, P=0.786). There were no statistically significant differences in the heart rate, mean arterial pressure, or pulse oxygen saturation between the two groups before administration (all P>0.05). The heart rate and mean arterial pressure of the low-dose group were higher than those of the high-dose group 10 to 50 min after sedation (all P<0.05). The pulse oxygen saturation of the low-dose group was higher than that of the high-dose group 10 to 40 min after sedation (all P<0.05), and there was no statistically significant difference between the two groups 50 min after sedation (P>0.05). There was no statistically significant difference in the Ramsay score between the two groups 10 to 50 min after sedation (all P>0.05). The incidence of adverse events in the low dose group was lower than that in the high dose group [4.76% (2/42) vs. 19.05% (8/42)], with a statistically significant difference (χ2=4.086, P=0.043). Conclusion Low-dose dexmedetomidine combined with midazolam administered nasally is safe and effective, suitable for children with mental disorders undergoing cranial MRI. Reference | Related Articles | Metrics

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Clinical effect of rt-PA combined with edaravone dexborneol for patients with ischemic stroke Zhang Xiaojing, Wang Xiaoqin, Qu Yuan International Medicine and Health Guidance News    2024, 30 (7): 1131-1136.   DOI: 10.3760/cma.j.issn.1007-1245.2024.07.015 Abstract （94）            Knowledge map    Save Objective To evaluate the effect of intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) combined with edaravone dexborneol on neurologic function and oxidative stress in patients with ischemic stroke (IS). Methods Seventy-eight patients with IS treated in Baoji Gaoxin Hospital from January 2020 to October 2023 were selected for the randomized controlled trial. They were divided into a control group and an observation group by the random number table method, with 39 cases in each group. There were 23 males and 16 females in the control group; they were (63.03±6.42) years old; their disease course was (31.12±6.43) h. There were 22 males and 17 females in the observation group; they were (62.88±6.29) years old; their disease course was (30.74±6.39) h. The control group took intravenous thrombolysis by rt-PA; in addition, the observation group were treated with edaravone dexborneol. The treatment efficacies, scores of neurological function [National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS)], and levels of oxidative stress indicators [glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), malondialdehyde (MDA), and reactive oxygen species (ROS)] and inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-sensitivity c-reactive protein (hs-CRP)] were compared between the two groups. χ2 and t tests were applied. Results After two weeks' treatment, the overall efficacy in the observation group was higher than in the control group [79.49% (31/39) vs. 56.41% (22/39)], with a statistical difference (χ2=4.77; P<0.05). After two weeks' treatment, the scores of NIHSS and mRS in the observation group were lower than those in the control group [(7.87±0.96) vs. (9.88±1.83) and (1.78±0.14) vs. (2.04±0.21)], with statistical differences (t=6.07 and 6.43; both P<0.05). After two weeks' treatment, the levels of GSH Px, SOD, MDA, and ROS in the observation group were better than those in the control group [(219.78±24.13) mg/L vs. (189.88±23.12) mg/L, (154.78±11.95) U/ml vs. (138.67±13.16) U/ml, (47.01±5.64) μmol/L vs. (51.94±6.34) μmol/L, and (508.57±36.34) μmol/L vs. (576.34±38.44) μmol/L], with statistical differences (t=5.59, 5.66, 3.63, and 8.00; all P<0.05). After two weeks' treatment, the serum levels of IL-6, TNF-α, and hs-CRP in the observation group were lower than those in the control group [(8.45±3.12) ng/L vs. (13.67±3.96) ng/L, (0.72±0.28) ng/L vs. (1.23±0.34) ng/L, and (9.67±4.28) ng/L vs. (14.78±4.55) ng/L], with statistical differences (t=6.47, 7.23, and 5.11; all P<0.05). Conclusion Intravenous thrombolysis by rt-PA combined with edaravone dexborneol for patients with IS can significantly improve the treatment efficacy and their neurological function and reduce the levels of oxidative stress and inflammatory factors, and has better therapeutic effects than rt-PA alone. Reference | Related Articles | Metrics

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Therapeutic effect of acupuncture and moxibustion combined with proprioceptive neuromuscular facilitation for patients with limb dysfunction after stroke Lyu Yunliang, Wan Cailing, Wang Futao, Chang Liguo International Medicine and Health Guidance News    2024, 30 (3): 398-403.   DOI: 10.3760/cma.j.issn.1007-1245.2024.03.010 Abstract （94）            Knowledge map    Save Objective To explore the curative effect of acupuncture and moxibustion combined with proprioceptive neuromuscular facilitation (PNF) for patients with limb dysfunction after stroke. Methods Ninety-eight patients with limb dysfunction after stroke admitted to Liaocheng Third People's Hospital from January 2022 to January 2023 were selected for the randomized controlled trial. They were divided into a single group and an experimental group by the random number table method, with 49 patients in each group. There were 30 males and 19 females in the single group; they were (62.67±6.71) years old. There were 29 males and 20 females in the experimental group; they were (63.75±6.76) years old. The single group were treated with PNF, and the experimental group with PNF, acupuncture, and moxibustion. The total clinical response rates and related scores [Berg Balance Scale (BBS), Neurological Deficit Scale (NIHSS), Modified Barthel Index (MBI), and Functional Comprehensive Assessment Scale (FCA)], limb function [Free Hand Muscle Strength Scale (MMT) and Fugl Meyer Motor Function Score (FMA)], and gait spatiotemporal parameters (stride speed, stride length, stride frequency, affected side swing phase, affected side support phase, and bilateral support phase level), and kinematic parameters [peak joint torque (hip, knee, and ankle) and maximum flexion and extension angle (hip and knee)] before and after the treatment were compared between the two groups. t and χ2 tests were applied. Results The total clinical effective rate after the treatment of the experimental group was higher than that of the single group [95.92% (47/49) vs. 79.59% (39/49)], with a statistical difference (χ2=4.653; P=0.031). The scores of FCA, MBI, BBS, and NIHSS in the experimental group were (65.19±4.23), (73.82±8.56), (43.18±3.45), and (3.15±1.17); the scores in the single group were (61.86±5.35), (66.79±5.98), (34.59±2.80), and (5.27±2.38); there were statistical differences between the two groups (t=3.418, 4.713, 13.533, and 5.596; all P<0.05). After the treatment, the scores of upper and lower limb FAM and MMT in the experimental group were higher than those in the single group [(55.79±6.55) vs. (49.65±5.25), (27.06±3.67) vs. (24.68±3.35), and (4.07±0.62) vs. (3.46±0.87)], with statistical differences (t=5.120, 3.353, and 3.997; all P<0.05). After the treatment, the stride frequency, stride length, stride speed, and affected side swing phase level in the experimental group were higher than those in the single group [(107.76±10.96) steps/min vs. (95.19±9.25) steps/min, (40.67±6.48) cm vs. (36.50±5.71) cm, (0.63±0.13) m/s vs. (0.45±0.11) m/s, and (42.84±6.01)% vs. (39.76±5.24)%]; the levels of the affected side support phase and bilateral support phase in the experimental group were lower than those in the single group [(57.21±5.01)% vs. (61.89±5.06)% and (31.16±6.11)% vs. (37.46±7.06)%]; there were statistical differences (t=6.135, 3.380, 7.399, 2.704, 4.601, and 4.723; all P<0.05). After the treatment, the peak torque of hip joint, the maximum flexion and extension angle of hip joint, the peak torque of knee joint, the maximum flexion and extension angle of knee joint, and the peak torque of ankle joint in the experimental group were bigger than those in the single group [(0.64±0.13) Nm vs. (0.55±0.11) Nm, (34.35±7.09)° vs. (29.64±6.71)°, (1.59±0.32) Nm vs. (1.37±0.31) Nm, (49.46±8.02)° vs. (42.98±7.61)°, and (1.59±0.27) Nm vs. (1.45±0.24) Nm], with statistical differences (t=3.700, 3.378, 3.457, 4.103, and 2.713; all P<0.05). Conclusion Acupuncture and moxibustion + PNF for patients with limb dysfunction after stroke can improve the curative effect and their limb muscle strength, balance ability, motor function, walking ability, nerve injury, and quality of life. Reference | Related Articles | Metrics

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Application of WES accompanied by CNVseq in the diagnosis of pediatric genetic diseases Zhang Hua, Liu Min, Yuan Lu, Yang Liming, Zhang Fuqing International Medicine and Health Guidance News    2024, 30 (4): 529-534.   DOI: 10.3760/cma.j.issn.1007-1245.2024.04.001 Abstract （94）            Knowledge map    Save Objective To explore the significance of whole exome sequencing (WES) accompanied by copy number variation sequencing (CNVseq) in the diagnosis of pediatric genetic diseases. Methods Children with suspected genetic diseases or unclear clinical diagnosis admitted to the departments of neonatology and pediatrics of Women & Infants Hospital of Zhengzhou from August 2019 to July 2023 were selected as the study objects. The peripheral blood of the children and their parents were collected for WES and CNVseq. The detected genetic mutations were classified according to American College of Medical Genetics and Genomics (ACMG) classification, and Sanger sequencing or qPCR was performed to verify the mutations. Results A total of 33 children were enrolled, including 18 boys and 15 girls, aged 1 d to 8 years. The positive detection rate of WES was 36.4% (12/33), the positive detection rate of CNVseq was 9.1% (3/33), and the positive detection rate of the combination of WES and CNVseq was 45.5% (15/33). Conclusion WES accompanied by CNVseq is a powerful tool for molecular diagnosis of pediatric genetic diseases and can be widely used as a first-line detection method in clinical practice. Reference | Related Articles | Metrics

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Comparative analysis of the clinical efficacies of furmonertinib and gefitinib in the treatment of advanced EGFR-mutated non-small cell lung cancer Fan Chengtao, Yu Fang International Medicine and Health Guidance News    2024, 30 (6): 913-917.   DOI: 10.3760/cma.j.issn.1007-1245.2024.06.006 Abstract （93）            Knowledge map    Save Objective To explore the efficacies and safeties of furmonertinib and gefitinib in the treatment of advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) sensitive mutations. Methods This study was a prospective, randomized, controlled, and single-center clinical study. A total of 90 patients with advanced NSCLC admitted to Shangluo Central Hospital from April 2021 to April 2022 were selected and were divided into an experimental group and a control group according to the random number table method. In the experimental group, 45 cases were screened, 2 cases were excluded, and 43 cases were finally included in the analysis, including 29 males and 14 females, aged (51.79±6.28) years, and 43 cases of adenocarcinoma. In the control group, 45 cases were screened, 3 cases were excluded, and 42 cases were finally included in the analysis, including 26 males and 16 females, aged (52.06±5.41) years, and 42 cases of adenocarcinoma. Both groups were treated with pemetrexed 500 mg/m2 intravenously, once every 21 days, on the first day of each treatment cycle. The control group was treated with gefitinib tablets, 250 mg each time, once a day, 21 days as 1 treatment cycle. The experimental group was treated with oral furmonertinib mesylate tablets, 40 mg each time, twice a day, 21 days as 1 treatment cycle. Both groups were treated for 3 cycles. The carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), cytokeratinin-19 fragment antigen 21-1 (CYFRA21-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), efficacy, and safety were compared between the two groups. The patients were followed up for 18 months, and the survival prognosis was recorded. Independent sample t test, paired t test, and χ2 test were used. Results After treatment, the total effective rates of the experimental group and the control group were 69.77% (30/43) and 47.62% (20/42), respectively, with a statistically significant difference (χ2=4.303, P=0.038). After treatment, the CEA levels in the experimental group and the control group were (20.21±5.72) and (25.31±4.16) µg/L, the CA19-9 levels were (26.85±3.92) and (29.62±4.15) µg/L, the CYFRA21-1 levels were (2.61±0.76) and (3.62±0.91) µg/L, the MMP-9 levels were (102.86±20.37) and (117.41±22.06) µg/L, and the TIMP-1 levels were (608.31±60.43) and (635.93±61.15) µg/L, with statistically significant differences (all P<0.05). The total incidence of adverse drug reactions in the experimental group and the control group were 39.53% (17/43) and 30.95% (13/42), respectively (χ2=0.685, P=0.408). At the end of follow-up, 2 patients in the experimental group were lost to follow-up, the median progression-free survival (PFS) was 8 months, and 8 patients died. In the control group, 2 patients were lost to follow-up, the median PFS was 14 months, and 17 patients died. Median overall survival (OS) was not achieved in both groups, and the difference in the OS survival curve between the two groups was statistically significant (Log-rank χ2=4.939, P=0.026). Conclusion Compared to gefitinib, furmonertinib is more helpful in improving the disease remission rate and prolonging the PFS and OS in the treatment of advanced NSCLC, with good safety. Reference | Related Articles | Metrics

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Evaluation of the efficiency of high-resolution CT combined with maximum intensity projection reconstruction in the detection of pulmonary nodules Liu Dengping, Zhang Jie, Song Xueyan, Lu Shan International Medicine and Health Guidance News    2024, 30 (2): 288-291.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.022 Abstract （92）            Knowledge map    Save Objective The differences in the detection of pulmonary nodules between conventional thin-slice images and high resolution combined with maximum intensity projection (HR-MIP) reconstruction images were compared, and the detection efficiency of HR-MIP for pulmonary nodules was evaluated. Methods A total of 90 patients who underwent chest CT examination in Chu Hsien-I Memorial Hospital from December 2021 to June 2022 were randomly selected, including 52 males and 38 females, aged 18-82 (43±12.5) years. Conventional thin-slice images with a thickness of 2 mm and HR-MIP reconstruction images with a thickness of 4 mm were used to observe the situation of pulmonary nodules, and the nodules were divided into <5 mm and ≥5 mm groups according to their size. The number, size, and nature of nodules (solid, part-solid, and ground glass) were recorded by two radiologists, and the time spent reading the images of each patient was recorded. The differences of nodule detection rate and time consumption were compared between the conventional and HR-MIP groups. Paired t test and χ2 test were used. Results There were 313 nodules in the 90 patients, with 255 nodules <5 mm and 58 nodules ≥5 mm. The total numbers of nodules detected in the conventional and HR-MIP groups were 253 (80.1%) and 285 (91.0%), respectively. The detection rate of HR-MIP was higher than that of conventional thin-slice images, with a statistically significant difference (χ2=13.523, P<0.001). The numbers of <5 mm and ≥5 mm nodules detected in the conventional and HR-MIP groups were 208 vs.235 and 45 vs.50, respectively. There was a statistically significant difference in the <5 mm group (χ2=12.517, P<0.001); there was no statistically significant difference in the ≥5 mm group (χ2=1.408,P=0.237). The numbers of solid, part-solid, and ground glass density nodules were 261, 22, and 30, respectively. The numbers of solid, part-solid, and ground glass density nodules in the conventional and HR-MIP groups were 210 vs.245, 15 vs.17, and 28 vs.23, respectively. There was a statistically significant difference in the detection rate of solid nodules between the two groups (χ2=34.812, P<0.001), but there were no statistically significant differences in the part-solid and ground glass nodules (χ2=0.631, P=0.407; χ2=1.231, P=0.224). The time consumption of the conventional group was (215.3±23.8) s, and that of the HR-MIP group was (133.2±19.1) s, with a statistically significant difference (t=18.013,P<0.001). Conclusions HR-MIP reconstruction can improve the detection rate of small solid pulmonary nodules and shorten the reading time to improve diagnostic efficiency. However, part-solid and ground glass nodules still need to be carefully observed. Reference | Related Articles | Metrics

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Effect of Shengshu Sanhuang decoction combined with Zijie Shengji ointment on patients with severe mixed hemorrhoids (damp heat bottom pour type) after surgery Liu Na, Liu Xiaozhuan, Fan Huixia, Wang Yingying, Ding Jianhua International Medicine and Health Guidance News    2024, 30 (2): 269-274.   DOI: 10.3760/cma.j.issn.1007-1245.2024.02.018 Abstract （91）            Knowledge map    Save Objective To explore the effect of Shengshu Sanhuang decoction combined with Zijie Shengji ointment on severe mixed hemorrhoids (damp heat bottom pour type) after surgery. Methods This was a randomized controlled trial. A total of 188 patients with severe mixed hemorrhoids (damp heat bottom pour type) who underwent external peeling and internal ligation surgery in Shangqiu Hospital of Traditional Chinese Medicine from January 2021 to February 2023 were prospectively selected as the study objects, and were divided into group A, group B, group C, and group D according to the random number table method, with 47 cases in each group. In group A, 22 males and 25 females, aged (45.26±8.32) years, received routine intervention. In group B, 21 males and 26 females, aged (46.38±8.59) years, received routine intervention + Shengshu Sanhuang decoction. In group C, 20 males and 27 females, aged (47.13±8.67) years, received routine intervention + Zijie Shengji ointment. In group D, 23 males and 24 females, aged (45.89±8.45) years, received routine intervention + Shengshu Sanhuang decoction + Zijie Shengji ointment. Clinical indicators and levels of inflammatory factors and anal function before and after treatment were compared among the four groups, and the clinical efficacy and adverse events were compared among the four groups. t test, F test, and SNK-q test were used for the measurement data, and χ2 test and rank sum test were used for the count data. Results The pain time, edema time, bloody stool time, anal prolapse time, and wound healing time in group D [(7.15±1.59) d, (7.93±1.76) d, (6.23±1.38) d, (5.98±1.33) d, and (11.56±2.57) d] were shorter than those in group A [(8.97±1.99) d, (9.78±2.17) d, (7.82±1.74) d, (7.45±1.66) d, and (16.16±3.59) d], group B [(8.06±1.79) d, (8.86±1.97) d, (7.05±1.57) d, (6.73±1.51) d, and (14.39±3.24) d], and group C [(7.93±1.76) d, (8.75±1.94) d, (6.91±1.54) d, (6.65±1.48) d, and (13.38±2.97) d], with statistically significant differences (all P<0.05). After treatment, the levels of hypersensitive C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) and anal high-pressure zone length in the four groups were all lower than those before treatment, while the anal canal systolic blood pressure and anal canal resting pressure were both higher than those before treatment, with statistically significant differences (all P<0.05). After treatment, the levels of hs-CRP and TNF-α and anal high-pressure zone length in group D [(11.15±2.48) mg/L, (25.12±5.58) ng/L, and (2.47±0.54) cm] were lower than those in group A [(16.56±3.68) mg/L, (32.78±7.28) ng/L, and (3.05±0.68) cm], group B [(13.17±2.93) mg/L, (28.56±6.35) ng/L, and (2.77±0.62) cm], and group C [(12.56±2.79) mg/L, (27.88±6.21) ng/L, and (2.72±0.61) cm], with statistically significant differences (all P<0.05). After treatment, the anal canal systolic blood pressure and anal canal resting pressure in group D [(135.86±30.19) mmHg (1 mmHg=0.133 kPa) and (60.72±13.49) mmHg] were higher than those in group A [(111.38±24.75) mmHg and (49.76±11.06) mmHg], group B [(122.45±27.19) mmHg and (54.62±12.14) mmHg], and group C [(123.57±27.46) mmHg and (55.35±12.31) mmHg], with statistically significant differences (all P<0.05). The total effective rate of group D [95.74% (46/47)] was higher than that of group A, B, and C [70.21% (33/47), 80.85% (38/47), and 82.98% (39/47)], with statistically significant differences (all P<0.05). There was no statistically significant difference in the incidence of adverse events among the four groups (P>0.05). Conclusion Shengshu Sanhuang decoction combined with Zijie Shengji ointment has definite postoperative effect on patients with severe mixed hemorrhoids (damp heat bottom pour type) after surgery, which can effectively relieve the clinical symptoms, reduce the levels of inflammatory factors, and improve the anal function, with high safety. Reference | Related Articles | Metrics

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Effect of Qili Qiangxin capsules combined with rhBNP on patients with heart failure after acute myocardial infarction Xu Xin, Wang Lanlan International Medicine and Health Guidance News    2024, 30 (8): 1269-1273.   DOI: 10.3760/cma.j.issn.1007-1245.2024.08.008 Abstract （91）            Knowledge map    Save  Objective To investigate the effects of Qili Qiangxin capsules combined with recombinant human brain natriuretic peptide (rhBNP) on the cardiac function and expressions of angiotensin Ⅱ (AngⅡ), Periostin, and growth arrest-specific protein 6 (GAS6) in patients with heart failure after acute myocardial infarction. Methods A total of 82 patients with heart failure after acute myocardial infarction admitted to Liaocheng Third People's Hospital from April 2021 to April 2023 were simply randomly divided into two groups. In the control group, there were 19 males and 22 females, aged (59.35±8.64) years, 7 cases of grade II, 18 cases of grade III, and 16 cases of grade IV. In the observation group, there were 20 males and 21 females, aged (60.27±9.12) years, 9 cases of grade Ⅱ, 19 cases of grade Ⅲ, and 13 cases of grade Ⅳ. The control group received 1.5 μg/kg of rhBNP treatment for 7 days, and the observation group received oral administration of Qili Qiangxin capsules on the basis of the control group for 21 days (1.2 g/time, 3 times/day). The therapeutic effects, cardiac function [left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), and left ventricular end-diastolic diameter (LVEDD)], AngⅡ, Periostin, and GAS6 levels before treatment and 21 days after treatment, and adverse reactions of the two groups were compared. t test and χ2 test were performed. Results The total effective rate of the observation group was higher than that of the control group [92.68% (38/41) vs. 75.61% (31/41)] (P<0.05). After treatment, the LVEF of the observation group [(54.56±5.15)%] was higher than that of the control group [(46.32±5.44)%], while the LVEDD [(42.34±6.18) mm], LVESD [(37.32±4.52) mm], AngⅡ [(112.37±9.58) ng/L], Periostin [(89.47±9.25) ng/L], and GAS6 [(13.41±3.68) μg/L] were lower than those of the control group [(51.17±5.26) mm, (40.92±4.11) mm, (118.13±9.61) ng/L, (98.54±9.72) ng/L, and (15.72±3.21) μg/L] (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group [12.20% (5/41)] and the control group [17.07% (7/41)] (P>0.05). Conclusion The combination of Qili Qiangxin capsules combined with rhBNP has a significant therapeutic effect on heart failure after acute myocardial infarction, improving the heart function and reducing the Ang Ⅱ, Periostin, and GAS6 levels, which can be widely promoted in clinical practice. Reference | Related Articles | Metrics

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Effects of prone position ventilation at different angles on patients with acute respiratory distress syndrome Liang Yandong, He Weifeng, Liu Qiujiang, Li Yanhong, Yu Jiayan International Medicine and Health Guidance News    2024, 30 (12): 2063-2067.   DOI: 10.3760/cma.j.issn.1007-1245.2024.12.027 Abstract （91）            Knowledge map    Save Objective To evaluate the effects of prone position ventilation at different angles on patients with acute respiratory distress syndrome (ARDS). Methods This prospective, randomized, controlled clinical trial included 96 patients with ARDS admitted to the Intensive Care Unit (ICU) of Guangdong Second Hospital of Traditional Chinese Medicine from July 2021 to June 2023. The patients were randomly divided into group A (0° prone position ventilation), group B (30° prone position ventilation), and group C (45° prone position ventilation), with 32 cases in each group. There were 19 males and 13 females in group A, aged (50.25±11.31) years, with a body mass index (BMI) of (23.42±3.16) kg/m2. There were 17 males and 15 females in group B, aged (51.93±12.48) years, with a BMI of (22.72±4.15) kg/m2. There were 20 males and 12 females in group C, aged (52.39±12.82) years, with a BMI of (24.76±4.31) kg/m2. The observation time was 5 days. The patients in group A were continuously ventilated in the prone position at 0° for 16 h every day and lifted up every 2 h to prevent stress injury. In group B, after maintaining 0° prone position for 2 h, the patients' body was tilted to the left for 30° with the 30° turning pad for 2 h, then it was tilted to the right for 30° for 2 h, finally returned to 0° prone position. This was repeated until 16 h of prone ventilation was completed. In group C, after maintaining 0° prone position for 2 h, the patients' body was tilted to the left for 45° with the 45° turning pad for 2 h, then it was tilted to the right for 45° for 2 h, finally returned to 0° prone position. This was repeated until 16 h of prone ventilation was completed. The changes in oxygenation indicators [oxygenation index (PaO2/FiO2), arterial oxygen saturation (SaO2), arterial partial pressure of oxygen (PaO2), and arterial partial pressure of carbon dioxide (PaCO2)], hemodynamic indexes [heart rate (HR), mean arterial pressure (MAP), and central venous pressure (CVP)], Murray Lung Injury Score (MLIS), Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score, and multiple organ dysfunction syndrome (MODS) score were compared among the three groups. The incidence of pressure injury was also observed. One-way analysis of variance, LSD method, paired t test, and χ2 test were used. Results After 5 days of prone position ventilation, the PaO2/FiO2, SaO2, PaO2, and PaCO2 in the three groups were improved compared with those before ventilation, and the improvement ranges of group A and group B were better than those of group C (all P<0.05). There were no statistically significant differences in the HR, MAP, or CVP among the three groups before and after 5 days of prone position ventilation (all P>0.05). After 5 days of prone position ventilation, the MLIS, APACHEⅡ, and MODS scores of the three groups were lower than those before ventilation; those of group A and group B were lower than those of group C [(1.72±0.37) points vs. (1.54±0.16) points vs. (1.89±0.26) points, (11.02±2.69) points vs. (11.01±2.01) points vs. (12.87±2.06) points, (5.64±0.37) points vs. (5.34±0.67) points vs. (6.19±0.43) points] (all P<0.05). The incidences of pressure injury in group B and group C were lower than that in group A [15.63% (5/32) vs. 18.75% (6/32) vs. 40.63% (13/32)] (P<0.05). Conclusions Prone position ventilation at different angles can improve the oxygenation and alleviate the condition in patients with ARDS. Among the studied angles, 30° prone position ventilation shows the most significant improvement and reduces the incidence of pressure injury. Reference | Related Articles | Metrics

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Finger exercises combined with gripping in reducing limb swelling in patients taking transradial coronary intervention Huang Libin International Medicine and Health Guidance News    2024, 30 (13): 2249-2252.   DOI: 10.3760/cma.j.issn.1007-1245.2024.13.026 Abstract （91）            Knowledge map    Save 桡动脉；经皮冠状动脉介入治疗；改良手指操；握力；疼痛程度；肿胀程度 Reference | Related Articles | Metrics