Most Read articles

Published in last 1 year |  In last 2 years |  In last 3 years |  All

All

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

The efficacy of 1565 nm non-ablative fractional laser treatment with different parametexs for hypertrophic scars  Ma Binx, Wang Yingqua, Ma Yunyu, Zhu Zhenlai International Medicine and Health Guidance News    2025, 31 (12): 2073-2077.   DOI: 10.3760/cma.j.cn441417-20240805-12028 Abstract （284）            Knowledge map    Save Objective To investigate the efficacy of 1 565 nm non-ablative fractional laser treatment with different parameters on hypertrophic scars and its impact on growth factors. Methods A prospective study was conducted from May 2020 to June 2023 involving 62 patients with hypertrophic scars treated at Yulin Hospital, First Affiliated Hospital of Xi'an Jiaotong University. The patients were divided into two groups using a random number table method. In Group A, there were 15 males and 16 females; the laser parameters were set as follows: energy 30 mJ and density 200 spots/cm²;the age was (25.85±4.54) years old, and the disease duration was (2.98±1.36) years. In Group B, there were 16 males and 15 females;the laser parameters were set as follows: energy 45 mJ and density 200 spots/cm;the age was (26.52±4.18) years old, and the disease duration was (3.02±1.30) years. Both groups were treated once a month for three consecutive months. The clinical indicators, scar scores before and after treatment, serum growth factor levels, and adverse reaction rates were compared between the two groups. Statistical analysis was performed using t-tests and χ² tests. Results After treatment, there were no statistically significant differences in the times for edema and erythema resolution between the two groups [(2.59 ± 0.48) d vs. (2.72 ± 0.43) d and (4.72 ± 1.25) d vs. (5.07 ± 1.29) d], with no statistically significant differences (both P > 0.05). However, the Vancouver Scar Scale (VSS), Observer Scar Assessment Scale (OSAS), and Patient Scar Assessment Scale (PSAS) scores were significantly lower in Group B compared to Group A [(3.42 ± 0.74) points vs. (4.31 ± 0.82) points, (21.46 ± 3.62) points vs. (24.68 ± 3.47) points, and (19.36 ± 3.21) points vs. (21.75 ± 3.13) points, respectively, with t-values of 4.486, 3.575, and 2.968, all P < 0.05]. The post-treatment serum levels of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and transforming growth factor-β1 (TGF-β1) were lower in Group B than in Group A [(185.43 ± 51.64) ng/L vs. (212.96 ± 52.83) ng/L, (179.35 ± 49.71) ng/L vs. (205.35 ± 50.24) ng/L, and (243.21 ± 48.78) ng/L vs. (275.64 ± 52.46) ng/L], with statistically significant differences (t = 2.075, 2.048, and 2.521, all P < 0.05). There were no statistically significant differences in the incidence rate of adverse reactions such as skin itching, pigmentation, and blisters [96.77% (30/31) vs. 93.55% (29/31), P > 0.05]. Conclusions The 1 565 nm non-ablative fractional laser is highly effective in treating hypertrophic scars. The scar scores (including OSAS and PSAS scores) and serum growth factor (VEGF, EGF, and TGF-β1) levels in the high-energy (45 mJ) treatment group were significantly lower than those in the low-energy (30 mJ) treatment group. Therefore, the high-energy setting of the 1 565 nm non-ablative fractional laser can be an effective choice for treating hypertrophic scars. Reference | Related Articles | Metrics

Select

Research progress on regulation mechanisms of synaptic plasticity and its relationship with nervous system diseases  Wang Linhua, Huo Yingqian, Li Tingting, Liu Yanmin, Xi Yalin, Wang Meiling International Medicine and Health Guidance News    2025, 31 (12): 1968-1971.   DOI: 10.3760/cma.j.cn441417-20240926-12007 Abstract （263）            Knowledge map    Save The regulatory mechanisms of synaptic plasticity are complex and diverse, and are closely related to many diseases of the nervous system. Impaired synaptic plasticity is found in many neurodegenerative and demyelinating diseases. What is synaptic plasticity? Which factors regulate synaptic plasticity? Can we slow down the progression of the diseases and improve the prognosis regulating synaptic plasticity? In this review, we summarize the regulatory mechanisms of synaptic plasticity and its relationship with nervous system diseases, and explore new therapeutic targets and possible mechanisms for treatment. Reference | Related Articles | Metrics

Select

The mechanism and research progress of ferroptosis in ischemic stroke Liu Yanmin, Wang Linhua, Li Tingting, Song Yingxian, Wang Meiling International Medicine and Health Guidance News    2025, 31 (22): 3698-3703.   DOI: 10.3760/cma.j.cn441417-20250515-22001 Abstract （229）            Knowledge map    Save Ischemic stroke (IS), a cerebrovascular disease with high global morbidity and mortality, has long lacked effective therapeutic approaches. Ferroptosis, an iron-dependent form of cell death, has been progressively elucidated in IS pathogenesis through ongoing research. Ferroptosis not only exacerbates neurological damage through iron overload, redox imbalance, and lipid peroxidation, but is also regulated by associated signaling pathways. Currently, inhibitors targeting ferroptosis mechanisms have been demonstrated to mitigate post-IS neuronal damage and improve prognosis. This review systematically summarizes the pathogenic role of ferroptosis in IS, analyzes its associated signaling pathways, the potential therapeutic effects of associated inhibitors, and its interplay with other forms of cell death, aiming to provide novel insights and directions for future clinical research and therapeutic strategies. Reference | Related Articles | Metrics

Select

The effect of Xuefu Zhuyu decoction and Si Junzi decoction combined with nilotinib in the treatment of postoperative patients with non-small cell lung cancer Ma Xiaohong, Zhang Chen, Wu Anhong International Medicine and Health Guidance News    2025, 31 (15): 2578-2582.   DOI: 10.3760/cma.j.cn441417-20240927-15022 Abstract （228）            Knowledge map    Save Objective To analyze the effect of Xuefu Zhuyu decoction and Si Junzi decoction combined with nilotinib in the treatment of postoperative patients with non-small cell lung cancer (NSCLC). Methods A total of 118 postoperative patients with NSCLC who were admitted to Ankang Hospital of Traditional Chinese Medicine from September 2020 to August 2022 were selected as the research subjects. According to the different treatment methods, the patients were divided into the control group (57 cases) and the observation group (61 cases). There were 33 males and 24 females in the control group, aged 19-78 (48.56±4.58) years. There were 34 males and 27 females in the observation group, aged 20-77 (46.84±4.86) years. The control group was treated with nilotinib capsules, while the observation group was treated with the combination of Xuefu Zhuyu decoction and Si Junzi decoction in addition to the treatment of the control group. Both groups were treated continuously for 8 weeks. The therapeutic effects, adverse reactions and long-term outcomes were compared between the two groups, as well as the traditional Chinese medicine symptom scores, quality of life [Karnofsky Performance Status Score (KPS), Functional Assessment of Cancer Therapy-Lung cancer (FACT-L)], immune indicators (CD3+, CD4+, CD8+) before and after treatment. Independent sample t test, paired t test, and χ2 test were used for statistical analysis. The survival rate was estimated using the Kaplan-Meier method, and the survival analysis was conducted using the Log-rank χ2 test. Results The disease remission rate and disease control rate in the observation group were both higher than those in the control group [75.41% (46/61) vs. 43.86% (32/57), 88.52% (54/61) vs. 73.68% (42/57)] (both P<0.05). After treatment, the traditional Chinese medicine symptom scores (main symptoms and secondary symptoms) of the observation group were lower than those of the control group (both P<0.05); the KPS score and FACT-L score of the observation group were higher than those of the control group [(79.85±4.58) points vs. (76.52±3.89) points, (83.24±5.63) points vs. (78.29±5.24) points] (both P<0.05); the levels of CD3+ and CD4+ in the observation group were higher than those in the control group [(68.45±4.85)% vs. (64.15±4.28)%, (42.63±4.15)% vs. (40.25±3.89)%], while the level of CD8+ was lower than that in the control group [(20.36±2.47)% vs. (25.03±2.95)%] (all P<0.05). During the treatment period, there was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). After a 2-year follow-up, 14 patients were lost (5 in the control group and 9 in the observation group) due to lost contact information or changes in their home addresses. The mortality rate in the observation group was lower than that in the control group [11.54% (6/52) vs. 19.23% (10/52)], and the difference was not statistically significant (P>0.05). Conclusion Xuefu Zhuyu decoction and Si junzi decoction combined with nilotinib has a better therapeutic effect on postoperative NSCLC patients. It can effectively reduce the traditional Chinese medicine syndrome score, improve the quality of life, enhance the immune status of the body, and reduce the mortality rate. Reference | Related Articles | Metrics

Select

Changes of serum levels of GFAP and HSP47 in patients with hypertensive intracerebral hemorrhage and their relationship with neurological function  Li Lin, Yang Jie, Zhai Haiyan, Zhu Lifang, Zhang Xiao International Medicine and Health Guidance News    2025, 31 (12): 1938-1942.   DOI: 10.3760/cma.j.cn441417-20250117-12001 Abstract （214）            Knowledge map    Save Objective To study and explore the changes of serum levels of glial fibrillary acidic protein (GFAP) and heat shock protein 47 (HSP47) in patients with hypertensive intracerebral hemorrhage and their relationship with neurological function. Methods One hundred and twenty-four patients with hypertensive intracerebral hemorrhage treated in No. 215 Hospital of Shaanxi Nuclear Industry from June 2023 to June 2024 were selected for the retrospective study.There were 62 male cases and 62 female cases, with an age of ≥18 years old. According to the scores of modified Rankin Scale (mRS) evaluated within one month after the hospitalization treatment, they were divided into a good prognosis group (the score of mRS 0-3, 76 cases) and a poor prognosis group (the score of mRS 4-6, 48 cases). The gender, bleeding site, smoking history, drinking history, diabetes, hyperlipidemia, operation method, blood routine, and other indicators of the two groups were collected. The levels of GFAP, HSP47, interleukin (IL)-6, and neuron-specific enolase (NSE) and bleeding volumes were compared between the two groups. The correlation of prognosis with GFAP and HSP47 was analyzed. The impact of GFAP and HSP47 on their prognosis was analyzed. The sensitivities and specificities of GFAP and HSP47 in predicting their prognosis were explored. The rank sum test and χ2 test were used for the statistical comparisons. The correlation of prognosis with GFAP, HSP47, IL-6, NSE, bleeding volume, and score of Glasgow Coma Scale (GCS) were analyzed by the Spearman correlation analysis. The receiver operating characteristic curve was used to analyzed the efficacies of the indicators in the evaluation of the patients' prognosis. Results The levels of GFAP, HSP47, IL-6, and NSE and bleeding volume in the good prognosis group were lower than those in the poor prognosis group, and the score of GCS was higher, with statistical differences (all P<0.05). The prognosis was positively correlated with GFAP, HSP47, IL-6, NSE, and bleeding volume (r=0.499, 0.388, 0.479, 0.736, and 0.491; all P<0.001), and negatively with the score of GCS (r=-0.775; P<0.001). The areas under the curves of GFAP and HSP47 in the prediction of the prognosis were both greater than 0.7, indicating that both had certain diagnostic efficacy (both P<0.05). GFAP, HSP47, NSE, and bleeding volume were risk factors for prognosis, and the score of GCS a protective factor. Conclusions The serum levels of GFAP and HSP47 are related to neurological function in patients with hypertensive intracerebral hemorrhage. The higher the levels of GFAP and HSP47, the worse their neurological function. Both are risk factors for evaluating patients with hypertensive intracerebral hemorrhage. Reference | Related Articles | Metrics

Select

Effect of yang-entering-yin breath guidance massage combined with ear acupressure on improving symptoms of patients with insomnia Wang Jing, Wang Xiaoling, Wang Xuanmei International Medicine and Health Guidance News    2025, 31 (18): 3126-3131.   DOI: 10.3760/cma.j.cn441417-20241107-18027 Abstract （208）            Knowledge map    Save Objective To analyze the effect and improvement of symptoms in patients with insomnia by yang-entering-yin breath guidance massage and ear acupressure. Methods A total of 120 patients with insomnia diagnosed and treated in Department of Brain Diseases, Ankang Traditional Chinese Medicine Hospital from January to September 2024 were randomly divided into a control group, an observation group 1, an observation group 2, and an observation group 3, with 30 cases in each group. There were 13 males and 17 females in the control group; they were (45.07±5.47) years old; their disease course was (2.37±0.42) years. There were 12 males and 18 females in the observation group 1; they were (44.17±6.52) years old; their disease course was (2.40±0.49) years. There were 11 males and 18 females in the observation group 2; they were (45.79±5.73) years old; their disease course was (2.28±0.36) years; 1 case could not stick to the treatment scheme, and were excluded from the study. There were 11 males and 17 females in the observation group 3; they were (44.86±6.28) years old; their disease course was (2.46±0.41) years; 1 case quit during the treatment, and 1 case was not treated according to the treatment scheme, so they were excluded from the study. The control group orally took eszopiclone tablets; the observation group 1 took yang-entering-yin breath guidance massage; the observation group 2 took ear acupressure therapy; the observation group 3 took yang-entering-yin breath guidance massage and ear acupressure; all the 4 groups were treated continuously for 4 weeks. The scores of traditional Chinese medicine symptoms, sleep status, anxiety, and depression before the treatment and after 2 and 4 weeks' treatment were compared between the 4 groups. The clinical efficacies and safety were evaluated. The repeated measurement analysis of variance, LSD-t test, one-way analysis of variance, SNK-q test, χ2 test, and Fisher's precision probability test were used for the statistical analysis. Results Before the treatment, after 2 weeks' treatment, and 2 weeks after discharge, the scores of traditional Chinese medicine symptoms, Insomnia Severity Index, Pittsburgh Sleep Quality Index, Anxiety Self-evaluation Scale, and Depression Self-evaluation Scale in the four groups decreased successively (all P<0.05); the scores of the observation group 1, the observation group 2, and the observation group 3 were lower than those of the control group after 2 and 4 weeks' treatment (all P<0.05); the scores of the observation group 3 were lower than those of the observation group 1 and the observation group 2 after 2 and 4 weeks' treatment (all P<0.05). The total effective rates of the control group, the observation group 1, the observation group 2, and the observation group 3 were 63.33% (19/30), 80.00% (24/30), 75.86% (22/29), and 96.43% (27/28), respectively, with a statistical difference between the 4 groups (P<0.05); the total effective rate of the observation group 3 was higher than that of the control group (P<0.05). During the treatment, 1 patient in the control group experienced fatigue, and 1 patient dizziness; the other three groups did not have any adverse reactions; there was no statistical difference (P>0.05). Conclusion The combination of yang-entering-yin breath guidance massage and ear acupressure therapy for insomnia can not only improve the efficacy and safety, but also is more effective in improving insomnia, depression, and anxiety. Reference | Related Articles | Metrics

Select

From inflammation to carcinogenesis: molecular mechanisms and intervention strategies in progression from ulcerative colitis to colorectal cancer Feng Zizhao, Jiang Weiwei International Medicine and Health Guidance News    2025, 31 (20): 3395-3402.   DOI: 10.3760/cma.j.cn441417-20250423-20011 Abstract （203）            Knowledge map    Save Ulcerative colitis-related colorectal cancer (UC-CRC) is a typical inflammation-related cancer with a unique and complex carcinogenic mechanism. Identifying its core mechanisms is of significant clinical importance for its early diagnosis and precise prevention. This review systematically summarizes the roles and research progress of chronic inflammation-driven DNA damage, characteristic genetic and epigenetic alterations, tumor microenvironment remodeling, immune evasion mechanisms, and gut microbiota dysbiosis in the carcinogenic process of ulcerative colitis. Studies have shown that UC-CRC exhibits early p53 mutations, a significant increase in microsatellite instability, and relatively delayed KRAS and APC mutations in terms of genetic characteristics. In the tumor microenvironment, its features include the activation of cancer-associated fibroblasts, angiogenesis, and abnormal expansion of cancer stem cells. Moreover, immune evasion mechanisms, such as macrophage polarization, dendritic cell dysfunction, T-cell exhaustion, etc. further promote carcinogenesis. Additionally, the abnormal colonization of pro-carcinogenic gut microbiota exacerbates chronic inflammation and immune imbalance in the host, significantly increasing the risk of malignancy. Future research directions will focus on the early identification of p53 mutations, microsatellite instability, and characteristic microbial populations, precise targeted intervention in key pathways, and the fine-tuned regulation of the gut microbiota as crucial strategies for the early diagnosis and precision treatment of UC-CRC. Reference | Related Articles | Metrics

Select

Current status and influencing factors of fear in patients before gastrointestinal endoscopy Tan Wenhui, Sun Yining, Liang Biao, Lyu Fang, Wang Yimin International Medicine and Health Guidance News    2025, 31 (22): 3815-3820.   DOI: 10.3760/cma.j.cn441417-20250618-22023 Abstract （195）            Knowledge map    Save Objective To investigate the current status of fear and its influencing factors in patients before gastrointestinal endoscopy, and to provide a basis for developing targeted psychological interventions. Methods A total of 528 patients scheduled for gastrointestinal endoscopy at Guangdong Second Provincial General Hospital between May and December 2024 were selected by the convenient sampling method for the cross-sectional survey. Their demographic data were collected. The Self-Rating Anxiety Scale (SAS) and Fear of Progression Questionnaire-Short Form (FoP-Q-SF) were used to assess their anxiety levels and fear of disease progression. The Pearson correlation analysis and multiple linear regression analysis were utilized to identify the influencing factors. Results The total FoP-Q-SF score was 23.22±10.39. Notably, 16.90% of the patients exhibited a high level of fear (FoP-Q-SF score≥34). The univariate analysis revealed significantly higher fear levels in the females, patients who were 18-30 years old, unmarried individuals, and patients with chronic diseases (all P<0.05). The total SAS score was positively correlated with the total FoP-Q-SF score (r=0.745, P<0.01). The multiple linear regression analysis identified the history of chronic diseases (β= 0.050, P=0.017) and anxiety level (β=0.721, P < 0.001) as the independent predictors of fear. Conclusions Fear is prevalent among patients before gastrointestinal endoscopy and is influenced by anxiety levels, history of chronic diseases, and specific demographic characteristics (female gender and being 18-30 years old). Implementing stratified interventions targeting high-risk groups is warranted. These interventions should focus on cognitive restructuring, anxiety management, and reframing disease perceptions to enhance procedural adherence and improve the overall healthcare experience. Reference | Related Articles | Metrics

Select

Effects of individualized nutritional management using the WeChat platform for patients taking peritoneal dialysis Chen Xiaoqing, Sun Wenli, Huang Chunhong, Weng Bixia, Shao Yixin, Hu Fang, Zheng Haiying International Medicine and Health Guidance News    2025, 31 (22): 3844-3848.   DOI: 10.3760/cma.j.cn441417-20250615-22030 Abstract （195）            Knowledge map    Save Objective To explore the impact of an individualized nutrition management plan based on the WeChat platform on the nutritional status, dietary compliance with renal diet, and related anthropometric indicators of peritoneal dialysis (PD) patients. Methods A prospective study was adopted. The patients who were regularly followed up at the PD nursing specialty clinic of the First Affiliated Hospital of Fujian Medical University from August 2022 to November 2023 were selected and divided into two groups using the random number table method. The control group consisted of 29 males and 13 females, with an age of (50.81±12.22) years. They received routine nutritional management. The intervention group consisted of 24 males and 19 females, with an age of (47.09±12.88) years. They received individualized nutritional management based on the WeChat platform. Both groups were intervened for 3 months. The nutritional status, the score of the Renal Diet Adherence Questionnaire (RABQ), and the related human measurement indicators of nutrition were compared between the two groups. Statistical methods employed were t-test, Mann-Whitney U test, and χ2 test. Results After the intervention, the incidence rate of malnutrition in the intervention group was lower than that in the control group [9.30% (4/43) vs. 28.57% (12/42)], and the RABQ score was higher [89.0 (88.0, 90.0) points vs. 84.0 (77.8, 89.0) points], and the differences were statistically significant (χ2=5.163 and Z=-4.087; both P<0.05). The anthropometric indicators of the intervention group, such as triceps skinfold thickness (TSF) and upper arm circumference (MAC), were both greater than those of the control group [16.0 (13.3, 18.5) mm vs. 11.8 (9.0, 17.0) mm and 27.0 (25.0, 30.0) cm vs. 24.5 (22.0, 28.0) cm], and the differences were statistically significant (Z=-2.089 and -2.552; both P<0.05). Conclusion Implementing individualized nutritional management for PD patients through the WeChat platform can help improve their nutritional status and enhance the compliance of their dietary behaviors regarding kidney diseases. Reference | Related Articles | Metrics

Select

Analysis of influenza surveillance results in Haizhu district of Guangzhou from 2021 to 2024 Chen Qiujie, Bai Shanshan, Tan Yonghui, Cai Zhenlian, Wu Xiaobin International Medicine and Health Guidance News    2025, 31 (22): 3793-3798.   DOI: 10.3760/cma.j.cn441417-20250208-22019 Abstract （192）            Knowledge map    Save Objective To analyze the epidemic patterns and pathogenic characteristics of influenza viruses in Haizhu District from 2021 to 2024, and to provide scientific basis and technical support for formulating influenza prevention and control measures. Methods From March 2021 to December 2024, 5 120 throat swab samples from influenza-like cases were sent for nucleic acid testing in the Huizhou District Center for Disease Control and Prevention. The number of male samples tested was 2 698, and the number of female samples tested was 2 422. The age ranged from 1 day to 98 years old. The detection rates of influenza A/B viruses in the samples were analysed, and the population and seasonal distribution characteristics of different types of influenza viruses were compared. The statistical methodology employed the χ2 test and the Bonferroni method for multiple comparisons. Results A total of 5 120 throat swab samples were tested, and 2 578 samples were found to be positive for the influenza virus. The positive detection rate was 50.34%. Among them, the positive detection rate of influenza A was 68.11% (1 756/2 578), and the positive detection rate of influenza B was 31.89% (822/2 578). The predominant infection was caused by the influenza A virus, especially in 2023, when the positive detection rate of the influenza A virus reached as high as 75.12%. The positive detection rates in winter [63.86% (569/891)] and in spring [62.17% (1 047/1 684)] were both higher than those in summer and autumn. There was a statistically significant difference in the positive detection rate of influenza viruses between different seasons (χ2=1 313.806, P<0.001). The detection results of different seasonal influenza virus subtypes were analyzed. The proportion of type A (H1N1) influenza virus was the highest in spring (77.9%), while the detection rate of type A (H3N2) virus was higher in winter (37.65%). In autumn, there was a dual dominant trend of type A (H3N2) and type B (Victoria) subtypes, and the difference was statistically significant (χ2=490.000, P<0.001). The positive detection rates for males and females in the test samples were 50.22% (1,355/2,698) and 50.50% (1,223/2,422), respectively. For 939 of the samples, subtype detection of the influenza virus was conducted. The results showed that among all the subtypes, the detection rate of influenza subtypes in males was higher than that in females, and the difference was statistically significant (χ2=214.892, P<0.001). The highest positive detection rate of influenza virus nucleic acid was observed in the age group of 5 to <15 years old, with a detection rate of 73.55% (2 077/2 824), while the detection rate for the elderly in the ≥60-year-old age group was the lowest, only 8.14% (31/381). The detection rates of influenza A in all age groups were higher than those of influenza B. There was a statistically significant difference in the positive detection rate of influenza viruses between different age groups (χ2=12.095, P=0.017). The positive detection rate of influenza virus of the student group was higher than those of other groups. There was a statistically significant difference in the detection rate between different occupations (χ2=2 157.191, P<0.001). Conclusions At the Haizhu District of Guangzhou City, the dominant influenza strains showed seasonal alternation in their prevalence from 2021 to 2024. The prevalence of type A influenza was generally higher than that of type B influenza. The detection rate was higher among children aged 5 to <15 years old and students. Continuous influenza pathogen monitoring should be carried out in schools. Through vaccination and health education measures, the monitoring and prevention of influenza outbreaks in kindergartens and primary and secondary schools should be strengthened. Reference | Related Articles | Metrics

Select

Value of procalcitonin, C-reactive protein, and blood routine indicators in diagnosis of children with respiratory tract infections  Shen Liaoliao, Lei Fang, Song Jingrong International Medicine and Health Guidance News    2025, 31 (12): 1984-1988.   DOI: 10.3760/cma.j.cn441417-20241104-12011 Abstract （190）            Knowledge map    Save Objective To analyze the value of procalcitonin (PCT), C-reactive protein (CRP), and blood routine indicators in the diagnosis of children with respiratory tract infections. Methods A total of 85 hospitalized children treated at Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University from May 2021 to September 2023 were selected for the retrospective study, including 52 boys and 33 girls. They were 3-12 years old. Their body weight was 20-33 kg. They were divided into a respiratory tract infection group (35 cases) and a non-respiratory tract infection group (50 cases) according to whether they had infections. The binary logistic regression model was used to analyze the factors influencing respiratory tract infections in the children. The receiver operating characteristic curve (ROC) was drawn to evaluate the diagnostic value of the children with respiratory tract infections. According to the types of pathogens, the children were divided into a bacterial infection group (11 cases), a mycoplasma infection (11 cases), and a viral infection group (13 cases), and the levels of PCT, CRP, and blood routine indicators were compared between the 3 groups. t, χ2, and F tests were used as the statistical methods. Results The PCT, CRP, platelet count (PLT), white blood cell count (WBC), and percentage of neutrophils (NEUT) in the respiratory tract infection group were higher than those in the non-respiratory tract infection group, with statistical differences (t=4.537, 4.472, 4.570, 4.297, and 4.453 ; all P<0.05). The results of the logistic regression model analysis showed that PCT (OR=16.750, 95%CI 3.777-74.283), CRP (OR=1.478, 95%CI 1.193-1.831), PLT (OR=10.071, 95%CI 2.911-34.843), WBC (OR=1.669, 95%CI 1.257-2.216), and NEUT (OR=1.187, 95%CI 1.083-1.301) were influential factors in the diagnosis of respiratory tract infections in the children (all P<0.05). According to ROC analysis, the sensitivities of PCT, CRP, PLT, WBC, and NEUT in the diagnosis of respiratory tract infections in the children were 0.686, 0.743, 0.714, 0.829, and 0.543, respectively; the specificities were 0.620, 0.600, 0.800, 0.780, and 0.820, respectively. The area under the curve of the combination of PCT, CRP, PLT, WBC, and NEUT in the diagnosis of respiratory tract infections in the children was 0.897. Conclusion PCT and CRP combined with blood routine are of high value in the diagnosis of respiratory tract infections in children, and can provide reliable basis for clinicians to diagnose the pathogen types. Reference | Related Articles | Metrics

Select

Correlation between nurse-patient relationship and professional identity in post-2000s generation nursing students Wang Yuan, Hu Guangqian, Li Huafen International Medicine and Health Guidance News    2025, 31 (18): 3159-3164.   DOI: 10.3760/cma.j.cn441417-20250107-18033 Abstract （188）            Knowledge map    Save Objective To understand the current status of nurse-patient relationships and professional identity in post-2000s generation nursing students, and to explore the correlation between these two factors. Methods Three hundred and ninety-five post-2000s generation nursing interns were selected from 3 grade A tertiary hospitals in Guangzhou and 1 grade A tertiary hospital in Foshan as the study objects by the convenient sampling method, including 53 males and 342 females who were (19.54±2.39) years old. The General Information Questionnaire, Nurse-Patient Relationship Self-Assessment Scale, and Nurses' Professional Identity Scale were used to investigate the interns. The general data, nurse-patient relationship, and scores of professional identity were analyzed by the descriptive statistical analysis. The correlation between nurse-patient relationship and professional identity was analyzed by the Spearman correlation analysis. The influence of nurse-patient relationship on the interns' professional identity was analyzed by the hierarchical multiple regression. Results The interns' total scores of professional identity and nurse-patient relationship were 118.37±20.65 and 37.33±5.55, respectively. There was a positive correlation between nurse-patient relationship and professional identity (r=0.789; P<0.001). The hierarchical multiple regression analysis results showed that nurse-patient relationship was included into the professional identity influencing factor model (F=63.158; P<0.001), and positively influenced professional identity. Conclusions Post-2000s generation nursing students' nurse-patient relationship can influence their professional identity. Clinical nursing educators should develop clinical teaching and practice plans to improve their nurse-patient relationship and professional identity. Reference | Related Articles | Metrics

Select

Analysis of the effects of Di'ao Xinxuekang Capsules combined with diltiazem on clinical symptoms and serum cytokine levels in patients with angina pectoris of coronary heart disease  Jin Xingshan, Yang Li International Medicine and Health Guidance News    2025, 31 (11): 1791-1795.   DOI: 10.3760/cma.j.cn441417-20241128-11006 Abstract （186）            Knowledge map    Save Objective To analyze the efficacy of Di'ao Xinxuekang Capsules combined with diltiazem in the treatment of angina pectoris of coronary heart disease. Methods A total of 96 patients with angina pectoris of coronary heart disease who were admitted to the First People's Hospital of Zhumadian from March 2022 to July 2024 were selected as the study subjects. According to the treatment plan, the patients were divided into the control group (49 cases) and the study group (47 cases). There were 20 males and 29 females in the control group, aged 54-70 (61.97±3.35) years, course of the disease 5-15 (10.24±1.96) months. There were 19 males and 28 females in the study group, aged 53-70 (62.08±3.46) years, course of the disease 5-16 (10.31±1.89) months. The control group was treated with diltiazem, while the study group was treated with Di'ao Xinxuekang capsules in addition to the treatment of the control group. Both groups received continuous treatment for 3 months. Compare the therapeutic effects and adverse reactions of the two groups, as well as the clinical symptoms (frequency and duration of angina pectoris attacks), cardiac function [left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD)], and levels of serum-related cytokines [serum N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), high-sensitivity C-reactive protein (hs-CRP) levels, and the ratio of neutrophils to lymphocytes (NLR)] before and after treatment. Independent sample t test, paired t test, and χ2 test were used for statistical analysis. Results The total effective rate of the study group was higher than that of the control group [95.75% (45/47) vs. 77.55% (38/49)] (P<0.05). After treatment, the frequency of angina pectoris attacks in the study group was lower than that in the control group [(2.30±0.49) times/week vs. (3.22±0.51) times/week], and the duration was shorter than that in the control group [(3.22±0.71) min/time vs. (4.61±0.85) min/time] (both P<0.05); the LVEF of the study group was higher than that of the control group [(48.02±0.61)% vs. (45.91±0.52)%], and the LVESD was lower than that of the control group [(40.15±2.98) mm vs. (44.05±3.07) mm] (both P<0.05); the levels of serum NT-proBNP, cTnI, hs-CRP and NLR in the study group were all lower than those in the control group [(246.51±29.52) ng/L vs. (378.54±31.74) ng/L, (0.20±0.04) μg/L vs. (0.39±0.05) μg/L, (3.05±0.74) mg/L vs. (4.65±0.92) mg/L, 1.98±0.35 vs. 2.61±0.39] (all P<0.05). The comparison of the total incidence rates of adverse reactions between the two groups showed no statistically significant difference (P>0.05). Conclusion The combination of Di'ao Xinxuekang Capsules and diltiazem is effective in treating angina pectoris of coronary heart disease. It can inhibit the occurrence of angina pectoris, reduce inflammatory responses, improve cardiac function, and alleviate the degree of myocardial damage. It also has good safety. Reference | Related Articles | Metrics

Select

Influencing factors of postoperative sore throat in adult patients taking tracheal intubation under general anesthesia: a meta-analysis Lu Jing, Wang Renzhong, Qu Junchao, Wang Jing, Liu Huifang, Gu Yuanyuan International Medicine and Health Guidance News    2025, 31 (22): 3718-3722.   DOI: 10.3760/cma.j.cn441417-20250217-22005 Abstract （186）            Knowledge map    Save Objective To conduct a meta-analysis on the influencing factors of postoperative sore throat (POST) in adult patients taking tracheal intubation under general anesthesia, to provide evidences for early identification of POST in adult patients with tracheal intubation under general anesthesia, and to reduce the incidence of POST.  Methods The literature related to POST risk factors of adult patients taking tracheal intubation under general anesthesia was systematically searched from self-established databases of each database to June 20, 2024, and  the relevant data were extracted from the included literature. The literature quality was evaluated by using the Neuskarl-Ottawa Scale (NOS), and the relevant data was meta-analyzed by Revman 5.3.  Results A total of 6 literatures were included, involving 1 754 adult patients, and the incidence rate of POST in the adult patients taking tracheal intubation under general anesthesia was 38.7%. Meta-analysis showed that multiple attempts at tracheal intubation ( OR=2.49, 95% CI 1.55-3.99), high tracheal tube pressure ( OR=2.02, 95% CI 1.20-3.41), female ( OR=1.74, 95% CI 1.30-2.33) and cough during extubation ( OR=2.99, 95% CI 1.87-4.80) were risk factors for POST in the adult patients taking tracheal intubation under general anesthesia.  Conclusions The POST of adult patients taking tracheal intubation under general anesthesia is affected by many factors, such as multiple attempts of tracheal intubation, high pressure of tracheal cuff, female and cough during extubation. Clinical medical staff should identify the occurrence of POST in adult patients taking tracheal intubation under general anesthesia early, and provide predictive nursing for POST in adult patients taking tracheal intubation under general anesthesia. Reference | Related Articles | Metrics

Select

One case of intracranial hemorrhage caused by ruxolitinib and voriconazole Han Hua, Zhang Meixiang, Ren Hanyun, Wei Mingxia, Wang Chunjian International Medicine and Health Guidance News    2025, 31 (22): 3821-3823.   DOI: 10.3760/cma.j.cn441417-20250519-22024 Abstract （186）            Knowledge map    Save A 74-year-old male patient with systemic lupus erythematosus who had been taking methylprednisolone tablets for a long time. He had primary myelofibrosis, and took ruxolitinib phosphate tablets 15 mg twice a day, hydroxyurea tablets 0.5 g twice a day, and stanzolol 2 mg three times a day. The patient was admitted to hospital due to bacterial pneumonia and invasive pulmonary aspergillosis. At that time, the white blood cell count was 19.29×10 9/L, hemoglobin 70 g/L, and platelet count 113×10 9/L. In the anti-bacterial aspect, imipenem and cilastatin sodium for injection, ceftazidime for injection, and cefoperazone and sulbactam sodium for injection were successively given. Voriconazole for injection was given for antifungal treatment. After that, the patient's body temperature returned to normal, and the symptoms of coughing and expectoration improved compared to before. On the 14th day of admission, the patient's family member noticed that the patient fell off the chair and landed on the ground, and then developed consciousness disorders. After that, the body temperature was normal, and the cough and sputum production were better than before. On the 14th day of admission, the family member found that the patient had slipped to the floor in his sitting position and had disturbance of consciousness. At that time, the white blood cell count was 11.69×10 9/L, hemoglobin 88 g/L, and platelet count 63×10 9/L; head CT showed extensive hemorrhage in the ventricular system. Cerebral hemorrhage is considered to be highly associated with ruxolitinib. His family member requested conservative treatment and died of respiratory and circulatory failure. Reference | Related Articles | Metrics

Select

To investigate effect of Jinkui Shenqi pills combined with chlorosartan potassium tablets on renal fibrosis indicators in elderly patients with diabetic nephropathy based on TGF-β1/Smads signal pathway  Qin Gangxin, Su Yanjin, Zhao Li, Wang Huiling, Yang Jinxin International Medicine and Health Guidance News    2025, 31 (12): 2033-2038.   DOI: 10.3760/cma.j.cn441417-20241120-12021 Abstract （185）            Knowledge map    Save Objective To investigate the effect of Jinkui Shenqi pills combined with chlorosartan potassium tablets on renal fibrosis indicators in elderly patients with diabetic nephropathy of the yin-yang deficiency type based on the transforming growth factor-β1 (TGF-β1) /Smads signal pathway. Methods A total of 110 elderly patients with diabetic nephropathy of the yin-yang deficiency type treated at Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from January 2023 to January 2024 were selected for the randomized controlled trial, and were divided into a control group and an observation group by the random number table method, with 55 cases in each group. There were 29 males and 26 females in the observation group; they were (68.59±5.48) years old; their disease course was (2.14±0.72) years. There were 32 males and 23 females in the control group; they were (69.25±5.74) years old; their disease course was (2.37±0.68) years. The control group took chlorosartan potassium tablets and conventional treatment; in addition, the observation group took Jinkui Shenqi pills. Both groups were treated continuously for 2 months. The scores of Chinese medicine symptoms, blood glucose levels [fasting blood glucose (FBG) and 2-hour postprandial blood glucose (2hPBG)], levels of renal function indicators [blood urea nitrogen (BUN), serum creatinine (SCr), and 24-hour urinary protein (24hUpro)], levels of renal fibrosis indicators [connective tissue growth factor (CTGF), procollagen type Ⅲ (PCⅢ), laminin (LN), and collagen type Ⅳ (CⅣ)], and protein and mRNA expressions of TGF-β1, Smad2, Smad3, and Smad7 were compared between the two groups before and after the treatment. The clinical efficacies and incidence rates of adverse reactions were compared between the two groups. t and χ2 tests were used for the statistical analysis. Results Before the treatment, there were no statistical differences in the score of traditional Chinese medicine symptoms, levels of FBG, 2hPBG, BUN, SCr, 24hUpro, LN, PCⅢ, CⅣ, and CTGF, and protein and mRNA expressions of TGF-β1, Smad2, Smad3, and Smad7 between the two groups (all P>0.05). After the treatment, the scores of traditional Chinese medicine symptoms, levels of FBG, 2hPBG, BUN, SCr, 24hUpro, LN, PCⅢ, CⅣ, and CTGF, and protein and mRNA expressions of TGF-β1, Smad2, and Smad3 were lower than those before the treatment in both groups, and those in the observation group were lower than those in the control group (all P<0.05). After the treatment, the protein and mRNA expressions of Smad7 were higher than those before the treatment in both groups, and those in the observation group were higher than those in the control group (all P<0.05). The total clinical effective rate of the observation group was higher than that of the control group [92.73% (51/55) vs. 72.73% (40/55); χ2=7.698; P<0.05]. There was no statistical difference in the total incidence rate of adverse reactions between the two groups (χ2=0.440; P>0.05). Conclusion Jinkui Shenqi pills combined with chlorosartan potassium tablets in the treatment of elderly patients with diabetic nephropathy of the yin-yang deficiency type is effective, which may improve their clinical symptoms and renal function inhibiting the expression of the TGF-β1/Smads signal pathway, and reduce the degree of renal fibrosis. Reference | Related Articles | Metrics

Select

Effect of intermittent pneumatic compression combined with anticoagulants in prevention of deep venous thrombosis of lower extremity in patients after cesarean section Sun Jianfang, Bai Long International Medicine and Health Guidance News    2025, 31 (22): 3784-3788.   DOI: 10.3760/cma.j.cn441417-20240707-22017 Abstract （184）            Knowledge map    Save Objective To investigate the effect of intermittent pneumatic compression (IPC) combined with anticoagulants in the prevention of deep venous thrombosis of lower extremity in patients after cesarean section. Methods Ninety-six pregnant women undergoing cesarean section in Yan'an City Hospital of Traditional Chinese Medicine from July 2021 to June 2022 were included in the study, and were divided into a combination group and an anticoagulation group according to the treatment plans, with 48 cases in each group. The combination group were (28.98±3.81) years old, and had delivered (0.98±0.23) times. The the anticoagulation group were (29.52±4.06) years old, and had delivered (1.04±0.29) times. The anticoagulation group subcutaneously injected low molecular weight heparin sodium after cesarean section; in addition, the combination group took IPC. The incidences of venous thrombosis of lower extremity, perioperative coagulation function [prothrombin time (PT), thrombin time (TT), D-dimer (D-D), and fibrinogen (FIB)], hemorheology indicators [plasma viscosity (PV), high shear viscosity (HBV) of whole blood, and erythrocyte deformity-index (EDI)], and surgery-related indicators (postoperative exhaust time, postoperative off-bed time, and lower limb pain) were compared between the two groups. t test, repeated measure analysis of variance, and Fisher exact probability method were used for statistical comparisons. Results The incidence rate of venous thrombosis of lower extremity in the combination group was 0, and that in the anticoagulation group 4.17% (2/48), with no statistical difference (P=0.495). Five days after the surgery, the PT and TT were higher than those before the surgery in both groups, and the levels of D-D and FIB were lower; the PT, TT, and levels of D-D and FIB in the combination group were better than those in the anticoagulation group [(13.29±1.27) s vs. (12.67±1.62) s, (15.04±1.09) s vs. (14.38±1.17) s, (1.74±0.32) mg/L vs. (2.41±0.53) mg/L, and (4.39±0.51) g/L vs. (5.01±0.48) g/L], with statistical differences (all P<0.05). Five days after the surgery, the PV, HBV, and EDI were higher than those before the surgery in both groups; the PV and HBV in the combination group were lower than those in the anticoagualation group [(1.92±0.44) mPa/s vs. (2.17±0.51) mPa/s and (4.81±0.51) mPa/s vs. (5.12±0.57) mPa/s], and the EDI was higher (1.29±0.23 vs. 1.06±0.21), with statistical differences (all P<0.05). The postoperative exhaust time and off-bed time in the combination group were shorter than those in the anticoagulation group [(17.63±1.85) h vs. (20.17±1.73) h and (24.25±2.53) h vs. (31.88±2.46) h], and the score of Visual Analogue Scale was lower (1.27±0.45 vs. 2.08±0.28), with statistical differences (all P<0.05). Conclusion PIC combined with anticoagulants can effectively improve the coagulation function and hemodynamics of parturients after cesarean section, effectively prevent the formation of deep venous thrombosis of lower extremity, and promote their recovery. Reference | Related Articles | Metrics

Select

Effect analysis of Jieyu Shugan Decoction in treating polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome) Zhang Zhaohong, Liu Yan, Lei Jing, Jiang Lili, Liu Lan, Hu Yaping International Medicine and Health Guidance News    2025, 31 (12): 2046-2051.   DOI: 10.3760/cma.j.cn441417-20250109-12023 Abstract （183）            Knowledge map    Save Objective To analyze the effect of Jieyu Shugan Decoction on polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome). Methods A retrospective analysis was conducted. A total of 101 patients with polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome) admitted to Baoji Maternal and Child Health Hospital during January 2022 to December 2023 were selected and divided into a control group and an observation group based on different treatment methods. The control group received oral cyproterone acetate and ethinyl estradiol tablets, while the observation group received the same tablets plus modified Jieyu Shugan Decoction. The control group consisted of 50 patients with age of (29.67 ± 3.52) years and disease duration of (3.31 ± 0.64) years. The observation group consisted of 51 patients with an average age of (30.43 ± 3.64) years and an average disease duration of (3.48 ± 0.73) years. Both groups were treated continuously for 12 weeks. The clinical efficacy, adverse reactions, and changes in traditional Chinese medicine (TCM) symptom scores, serum hormone levels [follicle stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH), testosterone (T), anti-mullerian hormone (AMH)], and uterine artery hemodynamics [pulsatility index (PI) and resistance index (RI)] were compared between the two groups. Statistical analysis was performed using t and χ2 tests.Results After treatment, the total effective rate of treatment in the observation group was higher than that in the control group [94.12% (48/51) vs. 78.00% (39/50)], and the difference was statistically significant (P<0.05). The TCM syndrome score, serum LH, T, and AMH levels, PI, and RI in the observation group were all lower than those in the control group [(8.61±2.13) points vs. (14.52±3.27) points, (9.05±1.37) IU/L vs. (11.16±1.52) IU/L, (0.92±0.17) pmol/L vs. (1.11±)] 0.23) pmol/L, (7.29±1.14) μg/L vs. (9.46±1.37) μg/L, 2.16±0.26 vs. 2.52±0.39, 0.62±0.11 vs. 0.73±0.10](t=10.783, 12.026, 12.534, 15.904, 5.468, 5.256, all P<0.05), and the levels of serum FSH and E2 were both higher [(5.91±0.61) IU/L vs. (5.64±0.57) IU/L, (204.62±23.57) ng/L vs. (165.38±16.82) ng/L];the differences were all statistically significant (all P<0.05).The total occurrence of adverse reactions in the observation group showed no statistically significant difference compared with that in the control group [7.84% (4/51) vs. 10.00% (5/50), P>0.05].Conclusion Jieyu Shugan Decoction in the treatment of polycystic ovary syndrome (liver-stagnation and kidney deficiency syndrome) can improve the therapeutic effect, alleviate symptoms, regulate serum hormone levels, and improve endometrial blood flow state, without increasing the occurrence of adverse reactions. Reference | Related Articles | Metrics

Select

Effect of multidisciplinary collaboration for Chemotherapy induced peripheral neuropathy in Patients with breast cancer  Wang Xiao, Deng Zhiping, Zhang Xifan, Li Yang, Zhang Yu International Medicine and Health Guidance News    2025, 31 (12): 2093-2097.   DOI: 10.3760/cma.j.cn441417-20241029-12032 Abstract （182）            Knowledge map    Save Objective To explore the actual effectiveness and feasibility of multidisciplinary collaborative nursing interventions in alleviating symptoms of chemotherapy-induced peripheral neuropathy (CIPN) after breast cancer chemotherapy. Methods A single-center prospective randomized controlled trial was conducted. The study involved 128 patients with CIPN treated at Shaanxi Provincial Cancer Hospital from February 2022 to January 2024.The patients were randomly divided into a control group and a study group, each consisting of 64 patients. The control group including 1 male and 63 females, aged 31-56 (32.84±2.75) years; the study group including 1 male and 63 females, aged 36-52 (33.27±3.17) years.The control group received routine nursing care, while the study group was administered a multidisciplinary nursing intervention protocol in addition to standard care.Both groups received the allocated interventions for 3 months. Medical Coping Modes Questionnaire (MCMQ), Herth Hope Index (HHI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Visual Analogue Scale (VAS) for pain, and the Neurotoxicity Quality of Life Scale (FACT/GOG Ntx) score of the American Cancer Treatment Functional Evaluation System were compared between two groups. t test and χ2 test were used for statistically analysis. Results After three months of intervention, the study group showed lower scores in the dimensions of submission and avoidance compared to the control group [(12.57±2.64) points vs. (14.13±3.18) points and (14.62±2.23) points vs. (17.28±2.56) points], while the score of the facing dimension was higher than the control group [(19.13±2.82) points vs. (17.65±2.63) points] (all P<0.05). The study group demonstrated significantly higher HHI scores compared to the control group[(40.81±4.51) points vs. (36.67±4.26) points], but showing lower scores on both SAS and SDS [(55.82±5.24) vs. (60.19±5.73)points and (54.18±6.04) points vs. (59.57±6.38) points], with all differences being statistically significant (all P< 0.05).The study group demonstrated significantly lower neuropathic pain VAS scores than the control group at both 1-month and 3-month post-chemotherapy [(1.83±0.73) points vs. (2.46±0.86)points、(0.58±0.17) points vs. (1.04±0.39)points]. Similarly, FACT/GOG-Ntx scores were significantly reduced in the study group compared to the control group at both 1-month and 3-month post-chemotherapy[(7.23±1.86) points vs. (10.84±2.49)points and (3.56±1.12) points vs. (5.27±1.58) points](t=9.292 and 7.064，both P<0.05). Conclusion Nursing interventions within a multidisciplinary context effectively improve the psychological state, pain level, and quality of life of patients suffering from CIPN following breast cancer chemotherapy. Reference | Related Articles | Metrics

Select

Analysis of multi-dimensional influencing factors on the current social function and self-efficacy of young and middle-aged patients with coronary heart disease returning to work after PCI Luo Zhaochuan, Qiu Yun, Lai Xiaowen, Yang Xiaoyan, Niu Qiang International Medicine and Health Guidance News    2025, 31 (22): 3762-3766.   DOI: 10.3760/cma.j.cn441417-20250804-22013 Abstract （180）            Knowledge map    Save 目的 探讨中青年冠心病（CHD）患者经皮冠状动脉介入术（PCI）后重返工作岗位（RTW）社会功能现状及自我效能的多维度影响因素。方法 选取2023年1月至2025年1月广汉市人民医院接受PCI治疗的中青年CHD患者153例，评估一般资料问卷、重返工作自我效能量表（RTW-SE）、重返工作准备度量表（RRTW）、社会支持量表（SSRS）、患者积极度量表（PAM）、匹兹堡睡眠质量指数（PSQI）和焦虑自评量表（SAS），采用采用 t检验、 χ 2检验、单因素分析、多因素logistic回归分析Pearson相关性分析评价结果。结果 患者RTW-SE总均分（41.25±7.21）分，条目均分（3.75±0.82）分，处于中低水平；RRTW总均分（42.51±1.58）分，处于中低水平；SSRS总均分（33.23±5.82）分，处于中等水平；PAM总均分（29.12±5.82）分，处于中等水平；PSQI总均分（9.55±2.62）分，处于睡眠质量较差水平；SAS总均分（52.02±9.45）分，处于轻度焦虑水平。RTW-SE评分与RRTW、SSRS、PAM评分呈显著正相关性（ r=0.652、0.439、0.753，均 P<0.001），而与PSQI、SAS评分呈显著负相关性（ r=-0.259、-0.821，均 P<0.001）。经单因素与logistic多因素分析显示，CHD病程、SAS、PSQI评分均为独立危险因素，RRTW、SSRS和PAM均为保护因素（均 P<0.05）。结论 中青年CHD患者PCI术后RTW社会功能亟待提高，针对性提供心理干预、社会支持及睡眠指导等综合性干预可能有利于提高其RTW自我效能与积极度。 Reference | Related Articles | Metrics

Select

Analysis of influencing factors and risk prediction of coronary heart disease complicated with cardiogenic stroke Di Haili, Liao Yongbin, Guo Xian International Medicine and Health Guidance News    2025, 31 (22): 3731-3737.   DOI: 10.3760/cma.j.cn441417-20250819-22008 Abstract （178）            Knowledge map    Save Objective To analyze the influencing factors of in patients with cardiogenic stroke in patients with, and to construct a risk prediction model.  Methods The clinical data of 249 patients with coronary heart disease admitted to the Northwest University First Hospital from January 2022 to January 2025 were retrospectively analyzed. The patients with cardiogenic stroke were counted, and these patients were classified as a case group (105 cases). Meanwhile, gender, age, body mass index, smoking history, and drinking history were used as matching variables. The patients without concurrent cardiogenic stroke were matched at a 1:1 ratio as a control group (105 cases). There were 58 males and 47 females in the case group, aged (66.23±6.53) years. There were 54 males and 51 females in the control group, aged (64.85±6.91) years old. The clinical data of the two groups were compared, and the influencing factors of coronary heart disease complicated with cardiogenic stroke were analyzed by multivariate logistic regression. A nomogram model of coronary heart disease complicated with cardiogenic stroke was drawn; the calibration curve, receiver operating characteristic curve (ROC), and decision curve analysis (DCA) were used to evaluate the predictive performance of the nomogram model. t test and χ 2 test were used as the statistical methods. Results The proportion of the patients with hypertension, arrhythmia, cardiac mural thrombus, carotid plaque, severe coronary artery disease, left atrial diameter (LAD), left atrial diameter index (LADi), and homocysteine (Hcy) in the case group were higher than those in the control group [65.71% (69/105) vs. 40.95% (43/105), 71.43% (75/105) vs. 29.52% (31/105), 21.90% (23/105) vs. 6.67% (7/105), 48.57% (51/105) vs. 26.67% (28/105), 22.86% (24/105) vs. 5.71% (6/105), (38.16±5.81) mm vs. (35.92±4.73) mm, (22.69±3.24) mm/m 2  vs. (19.41±2.78) mm/m 2, and (16.92±4.20) μmol/L vs. (13.67±3.74) μmol/L], and the left ventricular ejection fraction (LVEF) was lower [(52.58±11.83)% vs. (57.40±9.89)%], with statistical differences (all P<0.05). The multivariate logistic regression analysis showed that hypertension, arrhythmia, cardiac mural thrombus, carotid plaque, severe coronary artery disease, LAD enlargement, high LADi, and high Hcy were risk factors for coronary heart disease and cardiogenic stroke (all P<0.05), and high LVEF was a protective factor ( P<0.05). The internal verification of the nomogram model constructed based on the results of multivariate analysis showed that the predicted curve was similar to the actual curve, and the consistency index was 0.847. The results of ROC showed that the area under the curve (AUC), sensitivity, and specificity of the nomogram model in predicting coronary heart disease complicated with cardiogenic stroke were 0.836 (95% CI 0.779-0.884), 82.86%, and 80.95%, respectively. The results of DCA curve showed that the nomogram model had better clinical benefits when the threshold range was 0.08-0.93.  Conclusions Hypertension, arrhythmia, cardiac mural thrombus, carotid plaque, degree of coronary artery disease, LAD, LADi, LVEF, and Hcy are the influencing factors of coronary heart disease and cardiogenic stroke. The nomogram prediction model constructed based on the above factors has good clinical value. Reference | Related Articles | Metrics

Select

Levels of Lp-PLA2 and sST-2 and their correlation with cardiac function and inflammatory factors in patients with coronary heart disease and heart failure Yang Yanchi International Medicine and Health Guidance News    2025, 31 (22): 3761-3765.   DOI: 10.3760/cma.j.cn441417-20250703-22012 Abstract （178）            Knowledge map    Save Objective To investigate the levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and soluble growth stimulating expression factor-2 (sST-2) and their correlation with cardiac function and inflammatory factors in patients with coronary heart disease and heart failure. Methods A total of 85 patients with coronary heart disease (including 41 patients with heart failure) diagnosed and treated in Qidong Second People's Hospital from January 2024 to May 2025 were selected as the study objects. The general data, levels of Lp-PLA2 and sST-2, cardiac function indicators [left ventricular ejection fraction (LVEF), cardiac output (CO), left ventricular end-systolic diameter (LVESD), and left ventricular end-diastolic diameter (LVEDD)], and inflammatory factors [neutrophil count (NEUT), procalcitonin (PCT), and heparin-binding protein (HBP)] were compared between the patients complicated with heart failure and the patients with only coronary heart disease. The Pearson correlation coefficient was used to analyze the levels of Lp-PLA2 and sST-2 in the patients with coronary heart disease and heart failure, as well as their correlation with cardiac function and inflammatory factors. Statistics were performed using t-test, χ2 test, and Pearson correlation analysis. Results There were no statistical differences in the general data between the two groups (all P>0.05). The levels of Lp-PLA2, sST-2, NEUT, PCT, and HBP, LVESD, and LVEDD in the heart failure group were higher than those in the simple coronary heart disease group, and the LVEF and CO were lower (all P<0.05). The NEUT, PCT and HBP in the heart failure group were significantly higher than those in the simple coronary heart disease group (all P<0.05). The Pearson correlation analysis showed that the levels of Lp-PLA2 and sST-2 were positively correlated with LVESD, LVEDD, NEUT, PCT, and HBP (r=0.708, 0.594, 0.401, 0.412, 0.328, 0.732, 0.610, 0.419, 0.448, and 0.357), and negatively with LVEF and CO (r=-0.694, -0.525, -0.718, and -0.573) in the patients with heart failure. Conclusion The expression of Lp-PLA2 and sST-2 in patients with coronary heart disease and heart failure is further increased, and their levels are correlated with cardiac function and inflammatory factors. Reference | Related Articles | Metrics

Select

Application of eating posture guidance combined with swallowing training in patients with dysphagia after cerebral infarction Zhong Hui, Liu Dan, Zhou Jia, Li Xia International Medicine and Health Guidance News    2025, 31 (18): 3117-3121.   DOI: 10.3760/cma.j.cn441417-20250219-18025 Abstract （177）            Knowledge map    Save Objective To explore the intervention effect of implementing eating position guidance combined with swallowing training for patients with dysphagia after cerebral infarction. Methods A prospective study was conducted on 98 patients with post-cerebral infarction dysphagia who were admitted to Zhongshan Central Hospital in Dezhou from October 2022 to October 2024. They were randomly divided into a control group and an observation group, with 49 cases in each group using the random number table method.Control group: 26 males and 23 females, aged 51 to 72(61.59±3.36) years. Received routine intervention. Observation group: 27 males and 22 females, aged 52 to 71(61.68±3.40) years. In addition to the routine intervention, they received guidance on eating postures combined with swallowing training.Both groups underwent continuous training intervention for 30 days. The recovery of swallowing function, incidence of choking and aspiration, eating situation, nutritional status, and quality of life were compared between the two groups before and after the intervention.Statistical analysis was conducted using t-test and χ2 test. Results After the intervention, the clinical examination, water intake test and normal eating score of the observation group were all lower than those of the control group (t=19.287, 16.470, and 27.787; all P<0.05). The incidences of choking cough and aspiration were both lower in the experimental group compared to the control group [20.41% (10/49) vs. 38.78% (19/49) and 8.16% (4/49) vs. 24.49%(12/49)], and the differences were statistically significant (χ2=3.967 and 4.781; both P<0.05). The time for the observation group to achieve self-feeding was shorter than that of the control group, and the actual proportion of self-feeding was higher than that of the control group (t=10.560 and 7.291; both P<0.05). After the intervention, the levels of hemoglobin (Hb), albumin (ALB), and prealbumin (PA) in the observation group were all higher than those in the control group [(118.78±12.96) g/L vs. (106.67±12.73) g/L, (44.70±4.38) g/L vs. (40.78±4.32) g/L, and (245.77±25.96) mg/L vs. (211.15±22.59) mg/L], and the differences were statistically significant (t=4.666,4.460, and 7.042; all P<0.05).After the intervention, the scores in each item of the Specific Quality of Life Scale for Dysphagia (SWAL-QOL) in the observation group were all higher than those in the control group (all P<0.05). Conclusion Guidance on eating postures combined with swallowing training can improve the swallowing function of patients with post-stroke dysphagia, reduce the occurrence of choking and aspiration and other accidents, facilitate better eating for patients, enhance their nutritional status, and improve their quality of life. Reference | Related Articles | Metrics

Select

Mediating effect and nursing plan of postoperative health behavior of coronary heart disease patients on mindfulness level and quality of life based on structural equation analysis Li Hongyan International Medicine and Health Guidance News    2025, 31 (15): 2630-2635.   DOI: 10.3760/cma.j.cn441417-20250114-15033 Abstract （176）            Knowledge map    Save Objective To analyze the mediating effect of postoperative health behavior on mindfulness level and quality of life in patients with coronary heart disease, as well as nursing plans. Methods This study is a cross-sectional study. A total of 96 patients with coronary heart disease who were admitted to Fuwai Central China Cardiovascular Hospital from May 2022 to June 2023 were selected as the study subjects. Among them, 61 were male and 35 were female; the age ranged from 37 to 64 (53.59±4.86) years; the disease duration was 2 to 4 (3.48±0.61) years; educational level: 46 had a junior high school education or below, 35 had a high school education, and 15 had a college degree or above. The patients' mindfulness level [Mindful Attention Awareness Scale (MAAS)] was compared at 24 hours and 1 month after surgery, as well as their quality of life [World Health Organization quality of life-BREF (WHOQOL-BREF)] and postoperative health behavior (Active Health Behavior Scale for Patients with Chronic Diseases). Paired t test, Wilcoxon signed-rank test, and χ2 test were used for statistical analysis. The relationship between postoperative health behavior and mindfulness level, as well as quality of life in patients with coronary heart disease, was analyzed using bivariate correlation Person method. The mediating effect of postoperative health behavior on the relationship between mindfulness level and quality of life was analyzed using the structural equation model. Results The MAAS score of patients with coronary heart disease one month after surgery was higher than that 24 hours after surgery [(58.74±6.49) points vs. (45.63±5.01) points] (P<0.05). The scores of each dimension of the WHOQOL-BREF, the overall quality of life score and the total score of the patients with coronary heart disease one month after surgery were all higher than those at 24 hours after surgery (all P<0.05). The scores of each dimension and the total score of the Active Health Behavior Scale for Patients with Chronic Diseases of the patients with coronary heart disease one month after surgery were all higher than those at 24 hours after surgery (all P<0.05). The total score of the Active Health Behavior Scale for Patients with Chronic Diseases for coronary heart disease patients was positively correlated with the MAAS score (r=0.890, P<0.001), and the total score of the Active Health Behavior Scale for Patients with Chronic Diseases was positively correlated with the total score of the WHOQOL-BREF (r=0.885, P<0.001). The MAAS score was positively correlated with the total score of the WHOQOL-BREF (r=0.892, P<0.001). The results of the structural equation analysis show that the regression effect of equation Y=cX+e1 is significant, with c=0.885, P<0.001. The regression effect of equation M=aX+e2 is also significant, with a=0.890, P<0.001. The regression effect of equation Y=c'X+bM+e3 is also significant, with b=0.504, P<0.001; c'=0.436, P<0.001, representing a partial mediation effect model. The contribution rate of the mediating effect to the total effect is: ab/c×100%=50.68%. Conclusion The postoperative health behavior of patients with coronary heart disease has a certain correlation with the level of mindfulness and quality of life. Moreover, the postoperative health behavior has a mediating effect between the level of mindfulness and the quality of life. Clinically, improving the postoperative health behavior of patients can enhance the level of mindfulness and the quality of life. Reference | Related Articles | Metrics

Select

Investigation of mechanism of Guishen pills in treatment of thin endometrium based on PI3K/AKT signaling pathway Qiu Chao, Liu Yan, Guan Yongge, Song Yang International Medicine and Health Guidance News    2025, 31 (16): 2641-2646.   DOI: 10.3760/cma.j.cn441417-20241021-16001 Abstract （176）            Knowledge map    Save Objective To explore the mechanism of aqueous extract of Guishen pills in the treatment of thin endometrium, and its relationship with the phos-phatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. Methods The study was from September 2017 to December 2019. The bone marrow mesenchymal stem cells (BMSCs) were taken from 3 weeks old SD rats (3 rats, each weighs approximately 50 grams) to prepare primary cell models. The aqueous extract of Guishen pills was used for in vitro induction. The relative expression levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), phosphorylated PI3K (p-PI3K), and phosphorylated AKT (p-AKT) in each group were detected by Western blotting. The expressions of leukocyte inhibition factor (LIF) and vascular endothelial growth factor (VEGF) were detected by the immunofluorescence method. The expression of integrin αvβ3 (ITGαvβ3) in the serum of BMSCs in each group was detected by enzyme linked immunosorbent assay. One-way analysis of variance and rank sum test were used for the statistical analysis. Results The expressions of PI3K, p-PI3K, AKT, and p-AKT proteins in the aqueous extract intervention group were higher than those in the blank control group and the estrogen group (0.69±0.03 vs. 0.56±0.02 vs. 0.56±0.05, 0.55±0.01 vs. 0.43±0.04 vs. 0.45±0.02, 0.52±0.06 vs. 0.42±0.00 vs. 0.35±0.02, and 0.32±0.05 vs. 0.26±0.02 vs. 0.18±0.01; all P<0.05). No expression of LIF and VEGF proteins was observed in the blank control group. Both the estrogen group and the Guishen pill group showed expression of LIF and VEGF, and the expression levels in the Guishen pill group were higher than those in the estrogen group. There was no statistical difference in the expression level of ITGαvβ3 between the groups (P>0.05). Conclusions Both Guishen pills and estrogen in the treatment of thin endometrium may be by regulating the PI3K/AKT signaling pathway, promoting angiogenesis factors, and improve the endometrial lining. The induction action of aqueous extract of Guishen pills is better than estrogen. Reference | Related Articles | Metrics

Select

Application of auricular acupoint compression and percutaneous acupoint potential stimulation pretreatment in postoperative patients with breast cancer based on meridian flow theory  Li Ying, Deng Liuxiang, Xia Lingyi, Zhong Yuting International Medicine and Health Guidance News    2025, 31 (12): 2069-2072.   DOI: 10.3760/cma.j.cn441417-20250102-12027 Abstract （176）            Knowledge map    Save Objective To investigate the effects of auricular point compression and bean compression combined with percutaneous point potential stimulation pretreatment on sleep quality, emotional state, and quality of life of patients after breast cancer surgery based on the theory of meridian flow. Methods A total of 120 patients treated in the First Affiliated Hospital of Gannan Medical University from August 2023 to August 2024 underwent radical mastectomy. According to the random number table method, they were divided into a conventional treatment group (Group A), a auricular point bean pressing group (Group B), a percutaneous point potential stimulation group (Group C), and a combined treatment group (Group D, auricular point bean pressing combined with percutaneous point potential stimulation), with 30 cases in each group. The age of group A was (41.35 ± 3.28) years, with 8 cases of Stage Ia, 12 cases of Stage Ib, and 10 cases of Stage Ⅱa breast cancer. The age of group B was (42.05 ± 4.17) years, with 9 cases of stage Ia, 11 cases of stage Ib, and 10 cases of stage Ⅱa breast cancer.The average age of Group C was (42.13 ± 2.73) years, with 10 cases of stage Ia, 11 cases of stage Ib, and 9 cases of stage Ⅱa breast cancer.The age of Group D was (42.42 ± 3.47)years, with 8 cases of stage Ia, 13 cases of stage Ib, and 9 cases of stage Ⅱa breast cancer. Patients in all 4 groups were intervened for one week. The Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and quality of life scores were compared before and after the intervention between the four groups. The clinical indicators, scar scores before and after treatment, serum growth factor levels, and adverse reaction rates were compared. Statistical analysis was performed using t-tests. Results After one week of intervention, PSQI scores in groups B, C and D were significantly decreased compared with group A (P < 0.05). The HAMA and HAMD scores in group D were significantly lower than those in groups A, B and C [(6.13±0.51) points vs. (11.48±1.37), (9.32±1.43), (8.22±1.28) points, (12.84 ± 1.75) points vs. (17.93 ± 1.68), (15.74±1.57), (15.46±1.64) points], with a statistically significant differences (all P < 0.05). The quality of life score of group D was significantly higher than that of group A [(84.39 ± 3.26) points vs. (79.84 ± 4.34) points], with statistically significant differences (P < 0.05). Conclusion Based on the theory of meridian injection, auricular acupoint compression combined with percutaneous acupoint potential stimulation pretreatment can significantly improve the sleep quality, anxiety, depression, and quality of life of patients after breast cancer surgery. Reference | Related Articles | Metrics

Select

Sleep status of primary and secondary school students in Bincheng District, Binzhou City and its influencing factors Liu Yandi, Li Yingying, Huo Yingqian, Li Dongyang, Guo Ao, Ma Wenbin International Medicine and Health Guidance News    2025, 31 (22): 3865-3869.   DOI: 10.3760/cma.j.cn441417-20250527-22033 Abstract （175）            Knowledge map    Save Objective To understand the sleep status of primary and secondary school students in the Bincheng District of Binzhou City and analyze its influencing factors, and oprovide countermeasures for improving the sleep quality of primary and secondary school students. Methods This survey was conducted from May to June 2023. A stratified sampling method was adopted to select 534 primary and secondary school students in the Bincheng District of Binzhou City as the survey objects. A self-designed electronic questionnaire was used to investigate the sleep status of primary and secondary school students. Results 14.79% of primary school students sleeped less than 8 hours, 40.96 percent of middle school students between the than 7 hours, and 52.26 percent of high school students between the less than 6 hours. The sleeping time of primary school students mainly concentrated in 21:00－22:00 (47.47%) and 22:00－23:00 (38.52%). The sleeping time of junior and senior students was mainly 22:00－23:00 (35.74%) and 23:00－24:00 (19.13%), the waking time of primary school students mainly 06:30－07:00 (61.48%), and that of junior and senior high school students 05:30－06:00 (54.15%). There were significant differences in the time of falling asleep and getting up in the morning between the students of different school ages (P<0.05). The most prominent sleep-related psychological problems of primary and secondary school students were morning difficulty (35.77%); It was followed by daytime sleepiness (14.79%), poor attention (14.05%), poor memory (11.61%), anxiety (10.67%), and depression (8.05%). Multivariate logistic regression analysis showed that late bedtime (OR=4.205, 95%CI: 1.608～10.997) and distance from home to school (OR=1.946, 95%CI: 1.108-3.419) affected the sleep time of primary school students (P<0.05). Late sleep time (OR=7.106, 95%CI: 3.718～13.578) affected the sleep time of middle and high school students (P<0.05). Conclusions The majority of primary and middle school students in Binzhou City have insufficient sleep time, some of them have sleep-related psychological problems and late sleep time is a risk factor affecting sleep time. It is suggested that relevant departments should pay attention to and strengthen children's sleep health education, home-school co-education, and effectively improve the sleep quality of primary and secondary school students. Reference | Related Articles | Metrics

Select

Clinical efficacy observation of early intervention with electrophysiological technology for rapid urinary control after laparoscopic radical prostatectomy  Pan Bin, Wang Guikang, Xu Jiaxin, Yang Zhihuang, Yang Xi, Gao Ping, Chen Guo, Li Yutong, Zhou E, Chen Jie International Medicine and Health Guidance News    2025, 31 (13): 2113-2117.   DOI: 10.3760/cma.j.cn441417-20250513-13001 Abstract （174）            Knowledge map    Save Objective To evaluate the clinical efficacy of early intervention with electrophysiological technology in achieving rapid urinary control following laparoscopic radical prostatectomy. Methods From July 2021 to May 2025, 31 patients who underwent laparoscopic radical prostatectomy in the Department of Urology at the First Affiliated Hospital of Jinan University were included. On postoperative day 1, visual electrodiagnosis was performed using a medical infrared thermography device (TMT9000). Their age was (69.74±7.12) years old, and the prostate-specific antigen (PSA) level was 14.31 (8.30, 44.19) μg/L. Individualized electrical stimulation parameters were selected, and a treatment plan was formulated. Subsequently, percutaneous low-frequency pulsed neuromuscular electrical stimulation therapy was administered. Post-treatment outcomes were assessed using the International Consultation on Incontinence Questionnaire-Short Form (ICI-Q-SF) score, the Incontinence Quality of Life Questionnaire (I-QOL) score, and 24-hour pad usage. Results All patients successfully completed the surgery, with an operative time of (5.27±1.03) hours, a blood loss of 50 (30, 54) ml, a pelvic drainage tube removal time of (4.96±2.05) days, and a catheter removal time of (12.70±2.51) days. After treatment, the ICI-Q-SF score was (4.90±3.46) points, and the I-QOL score was (94.51±7.86) points. Immediate urinary control after catheter removal was achieved in 77.4% (24/31) of the patients: 18 (58.1%) had no stress urinary incontinence (SUI) and required no pads, while 6 (19.4%) used only 1 pad on the day of catheter removal, with 24-hour pad usage less than 1. The remaining 7 patients (22.6%) experienced SUI, using more than 1 pad per day. After 6 months of follow-up, only 1 patient still had SUI, requiring more than 1 pad daily. Conclusion Early intervention with electrophysiological technology after laparoscopic radical prostatectomy facilitates rapid urinary control and is safe and effective, which may serve as a sequential treatment to reduce the incidence of SUI following radical prostatectomy. Reference | Related Articles | Metrics

Select

Research progress of minimally invasive interventional therapy for pain in patients with advanced cancer Dai Wei , Cui Dongmei , Wang Wenjun , Yang Wenjing , Ma Shigang , Zhang Yanying , Wang Tao , Man Tao International Medicine and Health Guidance News    2025, 31 (15): 2466-2470.   DOI: 10.3760/cma.j.cn441417-20250609-15001 Abstract （172）            Knowledge map    Save Cancer pain is a common and severe symptom that significantly affects the quality of life of cancer patients, particularly those with advanced cancer. Traditional pharmacological treatments have many limitations; therefore, minimally invasive interventional therapies have gradually shown advantages in the management of cancer pain. This article reviews the indications and contraindications for minimally invasive interventional treatment in cancer pain patients, commonly used methods for different anatomical sites, including nerve block and ablation,percutaneous vertebroplasty, radiofrequency ablation, and intrathecal drug delivery system implantation for pain management in advanced cancer. It also discusses the timing of interventional interventions for refractory cancer pain, analyzing their principles, efficacy, advantages, and associated risks. The aim is to provide a reference for better selection and application of minimally invasive interventional therapies for cancer pain in clinical practice to improve patient quality of life. Reference | Related Articles | Metrics

Select

Clinical characteristics and prognostic analysis of neonatal adrenal neuroblastoma Huang Yiwen, Chai Chengwei, Li Peng, Huang Baisha, Dong Chou, Cen Long, Xiao Jing, Li Ganglong International Medicine and Health Guidance News    2025, 31 (17): 2864-2867.   DOI: 10.3760/cma.j.cn441417-20250311-17009 Abstract （172）            Knowledge map    Save Objective To summarize the clinical characteristics of neonatal adrenal neuroblastoma (NB) and explore the diagnosis and treatment of neonatal adrenal NB. Methods Clinical data were collected from 10 cases of neonatal adrenal NB diagnosed by pathology at Guangdong Provincial Maternal and Child Health Hospital from August 2018 to August 2024, including age, sex, time of discovery, staging, treatment regimens, etc, and a retrospective analysis was conducted. Results Among the 10 patients, there were 4 males and 6 females, with the time of discovery ranging from prenatal at 31 weeks of gestation to within 1 month after birth. 7 cases were identified by prenatal ultrasound, and 3 cases were found through abdominal ultrasound due to postnatal abdominal distension. All tumors originated from the adrenal gland, with 6 on the right side and 4 on the left. Preoperative ultrasound and CT scans indicated a round solid mass in the adrenal region in 9 cases and a cystic lesion in 1 case, with the shortest diameter ranging from 1.9 to 4.1 cm and the longest diameter from 2.1 to 5.7 cm. According to the International Neuroblastoma Staging System (INSS), there were 3 cases of stage 4S with liver metastasis and 7 cases of stage 1. The age at surgery ranged from 12 to 84 days, with a median of 29 days. Pathological classification revealed 7 cases as poorly differentiated and 3 as undifferentiated. All patients showed no MYCN gene amplification and had no 1p/11q deletions. All patients were classified into the very low-risk group and underwent primary tumor resection. Among them, 2 cases with liver metastasis (1 with multiple cystic lesions in the liver and 1 with diffuse hepatic enlargement) received chemotherapy for 6 cycles according to the low-risk group protocol, while the remaining cases underwent complete resection without postoperative chemotherapy and were followed up. All 10 patients were followed for 9 to 69 months and remained alive, with 7 stage 1 patients achieving complete remission and 3 stage 4S patients living with the tumor. Conclusions NB has its clinical specificities, mostly stage one and 4S. Currently, the main treatment is complete resection of the primary tumor lesion. In this study, tumor resection in the neonatal period was found to be safe and effective, but individualized chemotherapy was needed for children in the very low-risk group. The overall prognosis of children with NB is good. Reference | Related Articles | Metrics

Select

Research on application value of goal-oriented progressive nursing mode in elderly patients with lumbar vertebral compression fractures Han Chonglan, Zhang Xiaowen, Xu Huiyun, Hou Weikun International Medicine and Health Guidance News    2025, 31 (22): 3828-3832.   DOI: 10.3760/cma.j.cn441417-20250314-22026 Abstract （172）            Knowledge map    Save Objective To evaluate the clinical efficacy of the goal-oriented progressive nursing model in the rehabilitation process of elderly patients with vertebral compression fractures, as well as its impact on the quality of life of these patients. Methods A prospective randomized controlled study was conducted, including 120 elderly patients with lumbar vertebral compression fractures who were treated at Ankang Hospital of Traditional Chinese Medicine from April 2023 to March 2024. They were divided into an observation group and a control group by the random number table method, with 60 cases in each group. The observation group had 28 males and 32 females, with an age of (72.5±6.3) years and a disease duration of (3.2±1.4) months. The control  group had 26 males and 34 females, with an age of (73.1±6.5) years and a disease duration of (3.4±1.5) months. The control group received routine nursing measures, while the observation group was given the additional targeted and stepwise nursing intervention plan on top of the routine measures. Both groups were intervened for 8 weeks. The Visual Analogue Scale (VAS) scores, Activities of Daily Living (ADL) scores, as well as the incidence rates of complications and nursing satisfaction before and after the intervention in the two groups were compared. Statistical methods employed t-test and χ2 test. Results After the intervention, the VAS score of the observation group was lower than that of the control group [(3.1±0.8) points vs. (4.5±1.0) points], and the ADL score was higher than that of the control group [(45.8±5.1) points vs. (38.6±4.8) points], with statistical differences(t=8.526 and 7.843; both P<0.05). The total incidence rate of complications in the observation group was lower than that in the control group [6.7% (4/60) vs. 20.0% (12/60)], and the nursing satisfaction rate was higher [96.7% (58/60) vs. 83.3% (50/60)], with statistical differences were statistically significant (χ2=4.385 and 5.926; both P<0.05). Conclusions The goal-oriented progressive nursing mode can effectively alleviate the pain of elderly patients with lumbar vertebral compression fractures, enhance their ability to take care of daily life, reduce the incidence of related complications, and increase their satisfaction with the nursing services. It has high clinical promotion value. Reference | Related Articles | Metrics

Select

Continuous improvement of pediatric outpatient waiting time using PDCA Chen Chunmei, Huang Junbin, Lai Min, Liu Su International Medicine and Health Guidance News    2025, 31 (22): 3770-3774.   DOI: 10.3760/cma.j.cn441417-20241021-22014 Abstract （171）            Knowledge map    Save Objective This study aimed to implement the PDCA (Plan-Do-Check-Act) cycle in pediatric outpatients to shorten the waiting time and improve patient satisfaction.  Methods A project team was established to carry out improvement work. The waiting time and patient satisfaction of 28 612 pediatric outpatients in the Seventh Affiliated Hospital of Sun Yat-sen University from January 2024 to June 2024 were analyzed retrospectively. According to the PDCA management method, we analyzed the possible causes, supervised the implementation of measures, and compared the differences in waiting time and patient satisfaction between before and after implementation.  Results The main factors affecting waiting time in pediatric outpatients included: late arrival of patients who have made appointments, low proportion of appointments in advance, disordered follow-up visits, and unreasonable allocation of registration. After the implementation of PDCA cycle, the waiting time was shortened ( P<0.05), particularly for the patients who made appointments, registered on-site, and visitsed in the afternoon; the patient satisfaction was improved ( P<0.05).  Conclusion The PDCA method is helpful in shortening waiting time and improving patient satisfaction in pediatric outpatients. Reference | Related Articles | Metrics

Select

The application value of dual-dimensional psychological and behavioral interest induction in preschool children with type 1 diabetes Lin Fangbing, Guo You, Gu Jianping, Wei Shupei International Medicine and Health Guidance News    2025, 31 (22): 3843-3848.   DOI: 10.3760/cma.j.cn441417-20250311-22029 Abstract （170）            Knowledge map    Save Objective To explore the effects of dual-dimensional psychological-behavioral interest-inducing nursing on the blood glucose levels and dietary compliance of preschool children with type 1 diabetes. Methods A prospective study was adopted. A total of 104 preschool children with type 1 diabetes who were admitted to Henan Children's Hospital from November 2022 to November 2024 were selected. They were randomly divided into a conventional group and a research group, with 52 cases in each group. The research group had 30 males and 22 females, with an age of (4.79±1.12) years and a disease duration of (8.04±2.39) months; They received dual-dimensional fun-inducing psychological and behavioral nursing. The control group had 28 males and 24 females, with an age of (4.72±1.05) years and a disease duration of (7.89±1.78) months; They received routine care. The blood glucose levels and dietary compliance before and after the intervention were compared between the two groups. The Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) were used to assess the psychological state of the main caregivers. The burden level of the main caregivers was evaluated using the Chinese version of the Caregiver Burden Inventory (CBI). Statistical methods employed t-test and χ2 test. Results After the intervention, the fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and 2-hour postprandial blood glucose (2 hPG) in the study group were all lower than those in the control group [(5.04±0.87) mmol/L vs. (6.41±0.66) mmol/L, (6.29±0.89)% vs. (7.20±0.75)%, and (6.31±1.22) mmol/L vs. (7.43±1.07) mmol/L], and the differences were statistically significant (t=9.047, 5.638, and 4.977; all P<0.05). The dietary compliance scores of the research group were all higher than those of the control group (all P<0.05). The SAS and SDS scores of the research group were both lower than those of the control group [(41.65±5.19) points vs. (45.93±3.65) points and (40.02±4.31) points vs. (44.61±6.10) points], and the differences were statistically significant (t=4.864 and 4.432; both P<0.05). The CBI score of the research group was lower than that of the control group [(40.51±5.13) points vs. (46.78±7.06) points], and the difference was statistically significant (t=5.181, P<0.05). Conclusion The dual-dimensional psychological-behavioral interest-inducing nursing method can not only effectively improve the blood glucose levels of children with type 1 diabetes and enhance their dietary compliance, but also alleviate the negative emotions of the main caregivers and reduce the burden of care. Reference | Related Articles | Metrics

Select

Application of Omaha system-based continuous nursing care in rehabilitation for patients with hypertensive intracerebral hemorrhage Ouyang Ling, Lian Pinghong, Peng Hong, Huang Rong, Liu Changhua, Chen Gang, Zhang Shangming International Medicine and Health Guidance News    2025, 31 (16): 2798-2801.   DOI: 10.3760/cma.j.cn441417-20241106-16032 Abstract （170）            Knowledge map    Save Objective To investigate the efficacy of Omaha system-based continuous nursing care in the rehabilitation for patients with hypertensive intracerebral hemorrhage (HICH). Methods A total of 76 patients with HICH treated at the 73rd Group Army Hospital of PLA from May 2021 to May 2023 were selected for the randomized controlled trial, and were divided into an observation group and a control group by the random number table method, with 38 cases in each group. The control group included 25 males and 13 females; they were 41-80 (66.08±11.89) years old. The observation group included 22 males and 16 females; they were 39-77 (65.69±11.32) years old. The control group received routine post-discharge rehabilitation guidance; in addition, the observation group took Omaha system-based continuous nursing care. The rehabilitation outcomes were compared between the two groups by t test. Results The scores of status, behaviors, and cognition in the observation group were 3.55±0.48, 3.02±0.44, and 2.63±0.54, which were higher than those in the control group, with statistical differences (all P<0.05). The scores of Functional Independence Measure (FIM) and Quality of Life Index (QLI) in the observation group were 95.06±20.55 and 7.99±2.01, which were higher than those in the control group, with statistical differences (both P<0.05). Conclusion Omaha system-based continuous nursing care for patients with HICH can effectively improve their cognitive function, behavioral outcomes, clinical status, self-care ability, and quality of life. Reference | Related Articles | Metrics

Select

Progress in assessment of post-stroke hand dysfunction Guan Menghan, Wu Mingrui, Zhang Jingsha, Liu Xixian International Medicine and Health Guidance News    2025, 31 (18): 2993-2998.   DOI: 10.3760/cma.j.cn441417-20250402-18001 Abstract （169）            Knowledge map    Save Stroke is a common disease caused by cerebrovascular disorders. Its high-risk factors include hypertension, diabetes mellitus, aging, etc. Post-stroke hand dysfunction, one of the common sequelae, manifests as reduced muscle strength, impaired coordination, and loss of fine motor skills, and directly affects patients' daily living activities (e.g., grasping, eating, dressing, and so on), occupational development, and learning abilities, while potentially triggering psychological issues such as depression and anxiety. Consequently, disease assessment is critical in its subsequent treatment. In recent years, artificial intelligence technologies have provided new pathways for dynamic monitoring and evaluation alongside traditional methods. This article reviews and analyzes clinically used assessment approaches and emerging technologies for evaluating post-stroke hand dysfunction. Reference | Related Articles | Metrics

Select

The predictive value of uterine artery blood flow parameters combined with echocardiography for early-onset preeclampsia Dai Aiying, Liu Wei, Tian Rui International Medicine and Health Guidance News    2025, 31 (22): 3779-3783.   DOI: 10.3760/cma.j.cn441417-20250310-22016 Abstract （169）            Knowledge map    Save Objective To explore the predictive value of uterine artery blood flow parameters combined with echocardiography for early-onset preeclampsia (PE). Methods A retrospective study was conducted to collect the data of 90 patients with early-onset PE admitted to Shangluo Central Hospital from June 2022 to August 2024. The patients were included in a case group [age 21-45 (30.21±4.17) years]. In addition, the data of 90 healthy pregnant women who received regular prenatal examination in the hospital during the same period were collected according to the ratio of 1:1 and included in a control group [age 20-45 (29.32±4.45) years]. The uterine artery blood flow parameters [resistance index (RI), pulsatility index (PI), and systolic phase/diastolic phase (S/D)] and echocardiographic parameters [left ventricular ejection fraction (LVEF), fractional shortening (FS), cardiac index (CI), and early diastolic flow velocity/late diastolic flow velocity (E/A)] were collected and compared between the two groups at 14-20 weeks of gestation. The measurement data were of the normal distribution, and the independent sample t test was used to test the differences between the groups. The Mann-Whitney U test was used to test the difference between the groups. The χ2 test was used to test the differences between the groups. The receiver operating characteristic curve (ROC) and the area under the curve (AUC) were used to evaluate the predictive value of uterine artery blood flow parameters combined with echocardiography for early onset PE. Results The RI, PI, and S/D in the case group were all higher than those in the control group (0.84±0.25 vs. 0.68±0.13, 1.08±0.29 vs. 0.86±0.17, and 2.60±0.58 vs. 2.12±0.25), and the LVEF, E/A values were lower [(61.58±5.74)% vs. (66.44±6.02)%, and 0.93±0.22 vs. 1.17±0.36], with statistical differences (all P<0.05). The ROC showed that the combined prediction of AUC for early-onset PE by logistic regression probability models of RI, PI, S/D, LVEF, E/A alone and several at 14-20 weeks of pregnancy was greater than 0.7 (95%CI 0.914-0.975 for joint prediction), which had certain predictive value, and the joint prediction value was higher than those of RI, PI, S/D, LVEF, and E/A alone (P<0.05). Conclusion Uterine artery blood flow parameters (RI, PI, and S/D) and echocardiographic parameters (LVEF and E/A) have certain predictive value for early-onset PE, and the combined predictive value is higher. Reference | Related Articles | Metrics

Select

Summary of best evidences for enteral nutrition management in patients with anastomotic leakage after esophageal neoplasms surgery Yu Jing, Sun Zhongwen, Lin Feiyun, Huang Wenting International Medicine and Health Guidance News    2025, 31 (21): 3676-3681.   DOI: 10.3760/cma.j.cn441417-20250625-21031 Abstract （169）            Knowledge map    Save Objective To identify and synthesize the best available evidences on enteral nutrition management for patients with anastomotic leakage after esophageal cancer surgery, and to provide some references for clinical nursing practice. Methods A systematic search was conducted across multiple databases and evidence sources, including Up To Date, BMJ Best Practice, NICE, GIN, RNAO, SIGN, YIMAITONG, CINAHL, PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang, and VIP, for clinical guidelines, systematic reviews, and other studies related to enteral nutrition management in these patients. The search covered the records from the databases' establishment to June 1st, 2024. Two researchers independently evaluated the quality of the retrieved literature, and extracted relevant evidences. Results Twelve articles were included: 5 guidelines, 2 expert consensus statements, 1 meta-analysis, and 4 quasi-experimental studies. Fifteen key pieces of best evidences were synthesized, and were categorized into 10 domains: nutritional assessment, nutrient intake, formula selection, patient positioning, initiation timing, infusion rate and temperature, prevention of gastrointestinal intolerance, tube care, and dynamic monitoring and evaluation. Conclusion This study synthesizes evidence-based best practices for managing enteral nutrition in patients experiencing anastomotic leakage after esophageal cancer surgery, and these findings may improve patient nutritional status and clinical outcomes. Reference | Related Articles | Metrics

Select

Bezafibrate for one patient with lipoprotein lipase deficiency and its molecular mechanism Wang Zhenjing, Tian Mingzhong, Liu Xin, Li Xin, Xu Chao, Wang Shuping International Medicine and Health Guidance News    2025, 31 (22): 3804-3808.   DOI: 10.3760/cma.j.cn441417-20250515-22021 Abstract （168）            Knowledge map    Save Objective To investigate the effect of bezafibrate in the treatment of lipoprotein lipase deficiency (LPLD) and its potential molecular mechanisms. Methods A case of LPLD caused by compound heterozygous mutations (c.3G>C and c.835_836delCT) in the lipoprotein lipase (LPL) gene was reported. The clinical data, treatment response, and follow-up data were analyzed. Molecular docking simulations of bezafibrate with both the wild-type and mutant LPL were performed using the AutoDock Vina software, and binding conformations were visualized using PyMol. Results After the treatment with bezafibrate, the triglyceride level in the patient decreased by 63.7%. The molecular docking showed that bezafibrate binded to the polypeptide "lid" domain and adjacent regions of the mutant LPL, with a binding energy of -5.305 kcal/mol, potentially inducing conformational changes that partially restore enzyme function. Additionally, as a pan-PPAR agonist, bezafibrate synergistically lowered the lipids activating the PPARα, β, and γ pathways. Conclusions Bezafibrate demonstrates significant efficacy for patients with LPLD. Its mechanism may be related to direct modulation of mutant LPL activity and systemic activation of PPAR pathways. Reference | Related Articles | Metrics

Select

Protective effect of Tianxiangdan  Granules against doxorubicin-induced myocardial toxicity in rats Liu Chong, Xuanyuan Huan, Shen Danting, Ye Shenyi International Medicine and Health Guidance News    2025, 31 (22): 3723-3729.   DOI: 10.3760/cma.j.cn441417-20250109-22006 Abstract （168）            Knowledge map    Save Objective To investigate the protective effect of Tianxiangdan Granules (TXD) against doxorubicin (DOX)-induced myocardial toxicity in rats and to explore its potential mechanisms.  Methods A total of 50 SD rats, 12 weeks old and 200-230 g in body weight, were divided into a control group, a DOX group, and TXD (10, 20, and 40 mg/kg) pre-treatment groups. The DOX-induced myocardial toxicity models and H9C2 cardiomyocyte models were established. The effects of TXD (10, 20, and 40 mg/kg) against DOX-induced myocardial toxicity were evaluated assessing heart function parameters, myocardial tissue pathology (HE staining), transmission electron microscopy, cell viability (TUNEL assay), reactive oxygen species (ROS) levels, and mitochondrial energy metabolism-related protein expression. One-way analysis of variance and SNK- q test were used for the statistical analysis.  Results Compared to the DOX group, TXD could significantly improve the rats' heart function indicators, reduce myocardial tissue pathological changes, protect mitochondrial structure in cardiomyocytes, increase cell viability, and regulate apoptosis-related protein expression. Furthermore, TXD could reduce the ROS level in cardiomyocytes, enhance Na + and K +-ATPase activity and ATP content, and improve mitochondrial energy metabolism-related protein expression.  Conclusion TXD can mediate mitochondrial energy metabolism pathways to alleviate DOX-induced myocardial injury, providing experimental evidences for the clinical prevention and treatment of doxorubicin-induced cardiotoxicity and heart protection. Reference | Related Articles | Metrics

Select

Effect of warfarin, aspirin, and clopidogrel for patients with atrial fibrillation and its influence on coagulation factors  Xu Dan, Zhao Ying, Gao Ting International Medicine and Health Guidance News    2025, 31 (12): 2027-2032.   DOI: 10.3760/cma.j.cn441417-20241216-12020 Abstract （168）            Knowledge map    Save Objective To analyze the effect of warfarin, aspirin, and clopidogrel for patients with atrial fibrillation (AF) and its influence on coagulation factors. Methods One hundred and four patients with AF treated at Xianyang Central Hospital from August 2023 to August 2024 were selected as the study objects. Among which, 59 cases were treated with aspirin and clopidogrel, and were set as a control group; the other 45 cases were treated with warfarin, aspirin, and clopidogrel, and were set as an observation group. There were 34 males and 25 females in the control group; they were (64.39±6.48) years old. There were 29 males and 16 females in the observation group; they were (63.82±4.61) years old. The total effective rates and coagulation function and vascular endothelial function before and after the treatment were compared between the two groups. The risk of vascular embolism and bleeding of the patients was assessed by the Congestive Heart Failure, Hypertension, Age≥75 years, Diabetes Mellitus, Stroke (doubled), Vascular Disease, Age 65-74, Sex Category (CHADS2-VASc) and Hypertension and Other Bleeding Risk Factors (HAS-BLED). The major adverse cardiovascular events (MACE) were counted during the treatment in both groups, and the related factors were analyzed using the logistic regression analysis. χ2 and t tests were used for the statistical analysis. Results The total effective rate in the observation group was higher than that in the control group [93.33% (42/45) vs. 79.66% (47/59); P<0.05]. After the treatment, the prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D) level, and thrombin time (TT) of the observation group were lower than those of the control group (all P<0.05), and the vascular endothelial function was better. The scores of CHADS2-VASc and HAS-BLED were lower after than before the treatment in both groups (all P<0.05), but there were no statistical differences between the two groups (both P>0.05). There was no statistical difference in the incidence rate of MACE between the two groups (P>0.05). The logistic regression analysis showed that age and HAS-BLED score were the independent risk factors for MACE (both P<0.05). Conclusion Warfarin triple therapy can effectively regulate the coagulation function and vascular endothelial function of patients with AF, and has high safety. Reference | Related Articles | Metrics