Most Download articles

Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month | Most Downloaded in Recent Year|

All

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Inhibitory effect and mechanism of sodium citrate on calcification of mouse vascular smooth muscle cells induced by high phosphorus Chen Hui, Yu Hui International Medicine and Health Guidance News    2021, 27 (6): 861-868.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.019 Abstract （485）      PDF （6555KB）（834）       Knowledge map    Save Objective To investigate the effect of sodium citrate (Na 3Cit) on calcification of vascular smooth muscle cells (MOVAS) in mice with chronic kidney disease (CKD) induced by high phosphorus and its mechanism, and to search for drugs that are anticoagulant and can improve vascular calcification (VC) of CKD. Methods MOVAS was cultured in high phosphorus and different concentrations of Na 3Cit for 14 days. Calcium deposition was detected by alizarin red staining and o-cphenolphthalein complex ketone method; phenotype transformation was detected by real-time fluorescent quantitative PCR and alkaline phosphatase (ALP) staining; apoptosis was detected by annexin V staining. Results Na 3Cit significantly inhibited the calcification of CKD MOVAS induced by high phosphorus, and the inhibitory effect of high concentration of Na 3Cit was better. Na 3Cit could inhibit calcium and phosphorus deposition by forming calcium citrate chelate, thus inhibiting calcification. Na 3Cit could also inhibit ALP activity and up-regulate SM22-α expression of smooth muscle cells under high phosphorus conditions, thus preventing smooth muscle cells from differentiating into osteoblast like phenotype; meanwhile, it could reduce apoptosis induced by high phosphorus to inhibit calcification. Conclusion Na 3Cit can effectively reduce the calcification of MOVAS induced by high phosphorus. As a blood anticoagulant, Na 3Cit may play an anti VC role in clinic. Reference | Related Articles | Metrics

Select

Surgical diagnosis and treatment of giant anterior superior mediastinal tumors Shen Tao, Lu Zhuming, Liang Xiangyuan, Duan Chuxiao, Zhang Dongxi International Medicine and Health Guidance News    2021, 27 (6): 807-809.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.005 Abstract （697）      PDF （987KB）（739）       Knowledge map    Save Objective To explore the surgical diagnosis and treatment methods and experience of giant anterior superior mediastinal tumors. Methods Through the retrospective analysis of 34 cases of giant anterior superior mediastinal tumors admitted to our hospital from 2013 to 2018, among them 13 cases underwent lateral anterolateral incision + sternal cross-split incision, and 21 cases underwent median thoracotomy. The surgical diagnosis and treatment methods of giant anterior superior mediastinal tumors were discussed. Results Thirty-four cases of giant anterior superior mediastinal tumors were surgically removed: 13 cases underwent lateral anterolateral incision + sternal cross-split incision, there were 12 (92.3%) cases of radical resection and 1 case of palliative resection; 21 cases underwent median thoracotomy, there were 18 (85.7%) cases of radical resection and 3 cases of palliative resection. In 34 cases, there were 3 cases of thymic squamous cell carcinoma, 1 case of highly aggressive B-cell lymphoma-diffuse large B-cell lymphoma, 14 cases of thymoma, 3 cases of sarcoma, 7 cases of mature teratoma, 3 cases of solitary fibrous tumor, 2 cases of seminoma, and 1 case of goiter. The operation time and blood loss of lateral anterolateral incision + sternal cross-split incision group were greater than those of the median thoracotomy group (both P<0.05), there was no statistically significant difference in the maximum tumor diameter between the two groups ( P>0.05). However, for giant anterior superior mediastinal tumors those were close to the posterior wall of the sternum with invaded lung tissue, lateral anterolateral incision on the main body of the tumor + sternal cross-split incision could be used as a surgical incision and the surgical field was safer. Conclusion Surgery is the preferred treatment method for giant anterior superior mediastinal tumors. Preoperative enhanced CT has an important reference value for the surgical method and risk assessment, and the choice of surgical incision has an important auxiliary effect on the success of surgery. Reference | Related Articles | Metrics

Select

The diagnostic value of breast ultrasound, mammography, and MRI for breast ductal carcinoma in situ Li Wei, Zhou Dan, Ye Guolin International Medicine and Health Guidance News    2021, 27 (6): 792-794.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.001 Abstract （672）      PDF （975KB）（659）       Knowledge map    Save Objective To evaluate the diagnostic value of breast ultrasound, mammography, and MRI for breast ductal carcinoma in situ. Methods Forty cases of breast ductal carcinoma in situ treated in our hospital from June 2015 to June 2018 were retrospectively collected. All 40 patients were examined by ultrasonography, mammography and MRI if necessary. The detection rates of three kinds of image diagnosis methods were observed. Results A total of 36 cases of breast ductal carcinoma in situ were detected by ultrasonography, with the detection rate of 90.00% (36/40); 13 cases of breast ductal carcinoma in situ were detected by mammography, with the detection rate of 61.90% (13/21); 14 cases of breast ductal carcinoma in situ were detected by MRI, with the detection rate of 93.33% (14/15); the difference was statistically significant ( P=0.011). When combined the three, the positive rate of diagnosis of breast ductal carcinoma in situ reached to 100.00% (40/40). Conclusion The sensitivity of ultrasonography and mammography in the diagnosis of breast ductal carcinoma in situ is general. The combined application of ultrasound, mammography, and MRI has a high detection rate of breast ductal carcinoma in situ. Reference | Related Articles | Metrics

Select

Application of IL-6 and SAA in the early diagnosis of neonatal sepsis Yang Xiaojuan, Li Xiaodong International Medicine and Health Guidance News    2021, 27 (6): 848-851.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.016 Abstract （387）      PDF （1059KB）（513）       Knowledge map    Save Neonatal sepsis has an acute onset and rapid progression, and is the main cause of neonatal death. Due to the lack of specific manifestations, the cultivation of pathogenic bacteria takes long time, it is often easily missed and misdiagnosed, delaying the early diagnosis and treatment of children. Inflammatory markers such as peripheral white blood cell count, C-reactive protein, and procalcitonin have been widely used in clinical practice. This article mainly reviews the research of interleukin-6 and serum amyloid A in the early diagnosis of neonatal sepsis. Reference | Related Articles | Metrics

Select

The effect of ultrasound-guided erector spinae plane block on postoperative analgesia in patients with laparoscopic cholecystectomy Zhang Xiaodan, Wang Hongyu, Zhang Yong, Han Liu International Medicine and Health Guidance News    2021, 27 (6): 813-817.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.007 Abstract （1229）      PDF （1357KB）（501）       Knowledge map    Save Objective To investigate the effectiveness and safety of ultrasound-guided erector spinae plane block (ESPB) combined with oxycodone patient controlled intravenous analgesia (PCIA) for postoperative analgesia in patients undergoing laparoscopic cholecystectomy (LC). Methods A total of 58 patients underwent laparoscopic cholecystectomy under general anesthesia, including 22 males and 36 females, with ASA I or II, they were randomly divided into two groups: single ESPB combined with PCIA group (group EP) and simple PCIA group (Group P). Patients in the group EP received ultrasound-guided ESPB before induction of anesthesia. Both groups were evaluated according to the numerical rating scale (NRS). When the NRS score was ≥4 points, oxycodone titration was administered intravenously until the NRS score was <4 points and then PCIA was used. Postoperative oxycodone titration; NRS scores before titration, at the end of titration, 1 h, 4 h, 8 h, 12 h, 16 h, 24 h later at rest and cough; the dose of oxycodone within 0~4 h, 4~8 h, 8~12 h, 12~16 h, and 16~24 h after surgery; the number of effective press of analgesic pump within 0~4 h, 4~8 h, 8~12 h, 12~16 h, and 16~24 h after surgery; the number of postoperative remedial analgesia and postoperative adverse reactions in the two groups were recorded. Results The postoperative titrated oxycodone dosage and the PCIA oxycodone dosage with 0~4 h and 4~8 h after surgery of the group EP were significantly less than those of the group P [0.0 (1.0, 2.0) mg vs.2.0 (0.0, 4.0) mg, 0.4 (0.4, 1.4) mg vs.0.4 (0.4, 1.4) mg, 0.4 (0.4, 0.4) mg vs.0.4 (1.4, 2.4) mg] (all P<0.05). The NRS scores at 1 hour after surgery at rest and cough in the group EP were significantly lower than those in the group P [(1.38±0.86) points vs.(1.92±0.83) points, (1.93±0.80) points vs.(2.50±0.59) points] (both P<0.05); the NRS scores at 4 hours after surgery at rest and cough in the group EP were significantly lower than those in the group P [(1.21±0.68) points vs.(1.71±0.69) points, (1.90±0.62) points vs.(2.29±0.69) points] (both P<0.05); the NRS scores at 8 hours after surgery at rest and cough in the group EP were significantly lower than those in the group P [(1.41±0.73) points vs.(2.00±0.59) points, (1.66±0.67) points vs.(2.21±0.83) points] (both P<0.01). The number of effective press of analgesic pump within 0~4 h and 4~8 h after surgery in the group EP were significantly lower than those in the group P [0.4 (0.4, 1.4) times vs.1.4 (0.4, 3.1) times, 0.4 (0.4, 0.4) times vs.1.4 (0.4, 2.4) times] (both P<0.05). Conclusion Ultrasound-guided ESPB can significantly reduce the PCIA dosage of oxycodone after LC, which is a safe and effective way of analgesia. Reference | Related Articles | Metrics

Select

Randomized controlled study of amantadine combined with dalingfu in the treatment of patients with Parkinson's disease Shao Keke, Ru Wenwen International Medicine and Health Guidance News    2021, 27 (6): 881-884.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.024 Abstract （888）      PDF （1057KB）（484）       Knowledge map    Save Objective To analyze the effect of amantadine combined with dalingfu on mental state and cognitive function of patients with Parkinson's disease. Methods A total of 122 patients with Parkinson's disease who were treated in our hospital from January 2017 to July 2019 were selected and were divided into the observation group (oral amantadine and dalingfu) and the control group (oral amantadine and levodopaand benserazide hydrochloride) by the random number table method. The clinical efficacy, mental status, cognitive function, symptom score, serum index, and adverse reactions of the two groups were observed. Results The effective rate of the observation group was 93.44% (57/61), which was higher than 78.69% (48/61) of the control group ( P<0.05). After treatment, the MMSE score and MoCA score of the observation group were higher than those before treatment and those of the control group, and the UPDRS score was lower than that before treatment and that of the control group (all P<0.05). After treatment, serum levels of GSH-Px, SOD, DA, 5-HT, NE, and BDNF in the observation group were higher than those before treatment and those in the control group, and serum levels of MDA, IL-6, and IL-1β were lower than those before treatment and those in the control group (all P<0.05). During the treatment period, the total incidence of complications in the observation group was 11.48% (7/61), and 8.20% (5/61) in the control group, without statistically significant difference ( P>0.05). Conclusion Amantadine combined with Dalingfu can effectively improve the cognitive function and mental state of patients with Parkinson's disease, and its effect may be related to the restoration of serum neurotransmitter levels. Reference | Related Articles | Metrics

Select

Parental stress and its influencing factors in parents of children with acute lymphoblastic leukemia Gao Lijing, Guo Haoqi, Xu Xianling International Medicine and Health Guidance News    2021, 27 (6): 856-860.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.018 Abstract （380）      PDF （1030KB）（483）       Knowledge map    Save Objective To probe into parental stress and its influencing factors in parents of children with acute lymphoblastic leukemia. Method A questionnaire survey was conducted among the parents of 180 children with acute lymphoblastic leukemia in 3 general hospitals of Henan province from February 2019 to August 2019 with general information questionnaire, Parenting Stress Scale, Perceived Social Support Scale, Simplified Coping Style Questionnaire, and Rosenberg Self-esteem Scale. Results The score of parenting stress was (103.12±16.48). Multivariate linear regression analysis results showed that treatment duration, immunophenotyping, monthly income, the number of children, participation in fundraising, and gender of children were the influencing factors of parenting stress, which could explain 63.4% of the total variation. The parenting stress in parents of children with acute lymphoblastic leukemia was negatively correlated with positive coping style, the total score and scores of all dimensions of social support, self-esteem of children, and was positively correlated with negative coping style (all P<0.05). Conclusion Parenting stress was higher in parents of children with acute lymphoblastic leukemia. Nursing staff should pay attention to the psychological intervention of the parents of children with acute lymphoblastic leukemia, guide them to adopt positive coping style, in order to reduce their parenting stress. Reference | Related Articles | Metrics

Select

PI3K/AKT signaling pathway and leukemia Wu Jianmin, Jia Xiuhong, Zhang Jian International Medicine and Health Guidance News    2021, 27 (6): 795-798.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.002 Abstract （480）      PDF （1021KB）（482）       Knowledge map    Save Leukemia is a malignant proliferative disease of hematopoietic stem cells derived from bone marrow. The PI3K/AKT signaling pathway is an intracellular signaling pathway, which is closely related to the survival of tumor cells. This paper reviews the correlation between PI3K/AKT signaling pathway and leukemia. Reference | Related Articles | Metrics

Select

A review on cognition and related factors of medical staff to ERAS Liu Ziwei, Guo Xiaoxia, Lin Siting, Zhang Zheng, Wang Shanshan International Medicine and Health Guidance News    2021, 27 (6): 945-948.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.041 Abstract （434）      PDF （1021KB）（482）       Knowledge map    Save With the development of China's medical and health services, "Enhanced Recovery after Surgery" (ERAS) has been put forward, aiming to optimize and improve the perioperative process. Studies have indicated that the application of ERAS can effectively reduce the traumatic stress response of patients and shorten the average length of hospital stays. The only way to build the concept of patient-friendly ERAS is to prepare medical staff, the main body of ERAS, with sufficient theoretical knowledge. Therefore, they can finally devote themselves to the clinical practice of ERAS. For this reason, the article is dedicated to make ERAS more universal, promote the application of ERAS in domestic general hospitals, and improve people's health status by describing the cognition current situation of domestic and foreign medical staff to ERAS as well as analyzing its related factors. Reference | Related Articles | Metrics

Select

The value analysis of periodontal pulp combined with semiconductor laser therapy for severe periodontitis Deng Wenjuan, Li Huajing International Medicine and Health Guidance News    2021, 27 (6): 890-893.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.027 Abstract （416）      PDF （1054KB）（476）       Knowledge map    Save Objective To evaluate the value of periodontal pulp combined with semiconductor laser in the treatment of severe periodontitis. Methods A total of 86 patients with severe periodontitis (86 teeth) from June 2017 to June 2019 were selected by simple random sampling. They were divided into two groups by drawing lots, 43 cases in each group. The control group received periodontal pulp treatment, and the study group received periodontal pulp combined with semiconductor laser therapy. The therapeutic effects of the two groups were compared. Results After treatment, the levels of interleukin-4 (IL-4) and tumor necrosis factor-α (TNF-α) in the study group were (15.82±5.05) ng/L and (0.95±0.12) ng/L, lower than those in the control group [(19.03±5.11) ng/L, (1.06±0.19) ng/L] (both P<0.05); probing depth (PD), loss of attachment (CAL), sulcus bleeding index (SBI) in the study group [(5.18±0.55) mm, (5.46±0.49) mm, (2.62±0.75) mm] were lower than those in the control group [(5.51±0.51) mm, (5.81±0.55) mm, (3.03±0.82) mm] (all P<0.05); the bleeding rate of the study group was 4.65% (2/43), lower than that of the control group [20.93% (9/43)] ( P<0.05); the tooth looseness score of the study group [(0.58±0.13)] was lower than that of the control group [(0.72±0.24)] ( P<0.05); the total effective rate of the study group was 93.02% (40/43), higher than that of the control group [76.74% (33/43)] ( P<0.05). Conclusion In severe periodontitis, the combination of periodontal pulp and semiconductor laser therapy can reduce the inflammatory reaction, improve the periodontal index, and enhance the curative effect. Reference | Related Articles | Metrics

Select

Analysis of influencing factors of catheter displacement in peritoneal dialysis patients Xu Qing International Medicine and Health Guidance News    2021, 27 (6): 912-914.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.033 Abstract （409）      PDF （1054KB）（476）       Knowledge map    Save Objective To analyze the influencing factors of catheter displacement in peritoneal dialysis patients, and to provide guidance for the prevention of catheter displacement. Methods The clinical data of 173 cases of peritoneal dialysis patients treated in our hospital from January 2018 to February 2020 were retrospectively analyzed. The incidence of catheter displacement within 4 weeks after peritoneal dialysis catheterization was statistically analyzed. The general data of patients, including age, gender, primary diseases, incision location, constipation, body mass index, and catheter type were recorded. The influencing factors of catheter displacement were analyzed by univariate and multivariate analysis. Results Within 4 weeks after peritoneal dialysis catheterization, 14 out of 173 patients had catheter displacement, with the incidence of 8.09%. There was no statistically significant difference in age, gender, primary diseases, or body mass index between patients with and without catheter displacement (all P>0.05), but there were statistically significant differences in incision location, incidence of constipation, and catheter type (all P<0.05). Multivariate logistic regression model was established after logistic regression analysis. It was found that the right umbilical incision, constipation, and tube insertion were the influencing factors of catheter displacement in peritoneal dialysis patients (all OR>1, P<0.05). Conclusion Right umbilical incision, constipation, and curved tube placement will increase the risk of catheter displacement in peritoneal dialysis patients. Reasonable intervention should be implemented to reduce the incidence of catheter displacement. Reference | Related Articles | Metrics

Select

Effects of Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture method on TCM syndrome score of patients with posterior circulation ischemic vertigo (turbid phlegm disturbing orifices type) Feng Zhen International Medicine and Health Guidance News    2021, 27 (6): 878-880.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.023 Abstract （709）      PDF （1062KB）（470）       Knowledge map    Save Objective To investigate the effects of Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture method on TCM syndrome score of patients with posterior circulation ischemic vertigo (turbid phlegm disturbing orifices type). Methods From June 2017 to August 2019, 122 patients with posterior circulatory ischemic vertigo (turbid phlegm disturbing orifices type) were selected in our hospital. They were divided into observation group ( n=61) and control group ( n=61) according to simple randomization method. The control group was given betahistine hydrochloride sodium chloride injection, and the observation group was given Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture on the basis of the control group. The efficacy, TCM syndrome score, peak blood flow velocity (Vs) of the vertebrobasilar artery during systole, vasoactive substance [thromboxane B2 (TXB2), 6-keto-PGF1α] before and 2 weeks after treatment were compared between the two groups. Results The total effective rate of the observation group was 91.80% (56/61), higher than that of the control group [77.05% (47/61)], with statistically significant difference ( P<0.05). After 2 weeks of treatment, the TCM syndrome score of the observation group was lower than that of the control group, the Vs of the vertebrobasilar artery in the observation group was higher than that in the control group, with statistically significant differences (both P<0.05). After 2 weeks of treatment, the level of plasma 6-keto-PGF1α of the observation group was higher than that of the control group, the level of plasma TXB2 was lower than that of the control group, with statistically significant differences (both P<0.05). Conclusion Banxia Baizhu Tianma decoction combined with Tongdu Tiaoshen acupuncture has a significant effect on posterior circulation ischemic vertigo (turbid phlegm disturbing orifices type), which can effectively improve the symptoms of patients and increase the blood flow velocity of the vertebrobasilar artery. Reference | Related Articles | Metrics

Select

Effect of vacuum sealing drainage combined with targeted nursing on angiogenesis in diabetic foot ulcer area Lou Xiue, Yang Huanzhi, Li Jing International Medicine and Health Guidance News    2021, 27 (6): 920-924.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.035 Abstract （304）      PDF （1082KB）（462）       Knowledge map    Save Objective To investigate the effect of vacuum sealing drainage combined with targeted nursing on angiogenesis in diabetic foot ulcer area. Methods A total of 116 patients with diabetic foot ulcer (DFU) admitted from July 2017 to October 2019 were selected as the research objects and were randomly divided into observation group and control group with 58 cases in each group. The control group was given conventional debridement, and the observation group was given vacuum sealing drainage (VSD) combined with targeted nursing on the basis of the control group. The differences of wound healing time, wound healing rate, wound angiogenesis index, SAS and SDS scores between the two groups were compared. Results The wound healing time of the observation group was significantly shorter than that of the control group [(16.12±2.66) d vs.(20.54±2.72) d], and the wound healing rate was significantly higher than that of the control group [(65.26±10.45)% vs.(38.98±11.26)%] (both P<0.05). There were no statistically significant differences in wound angiogenesis indexes between the two groups before treatment (all P>0.05); after 3, 5, 7 days of treatment, the expressions of VEGF, VEGFR, CD105, MMP9 protein in wound tissue of the observation group were significantly higher than those of the control group and those after treatment (all P<0.05). There were no statistically significant differences in SAS and SDS scores between the two groups (both P>0.05); after treatment, SAS and SDS scores in the observation group were (44.68±5.50) points, (42.56±5.52) points, which were significantly lower than those in the control group [(50.21±5.45) points, (52.16±5.47) points] (both P<0.05). Conclusion VSD can regulate the expression of VEGF, CD105, and other angiogenesis molecular factors in diabetic foot ulcer wound, promote angiogenesis of ulcer wound; combined with targeted nursing, it can relieve anxiety and depression of patients, shorten the healing time of DFU wound, and improve the wound repair rate. Reference | Related Articles | Metrics

Select

Correlation between interleukin-6 and frailty: a meta-analysis Qu Jiling, Shen Yijing, Hou Ping, Zhou Ting, Li Yongnan, Mao Xin'e, Liu Yongbing International Medicine and Health Guidance News    2021, 27 (6): 802-806.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.004 Abstract （315）      PDF （1145KB）（452）       Knowledge map    Save Objective To evaluate the correlation between interleukin-6 (IL-6) concentration and frailty through meta-analysis. Methods Case-control studies on the relationship between IL-6 and frailty were collected by searching home and aboard databases including PubMed, EMBASE, Cochrane library, CNKI, CBMdisc, Wanfang, VIP. The retrieval time was from the establishment of each database to the analysis of data by Stata15.0 in February 2020. Results Seven qualified case-control studies with 1 644 participants were involved, including 330 frailty patients and 1 314 controls, the IL-6 level in patients with frail was higher ( SMD=1.56, 95% CI: 0.81~2.31, P<0.001). The sensitivity analysis results were stable and the Egger's test indicated no significant publication bias ( t=1.61, P=0.169). Conclusion High level of interleukin-6 may be a risk factor for frailty, but further study on specific etiological associations need to be done in a larger population in the future. Reference | Related Articles | Metrics

Select

Analysis on the impact of traditional Chinese medical massage on PEF and C-ACT score in children with bronchial asthma Yang Xiaojuan, Xu Lei, Wang Lihua International Medicine and Health Guidance News    2021, 27 (6): 844-847.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.015 Abstract （319）      PDF （1068KB）（449）       Knowledge map    Save Objective To analyze the impact of traditional Chinese medical massage on PEF and C-ACT score in children with bronchial asthma. Methods Eighty-eight children with bronchial asthma who were admitted to our hospital from July 2018 to July 2020 were selected and were grouped with the method of single-blind random sampling (44 cases in each group). The patients in the control group received conventional western medicine treatment, and the patients in the experimental group received traditional Chinese medical massage therapy on the basis of the control group. The clinical efficacy, disappearance time of clinical symptoms, PEF, C-ACT score, and serum inflammatory factors of the two groups were compared. Results The total effective rate in the experimental group [95.45% (42/44)] was higher than that in the control group [70.45% (31/44)] ( P<0.05), the disappearance time of wheezing rale, gurgling with sputum, cough, and gasp in the experimental group were shorter than those in the control group, the PEF and C-ACT score of the experimental group after treatment for 14 d were higher than those of the control group, the levels of serum IL-6, CRP, and TNF-a of the experimental group after treatment for 14 d were lower than those of the control group, with statistically significant differences (all P<0.001). Conclusion Traditional Chinese medical massage could effectively improve the pulmonary symptoms of children with bronchial asthma and inhibit the release of inflammatory mediators, which presented obvious curative effect and was worth learning. Reference | Related Articles | Metrics

Select

Observation of curative effect of argon knife combined with iodophor pleurodesis by medical thoracoscopy in the treatment of malignant pleural effusion Wu Jingbo, Guo Lijuan, Song Pengcheng, Yu Junfang, Sui Xiaojun, Shi Xinjie International Medicine and Health Guidance News    2021, 27 (6): 869-870.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.020 Abstract （471）      PDF （981KB）（443）       Knowledge map    Save Objective To observe the efficacy and safety of argon knife combined with iodophor pleurodesis by medical thoracoscopy in the treatment of malignant pleural effusion. Methods A total of 54 patients with malignant pleural effusion who were hospitalized in Department of Respiratory and Critical Care Medicine of our hospital from October 2017 to May 2020 were retrospectively analyzed. Among them, 18 patients underwent argon knife combined with iodophor pleurodesis by medical thoracoscopy (observation group), and 36 patients underwent cis-platinum pleurodesis after thoracic closed drainage (control group). The efficiency and safety of the two groups were compared. Results The total effective rates of the observation group and the control group were 94.44% (17/18) and 52.78% (19/36), with statistically significant difference ( P<0.01). The adverse reactions rates of the observation group and the control group were 50.00% (9/18) and 41.67% (15/36), without statistically significant difference ( P>0.05). Conclusion Argon knife combined with iodophor pleurodesis by medical thoracoscopy has the advantages of high curative effect, high safety, and less adverse reactions in the treatment of malignant pleural effusion, which is worthy of clinical promotion. Reference | Related Articles | Metrics

Select

Analysis of influencing factors and improvement measures of "missing the optimal time window for thrombolysis" in patients with acute ischemic stroke Jiang Baoe, Jiang Wenting International Medicine and Health Guidance News    2021, 27 (6): 897-900.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.029 Abstract （459）      PDF （1011KB）（440）       Knowledge map    Save Objective To investigate the influencing factors and improvement measures of "missing the optimal time window for thrombolysis" in patients with acute ischemic stroke (AIS). Methods A total of 180 patients with AIS admitted in our hospital from March 2019 to March 2020 were selected, among them 36 patients (20.00%) received treatment within 3.5 h after onset (timely treatment group), and 144 patients (80.00%) received treatment over 3.5 h after onset (delayed treatment group). The clinical data of patients were collected by questionnaire survey. The main influencing factors of "missing the optimal time window for thrombolysis" were analyzed, and the improvement measures were determined accordingly. Results Multivariate logistic regression analysis showed that the influencing factors of "missing the optimal time window for thrombolysis" for AIS patients were living together with their families, the first hospital, initial symptoms as not fluent speech, blurred vision, and disturbance of consciousness, the mode of transportation, the cognitive score of stroke related knowledge of patients and their families (all P<0.05). Conclusions The average visit time of AIS patients is longer, the visit rate within 3.5 h is lower, and there is still a serious phenomenon of "missing the optimal time window for thrombolysis". In clinical practice, we should strengthen nursing strategies, improve the ability of patients and their families to recognize the initial symptoms of AIS, to finally shorten the treatment time, so that patients with AIS can be treated with thrombolysis as soon as possible. Reference | Related Articles | Metrics

Select

Effect of swallowing rehabilitation training on swallowing function and quality of life of stroke patients with swallowing dysfunction Huang Dinglan, Cui Xinhao, Xu Chunhua International Medicine and Health Guidance News    2021, 27 (6): 932-934.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.038 Abstract （318）      PDF （1001KB）（436）       Knowledge map    Save Objective To analyze the effect of swallowing rehabilitation training on swallowing function and quality of life of stroke patients with swallowing dysfunction. Methods A total of 50 patients from June 2017 to December 2020 were included in this study. The research objects were randomly divided into control group and experimental group by computer, 25 cases in each group. The control group received conventional nursing method, and the experimental group received swallowing rehabilitation training method on the basis. Their results were compared. Results After nursing, the swallowing dysfunction score of the experimental group (20.36±1.01) was significantly lower than that of the control group (31.28±1.21) ( P<0.05); the scores of quality of life (physiological function, psychological function, social relationship, and material life) of the experimental group were higher than those of the control group (all P<0.05); the total nursing satisfaction of the experimental group was higher than that of the control group [92% (23/25) vs.60% (15/25)] ( P<0.05). Conclusion The use of swallowing rehabilitation training measures can produce a positive effect on stroke patients with swallowing dysfunction, which is worthy of promotion. Reference | Related Articles | Metrics

Select

Research progress of remote ischemic postconditioning in ischemic vascular disease Zhang Yuanjie, Qu Fuzhen International Medicine and Health Guidance News    2021, 27 (6): 941-944.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.040 Abstract （657）      PDF （998KB）（436）       Knowledge map    Save Remote ischemic postconditioning (RIPostC) refers to the ability to activate the endogenous protective mechanism of the body to reduce the ischemia-reperfusion injury of important organs by giving rapid and intermittent stimulation of limb blood flow interruption after reperfusion. Early reperfusion treatment is the main method for the treatment of ischemic vascular disease, but a large number of studies and clinical evidences show that the recovery of blood perfusion and oxygen supply of some ischemic tissues and organs aggravates the tissue damage, i.e. ischemia-reperfusion injury, including myocardial ischemia/reperfusion (I/R) injury, such as arrhythmia, myocardial systolic and diastolic dysfunction, metabolic abnormality, myocardial ultrastructural changes, and increased cerebral infarction area. Studies at home and abroad have found that remote ischemic postconditioning can reduce the reperfusion injury of heart, brain, kidney, and other important organs. In order to deal with the challenge of reducing reperfusion injury, remote ischemic postconditioning has become a hot topic in clinical research. Reference | Related Articles | Metrics

Select

Clinical curative effect observation of ebastine, compound glycyrrhizin combined with pemirolast potassium in the treatment of chronic urticaria Gan Lu, Zhang Zhongkui, Liu Taihua, Zhou Zhou, Yang Ju, Fan Lili, Zhang Min, Pan Linxin International Medicine and Health Guidance News    2021, 27 (6): 887-889.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.026 Abstract （575）      PDF （1048KB）（430）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Nursing measures for patients with renal tubular acidosis caused by Sjogren syndrome treated with hormone Liu Xin International Medicine and Health Guidance News    2021, 27 (6): 908-911.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.032 Abstract （313）      PDF （1004KB）（429）       Knowledge map    Save Objective To observe the effect of hormone in the treatment of renal tubular acidosis caused by Sjogren syndrome, and to summarize nursing measures. Methods Fifty-nine patients with renal tubular acidosis caused by Sjogren syndrome who were admitted in our hospital from July 2017 to July 2019 were selected as the subjects of this study. All patients were treated with low-dose of cyclophosphamide combined with methotrexate, while targeted nursing measureswere carried out. The treatment compliance and adverse reactions (hypokalemia, malnutrition, hypocalcemia) of patients before and after treatment were compared. Results The rate of complications after treatment was 11.9% (7/59), which was lower than that before treatment [40.7% (24/59)] ( P<0.05). The treatment compliance after treatment was 98.3% (58/59), which was higher than that before treatment [88.1% (52/59)] ( P<0.05). The incidence of adverse reactions was 3.4% (2/59). Conclusion The clinical manifestations of renal tubular acidosis caused by Sjogren syndrome are complicated. The use of low-dose of cyclophosphamide combined with methotrexate treatment, supplemented by targeted nursing measures, can improve the patients' body function and reduce the occurrence of adverse reactions. Reference | Related Articles | Metrics

Select

Application value of B-type natriuretic peptide, D-dimer, and homocysteine in clinical diagnosis and risk classification of acute pulmonary embolism Liu Xiaoyi, Yang Wei, Chen Yongquan International Medicine and Health Guidance News    2021, 27 (6): 875-877.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.022 Abstract （759）      PDF （1072KB）（428）       Knowledge map    Save Objective To explore the application value of B-type natriuretic peptide (BNP), D-dimer (DD), and homocysteine (Hcy) in the clinical diagnosis and risk classification of acute pulmonary embolism (APE). Methods A total of 89 APE patients admitted to the intensive care unit (ICU) of our hospital and 30 healthy physical examination people from July 2018 to June 2020 were selected as the research objects. According to the severity of APE, the patients were divided into high-risk group (36 cases), medium-risk group (31 cases), low-risk group (22 cases). The levels of BNP, DD, and Hcy in the three groups were detected and analyzed. Results Through one-way analysis of variance, the levels of BNP, DD, and Hcy in different risk grade APE patient groups and healthy control group were not exactly the same (all P<0.001), the BNP and Hcy levels of the high-risk group, medium-risk group, and low-risk group were higher than those of the healthy control group (all P<0.05), and the DD levels of the high-risk group and the medium-risk group were higher than those of the low-risk group and the healthy control group (all P<0.05). ROC curve analysis showed that the areas under the curves (AUC) of BNP, DD, and Hcy were 0.762, 0.583, and 0.644, respectively. When BNP, DD, and Hcy took 153.62 μg/L, 1.13 μg/L, and 15.24 μmol/L, they achieved the maximum diagnostic efficiency, with the sensitivity and specificity of 88.7% and 82.4% for BNP, 72.5% and 79.3% for DD, and 63.6% and 90.8% for Hcy. Spearman correlation analysis showed that the levels of BNP, DD, and Hcy were positively correlated with the risk classification of APE patients ( r=0.736, 0.715, 0.628), with statistically significant differences (all P<0.05). Conclusion The levels of BNP, DD, and Hcy have important guiding significance in the clinical diagnosis and risk classification of APE. It is clinically recommended to perform these three tests at the same time for patients with suspected APE to obtain the best diagnostic accuracy. Reference | Related Articles | Metrics

Select

Effect of predictive nursing for patients with hypertensive intracerebral hemorrhage Ni Chengcheng International Medicine and Health Guidance News    2021, 27 (6): 929-931.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.037 Abstract （407）      PDF （1016KB）（423）       Knowledge map    Save Objective To explore the effect of predictive nursing for patients with hypertensive intracerebral hemorrhage. Methods From February 2019 to May 2020, 94 patients with hypertensive intracerebral hemorrhage were selected as the research objects. The patients were randomly divided into two groups, the control group and the observation group, with 47 cases in each group. The control group was given routine nursing care, while the observation group was given predictive nursing, psychological nursing, diet nursing, prevention and nursing of complications, to reduce the incidence of pulmonary infection, constipation, hyperpyrexia, pressure sores, and other complications as far as possible. The treatment effect, quality of life improvement, and complications of the two groups were compared. Results After the implementation of nursing intervention, the NIHSS score and Barthel score of the two groups were significantly different from those before nursing (all P<0.05); the NIHSS score of the observation group was lower than that of the control group [(15.78±4.14) vs.(27.23±4.11)] ( P<0.05), the Barthel score of the observation group was higher than that of the control group [(75.18±5.11) vs.(65.23±5.09)] ( P<0.05); the scores of physical function, mental function, social function, material life of GQOLI-74 in the observation group were (87.23±7.57), (87.15±10.24), (88.23±9.13), (88.03±7.18), respectively, which were higher than those in the control group [(78.01±6.23), (75.22±8.23), (78.15±9.05), (79.22±7.22)] (all P<0.05). The rates of complications of the observation group and the control group were 6.38% (3/47) and 23.40% (11/47), respectively, with statistically significant difference between the two groups ( P<0.05). Conclusion After the implementation of predictive nursing, the neurological function of patients with hypertensive intracerebral hemorrhage is significantly improved, the ability of daily life and quality of life are significantly improved, and the occurrence of complications is reduced, which helps patients obtain a good prognosis. Reference | Related Articles | Metrics

Select

The effect of hydrocortisone succinate combined with ademetionine on liver function and pregnancy outcomes of patients with intrahepatic cholestasis of pregnancy Feng Yunqian, Huo Yan, Wang Shuang International Medicine and Health Guidance News    2021, 27 (6): 799-801.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.003 Abstract （754）      PDF （1030KB）（419）       Knowledge map    Save Reference | Related Articles | Metrics

Select

The relationship between self-management level and quality of life in maintenance hemodialysis patients Yu Rong, Zhang Yuyu, Wu Chunying, Chen Xia International Medicine and Health Guidance News    2021, 27 (6): 825-827.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.010 Abstract （355）      PDF （1016KB）（415）       Knowledge map    Save Objective To explore the relationship between self-management level and quality of life in maintenance hemodialysis patients. Methods A total of 95 patients with maintenance hemodialysis who were admitted to our hospital from January 2019 to December 2019 were selected. Hemodialysis patient self-management scale and health survey summary table were used to evaluate the self-management level and quality of life of the patients, and their correlation was analyzed. Results Ninety-five patients had a low self-management level with a total score of (52.18±7.36). The scores of each dimension from low to high were emotional processing, partnership, problem solving, and self-care. The scores of physiological function, physical pain, physiological function, energy, social function, emotional function, mental health, overall health, and the total score of 95 patients were lower than the domestic norm, with statistically significant differences (all P<0.001). According to the results of Spearman analysis, the self-management behavior of patients was significantly positively correlated with quality of life ( P<0.05). Conclusion Maintenance hemodialysis patients have a low self-management level and poor quality of life. Self-management level and quality of life are positively correlated. Reference | Related Articles | Metrics

Select

Clinical observation of Shakuba Valsartan in the treatment of chronic heart failure Zhou Xuan International Medicine and Health Guidance News    2021, 27 (6): 894-896.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.028 Abstract （400）      PDF （993KB）（415）       Knowledge map    Save Objective To investigate the clinical efficacy of Shakuba Valsartan in the treatment of chronic heart failure. Methods A total of 60 patients who met the inclusion criteria from July 2018 to December 2019 were randomly divided into observation group and control group with 30 patients in each group. The observation group was treated with Shakuba Valsartan on the basis of conventional treatment, and the control group only received conventional treatment for 6 months. After the end of treatment, the differences in cardiac function, brain natriuretic peptide, blood pressure, renal function, efficacy, and other aspects between the two groups were observed. Results After the end of the course of treatment, the clinical efficacy of the patients in the observation group was significantly better than that in the control group [93.33% (28/30) vs. 73.33% (22/30)] ( P<0.05), the descend range of NT-proBNP and systolic blood pressure were better than those in the control group (both P<0.05), the protection of renal function was also better than that in the control group ( P<0.05). Conclusion Shakuba Valsartan has remarkable treatment effect in patients with chronic heart failure, with more secure treatment process and less adverse reactions, which is an ideal therapeutic schedule for chronic heart failure patients. Reference | Related Articles | Metrics

Select

Effect of H2H management model on self-efficacy and mood state of leukemia patients Gong Qinying, Chen Shuyan, Zhang Zhenli, Gong Shengzhu International Medicine and Health Guidance News    2021, 27 (6): 818-821.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.008 Abstract （1111）      PDF （1017KB）（412）       Knowledge map    Save Objective To explore the application value of H2H management model in improving self-efficacy and mood state of leukemia patients. Methods A total of 68 patients with leukemia admitted to our hospital from June 1, 2019 to April 30, 2020 were divided into observation group and control group with the random number table method with 34 cases in each group. The control group was given routine nursing management, oral education for patients, such as drug guidance, regular review, nutrition, hygiene, complications protection and so on. The observation group was given H2H management on the basis of routine nursing. Before and after 4 weeks of intervention, the self-efficacy and mood state of the two groups were evaluated by GSES and POMS-SF respectively, the differences were compared and analyzed. Results There were no statistically significant differences in self-efficacy and mood state scores between the two groups before intervention (all P>0.05). After 4 weeks of intervention, the self-efficacy score of the observation group was (32.41±3.58), significantly higher than that of the control group [(23.47±3.10)]; the total score and scores of six dimensions of mood state in the observation group were significantly lower than those in the control group, the total score of mood state in the observation group was (65.00±5.34), significantly lower than that of the control group [(98.24±6.70)], with statistically significant differences between the two groups (all P<0.05). Conclusion The implementation of H2H management model can effectively improve the self-efficacy and mood state of leukemia patients. Reference | Related Articles | Metrics

Select

Epidemiological characteristics of hepatitis E virus in blood donors in Qingdao Zhang Longmu, Zhang Zhijie, Xu Lei, Yang Zhongsi, Liu Li, Jiao Shuxian International Medicine and Health Guidance News    2021, 27 (6): 828-832.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.011 Abstract （224）      PDF （1013KB）（409）       Knowledge map    Save Objective To investigate the prevalence of hepatitis E virus (HEV) infection among Qingdao blood donors. Methods Blood samples were collected from donors in Qingdao from january 2015 to December 2016, included 773 eligible blood donors, and then tested for HEV related serological parameters (anti-HEV IgG, anti-HEV IgM, HEV Ag), compared with blood donors with elevated ALT (839 cases). Results The results of serum markers of HEV infection in 773 qualified blood donors showed anti-HEV IgG positive in 100 cases (12.94%), anti-HEV IgM positive in 6 cases (0.78%), no HEV Ag positive. The rate of anti-HEV IgG positive of the low age group was significantly lower than that of over 40 years old group (all P<0.01). There was no statistically significant difference in the rate of anti-HEV IgG, IgM positive between eligible blood donors and blood donors with elevated ALT (all P>0.05). HEV IgM reactive specimens were further detected for HEV RNA, all negative results. Conclusion The infection rate of HEV is lower among blood donors in Qingdao area. After the blood donors screened by ALT, the potential risk of transmission of HEV by blood transfusion is low. Reference | Related Articles | Metrics

Select

High-risk perinatal factors of small for gestational age infants whose birth weight <2 500 g versus whose birth weight ≥ 2 500 g Chen Xiaoli, Ye Zhenzhi, Chen Junlong International Medicine and Health Guidance News    2021, 27 (6): 833-836.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.012 Abstract （406）      PDF （1000KB）（409）       Knowledge map    Save Objective To explore the perinatal risk factors small for gestational age (SGA) infants whose birth weight <2 500 g versus whose birth weight ≥ 2 500 g by analyzing and evaluating the clinic documents about SGA infants whose birth weight <2 500 g and whose birth weight ≥ 2 500 g. Methods The data of the SGA infants treated at our department were collected. According to their birth weights, the infants were divided into an observation group ( n=169), whose birth weight <2 500 g, and a control group ( n=48), whose birth weight ≥ 2 500 g. The relevant perinatal information of the pregnant women and the infants were collected. The women's high risk factors during pregnancy were analyzed. The incidence of common diseases and the infection indicators were compared between the two groups. Results The incidence of diabetes, hypertension, multiple gestation, and GBS infection were 33.14% (56/169), 13.02% (22/169), 10.65% (18/169), and 6.51% (11/169) in the women of the observation group, with no statistical differences from those in the control group (all P>0.05). Six women had chronic fetal distress, 6 placental abnormality, 11 premature rupture of membranes, and 69 caesarean birth in the observation group, and 7, 6, 8, and 11 in the control group, with statistical differences (all P<0.05). The birth weight, Apgar score, body length, head circumference, and hospital stay were (2.25±0.16) kg, (9.34±0.64), (46.78±1.79) cm, (32.03±1.21) cm, and (5.03±2.50) d in the infants of the observation group, and were (2.61±0.12) kg, (9.05±0.88), (48.35±0.79) cm, (32.72±0.67) cm, and (3.76±1.35) d in those of the control groups, with statistical differences (all P<0.05). Conclusions Compared with the SGA infants whose birth weight ≥ 2 500 g, the SGA infants whose birth weight < 2 500 g have a higher disease incidence and a poor performance. Therefore, fortifying antenatal health education for pregnant women and lying-in women and ensuring a regular production inspection to discover high-risk pregnant factors are conducive to reducing the birth rate of SGA fetuses and improving neonate quality. Reference | Related Articles | Metrics

Select

Effect of multiple continuous nursing on cardiac rehabilitation of patients with coronary heart disease undergoing percutaneous coronary interventional therapy Yu Fang, Ren Pingping, Yu Xingcai International Medicine and Health Guidance News    2021, 27 (6): 925-928.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.036 Abstract （479）      PDF （1012KB）（404）       Knowledge map    Save Objective To explore the effect of multiple continuous nursing on the cardiac rehabilitation of patients with coronary heart disease undergoing percutaneous coronary interventional therapy. Methods A total of 144 patients with coronary heart disease undergoing percutaneous coronary intervention in the department of cardiology of our hospital from January to December 2018 were randomly divided into two groups, 72 cases in each group. On the basis of routine health education, the continuous nursing group members used wechat, telephone, and patient health club to continue nursing for patients in the observation group, while the control group received routine health education. The compliance behavior, incidence of cardiovascular events, readmission rate, risk factors, patient satisfaction of the two groups at 3 months, 6 months, and 12 months after discharge were compared. Results The compliance behavior scores in the observation group at 3 months, 6 months, and 12 months after PCI were (6.05±0.85) points, (6.12±0.80) points, (5.97±0.88) points, which were significantly higher than those in the control group [(5.35±1.05) points, (5.15±1.12) points, (4.55±1.25) points] (all P<0.05). There were no statistically significant differences in the incidence of cardiovascular events and readmission rate between the two groups at 3 months after PCI (both P>0.05); there were statistically significant differences in the incidence of cardiovascular events and readmission rate between the two groups at 6, 12 months after PCI (all P<0.05). There was no statistically significant difference in risk factor control between the two groups at 3 months after PCI ( P>0.05); there were no statistically significant differences in risk factor control between the two groups at 6, 12 months after PCI (all P<0.05). The total satisfaction rates in the observation group at 3 months, 6 months, and 12 months after PCI were 94.4%, 91.7%, 97.2%, which were significantly higher than those in the control group (86.1%, 83.3%, 80.6%) (all P<0.05). Conclusion The effect of multiple continuous nursing on the restoration of coronary heart disease after percutaneous coronary intervention is good, which should be popularized. Reference | Related Articles | Metrics

Select

Analysis of humanistic care needs and influencing factors of elderly patients with primary liver cancer undergoing interventional therapy Ma Weiwei International Medicine and Health Guidance News    2021, 27 (6): 901-904.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.030 Abstract （782）      PDF （1000KB）（399）       Knowledge map    Save Objective To observe the current situation of humanistic care needs of elderly patients with primary liver cancer undergoing interventional therapy, and to analyze the influencing factors. Methods Eighty-six elderly patients with primary liver cancer who received interventional therapy in our hospital from January 2018 to August 2019 were selected as the research objects. The self-made humanistic care demand questionnaire was used to investigate the current situation of humanistic care needs of all the selected patients. According to the survey results, the selected patients were divided into high humanistic care demand group and low humanistic care demand group. All patients were investigated with self-made baseline data questionnaire. The baseline data of patients with primary liver cancer were collected, and all factors that may affect the demand for humanistic care were included. The single factor and multi factor analysis were carried out to analyze the factors leading to the high demand for humanistic care in elderly patients with primary liver cancer undergoing interventional therapy. Results According to the survey, 23 cases (26.74%) had high demand for humanistic care. The results of single factor and multiple logistic regression analysis showed that women, more hospitalization times, children as the main caregivers, poor awareness of primary liver cancer knowledge, and poor family support function were all influencing factors of higher demand for humanistic care in patients with primary liver cancer (all OR>1, P<0.05). Conclusion Women, more hospitalization times, children as the main caregivers, poor awareness of primary liver cancer knowledge, and poor family support function may be the important factors leading to the increase of humanistic care needs of elderly patients with primary liver cancer during interventional treatment, and early intervention should be given. Reference | Related Articles | Metrics

Select

Analysis of serum levels of vascular endothelial growth factor (VEGF) in neonates and premature infants with retinopathy with different gestational age Guo Tao, Meng Liangliang, Chen Xiaoyun, Chen Yan, Zhang Chengfang International Medicine and Health Guidance News    2021, 27 (6): 840-843.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.014 Abstract （169）      PDF （1075KB）（397）       Knowledge map    Save Objective To analyze the changes of serum levels of vascular endothelial growth factor (VEGF) in neonates and premature infants with retinopathy with different gestational age. Methods Sixty cases of premature infants with gestational age under 32 weeks who were born in Weifang Maternal and Child Health Hospital from September 2018 to September 2019 were selected as group A, 60 cases of premature infants with gestational age of 32-36 weeks as group B, 60 cases of term infants as group C, 60 cases of term infants with retinopathy of prematurity (ROP) as group D. All were tested for serum VEGF and the results were compared. Results At the first, third, and fifth weeks after birth, the VEGF levels in group D were (523.42±4.45) ng/L, (456.72±3.28) ng/L及(346.23±2.68) ng/L, respectively, which were higher than those in group A [(487.23±3.56) ng/L, (423.48±2.36) ng/L, (301.34±2.13) ng/L], group B [(435.63±3.24) ng/L, (386.32±2.32) ng/L, (250.92±3.22) ng/L], and group C [(245.21±3.21) ng/L, (245.17±3.30) ng/L, (245.06±3.28) ng/L], and those in group A and group B were higher than those in group C, those in group A were higher than those in group B, with statistically significant differences (all P<0.05). There were no statistically significant differences in VEGF levels between neonates with and without oxygen inhalation in group A and C (all P>0.05). At the first, third, and fifth weeks after birth, the VEGF levels of neonates with oxygen inhalation in group B were (330.42±3.28) ng/L, (265.92±3.28) ng/L, (207.56±2.64) ng/L, respectively, which were lower than those of neonates without oxygen inhalation [(334.35±2.79) ng/L, (301.56±2.56) ng/L, (210.24±2.38) ng/L], with statistically significant differences (all P<0.05). The VEGF levels in children with ROP were significantly higher than those in preterm infants, with statistically significant differences (all P<0.05). Conclusion The level of VEGF in children with ROP is higher than that in premature infants, and the smaller the gestational age of premature infants is, the higher the VEGF level is. The increase of VEGF level in premature infants may increase the risk of ROP. Reference | Related Articles | Metrics

Select

The effect of HFMEA model on warfarin anticoagulant management of patients after cardiac valve replacement Zhang Hongying International Medicine and Health Guidance News    2021, 27 (6): 915-919.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.034 Abstract （331）      PDF （1049KB）（396）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Therapeutic effect of painting therapy on tension type headache Liu Yunyun, Fu Bing, Li Min, Liu Huaiying International Medicine and Health Guidance News    2021, 27 (6): 822-824.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.009 Abstract （1109）      PDF （1017KB）（392）       Knowledge map    Save Objective To explore the effect of painting therapy in the treatment of tension type headache (TTH). Methods A total of 113 female patients with TTH from November 2016 to June 2018 in Boya Women's College of Lianyungang were randomly divided into observation group and control group. The control group was given routine treatment (relieving pain, regulating emotion, improving sleep, and so on), and the observation group was given painting therapy (free painting) on the basis of the control group. Visual analogue scale (VAS) was used to evaluate the degree of headache of the patients, Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to evaluate the mental state of the patients. The patients were followed up for 90 days after admission. Results Follow-up on the 90th day showed that the HAMA and HAMD scores of the observation group were (5.88±2.31) points, (6.48±2.76) points respectively, and those of the control group were (6.91±2.67) points, (7.72±3.11) points respectively, with statistically significant differences (both P<0.05); the VAS score of the observation group was (1.23±0.63) points, which was significantly lower than that of the control group [(1.60±0.88) points] ( P<0.05); the frequency of headache attack in the observation group was (5.50±2.61) times, which was significantly lower than that of the control group [(6.67±2.85) times] ( P<0.05); the proportion of taking analgesics in the observation group was significantly lower than that in the control group [5.4%(3/56) vs 17.9%(10/57)] ( P=0.042). Compared with the control group, the proportion of anti-anxiety and depression drugs used in the observation group decreased on the 60th and 90th days, and there was statistically significant difference between the two groups on the 90th day ( P<0.05). Conclusion Combined painting therapy can relieve the degree of headache, reduce the frequency of headache attacks, alleviate anxiety and depression symptoms in patients with tension type headache. Reference | Related Articles | Metrics

Select

The effect of hysteroscope on complications and β-HCG recovery time of scar pregnancy after cesarean section Guo Wenling, Ma Jianlin, Chen Xuemei, Yang Baoxia, Wang Sai International Medicine and Health Guidance News    2021, 27 (6): 885-886.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.025 Abstract （422）      PDF （1006KB）（379）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Design and application of arteriovenous synchronous blood exchange simulation device in neonates Huang Jun, Ma Liqiang, Chen Guangming, Wu Zaixin, Fang Hua, Ou Qiongxia International Medicine and Health Guidance News    2021, 27 (6): 852-855.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.017 Abstract （263）      PDF （1042KB）（378）       Knowledge map    Save Objective To investigate the safety of neonatal peripheral arteriovenous synchronous blood exchange. Methods A simulation device predicting the change in blood volume of children before peripheral arteriovenous synchronous exchange transfusion in neonates was designed. Before the simulation device started, two bags of normal saline were used for pre-flush of the tubes of blood transfusion sets of the two infusion pumps, and then connecting three bags of normal saline, turning on the two infusion pumps at the same time, running for 0.5 to 1 hour; three bags of normal saline were weighed with the electronic scale before and after turning on the infusion pumps, the difference in flow velocity between the artery and vein ends was calculated, and the change in blood volume of children was estimated. According to the calculation results, another peripheral venous infusion compensation path was opened during the exchange transfusion to compensate blood volume loss during the exchange transfusion. From January 2018 to December 2018, 13 children who underwent routine peripheral arteriovenous synchronous blood exchange were set as the control group; from January 2019 to December 2019, 11 children were set as the observation group, the blood volume change of children was estimated by the simulation device before peripheral arteriovenous synchronous blood exchange. Results The blood purging effect was ideal in both groups, but MAP, HR, RR, and SpO 2 in the control group showed significant fluctuations after 45 min of blood exchange (all P<0.05), indicating that there was a certain degree of blood volume change in the group. Compared with the control group, the above vital signs in the observation group were continuously stable, and none of the children in the observation group presented hemorrhagic shock and circulatory congestion, indicating that the hemodynamics of the children in the group were stable during blood exchange, and their blood volume did not change significantly. Conclusion The device can accurately predict the difference in blood flow velocity between the artery and vein ends and the change in the blood volume of children, ensure that the blood volume of the children is stable during blood exchange, and improve the safety of exchange transfusion in neonates. Reference | Related Articles | Metrics

Select

The value of popliteal sciatic nerve block in multi-modal analgesia after Hallux Valgus surgery Liu Linlin, Jian Chaojun, Wang Yanpin, Niu Qiang, Xu Xuebing International Medicine and Health Guidance News    2021, 27 (6): 810-812.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.006 Abstract （947）      PDF （1016KB）（374）       Knowledge map    Save Objective To evaluate the efficacy and safety of popliteal sciatic nerve block (PSNB) in multi-modal analgesia after Hallux Valgus surgery. Methods Forty-nine patients who underwent unilateral or bilateral Hallux Valgus surgery under intraspinal anesthesia from September 2014 to March 2020 were retrospective analyzed. The PSNB group ( n=14) underwent postoperative ultrasound guided PSNB with 15 ml of 0.5% ropivacaine, and oral analgesics (paracetamol, tramadol, and celecoxib); the Oral group ( n=35) only received aforementioned oral analgesics for pain control. The postoperative 6 h and 24 h rest/active pain NRS scores, the incidence of moderate to severe pain within postoperative 24 h, the requirement of rescue opioid analgesics, side effects, and patients' subjective satisfaction rating were observed and compared between the two groups. Results The median of postoperative 6 h rest NRS score in the PSNB group and the Oral group were 2.0 and 3.0 ( P<0.05); the median of postoperative 24 h rest/active pain NRS scores were 0.0/1.5 and 1.0/3.0, the incidences of moderate to severe pain within postoperative 24 h were 14.3% (2/14) and 22.9% (8/35), the incidences of remedial opioid analgesics were 7.1% (1/14) and 2.9% (1/35), there were no statistically significant differences in the above mentioned indices (all P>0.05). No side effect was found in the PSNB group, there was a case of post-dural puncture headache in the Oral group, and the subjective satisfaction rate was 100% in both groups. Conclusion Adding PSNB to multi-modal analgesia management strategy for Hallux Valgus surgery may improve short term postoperative pain control, but has no impact on the need of rescue analgesics after surgery. Reference | Related Articles | Metrics

Select

Comparative study of negative pressure combined ureteroscopic lithotripsy and flexible ureteroscopy combined holmium laser lithotripsy in the treatment of unilateral upper urinary tract calculi Lyu Wenwei, Wei Pengtao, Zhang Han, Kang Yanjie, Yang Lingbo, Liu Hongyan, Shang Yafeng, Sun Jiantao International Medicine and Health Guidance News    2021, 27 (6): 871-874.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.021 Abstract （684）      PDF （1000KB）（360）       Knowledge map    Save Objective To compare the clinical curative effect of negative pressure combined ureteroscopic lithotripsy and flexible ureteroscopy combined holmium laser lithotripsy (f-URS) on unilateral upper urinary tract calculi. Methods Eighty patients with unilateral upper urinary tract calculi who were treated in our hospital between June 2018 and June 2020 were enrolled. They were randomly divided into control group and study group, 40 cases in each group. The control group was treated with f-URS, while the study group was treated with negative pressure combined ureteroscopic lithotripsy combined holmium laser lithotripsy. The hospitalization time, operation time, stone clearance rate, as well as levels of hemoglobin (Hb) and serum creatinine (Cr) before and after treatment were compared between the two groups. The incidence of complications after treatment in both groups was statistically analyzed. Results The operation time in the study group was longer than that in the control group [(54.12±6.25) min vs.(35.41±5.73) min] ( P<0.05), the stone clearance rate within 24 h after surgery was higher than that in the control group [90.0% (36/40) vs.62.5% (25/40)] ( P<0.05), and the total incidence of complications was lower than that in the control group [5.0% (2/40) vs.25.0% (10/40)] ( P<0.05). There were no statistically significant differences in hospitalization time and stone clearance rate within 30 d after surgery between the two groups (both P>0.05). After treatment, Hb in both groups decreased (both P<0.05), and there was no statistically significant difference in Hb between the two groups ( P>0.05). There was no statistically significant difference in Cr before and after treatment, as well as between the two groups (all P>0.05). Conclusions For patients with unilateral upper urinary tract calculi, both negative pressure combined ureteroscopic lithotripsy and f-URS are effective treatment methods. Compared with f-URS, negative pressure combined ureteroscopic lithotripsy can avoid more complications, with more significantly curative effect on the stones with diameter longer than 20 mm. Reference | Related Articles | Metrics

Select

Investigation and analysis of the knowledge of ultrasonic examination patients Li Liang, Chen Chunyan, Liu Jian International Medicine and Health Guidance News    2021, 27 (6): 905-907.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.031 Abstract （508）      PDF （1010KB）（354）       Knowledge map    Save Objective To explore the understanding of ultrasonic examination in patients, to provide a theoretical basis for the development of health education plan for ultrasonic examination patients. Methods From April 5, 2020 to April 30, 2020, 130 patients who came to our hospital for ultrasonic examination were enrolled with the convenient sampling method. The knowledge awareness, knowledge sources, and the most recognized education methods of ultrasound examination were investigated. Results The awareness rate of ultrasound examination was 60.62%,incomplete knowledge acquisition. The sources of knowledge were oral education of medical staff, mobile network, and previous experience, accounting for 78.46% (102/130), 61.54% (80/130) and 60.00% (78/130) respectively. The most recognized educational needs were oral education, written notice, and mobile network, accounting for 68.46% (89/130), 67.69% (88/130), 66.92% (87/130) respectively. The awareness score on ultrasound examination in patients with higher education background was better than that in patients with lower education background [(14.46±2.35) points vs.(8.74±2.23) points], that in re-examination patients was better than that in initial examination patients [(12.80±3.24) points vs.(8.91±3.02) points] (both P<0.05). Conclusions The awareness rate of ultrasonic examination related knowledge is low. It is necessary to carry out targeted examination knowledge education for patients before examination, oral explanation combined with written notice is more acceptable, especially for those with lower education background, more attention should be paid. At the same time, we should not neglect to acquire knowledge from mobile websites, paying attention to content review before publishing on the website. Reference | Related Articles | Metrics

Select

Effect of adrenocorticotropic hormone on lymphocyte subsets and serum immunoglobulin levels in children with infantile spasm Cai Wenxian, Sun Guangfei, Zheng Qinliang, Li Qiubo International Medicine and Health Guidance News    2021, 27 (6): 837-839.   DOI: 10.3760/cma.j.issn.1007-1245.2021.06.013 Abstract （333）      PDF （1051KB）（349）       Knowledge map    Save Objective To explore the change of immune function and the effect of adrenocorticotropic hormone (ACTH) on lymphocyte subsets and serum immunoglobulin levels in children with infantile spasm. Methods Forty cases of infantile spasm treated in department of pediatrics of our hospital from October 2014 to October 2019 were selected as case group, 40 healthy children as normal control group. ACTH was administered for 4 weeks for patients. Flow cytometry was used to measure the percentages of lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD19 +, and CD20 +). Immunoturbidimetric assay was used to measure serum levels of immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG) before and after 4 weeks of treatment, and the results were compared with those of the control group. Results The count of CD8 + T cells in patients before treatment was significantly lower than that in the control group [(34.36±3.48)% vs.(32.33±3.08)%] ( P<0.01); the ratio of CD4 + /CD8 + T cell was significantly higher than that in the control group ( P<0.05). There were no statistically significant differences in the count of CD3 + T cells, CD4 + T cells, CD19 + B cells, CD20 + B cells, and the levels of immunoglobulin between patients before treatment and the control group (all P>0.05). After treatment with ACTH, the count of CD8 + T cells in patients [(36.34±4.18)%] was obviously higher than that before treatment ( P<0.01); the count of CD4 + T cells was obviously lower than that before treatment [(41.08±4.66)% vs.(45.54±5.04)%] ( P<0.01); the ratio of CD4 + /CD8 + T cell was obviously lower than that before treatment [(1.11±0.27) vs.(1.45±0.37)] ( P<0.01). There were no statistically significant differences in the count of CD3 + T cells, CD19 + B cells, CD20 + B cells, and the levels of immunoglobulin in patients before and after 4 weeks of treatment (all P>0.05). Conclusion Children with infantile spasm have immunological alterations, and ACTH can regulate the immune function in children and control the development of the disease. Reference | Related Articles | Metrics