Correlation between interleukin-6 and frailty: a meta-analysis

doi:10.3760/cma.j.issn.1007-1245.2021.06.004

Abstract

Abstract: Objective To evaluate the correlation between interleukin-6 (IL-6) concentration and frailty through meta-analysis. Methods Case-control studies on the relationship between IL-6 and frailty were collected by searching home and aboard databases including PubMed, EMBASE, Cochrane library, CNKI, CBMdisc, Wanfang, VIP. The retrieval time was from the establishment of each database to the analysis of data by Stata15.0 in February 2020. Results Seven qualified case-control studies with 1 644 participants were involved, including 330 frailty patients and 1 314 controls, the IL-6 level in patients with frail was higher (SMD=1.56, 95% CI: 0.81~2.31, P<0.001). The sensitivity analysis results were stable and the Egger's test indicated no significant publication bias (t=1.61, P=0.169). Conclusion High level of interleukin-6 may be a risk factor for frailty, but further study on specific etiological associations need to be done in a larger population in the future.

Key words: Interleukin-6, Frailty, Meta-analysis

摘要： 目的本研究通过meta分析对白细胞介素-6(interleukin-6,IL-6)浓度与衰弱(frailty)的相关性进行评价。方法通过检索PubMed、EMBASE、Cochrane图书馆、中国知网(CNKI)、中国生物医学文献数据库(CBMdisc)、万方数据库、维普网(VIP)等数据库收集IL-6与衰弱相关性的病例对照研究,检索时限从各个数据库建库至2020年2月。采用Stata15.0对数据进行分析。结果共纳入7篇文献,共1 644名参与者,包括衰弱组330例,对照组1 314例。结果显示衰弱组血清(或血浆)IL-6浓度高于对照组(SMD=1.56,95% CI:0.81~2.31,P<0.001)。敏感性分析结果稳定,经Egger's检验,提示不存在明显发表偏倚(t=1.61,P=0.169)。结论白细胞介素-6水平偏高可能是衰弱的危险因素,但具体病因相关性需要在更多的人群中进一步研究。

关键词: 白细胞介素-6, 衰弱, meta分析

Qu Jiling, Shen Yijing, Hou Ping, Zhou Ting, Li Yongnan, Mao Xin'e, Liu Yongbing. Correlation between interleukin-6 and frailty: a meta-analysis[J]. International Medicine and Health Guidance News, 2021, 27(6): 802-806.

渠吉皊, 沈易静, 侯苹, 周婷, 李永男, 冒鑫娥, 刘永兵. 白细胞介素-6与衰弱的相关性meta分析[J]. 国际医药卫生导报, 2021, 27(6): 802-806.

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