Abstract: Objective　To investigate the curative effects of single hole laparoscopic radical resection and traditional laparoscopic radical resection for colorectal cancer. Methods　This was a random control trial. Sixty patients with colorectal cancer treated in Department of Gastrointestinal Surgery, Wuzhou Red Cross Hospital from January 2020 to December 2021 were randomly selected, and were divided into an observation group and a control group by lottery, with 30 cases in each group. There were 19 males and 11 females in the observation group, and they were (59.00±6.00) years old. There were 18 males and 12 females in the control group, and they were (59.00±7.00) years old. The observation group were treated with single hole laparoscopic radical resection of colorectal cancer, and the control group with traditional laparoscopic radical resection of colorectal cancer. The short-term curative effects, operation and postoperative conditions, pain degrees, inflammatory reaction, oxidative stress indicators, and incidences of complications were compared between these two groups. Independent-sample t test and χ² test were applied. Results　The total effective rate of the observation group was significantly higher than that of the control group [96.67% (29/30) vs. 73.33% (22/30)], with a statistical difference (χ²=4.705, P=0.030). Compared with the control group, the observation group had less bleeding, less drainage on the 4th day after the operation, more lymph node dissection, shorter times for postoperative anal exhaust, early activity, and recovery of gastrointestinal function, shorter hospital stay, and lower pain degree, with statistical differences (all P<0.05). Before the operation, there were no statistical differences in the levels of inflammatory response and oxidative stress indicators between the two groups (all P>0.05). After the operation, the levels of C reaction protein, interleukin-6 (IL-6), and superoxide dismutase (SOD) were (13.57±5.34) mg/L, (16.28±5.64) ng/L, and (85.63±11.84) kU/L in the observation group, and were (26.84±5.12) mg/L, (33.54±7.50) ng/L, and (74.25±12.35) kU/L in the control group, with statistical differences between these two groups (all P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group [6.67% (2/30) vs. 30.00% (9/30)], with a statistical difference (χ²=5.454, P=0.019). Conclusion　Compared with traditional laparoscopic radical resection of colorectal cancer, single hole laparoscopic radical resection of colorectal cancer has better curative effect and high safety, and can improve inflammatory reaction and oxidative stress reaction and reduce pain.

Key words: Single hole laparoscopy, Colorectal cancer, Complications, Inflammatory reaction, Pain degree

摘要： 目的　探讨单孔腹腔镜结直肠癌根治术及传统腹腔镜结直肠癌根治术的疗效。方法　本研究为随机对照试验。2020年1月至2021年12月在梧州市红十字会医院胃肠外科收治的结直肠癌患者中随机抽取60例，以抽签法分为两组。观察组30例中男19例、女11例，年龄（59.00±6.00岁）；对照组30例中男18例、女12例，年龄（59.00±7.00岁）。观察组采用单孔腹腔镜结直肠癌根治术，对照组采用传统腹腔镜结直肠癌根治术。对比两组患者近期疗效、手术及术后情况、疼痛程度、炎性反应、氧化应激指标、并发症发生率。统计学方法采用独立样本t检验、χ²检验。结果　观察组手术总有效率显著高于对照组［96.67%（29/30）比73.33%（22/30）］，两组比较差异有统计学意义（χ²=4.705，P=0.030）；较于对照组，观察组手术出血量更少，术后第4天引流量更少，淋巴结清扫数目更多，术后肛门排气、早期活动、肠胃功能恢复、住院时间均更短，疼痛程度更低，差异均有统计学意义（均P<0.05）；术前，两组炎性反应、氧化应激指标水平比较差异均无统计学意义（均P>0.05）；术后，观察组的C反应蛋白（CRP）、白细胞介素-6（IL-6）水平均低于对照组［（13.57±5.34）mg/L比（26.84±5.12）mg/L、（16.28±5.64）ng/L比（33.54±7.50）ng/L］，超氧化物歧化酶（SOD）水平高于对照组［（85.63±11.84）kU/L比（74.25±12.35）kU/L］，两组比较差异均有统计学意义（均P<0.05）；观察组并发症总发生率低于对照组［6.67%（2/30）比30.00%（9/30）］，两组比较差异有统计学意义（χ²=5.454，P=0.019）。结论　与传统腹腔镜结直肠癌根治术比较，单孔腹腔镜结直肠癌根治术疗效更佳，安全性高，改善炎性反应、氧化应激反应，可减轻疼痛。

关键词: 单孔腹腔镜, 结直肠癌, 并发症, 炎性反应, 疼痛程度