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Expression levels and significance of anterior pituitary hormones and
thyroid hormones in patients with traumatic brain injury under different
disease severity degrees
- Huang Kefeng, Chen Guiping, Li Min, Duan Haifeng, Cui Jie, Zhang Hao
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2022, 28(14):
1931-1935.
DOI: 10.3760/cma.j.issn.1007-1245.2022.14.002
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Objective To explore and analyze the expression levels and significance of
anterior pituitary hormones and thyroid hormones in patients with traumatic
brain injury under different disease severity degrees. Methods A total of 103 patients with traumatic brain injury treated in Jincheng
People's Hospital from May 2017 to May 2020 were selected as an observation
group, including 58 males and 45 females, with an age of (43.12±4.11) years
old, with 5 cases of skull fractures, 7 cases of cerebral concussion, 11 cases
of cerebral contusion, 9 cases of epidural hematoma, and 8 cases of subdural
hematoma, with the admission time after injury of (30.25±4.11) h. Serum levels
of prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone
(LH), thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine
(T4) were measured by enzyme-linked immunosorbent assay (ELISA) on day 1, 7,
14, and 30 after traumatic brain injury. A total of 100 normal people who came
to Jincheng People's Hospital for routine physical examination during the same
period were selected as the control group, including 55 males and 45 females,
with an age of (43.20±4.34) years old, the same indicators mentioned above were
measured, and the levels of anterior pituitary hormones and thyroid hormones
were compared between the two groups. At the same time, the patients in the
observation group were divided into a mild group (13-14 points), a moderate
group (9-12 points), and a severe group (3-8 points) according to the Glasgow
Coma Scale (GCS) score, and were divided into a death group, a disability
group, and a good group according to the prognosis. The levels of anterior
pituitary hormones and thyroid hormones in different GCS groups and different
prognostic groups were compared. Independent sample t test was used for comparison of the measurement data between two
groups, F test was used for
comparison among multiple groups, and χ2 test was used for the count data. Results Compared with those
in the control group, the levels of PRL, FSH, LH, TSH, and T4 in the
observation group were higher on day 1 and 7 after craniocerebral injury, while
the level of T3 was lower; the levels of PRL, FSH, LH, TSH, and T4 in the
observation group decreased gradually and the level of T3 increased since day 7
after craniocerebral injury; the levels of PRL, FSH, LH, TSH, and T4 were still
higher than those of the control group on day 14 after craniocerebral injury,
while the level of T3 was lower, with statistically significant differences
(all P<0.05). The severe group had
higher levels of PRL, FSH, LH, TSH, and T4 and a lower level of T3 compared
with the moderate group and the mild group, respectively; the moderate group
had higher levels of PRL, FSH, LH, TSH, and T4 and a lower level of T3 compared
with the mild group, with statistically significant differences (all P<0.05). The death group had higher
levels of PRL, FSH, LH, TSH, and T4 and lower level of T3 compared with the
disability group and the good group, respectively; the disability group had
higher levels of PRL, FSH, LH, TSH, and T4 and lower level of T3 compared with
the good group, with statistically significant differences (all P<0.05). Conclusion After traumatic brain injury, the levels of anterior pituitary hormones
and thyroid hormones are significantly increased, and the changes of above
indicators are helpful to judge the disease severity degree and prognosis in
patients with traumatic brain injury, and provide reliable basis for clinical
treatment.
