Research progress on the mechanism of exosomes in myocardial
ischemia-reperfusion injury

doi:10.3760/cma.j.issn.1007-1245.2022.14.007

Abstract

Abstract: Exosomes are vesicle-like substances actively secreted by cells, they can transport proteins, cytokines, microRNAs, and other substances to participate in the process of intercellular communication, thus play a role in regulating the function of corresponding receptor cells. When cells are stimulated, the number of exosomes and substances they transport will change correspondingly. Reperfusion therapy after acute myocardial infarction is usually achieved through thrombolytic therapy or percutaneous coronary intervention, and myocardial injury after reperfusion is a common phenomenon after vascular recanalization and also the main reason affecting prognosis. At present, there are no effective prevention and treatment measures for myocardial ischemia-reperfusion injury. Studies have shown that exosomes play an important role in regulating inflammatory response, angiogenesis, oxidative stress, ventricular remodeling, and myocardial cell apoptosis in myocardial ischemia-reperfusion injury, so they have great potential clinical application values.

Key words: Exosomes, Myocardial ischemic reperfusion injury, Myocardial protection, Inflammation, Oxidative stress

摘要： 外泌体是细胞主动分泌的囊泡样物质，可以转运蛋白质、细胞因子以及微小核糖核酸等物质参与细胞间通讯等过程，进而发挥调控相应受体细胞功能的作用。细胞在受到一定刺激时，分泌的外泌体数量以及转运物质会发生相应的变化。急性心肌梗死后通常通过溶栓或者经皮冠状动脉介入治疗等实现再灌注治疗，而再灌注后心肌损伤是血管再通后的常见现象，也是影响预后的主要原因，目前临床上尚无针对心肌缺血再灌注损伤的有效的防治措施。研究发现，外泌体在心肌缺血再灌注损伤炎性反应、血管再生、氧化应激、心室重塑以及心肌细胞凋亡等过程中发挥着重要调控作用，因此具有巨大的潜在临床应用价值。

关键词: 外泌体, 心肌缺血再灌注损伤, 心肌保护, 炎症, 氧化应激

Li Xinxi, Liu Changmei, Zhu Hui, Zhai Miaobo, Shang Xue, Zhao Jiahao, Xu Huipu. Research progress on the mechanism of exosomes in myocardial ischemia-reperfusion injury[J]. International Medicine and Health Guidance News, 2022, 28(14): 1955-1958.

李昕玺　刘长梅　祝慧　翟淼浡　商雪　赵嘉昊　徐会圃. 外泌体在心肌缺血再灌注损伤中作用的研究进展[J]. 国际医药卫生导报, 2022, 28(14): 1955-1958.

References

[1] Heusch G. Cardioprotection: chances and challenges of its translation to the clinic[J]. Lancet, 2013, 381(9861):166-175. DOI: 10.1016/S0140-6736(12)60916-7.
[2] 龚志坚,温明华,程晓曙.外泌体与心肌缺血再灌注损伤的研究进展[J].中华心血管病杂志,2017,45(12):1112-1114. DOI:10.3760/cma.j.issn.0253-3758.2017.12.021.
[3] Melo SA, Sugimoto H, O'Connell JT, et al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis[J]. Cancer Cell, 2014, 26(5):707-721. DOI: 10.1016/j.ccell.2014.09.005.
[4] Johnstone RM, Adam M, Hammond JR, et al. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)[J]. J Biol Chem, 1987, 262(19):9412-9420.
[5] 李胜,李澜,郭蕊,等.外泌体改善心肌缺血再灌注损伤的作用机制研究进展[J].中西医结合心脑血管病杂志,2021,19(1):69-72. DOI:10.12102/j.issn.1672-1349. 2021. 01.015.
[6] Gupta S, Knowlton AA. HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway[J]. Am J Physiol Heart Circ Physiol, 2007, 292(6):H3052-H3056. DOI: 10.1152/ajpheart.01355.2006.
[7] Li G, Labruto F, Sirsjö A, et al. Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase[J]. Eur J Cardiothorac Surg, 2004, 26(5):968-973. DOI: 10.1016/j.ejcts.2004.06.015.
[8] Maxwell SR, Lip GY. Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options[J]. Int J Cardiol, 1997, 58(2):95-117. DOI: 10.1016/s0167-5273(96)02854-9.
[9] Reffelmann T, Kloner RA. The no-reflow phenomenon: a basic mechanism of myocardial ischemia and reperfusion[J]. Basic Res Cardiol, 2006, 101(5):359-372. DOI: 10.1007/s00395-006-0615-2.
[10] Guarnieri C, Flamigni F, Caldarera CM. Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart[J]. J Mol Cell Cardiol, 1980, 12(8):797-808. DOI: 10.1016/0022-2828(80)90081-4.
[11] Ambrosio G, Becker LC, Hutchins GM, et al. Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury[J]. Circulation, 1986, 74(6):1424-1433. DOI: 10.1161/01.cir.74.6.1424.
[12] Przyklenk K, Kloner RA. "Reperfusion injury" by oxygen-derived free radicals? Effect of superoxide dismutase plus catalase, given at the time of reperfusion, on myocardial infarct size, contractile function, coronary microvasculature, and regional myocardial blood flow[J]. Circ Res, 1989, 64(1):86-96. DOI: 10.1161/01.res.64.1.86.
[13] Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword?[J]. J Clin Invest, 1985, 76(5):1713-1719. DOI: 10.1172/JCI112160.
[14] Entman ML, Smith CW. Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease[J]. Cardiovasc Res, 1994, 28(9):1301-1311. DOI: 10.1093/cvr/28.9.1301.
[15] Wang RP, Yao Q, Xiao YB, et al. Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model[J]. Stress, 2011, 14(5):567-575. DOI: 10.3109/10253890.2011.571729.
[16] Ao L, Zou N, Cleveland JC, et al. Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70[J]. Am J Physiol Heart Circ Physiol, 2009, 297(1):H21-H28. DOI: 10.1152/ajpheart.00292.2009.
[17] Dong J, Xu M, Zhang W, et al. Effects of sevoflurane pretreatment on myocardial ischemia-reperfusion injury through the Akt/hypoxia-inducible factor 1-alpha (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway[J]. Med Sci Monit, 2019, 25:3100-3107. DOI: 10.12659/MSM.914265.
[18] Frank A, Bonney M, Bonney S, et al. Myocardial ischemia reperfusion injury: from basic science to clinical bedside[J]. Semin Cardiothorac Vasc Anesth, 2012, 16(3):123-132. DOI: 10.1177/1089253211436350.
[19] Wang Y, Zhao R, Liu D, et al. Exosomes derived from miR-214-enriched bone marrow-derived mesenchymal stem cells regulate oxidative damage in cardiac stem cells by targeting CaMKII[J]. Oxid Med Cell Longev, 2018, 2018:4971261. DOI: 10.1155/2018/4971261.
[20] Zhao J, Li X, Hu J, et al. Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization[J]. Cardiovasc Res, 2019, 115(7):1205-1216. DOI: 10.1093/cvr/cvz040.
[21] Agarwal U, George A, Bhutani S, et al. Experimental, systems, and computational approaches to understanding the microRNA-mediated reparative potential of cardiac progenitor cell-derived exosomes from pediatric patients[J]. Circ Res, 2017, 120(4):701-712. DOI: 10.1161/CIRCRESAHA.116.309935.
[22] Chen Q, Liu Y, Ding X, et al. Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7[J]. Mol Cell Biochem, 2020, 465(1-2):103-114. DOI: 10.1007/s11010-019-03671-z.
[23] Arslan F, Lai RC, Smeets MB, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury[J]. Stem Cell Res, 2013, 10(3):301-312. DOI: 10.1016/j.scr.2013.01.002.
[24] 陈琮.心肌细胞外泌体对心脏的主要作用及潜在机制分析[J].医药前沿,2020,10(18):72-73.
[25] Liu L, Jin X, Hu CF, et al. Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia/reperfusion injury by inducing cardiomyocyte autophagy via AMPK and Akt pathways[J]. Cell Physiol Biochem, 2017, 43(1):52-68. DOI: 10.1159/000480317.
[26] 常冀杨,孟晓菲,周佳奇,等.缺血再灌注损伤下微囊泡抑制心肌细胞凋亡的研究进展[J].国际医药卫生导报,2021,27(10):1571-1575. DOI:10.3760/cma.j.issn.1007-1245. 2021.10.041.
[27] Chen Q, Huang M, Wu J, et al. Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70[J]. Aging (Albany NY), 2020, 12(4):3682-3693. DOI: 10.18632/aging.102837.
[28] Ma T, Chen Y, Chen Y, et al. MicroRNA-132, delivered by mesenchymal stem cell-derived exosomes, promote angiogenesis in myocardial infarction[J]. Stem Cells Int, 2018, 2018:3290372. DOI: 10.1155/2018/3290372.
[29] Yu B, Kim HW, Gong M, et al. Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection[J]. Int J Cardiol, 2015, 182:349-360. DOI: 10.1016/j.ijcard.2014.12.043.

Research progress on the mechanism of exosomes in myocardial ischemia-reperfusion injury

外泌体在心肌缺血再灌注损伤中作用的研究进展

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