Abstract: Objective　To explore the effect of cluster nursing on medication compliance and quality of life in drug-resistant children with Helicobacter pylori (Hp) infection. Methods　The clinical data of 80 drug-resistant children with Hp infection treated in Children's Hospital Affiliated to Zhengzhou University from March 2019 to April 2021 were analyzed retrospectively. According to different nursing methods, they were divided into a control group [23 males, 17 females, with an age of (10.58±1.91) years old and a course of disease of (4.78±1.19) days] and an intervention group [21 males, 19 females, with an age of (10.68±2.31) years and a course of disease of (4.83±1.24) days], with 40 cases in each group. The control group was intervened by routine nursing mode, and the intervention group was intervened by cluster nursing mode. The medication compliance, treatment effect, scores of Screen for Child Anxiety Related Emotional Disorders (SCARED) and Quality of Life Scale for Children and Adolescents (QLSCA), and family satisfaction were compared between the two groups. Two independent sample t test was used for the measurement data, and χ² test was used for the count data. Results　The medication compliance and treatment effective rate in the intervention group were 87.5% (35/40) and 90.0% (36/40), respectively, which were higher than those in the control group [67.5% (27/40) and 72.5% (29/40)], with statistically significant differences (both P<0.05). After intervention, the SCARED score in the intervention group was lower than that in the control group [(19.50±1.72) vs. (21.48±2.01)], and the QLSCA score was higher than that in the control group [(61.08±3.29) vs. (58.50±4.33)], with statistically significant differences (both P<0.05). The satisfaction of the intervention group was higher than that of the control group, with a statistically significant difference (P<0.05). Conclusion　The application of cluster nursing mode intervention in drug-resistant children with Hp infection can improve the medication compliance and quality of life.

Key words: Helicobacter pylori, Cluster nursing, Medication compliance, Quality of life, Family satisfaction

摘要： 目的　探讨集束化护理对幽门螺旋杆菌（Hp）感染耐药患儿服药依从性及生活质量的影响。方法　回顾性分析郑州大学附属儿童医院2019年3月至2021年4月收治的80例Hp感染耐药患儿的临床资料，依照护理方式不同，将其分为对照组［男23例，女17例，年龄为（10.58±1.91）岁，病程（4.78±1.19）d］和干预组［男21例，女19例，年龄为（10.68±2.31）岁，病程（4.83±1.24）d］，各40例。对照组予以常规护理模式干预，干预组采用集束化护理模式干预。比较两组患儿服药依从性、治疗效果、儿童焦虑性情绪障碍筛查表（SCARED）评分、儿童少年生活质量量表（QLSCA）评分、家属满意度。计量资料采用两独立样本t检验，计数资料采用χ²检验。结果　干预组服药依从性、治疗有效率分别为87.5%（35/40）、90.0%（36/40），均高于对照组的67.5%（27/40）、72.5%（29/40），差异均有统计学意义（均P<0.05）。干预组干预后SCARED评分（19.50±1.72）分，低于对照组的（21.48±2.01）分，QLSCA评分（61.08±3.29）分，高于对照组的（58.50±4.33）分，差异均有统计学意义（均P<0.05）。干预组满意度高于对照组，差异有统计学意义（P<0.05）。结论　Hp感染耐药患儿采用集束化护理模式干预可提高服药依从性及生活质量。

关键词: 幽门螺旋杆菌, 集束化护理, 服药依从性, 生活质量, 家属满意度