脑血管病的研究进展

doi:10.3760/cma.j.issn.1007-1245.2024.13.001

国际医药卫生导报 ›› 2024, Vol. 30 ›› Issue (13): 2114-2118.DOI: 10.3760/cma.j.issn.1007-1245.2024.13.001

• 脑血管疾病 • 下一篇

脑血管病的研究进展

谢曦¹ 蔡志友² 王启征¹ 刘芮芳¹ 赵宇¹

¹深圳市第三人民医院南方科技大学第二附属医院神经内科，深圳　518112；²重庆市人民医院神经内科，重庆　401121

收稿日期:2024-01-17 出版日期:2024-07-01 发布日期:2024-08-01
通讯作者: 赵宇，Email：zy220916@163.com
基金资助:
重庆英才计划（GQYC20200303106）

Research progress of cerebrovascular diseases

Xie Xi¹, Cai Zhiyou², Wang Qizheng¹, Liu Ruifang¹, Zhao Yu¹

¹Department of Neurology, Shenzhen Third People's Hospital, Second Hospital, Southern University of Science and Technology, Shenzhen 518112, China; ²Department of Neurology, Chongqing People's Hospital, Chongqing 401121, China

Received:2024-01-17 Online:2024-07-01 Published:2024-08-01
Contact: Zhao Yu, Email: zy220916@163.com
Supported by:
Chongqing Talent Plan (GQYC20200303106)

摘要/Abstract

摘要：

脑血管病是我国致死率和致残率位居首位的疾病，研究脑血管病的主要目标是降低致死率，减少致残率，提高人们生活质量。通过对新型神经组织成像在脑血管病诊断中的研究可以提高诊断效率及精准度，对新型药物的开发和新治疗方案的研究可以缩短病程及促进恢复，对脑血管病预防措施的研究可以指导人们的健康生活方式。本文就近年来的脑血管病影像研究进展、新型药物及新治疗方案的研究进展及对脑血管病预防进行总结和分析，期待为脑血管病的防治提供更多帮助。

关键词:

脑血管病, 神经血管影像, 静脉溶栓药物, 血清素, 淀粉样蛋白β1-40, 地中海饮食, 进展

Abstract:

Cerebrovascular diseases are the first cause of death and disability in China, so the main goal of studying these diseases is to reduce the fatality rate, reduce the disability rate, and improve their life quality. Through the study of new imaging in the diagnosis of cerebrovascular diseases, it can improve the efficiency and accuracy of diagnosis. The researches on new drugs and treatment schemes can shorten the course of disease and promote their recovery. The researches on pre-action strategies may guide healthy lifestyles. This article summarizes and analyzes the latest cerebrovascular disease imaging, drugs and treatment methods, and lifestyle researches, so as to provide more help for the prevention and treatment of cerebrovascular diseases.

Key words:

Cerebrovascular diseases, Neurovascular imaging, Intravenous thrombolytic drugs, Serotonin, Amyloid beta 1-40, Mediterranean diet, Progress

谢曦蔡志友王启征刘芮芳赵宇.

脑血管病的研究进展 [J]. 国际医药卫生导报, 2024, 30(13): 2114-2118.

Xie Xi, Cai Zhiyou, Wang Qizheng, Liu Ruifang, Zhao Yu.

Research progress of cerebrovascular diseases [J]. International Medicine and Health Guidance News, 2024, 30(13): 2114-2118.

参考文献

[1] Lv B, Song G, Jing F, et al. Mortality from cerebrovascular diseases in China: exploration of recent and future trends[J]. Chin Med J (Engl), 2024,137(5):588-595. DOI: 10.1097/CM9.0000000000002760.
[2] GBD 2015 Neurological Disorders Collaborator Group. Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015[J]. Lancet Neurol, 2017,16(11):877-897. DOI: 10.1016/S1474-4422(17)30299-5.
[3] Hosseini-Alghaderi S, Baron M. Notch3 in development, health and disease[J]. Biomolecules, 2020,10(3):485. DOI: 10.3390/biom10030485.
[4] Joutel A, Andreux F, Gaulis S, et al. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients[J]. J Clin Invest, 2000,105(5):597-605. DOI: 10.1172/JCI8047.
[5] 祖煜,于莎莎,张玉婧,等. HTRA1基因杂合突变相关遗传性脑小血管病1例并文献复习[J]. 中国卒中杂志,2023,18(9):1054-1059. DOI:10.3969/j.issn.1673-5765.2023.09.012.
[6] Takamiya S, Kawabori M, Fujimura M. Stem cell therapies for intracerebral hemorrhage: review of preclinical and clinical studies[J]. Cell Transplant, 2023,32:9636897- 231158153. DOI: 10.1177/09636897231158153.
[7] 陈聪,刘昱南,刘玉苹. 脑出血后神经保护新策略的研究进展[J]. 中国疗养医学,2023,32(11):1192-1196. DOI:10.13517/j.cnki.ccm.2023.11.018.
[8] Li J, Xiao L, He D, et al. Mechanism of white matter injury and promising therapeutic strategies of mscs after intracerebral hemorrhage[J]. Front Aging Neurosci, 2021,13:632054. DOI: 10.3389/fnagi.2021.632054.
[9] Petersen NH, Sheth KN, Jha RM. Precision medicine in neurocritical care for cerebrovascular disease cases[J]. Stroke, 2023,54(5):1392-1402. DOI: 10.1161/STROKEAHA.122.036402.
[10] 朱文珍.推进人工智能在脑血管病精准诊疗中的应用[J].中华放射学杂志,2023,57(1):1-3.DOI:10.3760/cma.j.cn112149-20221111-00904.
[11] 杭春华.继往开来多轨并举推进脑血管病的精准化外科治疗[J]. 中国脑血管病杂志,2021,18(10):667-671. DOI:10.3969/j.issn.1672-5921.2021.10.002.
[12] 娄昕,王雪扬. 神经血管影像技术在脑血管病中的应用进展[J]. 国际医学放射学杂志,2023,46(2):125-130. DOI:10.19300/j.2023.S20520.
[13] Chen Z, Shi F, Zhang M, et al. Prediction of the multisegment clot sign on dynamic ct angiography of cardioembolic stroke[J]. AJNR Am J Neuroradiol, 2018,39(4):663-668. DOI: 10.3174/ajnr.A5549.
[14] Xu J, Rajah GB, Zhang H, et al. Imaging features of adult moyamoya disease patients with anterior intracerebral hemorrhage based on high-resolution magnetic resonance imaging[J]. J Cereb Blood Flow Metab, 2022,42(11):2123-2133. DOI: 10.1177/0271678X221111082.
[15] Wang Y, Li S, Pan Y, et al. Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial[J]. Lancet, 2023,401(10377):645-654. DOI: 10.1016/S0140-6736(22)02600-9.
[16] Zi W, Song J, Kong W, et al. Tirofiban for stroke without large or medium-sized vessel occlusion[J]. N Engl J Med, 2023,388(22):2025-2036. DOI: 10.1056/NEJMoa2214299.
[17] Liu X, Tao GZ. Effects of tirofiban on the reperfusion-related no-reflow in rats with acute myocardial infarction[J]. J Geriatr Cardiol, 2013,10(1):52-58. DOI: 10.3969/j.issn.1671-5411.2013.01.009.
[18] Zhang J, Zhang Y. The clinical effects of IABP pumps combined with tirofiban in the treatment of acute myocardial infarction and on patients' serum levels[J]. Am J Transl Res, 2021,13(8):9796-9801.
[19] Huo X, Ma G, Tong X, et al. Trial of endovascular therapy for acute ischemic stroke with large infarct[J]. N Engl J Med, 2023,388(14):1272-1283. DOI: 10.1056/NEJMoa2213379.
[20] Ma Y, Wang T, Wang H, et al. Extracranial-intracranial bypass and risk of stroke and death in patients with symptomatic artery occlusion: the CMOSS randomized clinical trial[J]. JAMA, 2023,330(8):704-714. DOI: 10.1001/jama.2023.13390.
[21] Wong AC, Devason AS, Umana IC, et al. Serotonin reduction in post-acute sequelae of viral infection[J]. Cell, 2023,186(22):4851-4867.e20. DOI: 10.1016/j.cell.2023.09.013.
[22] Chen HS, Cui Y, Zhou ZH, et al. Dual antiplatelet therapy vs alteplase for patients with minor nondisabling acute ischemic stroke: the ARAMIS randomized clinical trial[J]. JAMA, 2023,329(24):2135-2144. DOI: 10.1001/jama.2023.7827.
[23] Duperron MG, Knol MJ, Le Grand Q, et al. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease[J]. Nat Med, 2023,29(4):950-962. DOI: 10.1038/s41591-023-02268-w.
[24] Hu M, Li T, Ma X, et al. Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model[J]. Nat Commun, 2023,14(1):3945. DOI: 10.1038/s41467-023-39693-x.
[25] GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet, 2019,393(10184):1958-1972. DOI: 10.1016/S0140-6736(19)30041-8.
[26] Karam G, Agarwal A, Sadeghirad B, et al. Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis[J]. BMJ, 2023,380:e072003. DOI: 10.1136/bmj-2022-072003.
[27] Liu L, Li Z, Zhou H, et al. Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update[J]. Stroke Vasc Neurol, 2023,8(6):e3. DOI: 10.1136/svn-2023-002998.
[28] 周建国,符大勇,刘晓丽. 区域性动脉自旋标记技术在缺血性脑血管病灌注评估中的应用进展[J]. 国际医药卫生导报,2022,28(1):8-10. DOI:10.3760/cma.j.issn.1007-1245.2022.01.002.
[29] Yi HJ, Sung JH, Lee DH. Preliminary experience of neuroform atlas stenting as a rescue treatment after failure of mechanical thrombectomy caused by residual intracranial atherosclerotic stenosis[J]. J Korean Neurosurg Soc, 2021,64(2):198-206. DOI: 10.3340/jkns.2020.0146.
[30] Takayanagi A, Cheng PK, Feng L. A novel technique for stenting of intracranial stenosis using the Neuroform Atlas stent and Gateway balloon catheter[J]. Interv Neuroradiol, 2021,27(6):770-773. DOI: 10.1177/15910199211007295.
[31] Dabhi N, Mastorakos P, Sokolowski J, et al. Mechanical thrombectomy for the treatment of anterior cerebral artery occlusion: a systematic review of the literature[J]. AJNR Am J Neuroradiol, 2022,43(12):1730-1735. DOI: 10.3174/ajnr.A7690.

脑血管病的研究进展

Research progress of cerebrovascular diseases

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	曾宪虎李明李子龙项旭田慧李惠珠马龙杰方笑丽陈力唐冉. 中西医关于溃疡性结肠炎的研究进展 [J]. 国际医药卫生导报, 2024, 30(9): 1415-1418.
[2]	高雯雯张翔王红尹雁惠. 小肠细菌过度生长的治疗新进展 [J]. 国际医药卫生导报, 2024, 30(9): 1418-1421.
[3]	孙虓刘成霞王娜郝佳慧储琳琳栗成钰. 探讨胃“炎癌转化”中腐胺与巨噬细胞极化的关系 [J]. 国际医药卫生导报, 2024, 30(9): 1426-1429.
[4]	王文斌郭小花郑兆华郭曼孙力. 帕博利珠单抗联合白蛋白紫杉醇与卡培他滨方案治疗进展期胃癌患者的疗效评估 [J]. 国际医药卫生导报, 2024, 30(9): 1430-1434.
[5]	李纯杜巧婷刘令令. 初产妇产后缺乳中西医治疗研究进展 [J]. 国际医药卫生导报, 2024, 30(9): 1446-1449.
[6]	何祥琴杨芳丁国锋. 中成药相关肝损伤研究进展 [J]. 国际医药卫生导报, 2024, 30(9): 1450-1453.
[7]	杨寿娟张海涛崔明丽王建李洋程艳丽. Wnt信号通路在急性心肌梗死中的研究进展 [J]. 国际医药卫生导报, 2024, 30(8): 1291-1296.
[8]	邹皓珍杨佳席哲帆纪瑞董华. 单细胞RNA测序技术在肾病中的研究进展 [J]. 国际医药卫生导报, 2024, 30(8): 1307-1311.
[9]	邵爽郭纪伟孟玮. m⁶A及m⁵C甲基化修饰通过促进细胞增殖与转移影响癌症的发生和发展 [J]. 国际医药卫生导报, 2024, 30(8): 1316-1320.
[10]	赵博李思维邢甜高萍朱宏喆李敏. TRPV1通道在感染性疾病中的研究进展 [J]. 国际医药卫生导报, 2024, 30(7): 1057-1062.
[11]	李孟奇李朋杜刚强孙鸿朔张锴. 长骨骨不连的发病率及手术治疗研究进展 [J]. 国际医药卫生导报, 2024, 30(7): 1062-1066.
[12]	丁嘉雯李娜. ESBLs阳性肺炎克雷伯菌的研究进展 [J]. 国际医药卫生导报, 2024, 30(7): 1071-1074.
[13]	陈晓琳, 杨贞. HR-HPV载量与宫颈上皮内病变及宫颈癌相关性的研究进展 [J]. 国际医药卫生导报, 2024, 30(6): 932-935.
[14]	邹皓珍杨佳席哲帆纪瑞董华. 单细胞RNA测序应用于继发性肾病的研究进展 [J]. 国际医药卫生导报, 2024, 30(6): 936-940.
[15]	王宇威李瑞刘超梁葵香. 妊娠相关静脉血栓栓塞症的诊断和防治策略研究进展 [J]. 国际医药卫生导报, 2024, 30(6): 940-945.