关键词:

RNA甲基化修饰, 信号通路, N6-甲基腺苷, 5-甲基胞嘧啶, 癌症发生和发展, 进展

Abstract:

So far, more than 170 chemical modifications have been found in RNA. RNA methylation modification is an important post-transcriptional regulation process. N6-methyladenosine (m⁶A) and 5-methylcytosine (m⁵C) are ubiquitous in eukaryotes and prokaryotes. Additionally, more and more attention has been paid to the exploration of RNA methylation within regulating gene expression and regulating the cellular biological activity in the tumor cells. Furthermore, some known cell signal pathways involved in cellular proliferation and metastasis are closely related to cancers immunity and metabolic regulation, and these signal pathways play an important role in regulating organ size, tissue regeneration, and stem cell self-renewal, which ultimately affects the initiation and development of tumors. In this review, we discuss that the m⁶A and m⁵C methylation regulate the occurrence and development of cancers through some popular pathways in human cancers, which provides a new theoretical basis for understanding and seeking new therapeutic disease approaches.

Key words:

RNA methylation modification, Signal pathways, m⁶A, m⁵C, Initiation and development of cancers, Progress