综合护理干预在纳米微针治疗雄激素性脱发中的应用

doi:10.3760/cma.j.issn.1007-1245.2023.12.029

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (12): 1756-1759.DOI: 10.3760/cma.j.issn.1007-1245.2023.12.029

综合护理干预在纳米微针治疗雄激素性脱发中的应用

万长兰余泳杨坤霞沈秀玲吴慧李润祥李振洁

广州市皮肤病防治所中四门诊部，广州　510095

收稿日期:2023-02-13 出版日期:2023-06-15 发布日期:2023-06-26
通讯作者: 李振洁，Email：lizhen3564@163.com
基金资助:
广州市皮肤病防治所医药卫生科技项目（202101）；广州市中医药临床核心和特色诊疗技术建设项目（2023-00463）

Application of comprehensive nursing intervention in treatment of androgenetic alopecia with nano-microneedles

Wan Changlan, Yu Yong, Yang Kunxia, Shen Xiuling, Wu Hui, Li Runxiang, Li Zhenjie

Outpatient Department of Zhongshan Fourth Road, Guangzhou Institute of Dermatology, Guangzhou 510095, China

Received:2023-02-13 Online:2023-06-15 Published:2023-06-26
Contact: Li Zhenjie, Email: lizhen3564@163.com
Supported by:
Project of Medical and Health Science and Technology of Guangzhou Institute of Dermatology (202101); Construction Project of Clinical Core and Special Treatment and Diagnosis Technology of Traditional Chinese Medicine in Guangzhou (2023-00463)

摘要/Abstract

摘要：

目的　观察分析使用纳米微针导入5%米诺地尔酊治疗雄激素性脱发（AGA）患者时加强综合护理干预，患者治疗效果及焦虑抑郁情绪变化的情况。方法　选择2021年9月至2022年10月期间广州市皮肤病防治所中四门诊部收治的80例男性AGA患者，用随机数字表法将患者分为两组。对照组40例，年龄19～54（36.96±8.80）岁；观察组40例，年龄18～53（37.05±9.69）岁。两组均给予纳米微针导入5%米诺地尔酊治疗，对照组应用常规护理干预，观察组应用综合护理干预，对比两组患者治疗后临床疗效、新生毛发密度及粗度、焦虑抑郁评分，统计学方法采用t检验、χ²检验。结果　观察组总有效率为87.5%（35/40），高于对照组［67.5%（27/40）］，差异有统计学意义（χ²=4.59，P<0.05）；综合护理干预后，观察组头发数量高于对照组［（221.35±25.16）根/cm²比（204.38±28.12）根/cm²］，差异有统计学意义（t=2.84，P<0.05）；干预后，观察组焦虑自评量表（SAS）、抑郁自评量表（SDS）评分均低于对照组［（45.55±3.43）分比（48.20±4.71）分、（46.43±1.57）分比（49.33±4.23）分］，差异均有统计学意义（t=2.88、4.07，均P<0.05）。结论　综合护理干预能够有效缓解纳米微针治疗AGA患者的焦虑抑郁情绪，提升治疗效果。

关键词:

雄激素性脱发, 纳米微针, 综合护理干预, 焦虑, 抑郁

Abstract:

Objective　To observe and analyze the therapeutic effect and the changes of anxiety and depression in patients with androgenetic alopecia treated with 5% topical minoxidil introduced by nano-microneedles after strengthening comprehensive nursing intervention. Methods　Eighty male patients with androgenetic alopecia admitted to Outpatient Department of Zhongshan Fourth Road, Guangzhou Institute of Dermatology from September 2021 to October 2022 were selected and divided into a control group and an observation group by the random number table method, with 40 cases in each group. The control group were (36.96±8.80) years old, and the observation group (37.05±9.69). Both groups were treated with 5% topical minoxidil by nano-microneedles. The control group were given routine nursing intervention, and the observation group comprehensive nursing intervention. The clinical efficacies, densities and thicknesses of new hair, and anxiety and depression scores were compared between the two groups after the treatment. t and χ² tests were applied. Results　The total effective rate of the observation group was significantly higher than that of the control group [87.5% (35/40) vs. 67.5% (27/40)], with a statistical difference (χ²=4.59, P<0.05). After comprehensive nursing intervention, the number of hair in the control group was significantly higher than that in the observation group (221.35±25.16) pieces/cm² vs. (204.37±28.12) pieces/cm², with a statistical difference (t=2.84, P<0.05). After the intervention, the scores of Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) in the observation group were lower than those in the control group [(45.55±3.43) vs. (48.20±4.71) and (46.43±1.57) vs. (49.33±4.23)], with statistical differences (t=2.88 and 4.07; both P<0.05). Conclusions　Comprehensive nursing intervention can effectively alleviate the anxiety and depression of patients with androgenetic alopecia treated with nano-microneedles, and improve the therapeutic effect.

Key words:

Androgenetic alopecia, Comprehensive nursing intervention, Nano-microneedles, Anxiety, Depression

万长兰余泳杨坤霞沈秀玲吴慧李润祥李振洁.

综合护理干预在纳米微针治疗雄激素性脱发中的应用 [J]. 国际医药卫生导报, 2023, 29(12): 1756-1759.

Wan Changlan, Yu Yong, Yang Kunxia, Shen Xiuling, Wu Hui, Li Runxiang, Li Zhenjie.

Application of comprehensive nursing intervention in treatment of androgenetic alopecia with nano-microneedles [J]. International Medicine and Health Guidance News, 2023, 29(12): 1756-1759.

参考文献

[1] Wang TL,Zhou C,Shen YW,et al.Prevalence of androgenetic alopecia in China: a community-based study in six cities[J].Br J Dermatol,2010,162(4):843-847.DOI:10.1111/j.1365-2133.2010.09640.x.
[2] Xu F,Sheng YY,Mu ZL,et al.Prevalence and types of androgenetic alopecia in Shanghai, China: a community-based study[J].Br J Dermatol,2009,160(3):629-632.DOI:10.1111/j.1365-2133.2008.08909.x.
[3] 张建中.中国雄激素性秃发诊疗指南[J].临床皮肤科杂志,2014,43(3):182-186.DOI:10.16761/j.cnki.1000- 4963.2014.03.025.
[4] Adil A,Godwin M.The effectiveness of treatments for androgenetic alopecia: a systematic review and meta-analysis[J].J Am Acad Dermatol,2017,77(1):136-141.e5.DOI:10.1016/j.jaad.2017.02.054.
[5] 周城,张建中.中国雄激素性秃发诊疗指南BASP分型法解读[J].皮肤病与性病,2016,38(5):325-327.DOI:10.3969/j.issn.1002-1310.2016.05.006.
[6] 张凡,冯巾娣,杨一诺,等.电动微针联合中药提取物在中重度雄激素性脱发长期治疗的疗效观察[J].中国医疗美容,2022,12(6):40-43.DOI:10.19593/j.issn.2095-0721. 2022.06.010.
[7] 中国医师协会美容与整形医师分会毛发整形美容专业委员会.中国人雄激素性脱发诊疗指南[J].中国美容整形外科杂志,2019,30(1):前插2-前插6.DOI:10.3969/j.issn.1673-7040.2019.01.001.
[8] 周亚光,于水,赵纪敏,等.A型肉毒毒素治疗雄激素性脱发的临床研究[J].中国美容医学,2021,30(5):101-103.DOI:10.15909/j.cnki.cn61-1347/r.004413.
[9] Nyholt DR,Gillespie NA,Heath AC,et al.Genetic basis of male pattern baldness[J].J Invest Dermatol,2003,121(6):1561-1564.DOI:10.1111/j.1523-1747.2003.12615.x.
[10] Lee J,Rabbani CC,Gao H,et al.Hair-bearing human skin generated entirely from pluripotent stem cells[J].Nature,2020,582(7812):399-404.DOI:10.1038/s41586- 020-2352-3.
[11] Gorzelanny C,Mess C,Schneider SW,et al.Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?[J].Pharmaceutics,2020,12(7):684.DOI:10.3390/pharmaceutics12070684.
[12] Lee JC,Daniels MA,Roth MZ.Mesotherapy, microneedling, and chemical peels[J].Clin Plast Surg,2016,43(3):583-595.DOI:10.1016/j.cps.2016.03.004.
[13] Ramaut L,Hoeksema H,Pirayesh A,et al.Microneedling:Where do we stand now? A systematic review of the literature[J].J Plast Reconstr Aesthet Surg,2018,71(1):1-14.DOI:10.1016/j.bjps.2017.06.006.
[14] 钟勤.综合护理干预措施对慢性粒细胞白血病患者生活质量的影响[J].中华现代护理杂志,2013,19(8):928-931.DOI:10.3760/cma.j.issn.1674-2907.2013.08.020.
[15] 周海英.综合护理干预对带状疱疹患者心理健康及生活质量的影响[J].河北中医,2016,38(8):1257-1259.DOI:10.3969/j.issn.1002-2619.2016.08.037.
[16] 徐敏.综合护理干预对慢性荨麻疹患者心理状态及生活质量的影响[J].齐齐哈尔医学院学报,2017,38(1):124,封3.DOI:10.3969/j.issn.1002-1256.2017.01.061.
[17] 文兴禄.玫瑰痤疮患者的临床护理效果观察[J].家庭医药,2019(11):300.
[18] 张雪洋,谢宜彤,夏志宽,等.综合护理干预对玫瑰痤疮光电治疗后的临床观察[J].心理月刊,2020,15(18):163-165.DOI:10.19738/j.cnki.psy.2020.18.072.
[19] 卢换香,冼志峰,肖改欢.综合护理干预在先天性耳前瘘管反复感染中的影响效果[J].国际医药卫生导报,2022,28(13):1903-1907.DOI:10.3760/cma.j.issn.1007-1245. 2022.13.026.

综合护理干预在纳米微针治疗雄激素性脱发中的应用

Application of comprehensive nursing intervention in treatment of androgenetic alopecia with nano-microneedles

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