关键词:

肺癌根治术, 阿普唑仑, 焦虑, 药物不良反应

Abstract:

Objective　To observe the effect of alprazolam in radical operation of lung cancer and its effects on preoperative anxiety and postoperative stress response. Methods　This was a prospective randomized controlled trial. A total of 125 patients with lung cancer who received radical resection in The First Affiliated Hospital of Henan University from October 2020 to December 2022 were selected as the subjects, and were divided into two groups by the lottery method. In the control group, there were 42 males and 20 females, aged (60.44±5.36) years. In the observation group, there were 40 males and 23 females, aged (61.25±5.41) years. The control group only received routine intervention, and the observation group received alprazolam tablets assisted surgical treatment before surgery. The preoperative psychological state, preoperative and postoperative stresses, postoperative recovery, and occurrence of adverse drug reactions were compared between the two groups. Independent sample t test, χ² test, and Fisher exact probability method were used for statistical analysis.  Results　The scores of preoperative Self-rating Anxiety Scale (SAS) and state anxiety and trait anxiety of the State-Trait Anxiety Inventory (STAI) in the observation group were lower than those in the control group [(41.22±5.76) points vs. (44.49±5.33) points, (40.36±5.33) points vs. (44.46±5.49) points, (41.35±5.46) points vs. (45.11±5.47) points], with statistically significant differences (t=3.293, 4.237, and 3.846; all P<0.05). Before surgery, there were no statistically significant differences in the stress indexes between the two groups (all P>0.05). After surgery, the levels of norepinephrine (NE), cortisol (Cor), and prolactin (PRL) in the observation group were lower than those in the control group [(4.32±1.06) mg/kg vs. (5.77±1.36) mg/kg, (376.45±50.61) nmol/L vs. (405.33±50.12) nmol/L, (14.23±5.16) mmol/L vs. (17.44±5.28) mmol/L], with statistically significant differences (t=6.655, 3.205, and 3.438; all P<0.05). After surgery, the Visual Analog Scale (VAS) score [(4.11±1.24) points vs. (5.63±1.27) points], intrathoracic drainage volume within 24 after surgery [(88.45±10.47) ml vs. (93.11±10.36) ml], extubation time [(3.61±1.22) d vs. (4.77±1.48) d], and length of hospital stay [(6.64±1.23) d vs. (7.88±1.46) d] in the observation group were all lower than those in the control group, with statistically significant differences (t=6.771, 2.501, 4.785, and 5.174; all P<0.05). The incidence of drug-related adverse reactions in the observation group was slightly higher than that in the control group [6.35% (4/63) vs. 4.84% (3/62)], but the difference was not statistically significant (P>0.05). Conclusion　Alprazolam assisted radical resection of lung cancer can reduce the patients' preoperative anxiety level and postoperative stress response, which is conducive to the patients' postoperative rehabilitation and does not increase the incidence of adverse reactions.

Key words:

Radical resection of lung cancer, Alprazolam, Anxiety, Adverse drug reactions