关键词: 消化性溃疡伴出血, 注射用艾普拉唑钠, 炎性反应, 血液指标, 免疫功能, 药物不良反应

Abstract: Objective　To observe the clinical effect of ilaprazole injection on peptic ulcer patients with hemorrhage. Methods　It was a retrospective study. The study randomly selected 135 patients with peptic ulcer and hemorrhage from Pingdingshan Second People's Hospital from July 2020 to January 2022. After analyzing the patients' medical records, the patients were divided into a study group [68 cases, 36 males and 32 females, aged (50.45±2.31) years, ilaprazole adjuvant treatment] and a control group [67 cases, 37 males and 30 females, aged (50.16±2.72) years, endoscopic hemostasis + basic drugs]. The treatment efficiencies, ulcer healing time, abdominal pain and fever symptom relief time, hemostasis success rates, re-bleeding rates, and adverse reaction rates of the two groups were compared. Independent sample t test was used for the measurement data, and χ² test was used for the count data. Results　After treatment, the effective rate of the study group was 95.59% (65/68), which was higher than that of the control group [85.07% (57/67)], with a statistically significant difference (χ²=4.287, P=0.038). After treatment, there was no statistically significant difference in the hemostatic time between the two groups (P>0.05); the ulcer healing time, antipyretic time, and abdominal pain relief time in the study group [(2.21±0.35) d, (1.45±0.16) d, and (1.17±0.26) d] were lower than those in the control group [(3.44±0.72) d, (2.05±0.33) d, and (1.92±0.33) d], with statistically significant differences (all P<0.05). The success rate of hemostasis in the study group was 91.18% (62/68), which was higher than that in the control group [77.61% (52/67)] (χ²=6.991, P=0.008), and the re-bleeding rate was 3.23% (2/62), which was lower than that in the control group [19.23% (10/52)] (χ²=12.840, P<0.001). After treatment, there was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions　Ilaprazole sodium for injection can play a good auxiliary effect in patients with peptic ulcer and hemorrhage after receiving routine hemostasis and basic medication, and it can achieve the rapid hemostasis, promote the ulcer healing, achieve the complete hemostasis, and reduce the risk of re-bleeding. This drug has no serious adverse reactions in patients, with high safety, which is worthy of promotion.

Key words: Peptic ulcer with hemorrhage, Ilaprazole injection, Inflammatory reaction, Blood indexes, Immunity, Adverse drug reactions