关键词:

冠脉支架植入术, 冠心病, 血管内皮功能, 预后, 冠心Ⅱ号方颗粒

Abstract:

Objective　To investigate the effects of Guanxin Ⅱ granules on vascular endothelial function and prognosis in patients after coronary stenting. Methods　From March 1, 2021 to February 28, 2022, 120 patients with coronary heart disease after coronary stenting in Shunde Hospital of Guangzhou University of Traditional Chinese Medicine were selected and were divided into two groups by the random number table method, with 60 cases in each group. There were 32 males and 28 females in the control group, aged (52.34±7.86) years. There were 35 males and 25 females in the research group, aged (51.63±8.42) years. The control group was treated with conventional western medicine after operation, and the research group took Guanxin Ⅱ granules on the basis of the control group for 6 months. The efficacies of the two groups and the changes of traditional Chinese medicine (TCM) syndrome score, Seattle Angina Questionnaire (SAQ) score, flow-mediated humeral artery endothelial-dependent diastolic function (FMD value), serum nuclear transcription factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), nitric oxide (NO), and endothelin-1 (ET-1) before and after treatment were evaluated. Both groups were observed until 6 months after operation to record the incidences of in-stent restenosis (ISR) and major adverse cardiovascular events (MACE). The statistical methods used were independent sample t test, paired t test, and χ² test. Results　The total effective rate of the research group was higher than that of the control group [91.67% (55/60) vs. 73.33% (44/60)], with a statistically significant difference (χ²=6.984, P=0.008). After treatment, the SAQ score, FMD value, and serum NO level in both groups were higher than those before treatment, the TCM syndrome score and serum NF-κB, TNF-α, IL-6, and ET-1 levels were lower than those before treatment, and the improvement was more significant in the research group (all P<0.05). Six months after surgery, the incidences of ISR [1.67% (1/60) vs. 13.33% (8/60)] and MACE [5.00% (3/60) vs. 16.67% (10/60)] in the research group were lower than those in the control group (χ²=4.324, P=0.038; χ²=4.227, P=0.040). Conclusion　Guanxin Ⅱ granules are effective after coronary stenting, which can effectively inhibit the inflammation, improve the vascular endothelial function, relieve the clinical symptoms, reduce the risk of MACE and ISR after operation, and thus improve the prognosis.

Key words:

Coronary stenting, Coronary heart disease, Vascular endothelial function, Prognosis, Guanxin Ⅱ , granules