国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (9): 1197-1200..DOI: 10.3760/cma.j.issn.1007-1245.2023.09.004

• 医学新进展 • 上一篇    下一篇

骨肉瘤临床治疗现状与创新疗法研究进展

詹泽宇  林思恩  魏波   

  1. 广东医科大学附属医院骨科中心,湛江 524001

  • 收稿日期:2022-12-28 出版日期:2023-05-01 发布日期:2023-05-21
  • 通讯作者: 魏波,Email:webjxmc@163.com
  • 基金资助:

    国家自然科学基金(81874000);广东省自然科学基金(2020A1515010003);广东医科大学附属医院高水平医院建设登峰计划”2019年项目(广东医财政发[201960号)

Research progress on clinical treatment and innovative therapy of osteosarcoma

Zhan Zeyu, Lin Sien, Wei Bo   

  1. Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China

  • Received:2022-12-28 Online:2023-05-01 Published:2023-05-21
  • Contact: Wei Bo, Email: webjxmc@163.com
  • Supported by:

    National Natural Science Foundation of China (81874000); Natural Science Foundation of Guangdong Province (2020A1515010003); The 2019 Project of "Peak Climbing Plan" for High-Level Hospital Construction of Affiliated Hospital of Guangdong Medical University ([2019]60)

摘要:

骨肉瘤(osteosarcomaOS)是一种发生在骨组织中的高度恶性肿瘤,具有很高的转移倾向,其潜在机制在很大程度上仍不清楚。OS临床治疗预后较差,提高OS患者的生存率仍然是一个挑战。近年来,随着分子生物学和组织生物工程的发展,治疗方法也取得了迅速的进步,特别是在综合保肢治疗方面,显著提高了术后生活质量,提高了恶性肿瘤患者的5年生存率。本文对OS从手术、化学疗法和免疫疗法等方面进行综述,为当前OS的临床治疗提供参考。

关键词:

骨肉瘤, 临床治疗, 预后

Abstract:

Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high tendency to metastasize, the underlying mechanism of which is still largely unknown. Clinical treatment of OS has a poor prognosis, and improving the survival rate in patients with OS remains a challenge. In recent years, with the development of molecular biology and tissue bioengineering, treatment methods have also made rapid progress, especially in the aspect of comprehensive limb salvage therapy, which significantly improves the postoperative quality of life and 5-year survival rate in patients with malignant tumors. This article reviews the surgical method, chemotherapy, and immunotherapy of OS, to provide reference for the current clinical treatment of OS.

Key words:

Osteosarcoma, Clinical treatment, Prognosis