慢性肾脏病非透析患者服药依从性现状及其影响因素研究

doi:10.3760/cma.j.issn.1007-1245.2022.17.010

国际医药卫生导报 ›› 2022, Vol. 28 ›› Issue (17): 2414-2419.DOI: 10.3760/cma.j.issn.1007-1245.2022.17.010

慢性肾脏病非透析患者服药依从性现状及其影响因素研究

白荷荷¹ 姜明欢² 彭莉蓉¹ 聂晓静¹ 王金萍¹ 马莉¹ 夏丽¹

¹西安市中心医院药剂科，西安　710003； ²西安交通大学药品安全与政策研究中心，西安　710061

收稿日期:2022-06-09 出版日期:2022-09-01 发布日期:2022-10-11
通讯作者: 彭莉蓉，Email：2725433862@qq.com
基金资助:
陕西省科技项目（2020JQ-933）；

陕西省科技项目（2020JQ-079）；

西安市科技项目（20YXYJ00012）；

西安市中心医院科研项目（2022YB06）

Current status and influencing factors of medication adherence in patients with non-dialysis chronic kidney disease

Bai Hehe¹, Jiang Minghuan², Peng Lirong¹, Nie Xiaojing¹, Wang Jinping¹, Ma Li¹, Xia Li¹

¹Department of Pharmacy, Xi'an Central Hospital, Xi'an 710003, China; ²Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an 710061, China

Received:2022-06-09 Online:2022-09-01 Published:2022-10-11
Contact: Peng Lirong, Email: 2725433862@qq.com
Supported by:
Project of Science and Technology in Shaanxi (2020JQ-933);

Project of Science and Technology in Shaanxi (2020JQ-079);

Project of Science and Technology in Xi'an (20YXYJ00012);

Scientific Research Project of Xi'an Central Hospital (2022YB06)

摘要/Abstract

摘要： 目的　了解慢性肾脏病（CKD）非透析患者服药依从性现状，探讨分析其服药依从性的影响因素。方法　采用便利抽样法，选取2020年1月至2021年12月西安市中心医院收治的CKD非透析患者为研究对象。应用一般资料调查表、服药依从性量表、服药信念量表、多维领悟社会支持量表及医院焦虑抑郁量表对患者进行横断面问卷调查，采用单因素分析及多因素logistic回归分析CKD非透析患者服药依从性的影响因素。结果　共纳入342例CKD非透析患者，男性185例，女性157例，年龄（63.6±24.7）岁，服药依从性评分为（6.02±1.54）分，低依从性患者141例（41.23%）、中/高依从性患者201例（58.77%）。多因素分析显示，服药种数、CKD分期、药物不良反应经历、服药信念、社会支持、焦虑及抑郁是CKD非透析患者服药依从性的影响因素（均P<0.05）。结论　CKD非透析患者服药依从性现状不理想，医务人员应根据影响依从性的关键因素有针对性地采取干预措施，以提高其服药依从性、延缓CKD进展。

关键词: 慢性肾脏病, 服药依从性, 服药信念, 社会支持, 焦虑, 抑郁, 影响因素

Abstract: Objective　To investigate the status of medication adherence in patients with non-dialysis chronic kidney disease (CKD) and analyze the influencing factors. Methods　From January 2020 to December 2021, convenience sampling was used to select the non-dialysis CKD patients admitted to Xi'an Central Hospital as the research objects. A cross-sectional questionnaire survey was conducted with the General Data Questionnaire, 8-Item Morisky Medication Adherence Scale, Beliefs about Medicines Questionnaire, Multidimensional Scale of Perceived Social Support, and Hospital Anxiety and Depression Scale. Univariate analysis and multivariate logistic regression were used to analyze the influencing factors of medication adherence in the non-dialysis CKD patients. Results　A total of 342 non-dialysis CKD patients were enrolled, including 185 males and 157 females, and they were (63.6±24.7) years old. The medication adherence score was (6.02±1.54), including 141 patients with low adherence (41.23%) and 201 patients with moderate or high adherence (58.77%). Multivariate analysis showed that the number of drugs, CKD stage, experience of adverse drug reactions, belief about medication, social support, anxiety, and depression were the influencing factors of medication adherence in the non-dialysis CKD patients (all P<0.05). Conclusions　The status of medication adherence of non-dialysis CKD patients is still not ideal. Medical staff should take targeted intervention measures according to the key factors influencing adherence to improve their medication adherence and delay the progress of CKD.

Key words: Chronic kidney disease, Medication adherence, Belief about medication, Social support, Anxiety, Depression, Influencing factors

白荷荷姜明欢彭莉蓉聂晓静王金萍马莉夏丽. 慢性肾脏病非透析患者服药依从性现状及其影响因素研究[J]. 国际医药卫生导报, 2022, 28(17): 2414-2419.

Bai Hehe, Jiang Minghuan, Peng Lirong, Nie Xiaojing, Wang Jinping, Ma Li, Xia Li. Current status and influencing factors of medication adherence in patients with non-dialysis chronic kidney disease[J]. International Medicine and Health Guidance News, 2022, 28(17): 2414-2419.

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慢性肾脏病非透析患者服药依从性现状及其影响因素研究

Current status and influencing factors of medication adherence in patients with non-dialysis chronic kidney disease

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