阻塞性睡眠呼吸暂停低通气综合征与肠道菌群关系的研究进展

doi:10.3760/cma.j.issn.1007-1245.2024.10.001

摘要/Abstract

摘要：

阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是一种在睡眠时发生间歇性缺氧和复氧损伤的呼吸疾病。OSAHS与肠道菌群密切相关，可诱发肠道菌群紊乱、肠道代谢产物改变、肠道屏障受损和全身炎症反应；反过来，肠道菌群紊乱又可促进OSAHS进展，然而相关机制尚未完全阐明。本文就OSAHS与肠道菌群的相关研究进展进行综述。

关键词:

阻塞性睡眠呼吸暂停, 低通气, 肠道菌群, 进展

Abstract:

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a respiratory disorder characterized by intermittent hypoxia and impaired reoxygenation that manifests during sleep. Researches have demonstrated a significant association between OSAHS and gut well-being, as it has the potential to disrupt the gut microbiome, modify the gut metabolites, compromise the integrity of the intestinal barrier, and trigger the systemic inflammation. This article provides a comprehensive review of the current research advancements pertaining to the relationship between OSAHS and gut microflora, and highlighting the potential role of disturbances in gut microflora in the progression of OSAHS, albeit with an incomplete understanding of the underlying mechanisms.

Key words:

Obstructive sleep apnea, Hypopnea, Gut microflora, Progress

卢曼路朱继伟丁红红于燕潘磊.

阻塞性睡眠呼吸暂停低通气综合征与肠道菌群关系的研究进展 [J]. 国际医药卫生导报, 2024, 30(10): 1585-1589.

Lu Manlu, Zhu Jiwei, Ding Honghong, Yu Yan, Pan Lei.

Research progress on the relationship between obstructive sleep apnea hypopnea syndrome and gut microflora [J]. International Medicine and Health Guidance News, 2024, 30(10): 1585-1589.

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