干眼与抑郁的相关性研究进展

doi:10.3760/cma.j.issn.1007-1245.2024.23.009

摘要/Abstract

摘要：

干眼是以泪膜不稳定为核心特征的多因素眼表疾病，发病率呈逐年上升趋势，其带来的眼部不适和视力障碍对患者工作和生活产生严重影响，进而导致心理健康问题。而抑郁是一种常见的情感障碍类疾病，其发病率也呈不断上升趋势，己成为当前重要健康问题。与一般人群相比，干眼症和抑郁症之间存在显著双向关系，同时抗抑郁药物也与干眼的发生发展有关。因此，本文对干眼与抑郁的相关性进行总结分析。

关键词:

干眼, 抑郁, 抗抑郁药物, 进展

Abstract:

Dry eye is a multifactorial ocular surface disease with tear film instability as its core feature. Its incidence rate is increasing year by year. The eye discomfort and visual impairment caused by dry eyes have a serious impact on the patients' work and life. Depression is a common affective disorder, and its incidence rate is also on the rise. Depression has become an important health and social problem at present. Depression is more common in patients with dry eyes than in general population, and dry eyes is also more common in depressed patients. At the same time, antidepressants are also related to the occurrence and development of dry eyes. Therefore, this article summarizes and analyzes these possible related factors, so as to study the correlation between dry eyes and depression and make a brief review.

Key words:

Dry eyes, Depression, Anti-depressants, Progress

王磊高洪莲张凤一孙瑞婷张磊.

干眼与抑郁的相关性研究进展 [J]. 国际医药卫生导报, 2024, 30(23): 3925-3928.

Wang Lei, Gao Honglian, Zhang Fengyi, Sun Ruiting, Zhang Lei.

Correlation between dry eyes and depression [J]. International Medicine and Health Guidance News, 2024, 30(23): 3925-3928.

参考文献

[1] Rouen PA, White ML. Dry eye disease: prevalence, assessment, and management[J]. Home Healthc Now,2018,36(2):74-83.DOI:10.1097/NHH.000000000- 0000652.
[2] Papas EB. The global prevalence of dry eye disease: a bayesian view[J]. Ophthalmic Physiol Opt,2021,41(6):1254-1266.DOI:10.1111/opo.12888.
[3] The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop (2007)[J].Ocul Surf,2007,5(2):75-92.DOI:10.1016/s1542-0124(12)70081-2.
[4] 王华,刘祖国. 亚洲干眼协会干眼共识解读[J]. 中华实验眼科杂志,2020,38(10):871-876.DOI:10.3760/cma.j.cn115989-20200828-00614.
[5] 梁春波,郝少峰. 干眼与焦虑及抑郁相关性的研究进展[J]. 基层医学论坛,2019,23(10):1455-1457.DOI:10.19435/j.1672-1721.2019.10.078.
[6] Craig JP, Nichols KK, Akpek EK, et al. Tfos dews II definition and classification report[J].Ocul Surf,2017,15(3):276-283.DOI:10.1016/j.jtos.2017.05.008.
[7] 赵磊,杨笑薇,左韬,等. 杞参方对高渗诱导的干眼模型角膜上皮细胞保护机制的研究[J]. 中国医科大学学报,2022,51(1):12-16,22.DOI:10.12007/j.issn.0258-4646.2022. 01.003.
[8] Vieira GCF, Rodrigues BRO, Cunha CEXD, et al. Depression and dry eye: a narrative review[J].Rev Assoc Med Bras (1992),2021,67(3):462-467.DOI:10.1590/1806-9282. 20200888.
[9] Tsubota K, Yokoi N, Shimazaki J, et al. New perspectives on dry eye definition and diagnosis: a consensus report by the asia dry eye society[J].Ocul Surf,2017,15(1):65-76.DOI:10.1016/j.jtos.2016.09.003.
[10] Weatherby TJM, Raman VRV, Agius M. Depression and dry eye disease: a need for an interdisciplinary approach?[J].Psychiatr Danub,2019,31(Suppl 3):619-621.
[11] Bitar MS, Olson DJ, Li M, et al. The correlation between dry eyes, anxiety and depression: the sicca, anxiety and depression study[J].Cornea,2019,38(6):684-689.DOI:10.1097/ICO.0000000000001932.
[12] 高贵元,黄捷,刘丹,等. 抑郁症的发病机制及抗抑郁药物的研究进展[J]. 中国医药导报,2021,18(1):52-55,70.
[13] McCarron RM, Shapiro B, Rawles J, et al. Depression[J].Ann Intern Med,2021,174(5):ITC65-ITC80.DOI:10.7326/AITC202105180.
[14] Zheng Y, Wu X, Lin X, et al. The prevalence of depression and depressive symptoms among eye disease patients: a systematic review and meta-analysis[J].Sci Rep,2017,7:46453.DOI:10.1038/srep46453.
[15] Willcox MDP, Argüeso P, Georgiev GA, et al. Tfos dews II tear film report[J].Ocul Surf,2017,15(3):366-403.DOI:10.1016/j.jtos.2017.03.006.
[16] 刘祖国,王华. 关注干眼慢性疾病管理体系的建设[J]. 中华眼科杂志,2018,54(2):81-83.DOI:10.3760/cma.j.issn. 0412-4081.2018.02.001.
[17] Aleman A, Denys D. Mental health: a road map for suicide research and prevention[J].Nature,2014,509(7501):421-423.DOI:10.1038/509421a.
[18] Cozine EW, Wilkinson JM. Depression screening, diagnosis, and treatment across the lifespan[J].Prim Care,2016,43(2):229-243.DOI:10.1016/j.pop.2016.02.004.
[19] Kawashima M, Uchino M, Yokoi N, et al. Associations between subjective happiness and dry eye disease: a new perspective from the Osaka study[J].PLoS One,2015,10(4):e0123299.DOI:10.1371/journal.pone.0123299.
[20] Kaiser T, Janssen B, Schrader S, et al. Depressive symptoms, resilience, and personality traits in dry eye disease[J].Graefes Arch Clin Exp Ophthalmol,2019,257(3):591-599.DOI:10.1007/s00417-019-04241-1.
[21] Kaido M, Arita R, Mitsukura Y, et al. Autonomic nerve activity features according to dry eye type[J].Invest Ophthalmol Vis Sci,2023,64(7):19.DOI:10.1167/iovs.64.7.19.
[22] Hyon JY, Yang HK, Han SB. Association between dry eye disease and psychological stress among paramedical workers in Korea[J].Sci Rep,2019,9(1):3783.DOI:10.1038/s41598-019-40539-0.
[23] 杜向红,梁庆丰. 干眼患者心理障碍的研究进展[J]. 中华眼科杂志,2016,52(3):226-230.DOI:10.3760/cma.j.issn. 0412-4081.2016.03.017.
[24] Roy NS, Wei Y, Kuklinski E, et al. The growing need for validated biomarkers and endpoints for dry eye clinical research[J].Invest Ophthalmol Vis Sci,2017,58(6):BIO1-BIO19.DOI:10.1167/iovs.17-21709.
[25] Lee SY, Han SJ, Nam SM, et al. Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patients[J].Am J Ophthalmol,2013,156(2):247-253.e1.DOI:10.1016/j.ajo.2013.04.003.
[26] Makhija K, Karunakaran S. The role of inflammatory cytokines on the aetiopathogenesis of depression[J].Aust N Z J Psychiatry,2013,47(9):828-839.DOI:10.1177/0004867413488220.
[27] 孙飒,张俊杰. 抑郁症与干眼关系研究进展[J]. 眼科新进展,2016,36(11):1090-1093.DOI:10.13389/j.cnki.rao. 2016.0291.
[28] Zhang X, Yin Y, Yue L, et al. Selective serotonin reuptake inhibitors aggravate depression-associated dry eye via activating the NF-κB pathway[J].Invest Ophthalmol Vis Sci,2019,60(1):407-419.DOI:10.1167/iovs.18-25572.
[29] Chhadva P, Lee T, Sarantopoulos CD, et al. Human tear serotonin levels correlate with symptoms and signs of dry eye[J].Ophthalmology,2015,122(8):1675-1680.DOI:10.1016/j.ophtha.2015.04.010.
[30] Imada T, Nakamura S, Hisamura R, et al. Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor[J].Sci Rep,2017,7(1):6965.DOI:10.1038/s41598-017-06022-4.
[31] Yang Y, Ding R, Hu D, et al. Reliability and validity of a Chinese version of the HADS for screening depression and anxiety in psycho-cardiological outpatients[J].Compr Psychiatry,2014,55(1):215-220.DOI:10.1016/j.comppsych.2013.08.012.
[32] Katipoğlu Z, Abay RN. The relationship between dry eye disease and anticholinergic burden[J].Eye (Lond),2023,37(14):2921-2925.DOI:10.1038/s41433-023-02442-x.
[33] 梁庆丰,韦振宇. 关注干眼患者的心理问题[J]. 眼科,2020,29(3):166-168.DOI:10.13281/j.cnki.issn.1004-4469. 2020.03.002.
[34] Wen W, Wu Y, Chen Y, et al. Dry eye disease in patients with depressive and anxiety disorders in Shanghai[J].Cornea,2012,31(6):686-692.DOI:10.1097/ICO.0b013e3182261590.
[35] 葛薇,盛文燕,许琦彬,等. 选择性5-羟色胺再摄取抑制剂类抗抑郁药舍曲林对产后抑郁患者眼表功能影响[J]. 中国临床药理学与治疗学,2020,25(4):440-446.DOI:10.12092/j.issn.1009-2501.2020.04.014.
[36] Basilious A, Xu CY, Malvankar-Mehta MS. Dry eye disease and psychiatric disorders: a systematic review and meta-analysis[J].Eur J Ophthalmol,2022,32(4):1872-1889.DOI:10.1177/11206721211060963.
[37] Wu M, Liu X, Han J, et al. Association between sleep quality, mood status, and ocular surface characteristics in patients with dry eye disease[J].Cornea,2019,38(3):311-317.DOI:10.1097/ICO.0000000000001854.
[38] Li S, Ning K, Zhou J, et al. Sleep deprivation disrupts the lacrimal system and induces dry eye disease[J].Exp Mol Med,2018,50(3):e451.DOI:10.1038/emm.2017.285.
[39] Zibandeh N, Yıldız E, Özer B, et al. Androgen suppresses hyperosmolarity-induced inflammatory mediators in human corneal epithelial cells[J].Cornea,2020,39(7):886-891.DOI:10.1097/ICO.0000000000002291.
[40] Lim EWL, Chee ML, Sabanayagam C, et al. Relationship between sleep and symptoms of tear dysfunction in Singapore malays and Indians[J].Invest Ophthalmol Vis Sci,2019,60(6):1889-1897.DOI:10.1167/iovs.19-26810.