关键词:

败血症, 电针疗法, 氧化应激, 胆碱能抗炎通路, 进展

Abstract:

Sepsis is a disease in which the body loses control of infection and triggers systemic inflammation, which leads to organ dysfunction. In serious cases, multiple organ dysfunction syndrome (MODS) can be included. According to previous studies, approximately 48.90 million cases of sepsis occurred in 2017, of whom approximately 11.00 million resulted in related deaths, accounting for 19.7% of all deaths worldwide. Although the incidence and mortality related to septicemia has decreased since 1990, sepsis remains one of the major threats to human health worldwide. The latest epidemiology shows that there are 47.00 million to 50.00 million cases of sepsis worldwide each year, of whom 11.00 million die each year at least, and one in five deaths worldwide is related to sepsis. Although the treatment of sepsis has made great progress, such as fluid resuscitation, early application of antibiotics, organ support, and drug therapy, the mortality rate of sepsis is still high. The pathogenesis of sepsis is mainly related to excessive inflammatory response and oxidative stress. Sepsis makes the body lose the balance between pro-inflammatory response and anti-inflammatory response. Excessive inflammatory response leads to the formation of "inflammatory storm", and the mass production and release of inflammatory cytokines [such as tumor necrosis factor (TNF) -α, interleukin (IL) -1, etc.]. Sepsis also causes the imbalance of redox homeostasis in the body towards a pro-oxidation state, mitochondrial dysfunction, and excessive production of reactive oxygen species (ROS). A large number of inflammatory cytokines and ROS can cause systemic inflammatory response syndrome (SIRS), gradually destroying body tissues and organs, and eventually leading to the occurrence of MODS. In recent years, with the rise of electroacupuncture therapy, researches about electroacupuncture stimulation of some acupoints in the treatment of sepsis and related diseases become more and more, and electroacupuncture has a very broad prospects in clinical development. Now the regulations of electroacupuncture stimulation on sepsis and related diseases are summarized, in order to provide a more clear direction for the treatment of sepsis and related diseases.

Key words:

Sepsis, Electroacupuncture, Oxidative stress, Cholinergic anti-inflammatory pathway, Progress