关键词:

慢性萎缩性胃炎, 健脾消萎汤, 胃功能, 生长因子, 蛋白激酶B, 脾相关酪氨酸激酶

Abstract:

Objective　To explore the efficacy of Jianpi Xiaowei Tang combined with Western medicine for patients with chronic atrophic gastritis and precancerous lesions and its effect on the expression of protein kinase B (AKT) and spleen tyrosine kinase (SYK). Methods　From October 2020 to April 2022, 90 patients treated at Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine were selected for the randomized controlled trial, and were divided into a study group and a control group by the random number table method, with 45 cases in each group. There were 24 males and 21 females in the control group; they were (53.89±5.23) years old; their disease curse was (5.54±3.01) years. There were 22 males and 23 females in the study group; they were (54.32±5.45) years old; their disease curse was (5.67±2.88) years. The control group orally took rebamipide tablets and mosapride citrate tablets; in addition, the study group took Jianpi Xiaowei Tang; both groups were treated for 12 weeks. The traditional Chinese medicine symptom scores, gastric mucosal lesion scores, gastric function indicators [gastric pepsinogen I (PGI), gastric pepsinogen Ⅱ (PGⅡ), and gastrin-17 (G-17)], oxidative stress markers [acetaldehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px)], growth factors [vascular endothelial growth factor, (VEGF), epidermal growth factor (EGF), transforming growth factor alpha (TGF-α), and transforming growth factor beta 1 (TGF-β1)], and the expressions of AKT and SYK were compared between the two groups. t and χ² tests were applied. Results　After the treatment, the traditional Chinese medicine symptom scores (t=2.948, 2.058, 2.229, 2.330, and 2.829; all P<0.05) and gastric mucosal lesion scores (t=3.673, 4.189, and 5.328; all P<0.05) in the study group were lower than those in the control group; the levels of PGI, PGⅡ, and G-17 in the study group were higher than those in the control group (t=9.399, 6.757, and 2.056; all P<0.05); the level of MDA was lower and the levels of SOD and GSH-Px were higher in the study group than in the control group (t=4.278, 5.435, and 7.557; all P<0.05); the level of VEGF was higher and the levels of EGF, TGF-α, and TGF-β1 were lower in the study group than in the control group (t=6.570, 9.306, 4.842, and 5.400; all P<0.05); the levels of AKT and SYK in the study group were (2.23±1.11) and (3.16±1.18), and those in the control group were (2.75±1.06) and (2.58±0.92), with statistical differences (t=2.273 and 2.600; both P<0.05). Conclusions　Jianpi Xiaowei Tang combined with Western medicine for patients with chronic atrophic gastritis and precancerous lesions can effectively alleviate their clinical symptoms, and improve their gastric function and anti-oxidant. Its mechanism may relate to AKT and SYK's role in the regulation of gastric mucosal epithelial cells' malignant transformation.

Key words:

Chronic atrophic gastritis, Jianpi Xiaowei Tang, Gastric function, Growth factors, Protein kinase B, Spleen tyrosine kinase