HER2阳性型乳腺癌肿瘤间质淋巴细胞浸润程度表达的临床病理意义

doi:10.3760/cma.j.issn.1007-1245.2023.22.021

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (22): 3231-3235.DOI: 10.3760/cma.j.issn.1007-1245.2023.22.021

HER2阳性型乳腺癌肿瘤间质淋巴细胞浸润程度表达的临床病理意义

满其荣¹ 赵甜甜² 段超² 李苓¹

¹济宁医学院附属滕州市中心人民医院肿瘤科，滕州　277500；²济宁医学院附属滕州市中心人民医院病理科，滕州　277500

收稿日期:2023-06-06 出版日期:2023-11-15 发布日期:2023-11-23
通讯作者: 李苓，Email：lilingtz@163.com
基金资助:
山东省自然科学基金项目（ZR2020LZL019）；中国抗癌协会-HER2靶点中国科研基金

Clinicopathological significance of expression level of tumor-infiltrating lymphocytes in patients with HER2 positive breast cancer

Man Qirong¹, Zhao Tiantian², Duan Chao², Li Ling¹

¹Department of Oncology, Tengzhou Central People's Hospital, Jining Medical College, Tengzhou 277500, China; ²Department of Pathology, Tengzhou Central People's Hospital, Jining Medical College, Tengzhou 277500, China

Received:2023-06-06 Online:2023-11-15 Published:2023-11-23
Contact: Li Ling, Email: lilingtz@163.com
Supported by:
Project of Natural Science Foundation in Shandong Province (ZR2020LZL019); Anti-Cancer Association of China-China Research Fund of HER-2 Target

摘要/Abstract

摘要：

目的　探讨人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）阳性型乳腺癌患者肿瘤浸润淋巴细胞（tumor infiltrating lymphocytes，TILs）表达与临床病理特征的相关性及与患者预后的关系。方法　收集滕州市中心人民医院2016年10月至2018年10月期间收治的HER2阳性型乳腺癌患者，共94例，均为女性，中位年龄51岁（32～73岁）。其中，49例患者接受曲妥珠单抗靶向治疗和化疗，45例患者仅接受化疗；评估每位患者HE切片肿瘤区域内TILs浸润程度，使用χ²检验对分类资料进行统计分析，使用Kaplan-Meier生存曲线和Cox回归法行单因素和多因素分析，分析TILs浸润程度与患者临床病理特征的关系和对患者无复发生存期（recurrence-free survival，RFS）的影响。结果　94例HER2阳性型乳腺癌患者，61例呈轻度浸润，33例呈重度浸润。TILs浸润程度与各临床病理参数均无明显相关性（均P>0.05）。靶向治疗组：32例呈轻度浸润，17例呈重度浸润。TILs重度浸润患者RFS长于TILs轻度浸润者（P=0.036）；TNM分期和TILs浸润程度均是HER2阳性型乳腺癌患者预后的独立因素（P=0.003、P=0.029）。普通化疗组：29例呈轻度浸润，16例呈重度浸润。TILs重度浸润者的RFS长于TILs轻度浸润者（P=0.049）；TNM分期和TILs浸润程度均是患者预后相关的独立因素（P=0.001、P=0.028）。结论　TILs可作为HER2阳性型乳腺癌预测预后和治疗效果的肿瘤标志物，并有可能成为肿瘤新的治疗靶点。

关键词:

乳腺癌, 人表皮生长因子受体2, 肿瘤浸润淋巴细胞, 预后

Abstract:

Objective　To investigate the relationship between the expression of tumor-infiltrating lymphocytes (TILs) and clinicopathological characteristics, and the effect of TILs on prognosis in patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer. Methods　A total of 94 female patients with HER2 positive breast cancer treated at Tengzhou Central People's Hospital from October 2016 to October 2018 were collected, with a median age of 51 years (32-73 years). Among them, 49 patients took trastuzumab and chemotherapy, and 45 chemotherapy. The degree of TILs in the tumor area of each patient's HE section was evaluated. χ² test was used to analyze the category data. The Kaplan Meier survival curve and Cox proportional hazard regression model were used to analyze the prognostic factors. The relationship between the degree of TILs and the clinicopathological characteristics and the effect of TILs on the patients' recurrence free survival (RFS) were analyzed. Results　Among the 94 patients, 61 had low infiltration, and 33 high infiltration. There were no significant correlations between the degree of TILs and clinical pathological parameters (all P>0.05). In the targeted therapy group, 32 cases had low infiltration, and 17 cases high infiltration. The RFS of the patients with high TILs was longer than that of the patients with with low TILs (P=0.036); TNM stage and the degree of TILs were independent factors for the patients' prognosis (P=0.003 and 0.029). In the general chemotherapy group, 29 cases had low infiltration, and 16 cases high infiltration. The RFS of the patients with high TILs was longer than that of the patients with with low TILs (P=0.049); TNM stage and TILs were independent factors related to the patients' prognosis (P=0.001 and 0.028). Conclusions　TILs can be used as tumor markers in predicting the prognosis and therapeutic effect of patients with HER2 positive breast cancer, and may become new therapeutic targets for tumors.

Key words:

Breast cancer, Human epidermal growth factor receptor 2, Tumor-infiltrating lymphocytes, Prognosis

满其荣赵甜甜段超李苓.

HER2阳性型乳腺癌肿瘤间质淋巴细胞浸润程度表达的临床病理意义 [J]. 国际医药卫生导报, 2023, 29(22): 3231-3235.

Man Qirong, Zhao Tiantian, Duan Chao, Li Ling.

Clinicopathological significance of expression level of tumor-infiltrating lymphocytes in patients with HER2 positive breast cancer [J]. International Medicine and Health Guidance News, 2023, 29(22): 3231-3235.

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HER2阳性型乳腺癌肿瘤间质淋巴细胞浸润程度表达的临床病理意义

Clinicopathological significance of expression level of tumor-infiltrating lymphocytes in patients with HER2 positive breast cancer

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