关键词:

冠心病, 成纤维细胞生长因子21, 胰岛素样生长因子-1, 冠状动脉粥样硬化, 相关性

Abstract:

Objective　To analyze the relationships between fibroblast growth factor 21 (FGF21) and insulin-like growth factor 1 (IGF-1) levels and coronary atherosclerosis in elderly patients with coronary heart disease (CHD). Methods　Retrospective analysis was made on the clinical data of 96 CHD patients who were treated in Jinan Second People's Hospital from January 2020 to December 2021, including 54 males and 42 females, aged (72.24±8.93) years, 46 cases of mild sclerosis, 28 cases of moderate sclerosis, and 22 cases of severe sclerosis. Another 60 healthy people who were examined in the physical examination center of Jinan Second People's Hospital during the same period were selected as the control group, including 36 males and 24 females, aged (70.43±8.56) years. The relationships between serum FGF21 and IGF-1 levels and coronary atherosclerosis were analyzed. F test, independent sample t test, χ² test, receiver operating characteristic curve (ROC) analysis, multiple logistic regression analysis, and Spearman rank correlation analysis were used. Results　The level of FGF21 in the severe sclerosis group was higher than that in the moderate sclerosis group, the level of FGF21 in the moderate sclerosis group was higher than that in the mild sclerosis group, the level of IGF-1 in the severe sclerosis group was lower than that in the moderate sclerosis group, and the level of IGF-1 in the moderate sclerosis group was lower than that in the mild sclerosis group (all P<0.05). The serum level of FGF21 in the CHD patients was higher than that in the control group, and the level of IGF-1 was lower than that in the control group (both P<0.05). The ROC analysis proved that serum FGF21 and IGF-1 levels could be used in clinical evaluation of CHD, with the areas under the curve of 0.794 and 0.813, respectively, both P<0.05. Multivariate logistic regression analysis showed that FGF21≥590.68 ng/L and IGF-1≤82.67 µg/L were risk factors for CHD [both odds ratio (OR) >1, P<0.05]. Correlation analysis showed that serum FGF21 level was positively correlated with the degree of coronary atherosclerosis (r=0.753, P<0.05), and IGF-1 was negatively correlated with the degree of coronary atherosclerosis (r=-0.712, P<0.05). Conclusions　Both elevated serum FGF21 and reduced IGF-1 are related to the severity of coronary atherosclerosis. Clinically, FGF21≥590.68 ng/L and IGF-1≤82.67 µg/L can be used as biological indicators for clinical diagnosis of CHD in the elderly, providing references for clinical evaluation and treatment of the disease.

Key words:

Coronary heart disease, Fibroblast growth factor 21, Insulin-like growth factor-1, Coronary atherosclerosis,  , Correlation