D-二聚体与2型糖尿病周围神经病变相关性分析

doi:10.3760/cma.j.issn.1007-1245.2022.11.008

国际医药卫生导报 ›› 2022, Vol. 28 ›› Issue (11): 1512-1516.DOI: 10.3760/cma.j.issn.1007-1245.2022.11.008

D-二聚体与2型糖尿病周围神经病变相关性分析

黄珂¹ 石守森² 张艳芳¹

¹郑州大学附属洛阳中心医院内分泌科，洛阳　471000； ²郑州大学附属洛阳中心医院胃肠外科，洛阳　471000

收稿日期:2022-02-21 出版日期:2022-06-01 发布日期:2022-06-15
通讯作者: 张艳芳，Email：xxzhangin@163.com
基金资助:
河南省医学科技攻关计划联合共建项目（LHGJ20200873）；

河南省医学科技攻关项目（212102310193）

Correlation between D-dimer and peripheral neuropathy in type 2 diabetes mellitus

Huang Ke¹, Shi Shousen², Zhang Yanfang¹

¹Department of Endocrinology, Luoyang Central Hospital, Zhengzhou University, Zhengzhou 471000, China;
²Department of Gastrointestinal Surgery, Luoyang Central Hospital, Zhengzhou University, Zhengzhou 471000, China

Received:2022-02-21 Online:2022-06-01 Published:2022-06-15
Contact: Zhang Yanfang, Email: xxzhangin@163.com
Supported by:
Joint Co-construction Project of Problem-tackling Plan of Medical Science and Technology in Henan (LHGJ20200873);

Problem-tackling Project of Medical Science and Technology in Henan (212102310193)

摘要/Abstract

摘要： 目的　分析D-二聚体（D-D）与2型糖尿病性周围神经病变（DPN）相关性。方法　对2018年11月至2020年11月在郑州大学附属洛阳中心医院内分泌科住院符合条件的937例2型糖尿病（T2DM）患者进行回顾性横断面研究，根据有无DPN分为DPN组和无DPN组，并收集其一般资料及临床指标等，组间比较采用t检验，计数资料组间比较用卡方检验；通过统计学分析D-D与DPN相关性。结果　无DPN组男367例，女253例，年龄（53.49±12.40）岁；DPN组男194例，女123例，年龄（58.02±10.88）岁。与无DPN组相比，DPN组更高龄（P=0.001），病程更长（P<0.001），更高的糖化血红蛋白（HbA1c）（P=0.012）、肌酐（Cr）（P<0.001）、低密度脂蛋白胆固醇（LDL-C）（P=0.024）、D-二聚体（D-D）（P<0.001），以及更高比例的高血压（P=0.013）。将单因素中有意义的指标纳入多因素logistic分析模型中，结果发现：DPN与年龄［比值比（OR）：1.021，95%置信区间（CI）：1.006～1.035，P=0.004］、DM病程（OR：1.029，95%CI：1.006～1.053，P=0.013）、HbA1c（OR：1.155，95%CI：1.063～1.256，P=0.001）、Cr（OR：1.009，95%CI：1.001～1.016，P=0.025）、LDL-C（OR：1.221，95%CI：1.049～1.422，P=0.010）、D-D（OR：1.001，95%CI：1.000～1.002，P=0.004）有关。结论　D-D可能是DPN发生发展的危险因素。

关键词: D-二聚体, 2型糖尿病, 糖尿病性周围神经病变, 危险因素

Abstract: Objective　To explore the correlation between D-dimer (D-D) and type 2 diabetic peripheral neuropathy (DPN). Methods　Nine hundred and thirty-seven eligible patients with type 2 diabetes mellitus (T2DM) hospitalized in Department of Endocrinology, Luoyang Central Hospital, Zhengzhou University from November 2018 to November 2020 were collected for the retrospective cross-sectional study. According to whether they had DPN, the patients were divided into a DPN group and a non-DPN group. Their general data and clinical indicators were collected. The t test was used for the comparison between groups, and the chi-square test was used for the comparison of count data between groups. The correlation between D-D and DPN was statistically analyzed. Results　There were 367 males and 253 females in the non-DPN group, and they were (53.49±12.40) years old. There were 194 males and 123 females in the DPN group, and they were (58.02±10.88) years old. Compared with the non-DPN group, the DPN group were older (P=0.001), had a longer disease course (P<0.001), higher levels of glycosylated hemoglobin (HbA1c) (P=0.012), creatinine (Cr) (P<0.001), low density lipoprotein-cholesterol (LDL-C) (P=0.024), and D-dimer (D-D) (P<0.001), and a higher proportion of hypertension (P=0.013). The indicators with statistical differences were included into the multivariate logistic regression analysis model, and the results showed that DPN correlated with age (OR=1.021; 95%CI 1.006-1.035; P=0.004), T2DM duration (OR=1.029; 95%CI 1.006-1.053; P=0.013), HbA1c (OR=1.155;95%CI 1.063-1.256; P=0.001), Cr (OR=1.009; 95%CI 1.001-1.016; P=0.025), LDL-C (OR=1.221; 95%CI 1.049-1.422; P=0.010), and D-D (OR=1.001; 95%CI 1.000-1.002; P=0.004). Conclusion　D-D may be a risk factor for the development of DPN in patients with T2DM.

Key words: D-dimer, Type 2 diabetes mellitus, Diabetic peripheral neuropathy, Risk factors

黄珂, 石守森, 张艳芳. D-二聚体与2型糖尿病周围神经病变相关性分析[J]. 国际医药卫生导报, 2022, 28(11): 1512-1516.

Huang Ke, Shi Shousen, Zhang Yanfang. Correlation between D-dimer and peripheral neuropathy in type 2 diabetes mellitus[J]. International Medicine and Health Guidance News, 2022, 28(11): 1512-1516.

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D-二聚体与2型糖尿病周围神经病变相关性分析

Correlation between D-dimer and peripheral neuropathy in type 2 diabetes mellitus

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