外周血长链非编码RNA的生理功能及与2型糖尿病患者胰岛β细胞功能相关性

doi:10.3760/cma.j.issn.1007-1245.2022.11.034

摘要/Abstract

摘要： 糖尿病是由环境、遗传因素诱导的代谢性疾病，该病危害性较大，会影响患者肝、肾、神经、血管等多个器官功能。非编码RNA包括miRNA和长链非编码RNA（lncRNA），lncRNA作为信号分子包含具有调控功能的核酸序列，在特定时间和组织可调节生物生长发育，感知响应多种刺激，并可调控某些基因表达。在糖尿病中lncRNA作为一种新型治疗途径的靶点，其具体作用机制如何更好地用于临床值得深入探讨。

关键词: 长链非编码RNA, 生理功能, 2型糖尿病, 胰岛β细胞功能

梁健, 陈燕, 刘强, 胡玉花, 洪芸芸, 张燕. 外周血长链非编码RNA的生理功能及与2型糖尿病患者胰岛β细胞功能相关性[J]. 国际医药卫生导报, 2022, 28(11): 1625-1628.

Liang Jian, Chen Yan, Liu Qiang, Hu Yuhua, Hong Yunyun, Zhang Yan. Physiological function of long chain non-encoding RNA in peripheral blood and its correlation with islet β cell function in patients with type 2 diabetes mellitus[J]. International Medicine and Health Guidance News, 2022, 28(11): 1625-1628.

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