Research progress on Senolytics in cardiovascular diseases

doi:10.3760/cma.j.issn.1007-1245.2022.14.031

Abstract

Abstract: Aging is the primary risk factor of cardiovascular diseases such as coronary artery disease, heart failure, and myocardial infarction. The poor prognosis of these diseases is caused by the decline of immunity and long recovery period. At the same time, cardiovascular diseases have been the leading cause of death in 40% of individuals over 65 years old. Senescent cells can accelerate the progression of cardiovascular diseases by expressing pro-inflammatory and pro-fibrotic secreted proteins. It has been shown that some targeted drugs can induce the apoptosis of senescent cells, and these bioactive compounds that preferentially remove senescent cells are known as Senolytics. This paper focuses on the research progress of Senolytics in coronary heart disease, heart failure, myocardial infarction, and so on.

Key words: Senescence, Senolytics, Heart failure, Myocardial infarction, Coronary heart disease

摘要： 老龄化是导致冠心病、心力衰竭、心肌梗死等心血管疾病的首要危险因素，并因免疫力下降、恢复期较长等原因导致了此类疾病的预后不良；同时心血管疾病也是40% 65岁以上人群死亡的主要原因。衰老细胞可以通过促炎和促纤维化分泌蛋白的表达来加速心血管疾病的进展，已有研究表明，一些靶向药物可以诱导衰老细胞凋亡，而这些选择性清除衰老细胞的化合物被定义为衰老细胞清除剂（Senolytics）。本文将关注衰老细胞清除剂在冠心病、心力衰竭、心肌梗死等方面的研究进展，并作一综述。

关键词: 细胞衰老, 衰老细胞清除剂, 心力衰竭, 心肌梗死, 冠心病

Liu Jingyang, Sun Jingwu, Liu Zhen, Shi Xinye, Dong Wenjing. Research progress on Senolytics in cardiovascular diseases [J]. International Medicine and Health Guidance News, 2022, 28(14): 2062-2065.

刘婧玚孙经武刘振石新烨董文敬. 衰老细胞清除剂在心血管疾病中的研究进展[J]. 国际医药卫生导报, 2022, 28(14): 2062-2065.

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