Research progress of uric acid and cardiovascular diseases

doi:10.3760/cma.j.issn.1007-1245.2022.06.038

Abstract

Abstract: With the improvement of living standards, people's diet has improved, and uric acid also goes up gradually. Uric acid is the final metabolite of purine decomposition in vivo. Due to the lack of uric acid oxidase (an enzyme responsible for the conversion of uric acid to allantoin), human beings are exposed to 50 times of serum uric acid concentration than other mammals. Recent studies have shown that uric acid is related to cardiovascular diseases, and the relationship between them is complex and not yet clear. This review explains the correlation between uric acid and cardiovascular diseases, and hopes to reduce the prevalence and mortality of cardiovascular diseases.

Key words: Uric acid, Hyperuricemia, Hypertension, Heart failure, Coronary heart disease, Atrial fibrillation

摘要： 随着生活水平的提高，人类饮食水平逐渐改善，尿酸也逐渐升高，尿酸是嘌呤在人体分解的最终代谢产物，由于缺乏尿酸氧化酶（一种负责将尿酸转化为尿囊素的酶），人类暴露在比其他哺乳动物高出50倍的血清尿酸浓度中。最近多项研究表明，尿酸与心血管疾病有关，它们之间关系是复杂的，而且还没有完全阐明。现在阐述其二者的相关性，以期减少心血管疾病的患病率及病死率。

关键词: 尿酸, 高尿酸血症, 高血压, 心力衰竭, 冠心病, 心房颤动

Liu Zhen, Sun Jingwu, Zhang Ning, Liu Jingyang, Shi Xinye, Dong Wenjing. Research progress of uric acid and cardiovascular diseases[J]. International Medicine and Health Guidance News, 2022, 28(6): 884-888.

刘振, 孙经武, 张宁, 刘婧玚, 石新烨, 董文敬. 尿酸与心血管疾病的研究进展[J]. 国际医药卫生导报, 2022, 28(6): 884-888.

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