Relationships between H-FABP, salusin-β levels and disease severity,
prognosis in patients with chronic heart failure

doi:10.3760/cma.j.issn.1007-1245.2022.03.022

Abstract

Abstract:

Objective　To investigate the relationships between heart type fatty acid binding protein (H-FABP), salusin-β levels and disease severity, prognosis in patients with chronic heart failure (CHF). Methods　A total of 160 patients with CHF admitted to Inner Mongolia Baotou Steel Hospital between January 2019 and December 2020 were enrolled as a CHF group [95 males and 65 females, aged (54.23±4.68) years], while other 67 healthy controls during the same period were enrolled as a control group [39 males and 28 females, aged (53.92±4.27) years]. The levels of H-FABP and salusin-β in both groups were detected by enzyme-linked immunosorbent assay. According to the cardiac function grading, CHF patients were divided into grade Ⅰ-Ⅳ, and the levels of H-FABP and salusin-β in patients with different grading were compared. All patients were followed up for 6 months to statistically analyze the occurrence of cardiovascular adverse events. The relationships between H-FABP, salusin-β levels and prognosis were analyzed. For the measurement data, independent sample t test was performed between two groups, one-way ANOVA was performed for comparison among multiple groups, and LSD-t test was performed for pairwise comparison; the count data were tested by χ². Results　The levels of H-FABP and salusin-β in the CHF group were higher than those in the control group (both P<0.05). The receiver operating characteristic curve (ROC) showed that the area under the curve (AUC) of H-FABP combined with salusin-β in the diagnosis of CHF was 0.841, greater than that of H-FABP and salusin-β alone (0.787 and 0.738) (P<0.05). With the increase of cardiac function grading, the levels of H-FABP and salusin-β increased, and there were statistically significant differences among patients with different cardiac function grading (all P<0.05). The levels of H-FABP and salusin-β in patients with poor prognosis were higher than those in patients with good prognosis (both P<0.05). Conclusions　The levels of H-FABP and salusin-β are related to the occurrence of CHF, which are of certain diagnostic efficiency, and the diagnostic value of combined detection is relatively higher. H-FABP and salusin-β are positively correlated with cardiac function grading, which can be applied to determine the severity of CHF and are of great significances for prognosis evaluation of CHF.

Key words: Chronic heart failure, Heart type fatty acid binding protein, Salusin-β, Disease severity, Prognosis

摘要： 目的　探讨慢性心力衰竭（CHF）患者心型脂肪酸结合蛋白（H-FABP）、salusin-β水平与疾病严重程度及预后的关系。方法　选取2019年1月至2020年12月在内蒙古包钢医院住院的160例CHF患者为CHF组，其中男95例、女65例，年龄（54.23±4.68）岁。另取同期健康体检人群67例为对照组，其中男39例、女28例，年龄（53.92±4.27）岁。使用酶联免疫吸附法测定两组受试者H-FABP和salusin-β水平；按照心功能分级将CHF患者分为Ⅰ～Ⅳ级，比较不同心功能分级CHF患者H-FABP和salusin-β水平；对患者进行6个月随访，统计心血管不良事件发生情况，并比较H-FABP和salusin-β水平与预后的关系。计量资料两组间进行独立样本t检验，多组间比较进行单因素方差分析，两两比较进行LSD-t检验；计数资料以χ²进行检验。结果　CHF组H-FABP和salusin-β水平高于对照组（均P<0.05）；受试者工作特征曲线（ROC）显示，H-FABP诊断CHF的曲线下面积（AUC）为0.787，salusin-β诊断CHF的AUC为0.738，两者联合诊断CHF的AUC为0.841，高于单独诊断（P<0.05）。随着心功能分级升高，H-FABP和salusin-β水平依次升高，组间比较差异均有统计学意义（均P<0.05）。预后不良者H-FABP和salusin-β水平高于预后良好者（均P<0.05）。结论　H-FABP和salusin-β水平与CHF疾病的发生有关，具有一定的诊断效能，且两者联合诊断价值更高；H-FABP和salusin-β均与心功能分级正相关，可用于CHF疾病严重程度判断，对于CHF的预后评估具有重要意义。

关键词: 慢性心力衰竭, 心型脂肪酸结合蛋白, salusin-β, 疾病严重程度, 预后

Li Li, Jia Liqing. Relationships between H-FABP, salusin-β levels and disease severity, prognosis in patients with chronic heart failure[J]. International Medicine and Health Guidance News, 2022, 28(3): 390-394.

李丽, 贾利清. 慢性心力衰竭患者H-FABP、salusin-β水平与疾病严重程度及预后的关系[J]. 国际医药卫生导报, 2022, 28(3): 390-394.

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Relationships between H-FABP, salusin-β levels and disease severity, prognosis in patients with chronic heart failure

慢性心力衰竭患者H-FABP、salusin-β水平与疾病严重程度及预后的关系

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