Research progress of RBP4 and cardiovascular diseases

doi:10.3760/cma.j.issn.1007-1245.2022.04.035

Abstract

Abstract: Retinol-binding protein 4 (RBP4) is a member of the lipoprotein-troponin family. RBP4 is the only retinol (vitamin A) -specific transporter secreted by liver and adipose tissue, and plays an important role in insulin sensitivity. Despite the association between the level of RBP4 and the risk of cardiovascular diseases, there are few studies focused on the relationship between RBP4 and cardiovascular diseases. To sum up, it is of great significance to explore the role of RBP4 in cardiovascular diseases for the prevention, screening, and treatment of cardiovascular diseases. This article reviews the relationships between RBP4 and its related diseases.

Key words: Retinol binding protein 4, Cardiovascular diseases, Hypertension, Heart failure

摘要： 视黄醇结合蛋白4（RBP4）是脂钙蛋白家族的成员，它是从肝脏和脂肪组织分泌的唯一的视黄醇（维生素A）特异性转运蛋白，在胰岛素敏感性中起决定性作用。尽管RBP4水平与心血管疾病风险之间存在联系，但是目前有关RBP4与心血管疾病相关的研究甚少，因此深入探究RBP4在心血管疾病中的作用，对心血管疾病的预防、筛查和治疗有重要意义。本文对RBP4与其相关疾病的关系进行综述。

关键词: 视黄醇结合蛋白4, 冠心病, 高血压, 心力衰竭

Liu Zhen, Sun Jingwu, Zhang Ning, Shi Xinye, Liu Jingyang. Research progress of RBP4 and cardiovascular diseases[J]. International Medicine and Health Guidance News, 2022, 28(4): 586-589.

刘振, 孙经武, 张宁, 石新烨, 刘婧玚. RBP4与心血管疾病的研究进展[J]. 国际医药卫生导报, 2022, 28(4): 586-589.

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