超微血流成像在肿瘤中的应用进展

doi:10.3760/cma.j.issn.1007-1245.2024.16.019

摘要/Abstract

摘要：

超微血流成像是一种新型超声血流成像技术，可以显示更低速和更微小的血流信号，评价微血管的特征。血管变化对肿瘤的生长和转移具有重要意义，超微血流成像作为一种无创检查，能够为肿瘤的诊断、监测以及治疗提供有价值的信息，具有广阔的应用前景。本文主要对超微血流成像技术在肿瘤中的临床应用和研究现状进行阐述，评价超微血流成像在各种肿瘤中的应用价值。

关键词:

超声, 超微血流成像, 肿瘤, 微血管, 进展

Abstract:

The superb microvascular imaging is a new type of ultrasonic imaging technology that can display slower and smaller blood flow signals, evaluating the characteristics of microvessels. Vascular changes are of great significance for the growth and metastasis of tumors. Superb microvascular imaging, as a non-invasive examination, can provide valuable information for the diagnosis, monitoring, and treatment of tumors, and has broad application prospects. This article mainly elaborates on the clinical application and research status of superb microvascular imaging in tumors, and evaluates the application value of superb microvascular imaging in various tumors.

Key words:

Ultrasound, Superb micovascular imaging, Tumors, , Microvessel, Progress

段舒惠熊正彪徐浩洋闫俊红.

超微血流成像在肿瘤中的应用进展 [J]. 国际医药卫生导报, 2024, 30(16): 2727-2731.

Duan Shuhui, Xiong Zhengbiao, Xu Haoyang, Yan Junhong.

Applications of superb microvascular imaging in tumors [J]. International Medicine and Health Guidance News, 2024, 30(16): 2727-2731.

参考文献

[1] Lee GY, Kim S, Choi ST, et al. The superb microvascular imaging is more sensitive than conventional power Doppler imaging in detection of active synovitis in patients with rheumatoid arthritis[J]. Clin Rheumatol, 2019, 38(9):2613-2620. DOI: 10.1007/s10067-019- 04550-0.
[2] Tang K, Liu M, Zhu Y, et al. The clinical application of ultrasonography with superb microvascular imaging-a review[J]. J Clin Ultrasound, 2022, 50(5):721-732. DOI: 10.1002/jcu.23210.
[3] Artul S, Nseir W, Armaly Z, et al. Superb microvascular imaging: added value and novel applications[J]. J Clin Imaging Sci, 2017, 7:45. DOI: 10.4103/jcis.JCIS_79_17.
[4] Park AY, Seo BK. Up-to-date Doppler techniques for breast tumor vascularity: superb microvascular imaging and contrast-enhanced ultrasound[J]. Ultrasonography, 2018, 37(2):98-106. DOI: 10.14366/usg.17043.
[5] Woliński K, Szkudlarek M, Szczepanek-Parulska E, et al. Usefulness of different ultrasound features of malignancy in predicting the type of thyroid lesions: a meta-analysis of prospective studies[J]. Pol Arch Med Wewn, 2014, 124(3):97-104. DOI: 10.20452/pamw.2132.
[6] Zhu YC, Zhang Y, Deng SH, et al. A prospective study to compare superb microvascular imaging with grayscale ultrasound and color doppler flow imaging of vascular distribution and morphology in thyroid nodules[J]. Med Sci Monit, 2018, 24:9223-9231. DOI: 10.12659/MSM.911695.
[7] Li W, Gao L, Du Y, et al. Ultrasound microflow patterns help in distinguishing malignant from benign thyroid nodules[J]. Cancer Imaging, 2024, 24(1):18. DOI: 10.1186/s40644-024-00663-1.
[8] Yun G, Kim YK, Choi SI, et al. Medullary thyroid carcinoma: application of Thyroid Imaging Reporting and Data System (TI-RADS) Classification[J]. Endocrine, 2018, 61(2):285-292. DOI: 10.1007/s12020-018-1594-4.
[9] Zhu C, Zhong L, Lin M, et al. The value of TI-RADS combined with superb micro-vascular imagine in distinguishing benign and malignant thyroid nodules: a meta-analysis[J]. PLoS One, 2022, 17(1):e0261521. DOI: 10.1371/journal.pone.0261521.
[10] Zhao W, Lu R, Yin L, et al. The value of superb microvascular imaging (SMI) scoring assignment method in differentiating benign and malignant thyroid nodules by conventional ultrasound[J]. Clin Hemorheol Microcirc, 2021, 78(4):355-363. DOI: 10.3233/CH-211235.
[11] Hong MJ, Ahn HS, Ha SM, et al. Quantitative analysis of vascularity for thyroid nodules on ultrasound using superb microvascular imaging: can nodular vascularity differentiate between malignant and benign thyroid nodules?[J]. Medicine (Baltimore), 2022, 101(5):e28725. DOI: 10.1097/MD.0000000000028725.
[12] Fahad Ullah M. Breast cancer: current perspectives on the disease status[J]. Adv Exp Med Biol, 2019, 1152:51-64. DOI: 10.1007/978-3-030-20301-6_4.
[13] Xi G, Cao N, Guo W, et al. Label-free imaging of blood vessels in human normal breast and breast tumor tissue using multiphoton microscopy[J]. Scanning, 2019, 2019:5192875. DOI: 10.1155/2019/5192875.
[14] Gong P, Song P, Huang C, et al. Ultrasensitive ultrasound microvessel imaging for characterizing benign and malignant breast tumors[J]. Ultrasound Med Biol, 2019, 45(12):3128-3136. DOI: 10.1016/j.ultrasmedbio.2019. 08.009.
[15] Park AY, Seo BK, Woo OH, et al. The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: comparison with colour and power Doppler imaging regarding diagnostic performance[J]. Clin Radiol, 2018, 73(3):304-311. DOI: 10.1016/j.crad.2017.10.006.
[16] Park AY, Seo BK, Cha SH, et al. An innovative ultrasound technique for evaluation of tumor vascularity in breast cancers: superb micro-vascular imaging[J]. J Breast Cancer, 2016, 19(2):210-213. DOI: 10.4048/jbc.2016. 19. 2.210.
[17] Ma Y, Li G, Li J, et al. The diagnostic value of superb microvascular imaging (SMI) in detecting blood flow signals of breast lesions: a preliminary study comparing SMI to color doppler flow imaging[J]. Medicine (Baltimore), 2015, 94(36):e1502. DOI: 10.1097/MD.0000000000001502.
[18] Diao X, Zhan J, Chen L, et al. Role of superb microvascular imaging in differentiating between malignant and benign solid breast masses[J]. Clin Breast Cancer, 2020, 20(6):e786-e793. DOI: 10.1016/j.clbc.2020.06.009.
[19] Liang M, Ou B, Wu J, et al. Combined use of strain elastography and superb microvascular imaging with grayscale ultrasound according to the BI-RADS classification for differentiating benign from malignant solid breast masses[J]. Clin Hemorheol Microcirc, 2020, 74(4):391-403. DOI: 10.3233/CH-190693.
[20] Park AY, Kwon M, Woo OH, et al. A prospective study on the value of ultrasound microflow assessment to distinguish malignant from benign solid breast masses: association between ultrasound parameters and histologic microvessel densities[J]. Korean J Radiol, 2019, 20(5):759-772. DOI: 10.3348/kjr.2018.0515.
[21] Abedi M, Sahebi L, Eslami B, et al. Using a combination of superb microvascular imaging and other auxiliary ultrasound techniques to increase the accuracy of gray-scale ultrasound for breast masses[J]. BMC Cancer, 2024, 24(1):224. DOI: 10.1186/s12885-024-11981-9.
[22] Arslan FZ, Altunkeser A, Körez MK, et al. The importance of superb microvascular imaging for the differentiation of malignant breast lesions from benign lesions[J]. Eur J Breast Health, 2021, 18(1):48-54. DOI: 10.4274/ejbh.galenos.2021.2021-6-1.
[23] Zhang XY, Cai SM, Zhang L, et al. Association between vascular index measured via superb microvascular imaging and molecular subtype of breast cancer[J]. Front Oncol, 2022, 12:861151. DOI: 10.3389/fonc.2022.861151.
[24] Bakdik S, Arslan S, Oncu F, et al. Effectiveness of superb microvascular imaging for the differentiation of intraductal breast lesions[J]. Med Ultrason, 2018, 20(3):306-312. DOI: 10.11152/mu-1433.
[25] Yang JD, Hainaut P, Gores GJ, et al. A global view of hepatocellular carcinoma: trends, risk, prevention and management[J]. Nat Rev Gastroenterol Hepatol, 2019, 16(10):589-604. DOI: 10.1038/s41575-019-0186-y.
[26] Ariff B, Lloyd CR, Khan S, et al. Imaging of liver cancer[J]. World J Gastroenterol, 2009, 15(11):1289-1300. DOI: 10.3748/wjg.15.1289.
[27] 杨凡,刘春伟,忻晓洁,等.超微血管成像在肝脏局灶性病变中的应用价值[J].中华肿瘤杂志,2021,43(9):959-967. DOI:10.3760/cma.j.cn112152-20191008-00649.
[28] He MN, Lv K, Jiang YX, et al. Application of superb microvascular imaging in focal liver lesions[J]. World J Gastroenterol, 2017, 23(43):7765-7775. DOI: 10.3748/wjg.v23.i43.7765.
[29] Bae JS, Lee JM, Jeon SK, et al. Comparison of MicroFlow Imaging with color and power Doppler imaging for detecting and characterizing blood flow signals in hepatocellular carcinoma[J]. Ultrasonography, 2020, 39(1):85-93. DOI: 10.14366/usg.19033.
[30] D'Onofrio M, Crosara S, De Robertis R, et al. Contrast-enhanced ultrasound of focal liver lesions[J]. AJR Am J Roentgenol, 2015, 205(1):W56-66. DOI: 10.2214/AJR.14.14203.
[31] Kolenda C, Dubost R, Hacard F, et al. Evaluation of basophil activation test in the management of immediate hypersensitivity reactions to gadolinium-based contrast agents: a five-year experience[J]. J Allergy Clin Immunol Pract, 2017, 5(3):846-849. DOI: 10.1016/j.jaip.2017.01.020.
[32] Kratzer W, Güthle M, Dobler F, et al. Comparison of superb microvascular imaging (SMI) quantified with ImageJ to quantified contrast-enhanced ultrasound (qCEUS) in liver metastases-a pilot study[J]. Quant Imaging Med Surg, 2022, 12(3):1762-1774. DOI: 10.21037/qims-21-383.
[33] Yang F, Zhao J, Liu C, et al. Superb microvascular imaging technique in depicting vascularity in focal liver lesions: more hypervascular supply patterns were depicted in hepatocellular carcinoma[J]. Cancer Imaging, 2019, 19(1):92. DOI: 10.1186/s40644-019-0277-6.
[34] 路晓雯,刘梓洋.增强CT联合超声造影在HCC患者TACE疗效评估中的应用[J].国际医药卫生导报,2024,30(5):754-758. DOI:10.3760/cma.j.issn.1007-1245.2024. 05.010.
[35] Yan FH, Zhou KR, Cheng JM, et al. Role and limitation of FMPSPGR dynamic contrast scanning in the follow-up of patients with hepatocellular carcinoma treated by TACE[J]. World J Gastroenterol, 2002, 8(4):658-662. DOI: 10.3748/wjg.v8.i4.658.
[36] Kang HJ, Lee JM, Jeon SK, et al. Microvascular flow imaging of residual or recurrent hepatocellular carcinoma after transarterial chemoembolization: comparison with color/power doppler imaging[J]. Korean J Radiol, 2019, 20(7):1114-1123. DOI: 10.3348/kjr.2018.0932.
[37] Abrams RM, Beranbaum ER, Santos JS, et al. Angiographic features of cavernous hemangioma of liver[J]. Radiology, 1969, 92(2):308-312 passim. DOI: 10.1148/92.2.308.
[38] 邹玥,朱梅,陈强.超微血管成像评估肝血管瘤血流信号的临床价值[J].临床超声医学杂志,2020,22(11):869-872. DOI:10.3969/j.issn.1008-6978.2020.11.023.
[39] Jeon SK, Lee JY, Han JK. Superb microvascular imaging technology of ultrasound examinations for the evaluation of tumor vascularity in hepatic hemangiomas[J]. Ultrasonography, 2021, 40(4):538-545. DOI: 10.14366/usg.20177.
[40] Stock KF, Slotta-Huspenina J, Kübler H, et al. Innovative ultrasound-based diagnosis of renal tumors[J]. Urologe A, 2019, 58(12):1418-1428. DOI: 10.1007/s00120-019- 01066-y.
[41] Mao Y, Mu J, Zhao J, et al. The comparative study of color doppler flow imaging, superb microvascular imaging, contrast-enhanced ultrasound micro flow imaging in blood flow analysis of solid renal mass[J]. Cancer Imaging, 2022, 22(1):21. DOI: 10.1186/s40644-022-00458-2.
[42] Mao Y, Mu J, Zhao J, et al. The value of superb microvascular imaging in differentiating benign renal mass from malignant renal tumor: a retrospective study[J]. Br J Radiol, 2018, 91(1082):20170601. DOI: 10.1259/bjr.20170601.
[43] 张岱,穆洁,毛怡然,等.超微血流显像对不同大小肾实性肿瘤的诊断价值[J].中华肿瘤杂志,2021,43(11):1215-1221. DOI:10.3760/cma.j.cn112152-20191220-00832.
[44] Zhao L, Mao Y, Mu J, et al. The diagnostic value of Superb Microvascular Imaging in identifying benign tumors of parotid gland[J]. BMC Med Imaging, 2020, 20(1):107. DOI: 10.1186/s12880-020-00506-y.
[45] Cebeci H, Öztürk M, Durmaz MS, et al. Evaluation of benign parotid gland tumors with superb microvascular imaging and shear wave elastography[J]. J Ultrason, 2020, 20(82):e185-e190. DOI: 10.15557/JoU.2020.0031.
[46] Ryoo I, Suh S, Lee YH, et al. Vascular pattern analysis on microvascular sonography for differentiation of pleomorphic adenomas and warthin tumors of salivary glands[J]. J Ultrasound Med, 2018, 37(3):613-620. DOI: 10.1002/jum.14368.
[47] Zhu YC, Shan J, Zhang Y, et al. Prostate cancer vascularity: superb microvascular imaging ultrasonography with histopathology correlation[J]. Med Sci Monit, 2019, 25:8571-8578. DOI: 10.12659/MSM.918318.
[48] Zhu Y, Tang Y, Jiang Z, et al. Potential diagnostic value of quantitative superb microvascular imaging in premalignant and malignant cervical lesions[J]. Front Oncol, 2023, 13:1250842. DOI: 10.3389/fonc.2023. 1250842.
[49] 金琳,王迎春,封岚,等.超微血流成像技术评估高强度聚焦超声治疗子宫肌瘤疗效的应用价值[J].中华超声影像学杂志,2018,27(4):334-337. DOI:10.3760/cma.j.issn.1004- 4477.2018.04.015.