关键词:

非病毒性肝病, 超声, 肝穿刺活检

Abstract:

Objective　To study the characteristics of ultrasound-guided liver biopsy in non-viral liver diseases. Methods　The clinical data of 83 patients with non-viral liver diseases admitted to Huangshi Central Hospital from July 2021 to July 2022 were retrospectively analyzed, including 37 males and 46 females, aged (57.79±9.08) years. All the patients received blood routine and electrocardiogram examinations after admission (before treatment), and were instructed by nursing staff to perform breath-holding and expiratory training. Liver biopsy was performed under ultrasound guidance. The complications and results of ultrasound guided liver biopsy and its coincidence rate with clinical diagnosis were observed. Results　All the 83 patients with non-viral liver diseases successfully completed liver biopsy, and their vital signs were basically normal after liver biopsy, among whom 55.42% (46/83) had slight pain at the puncture site, and 4.82% (4/83) of chest tightness and 3.61% (3/83) of blood pressure decreased after puncture. Of the 83 patients, 93.98% (78/83) were confirmed by liver biopsy. Among them, 51.81% (43/83) were autoimmune liver disease, 18.07% (15/83) of non-alcoholic fatty liver disease, 14.46% (12/83) of alcoholic liver disease, 4.82% (4/83) of drug-induced liver injury, 3.61% (3/83) of liver vascular disease, and 1.20% (1/83) of neoplastic disease, and another 6.02% (5/83) failed to identify the cause. The coincidence rates of the above 6 diseases diagnosed by ultrasound-guided liver biopsy with clinical diagnosis were 93.48% (43/46), 100.00% (15/15), 92.31% (12/13), 100.00% (4/4), 100.00% (3/3), and 50.00% (1/2), with the overall coincidence rate of 93.98% (78/83). Conclusions　Ultrasound guided liver biopsy can effectively diagnose autoimmune liver disease, non-alcoholic fatty liver disease, alcoholic liver disease, drug-induced liver injury, liver vascular disease, and neoplastic disease. Autoimmune liver disease and non-alcoholic fatty liver disease are mainly found in female patients, and alcoholic liver disease is mainly found in male patients, which is able to provide help for the diagnosis of non-viral liver diseases.

Key words:

Non-viral liver diseases, Ultrasound, Liver biopsy