关键词:

小儿抽动症, 肝风内动型, 通督益髓针法, 凝神止抽汤, 临床效果

Abstract:

Objective　To explore the clinical efficacy and safety of Tongdu Yisui acupuncture combined with Ningshen Zhichou decoction in treating pediatric Tourette syndrome characterized by internal stirring of liver wind. Methods　This study was a randomized controlled trial. A total of 102 children with Tourette syndrome with internal stirring of liver wind admitted to Yulin Traditional Chinese Medicine Hospital from December 2021 to April 2024 were enrolled and were randomly divided into a treatment group and a control group, with 51 cases in each group. In the treatment group, 29 boys and 22 girls were (8.03±2.21) years old, and the course of disease was (3.86±0.62) months. In the control group, 27 boys and 24 girls were (7.89±2.15) years old, and the course of disease was (3.80±0.59) months. The control group was given tiapride hydrochloride tablets orally, the initial dose was 0.05 g/time, twice a day, and the dose was increased to 0.10 g/time, twice a day after the 3rd week, continuous treatment for 1 month. On the basis of the control group, the treatment group was given Tongdu Yisui acupuncture (3 times a week, with an interval of 1-2 days, a total of 1 month) combined with Ningshen Zhichou decoction (1 dose a day, 3 to 10 years old, 100 ml each time, twice a day; 11-12 years old, 200 ml each time, twice a day, taken warmly in the morning and evening, a total of 1 month). After treatment, the traditional Chinese medicine (TCM) syndrome score, Yale Global Tic Severity Scale (YGTSS) score, frequency and interval of tic occurrence, neurotransmitter balance, and humoral immunity level in the two groups were observed, and the safety was recorded. Independent sample t test and χ² test were used for statistical analysis. Results　After treatment, the TCM syndrome score of the treatment group was lower than that of the control group [(2.08±0.53) points vs. (3.31±0.88) points], and the scores of motor tics, vocal tics, and overall impairment and total YGTSS score of the treatment group were lower than those of the control group, with statistically significant differences (all P<0.05). After treatment, the daily frequency of the treatment group was lower than that of the control group (1.80±0.24 vs. 4.16±0.66), and the interval duration was longer than that of the control group [(10.48±1.53) h vs. (4.48±1.48) h] (both P<0.05). After treatment, the levels of neurotransmitters in the treatment group were higher than those in the control group, and the immune function was better than that in the control group, with statistically significant differences (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion　The use of Tongdu Yisui acupuncture combined with Ningshen Zhichou decoction in treating pediatric Tourette syndrome with internal stirring of liver wind significantly outperforms conventional drug treatment in terms of improving TCM syndromes, YGTSS score, tic frequency and interval, neurotransmitter balance, and humoral immune level, while maintaining a high level of safety.

Key words:

Pediatric Tourette syndrome, Internal stirring of liver wind, Tongdu Yisui , acupuncture, Ningshen Zhichou , decoction, Clinical efficacy