中药颗粒浸泡方联合萘替芬酮康唑治疗间擦糜烂型手足癣的疗效观察

doi:10.3760/cma.j.issn.1007-1245.2024.18.033

国际医药卫生导报 ›› 2024, Vol. 30 ›› Issue (18): 3146-3149.DOI: 10.3760/cma.j.issn.1007-1245.2024.18.033

中药颗粒浸泡方联合萘替芬酮康唑治疗间擦糜烂型手足癣的疗效观察

万长兰吴慧李辉燕莫小莹李振洁王艳芳

广州市皮肤病医院中四门诊部，广州　510095

收稿日期:2024-06-11 出版日期:2024-09-15 发布日期:2024-09-24
通讯作者: 王艳芳，Email：649086201@qq.com
基金资助:
广州市皮肤病防治所医药卫生科技项目（202101）；广州市中医药临床核心和特色诊疗技术建设项目（2023-00463）

Observation on the curative effect of Chinese medicine granule soaking formula combined with naftifine/ketoconazole cream in the treatment of interlacing erosion tinea of hands and feet

Wan Changlan, Wu Hui, Li Huiyan, Mo Xiaoying, Li Zhenjie, Wang Yanfang

Guangzhou Dermatology Hospital of Zhongshan Fourth Road, Guangzhou 510095, China

Received:2024-06-11 Online:2024-09-15 Published:2024-09-24
Contact: Wang Yanfang, Email: 649086201@qq.com
Supported by:
Medical and Health Technology Project of Guangzhou Dermatology Hospital (202101); Guangzhou Traditional Chinese Medicine Clinical Core and Characteristic Diagnosis and Treatment Technology Construction Project (2023-00463)

摘要/Abstract

摘要：

目的　观察中药颗粒浸泡方联合萘替芬酮康唑乳膏治疗间擦糜烂型手足癣患者的临床效果。方法　选取2023年4月至2024年4月广州市皮肤病医院门诊部收治的120例间擦糜烂型手足癣患者进行前瞻性研究，采取随机数字表法分为对照组和观察组，各60例。对照组男35例、女25例，年龄（37.65±10.66）岁，病程（16.75±9.16）个月；采用萘替芬酮康唑乳膏外涂治疗，用药量参照一指尖单位使用，2次/d。观察组男32例、女28例，年龄（38.25±10.17）岁，病程（15.23±8.41）个月；在对照组的治疗基础上联合协定中药颗粒浸泡方泡洗治疗，颗粒剂配方：苦参、蛇床子、黄柏、地榆颗粒，１次/d，每次20 min。两组均治疗4周。比较两组治疗前、后皮肤相关症状评分、治疗效果及治疗安全性。统计学方法采用χ²检验和t检验。结果　治疗后，观察组患者皮肤破损、瘙痒、渗液、疼痛症状积分均低于对照组［（0.45±0.15）分比（1.34±0.17）分、（0.66±0.14）分比（1.42±0.21）分、（0.53±0.14）分比（1.38±0.18）分、（0.55±0.12）分比（1.33±0.19）分］，差异均有统计学意义（t=10.78、10.53、10.56、10.11，均P<0.05）。观察组治疗总有效率高于对照组［88.33%（53/60）比65.00%（39/60）］，差异有统计学意义（χ²=9.37，P<0.05）。观察组真菌清除率高于对照组［86.67%（52/60）比68.33%（41/60）］，差异有统计学意义（χ²=8.67，P<0.05）。治疗期间，两组患者均未见明显的不良反应。结论　在萘替芬酮康唑乳膏的基础上辅以中药颗粒浸泡方治疗间擦糜烂型手足癣患者，可提高治疗效果，且安全性好，值得临床推广。

关键词:

中药颗粒浸泡方, 萘替芬酮康唑乳膏, 间擦糜烂型手足癣, 临床效果

Abstract:

Objective　To observe the effect of Chinese medicine granule soaking and washing combined with naftifine/ketoconazole cream in the treatment of interlacing erosion tinea of hands and feet. Methods　From April 2023 to April 2024, 120 patients with interlacing erosion tinea of hands and feet admitted to Guangzhou Dermatology Hospital of Zhongshan Fourth Road were selected for a prospective study, and were divided into a control group and an observation group by the random number table method, with 60 cases in each group. In the control group, there were 35 males and 25 females, aged (37.65±10.66) years, and the course of disease was (16.75±9.16) months. In the observation group, there were 32 males and 28 females, aged (38.25±10.17) years, and the course of disease was (15.23±8.41) months. The control group was treated with external application of naftifine/ketoconazole cream, and the dosage was one fingertip unit, twice a day. On the basis of the treatment of the control group, the observation group was treated with Chinese medicine granule soaking and washing, and the granule formula was: kuhseng, shechuangzi, cortexphellodendri, and garden burnet root granules, once a day, 20 min each time. Both groups were treated for 4 weeks. The scores of skin related symptoms before and after treatment, therapeutic effect, and safety were compared between the two groups. Statistical methods used were χ² test and t test. Results　After treatment, the scores of skin damage, pruritus, effusion, and pain in the observation group were lower than those in the control group [(0.45±0.15) points vs. (1.34±0.17) points, (0.66±0.14) points vs. (1.42±0.21) points, (0.53±0.14) points vs. (1.38±0.18) points, (0.55±0.12) points vs. (1.33±0.19) points], with statistically significant differences (t=10.78, 10.53, 10.56, and 10.11, all P<0.05). The total effective rate of the observation group was higher than that of the control group [88.33% (53/60) vs. 65.00% (39/60)], with a statistically significant difference (χ²=9.37, P<0.05). The fungal clearance rate of the observation group was higher than that of the control group [86.67% (52/60) vs. 68.33% (41/60)], with a statistically significant difference (χ²=8.67, P<0.05). During treatment, no significant adverse symptoms were observed in both groups. Conclusion　On the basis of naftifine/ketoconazole cream, combined application of Chinese medicine granule soaking formula can effectively improve the treatment effect of interlacing erosion tinea of hands and feet, and it is safe and worthy of clinical promotion.

Key words:

Chinese medicine granule soaking formula, Naftifine/ketoconazole cream, Interlacing erosion tinea of hands and feet, Clinical effect

万长兰吴慧李辉燕莫小莹李振洁王艳芳.

中药颗粒浸泡方联合萘替芬酮康唑治疗间擦糜烂型手足癣的疗效观察 [J]. 国际医药卫生导报, 2024, 30(18): 3146-3149.

Wan Changlan, Wu Hui, Li Huiyan, Mo Xiaoying, Li Zhenjie, Wang Yanfang.

Observation on the curative effect of Chinese medicine granule soaking formula combined with naftifine/ketoconazole cream in the treatment of interlacing erosion tinea of hands and feet [J]. International Medicine and Health Guidance News, 2024, 30(18): 3146-3149.

参考文献

[1] 李健慧,吴晓红,张剑聪,等. 伊曲康唑联合复方三酸散浸泡治疗足癣的临床疗效观察[J]. 国际医药卫生导报,2012,18(8):1071-1073. DOI:10.3760/cma.j.issn.1007-1245. 2012.08.006.
[2] 李玉成,邹娜娜,朱帅,等. 自拟中药泡洗浴联合萘替芬酮康唑乳膏治疗足癣的效果观察[J]. 临床医学工程,2023,30(7):953-954. DOI:10.3969/j.issn.1674-4659.2023.07.0953.
[3] 许甜甜,沈炳香,李向阳. 协定处方中药1号治疗丘疹鳞屑型手足癣的临床疗效[J]. 中国现代应用药学,2021,383(4):459-462. DOI:10.13748/j.cnki.issn1007-7693.2021. 04.013.
[4] 祁雯雯,李玉霞. 中药熏洗在临床中的应用现状[J]. 中华现代护理杂志,2013,19(29):3687-3689. DOI:10.3760/cma.j.issn.1674-2907.2013.29.045.
[5] 李勇,眭道顺,李东海,等. 中药浸洗方治疗角化过度型手足癣的效果[J]. 广东医学,2017,38(17):2711-2712. DOI:10.3969/j.issn.1001-9448.2017.17.035.
[6] 中国手癣和足癣诊疗指南工作组. 中国手癣和足癣诊疗指南(科普版2022)[J]. 中国真菌学杂志,2022,17(2):89-93. DOI:10.3969/j.issn.1673-3827.2022.02.001.
[7] 陈楚敏.治癣外洗方联合伊曲康唑治疗手足癣的临床研究[D].广州:广州中医药大学,2021.DOI:10.27044/d.cnki.ggzzu.2021.000706.
[8] 郑莜萸.中药新药临床研究指导原则[试行][M].北京:中国医药科技出版社,2002:292-295.
[9] 苏伟团,黎建海,伦振新. 口服特比萘芬联合萘替芬酮康唑乳膏治疗手足癣的疗效观察[J]. 国际医药卫生导报,2011,17(13):1610-1612. DOI:10.3760/cma.j.issn.1007-1245. 2011.13.033.
[10] 刘丽云,付丽彬,邹红. 除湿解毒足浴汤洗剂联合萘替芬酮康唑乳膏治疗浸渍糜烂型足癣40例[J]. 安徽医药,2021,25(2):400-403. DOI:10.3969/j.issn.1009-6469.2021. 02.046.
[11] 周继刚,付婷婷,汪鋆值,等. 海棠凝胶治疗手足癣的临床观察[J]. 中国中西医结合皮肤性病学杂志,2018,17(1):47-48. DOI:10.3969/j.issn.1672-0709.2018.01.017.
[12] 陈楚敏,曹艳红,谢佳芯. 眭道顺治疗手足癣经验[J]. 广州中医药大学学报,2021,38(4):822-825. DOI:10.13359/j.cnki.gzxbtcm.2021.04.031.
[13] 郭璐瑜,郭丽娟,吕美玲. 中药坐浴治疗痔疮的疗效观察[J]. 现代临床护理,2015(5):15-16,17. DOI:10.3969/j.issn.1671-8283.2015.05.005.
[14] 江莹. 中药外洗癣病方联合复方酮康唑软膏治疗手足癣临床观察[J]. 实用中医药杂志,2024,40(3):462-463.
[15] 梅蛟,李峰,代艳. 醋泡中药方与曲安奈德益康唑乳膏治疗手足癣患者的效果对比[J]. 中国医学创新,2024,21(6):65-68. DOI:10.3969/j.issn.1674-4985.2024.06.016.
[16] 吴哲,宁鹤丽,邓谦,等. 自制中药癣灵治疗顽固性手足癣的临床研究[J]. 中国处方药,2024,22(1):170-172. DOI:10.3969/j.issn.1671-945X.2024.01.049.
[17] 郑君. 分析口服特比萘芬治疗手足癣的临床疗效与安全性[J]. 北方药学,2022,19(8):117-119,122. DOI:10.3969/j.issn.1672-8351.2022.08.036.
[18] 李萌. 中药外洗联合1％硝酸咪康唑乳膏治疗手足癣及体股癣临床观察[J]. 实用中医药杂志,2021,37(9):1511-1512.
[19] 洪智源,江川,章靓,等. 基于中医传承计算平台的6 783例阴虚证处方的地骨皮组方规律分析[J]. 国际医药卫生导报,2023,29(7):962-968. DOI:10.3760/cma.j.issn.1007-1245. 2023.07.017.
[20] Drummond MVMS, Borges JR, Ribeiro AMQ,et al. Dermoscopy as an auxiliary tool for the diagnosis of acral squamous diseases: palmoplantar psoriasis, tinea pedis/manuum and eczema[J]. An Bras Dermatol,2024,99(4):578-581.DOI: 10.1016/j.abd.2023.05.008.
[21] Elsner P, Metz S, Schliemann S. Abdominale papeln bei einem patienten mit psoriasis vulgaris und tinea manuum[J]. Hautarzt, 2017 ,68(7):583-584. German.DOI: 10.1007/s00105-017-3966-8.
[22] 郑小景,段奇静,曹建军,等. 三黄除癣方联合联苯苄唑乳膏治疗手足癣临床研究[J]. 新中医,2020,52(6):98-100. DOI:10.13457/j.cnki.jncm.2020.06.031.
[23] Tamer F , Yuksel ME .Tinea manuum misdiagnosed as psoriasis vulgaris: a case of tinea incognito[J].Our Dermatology Online / Nasza Dermatologia Online, 2017, 8(1):60-62.DOI:10.7241/ourd.20171.16.
[24] Perrier P, Monod M. Tinea manuum caused by trichophyton erinacei: first report in switzerland[J]. Int J Dermatol, 2015,54(8):959-960.DOI: 10.1111/ijd.12291.
[25] 朱红梅,温海. 中国基层医疗机构手癣和足癣诊治现状调查[J]. 中国真菌学杂志,2021,16(1):10-13,23. DOI:10.3969/j.issn.1673-3827.2021.01.003.
[26] 兰晓鸥. 手足癣的诊断和治疗[J]. 中国实用乡村医生杂志,2020,27(7):33-34. DOI:10.3969/j.issn.1672-7185.2020. 07.017.
[27] 李国香. 自拟除癣外洗方治疗角化过度型手足癣的临床及体外抑菌实验研究[J]. 中国民间疗法,2021,29(2):71-74. DOI:10.19621/j.cnki.11-3555/r.2021.0228.

中药颗粒浸泡方联合萘替芬酮康唑治疗间擦糜烂型手足癣的疗效观察

Observation on the curative effect of Chinese medicine granule soaking formula combined with naftifine/ketoconazole cream in the treatment of interlacing erosion tinea of hands and feet

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