Objective To investigate the values of toll-like receptor 2 (TLR2), prostaglandin
E2 (PGE2), and interleukin-6 (IL-6) in the prediction of spontaneous preterm
birth (SPB).
Methods A total of 289
pregnant women with high risk factors of preterm delivery in Jinan Maternal and
Child Health Care Hospital from March 2019 to March 2020 were collected,
including 21 cases of SPB, 263 cases of term birth, 3 cases of therapeutic
preterm birth, 1 case of late abortion, and 1 case of missed follow up; at
last, 284 cases were included. The study group had 21 cases (SPB), and were
(34.08±2.16) weeks pregnant when they delivered. The control group had 263
cases (term birth), and were (39.25±1.11) weeks pregnant when they delivered.
The clinical data of the two groups were compared. The levels of TLR2, PGE2,
and IL-6 were detected. The measurement data of normal distribution was
described as (
x±s
), and were compared by independent-sample
t test. The enumeration data were compared by
χ2 test. The multivariate logistic regression model was
used to analyze the independent predictors of SPB. The values of serum TLR2,
PGE2, and IL-6 in the prediction of SPB were assessed by the receiver operating
characteristic curve (ROC).
Results The serum levels of
TLR2, PGE2, and IL-6 in the study group were significantly higher than those in
the control group (
t=8.971, 5.813,
and 5.228; all
P<0.05). Logistic
regression analysis showed that the odds ratios of TLR2, PGE2, and IL-6 were
1.590, 1.714, and 1.501, respectively, and were independent predictors of SPB
(all
P<0.05). The ROC analysis
showed that the areas under the curves of TLR2, PGE2, and IL-6 in the
prediction of SPB were 0.895, 0.807, and 0.900, respectively; the predictive
value of IL-6 was the highest, with a sensitivity of 90.48% and a specificity
of 77.78%.
Conclusion Serum TLR2, PGE2, and
IL-6 are independent predictors of SPB, and IL-6 has a higher predictive value.
