Objective To explore the antibacterial effect of a traditional Chinese medicine
compound preparation, Ze'er Fu Skin Bacteriostasis Lotion, and provide
experimental basis for the clinical application of the lotion.
Methods The antibacterial effects of 100.0%, 50.0%,
25.0%, and 12.5% Ze'er Fu Skin Bacteriostasis Lotion for 2, 5, 10, and 20 min
on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida
albicans were experimentally observed by the plate dilution method form
september to November 2021 at Dermatology Hospital, Southern Medical
University, with sterile saline as the blank control group. The data were
expressed as (
x±s
). The experimental data were analyzed by variance analysis and
correlation analysis.
Results The antibacterial
rates of 100.0%, 50.0%, 25.0%, and 12.5% Ze'er Fu Skin Bacteriostasis Lotion
for 2, 5, 10 and 20 minutes on Escherichia coli, Pseudomonas aeruginosa,
Staphylococcus aureus,and Candida albicans were all over 90.0%. When 100.0%
Ze'er Fu Bacteriostasis Lotion was used for 2, 5, 10, and 20 minutes, the
antibacterial rates were (0.97±0.02), (0.99±0.03), (1.00±0.00), (1.00±0.00),
respectively; when 50.0% Ze'er Fu Antibacterial Lotion was used for 2, 5, 10,
and 20 minutes, the antibacterial rates were (0.95±0.02), (0.96±0.02),
(0.97±0.01), and (0.98±0.01), respectively; when 25.0% Ze'er Fu Bacteriostasis
Lotion was used for 2, 5, 10, and 20 minutes, the antibacterial rates were
(0.93±0.01), (0.94±0.01), (0.95±0.01), and (0.97±0.01), respectively; when
12.5% Ze'er Fu Bacteriostasis Lotion was used for 2, 5, 10, and 20 minutes, the
antibacterial rates were (0.92±0.01), (0.93±0.01), (0.93±0.01), and
(0.95±0.02), respectively, there were statistical differences in the
antibacterial rates between Ze'er Fu Skin Bacteriostasis Lotion with different
concentrations for 2, 5, 10 and 20 minutes (
F=5.947,
7.030, 52.993, and 8.912; all
P<0.05).
The correlation analysis showed that the antibacterial rate was positively
correlated with the concentration of antibacterial lotion, and the Pearson
correlation coefficients of action for 2, 5, 10, and 20 min were 0.769, 0.789,
0.950, and 0.806, respectively (all
P<0.01).
At the same concentration, there were no statistical differences between the
antibacterial rate and strain species and durations of action (all
P>0.05).
Conclusion Ze'er Fu Skin Bacteriostasis Lotion has strong antibacterial effect on
Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida
albicans, and the antibacterial effect increases with the concentration.
