Protective effect of probucol in lung injury induced by paraquat poisoning

doi:10.3760/cma.j.issn.1007-1245.2023.07.006

Abstract

Abstract:

Paraquat can lead to injury of multiple organs, it can induce a range of adverse effects on various organs, such as the kidneys, heart, liver, gastrointestinal tract, and nervous system. Among them, lung injury is the most common. The current clinical treatment includes emetics, gastric lavage, catharsis, anti-oxidant therapy, immunoregulation, hemoperfusion, et al. The lack of effective antidotes is the significant cause of high mortality in paraquat poisoning. Probucol is a phenolic lipid-lowering agent with antioxidant, anti-inflammatory, and antifibrotic effects, which has been widely used in the clinical treatment and prevention of cardiovascular diseases. Recent studies have discovered that probucol can ameliorate the oxidative stress response and pulmonary fibrosis caused by drugs. The protective significance of probucol in lung injury induced by paraquat poisoning is reviewed in this paper.

Key words:

Paraquat, Probucol, Oxidative stress, Inflammatory response, Lung injury

摘要：

百草枯中毒可导致多种器官的损伤，其对肾脏、心脏、肝脏、消化道和中枢神经系统等许多器官都有不良影响，其中尤以肺部损伤最为常见。治疗方法主要包括催吐、洗胃、导泻、抗氧化、免疫调节、血液灌流等，但由于百草枯中毒缺乏特效解毒剂，目前病死率仍居高不下。普罗布考是一种酚类降脂剂，具有抗氧化、抗炎及抗纤维化特性，已广泛应用于心血管疾病的临床治疗和预防。近年来研究发现，普罗布考可减轻药物诱导产生的氧化应激反应及肺纤维化。本文就普罗布考在百草枯中毒所致肺损伤中的保护意义进行综述。

关键词:

百草枯, 普罗布考, 氧化应激, 炎症反应, 肺损伤

Xu Han, Li Wenpeng, Zhang Xiaohui, Zhang Jinying.

Protective effect of probucol in lung injury induced by paraquat poisoning [J]. International Medicine and Health Guidance News, 2023, 29(7): 913-916.

徐菡李文鹏张骁慧张金英.

普罗布考在百草枯中毒致肺损伤中的保护作用 [J]. 国际医药卫生导报, 2023, 29(7): 913-916.

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