Abstract:

Objective　To explore the current status and risk factors of discrimination perception among patients with colorectal cancer, and to analyze its correlation with health-related quality of life (HRQoL). Methods　From August 2024 to May 2025, a questionnaire survey was conducted among 420 colorectal cancer patients who visited three top-tier hospitals in the central and western regions (Nanchang First Hospital, Anning First People's Hospital, and the High-tech Hospital of the First Affiliated Hospital of Nanchang University) using the Social Data Questionnaire, the Cancer Stigma Perception Scale (CSPDS), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Descriptive statistical analysis was used to assess the current status of patients' perception of discrimination. Single-factor ANOVA and multiple-factor linear regression were employed to analyze the risk factors for patients' perception of discrimination, and to explore its correlation with HRQoL. Results　There was a widespread perception of discrimination among 420 patients with colorectal cancer, with a score of 48(40,55).Multivariate linear regression analysis showed that financial hardship, history of intestinal fistula, and introverted personality were all risk factors for patients' perception of discrimination (P<0.05). The patients' perception of discrimination was negatively correlated with HRQoL, five functional domains, overall health, symptom domains, and financial hardship (P<0.05). Conclusions　The widespread perception of discrimination is detrimental to the recovery and improvement of the quality of life of patients with colorectal cancer. Early identification and proactive, effective measures to address this issue are key to reducing the perception of discrimination and can serve as a starting point for further enhancing the health-related quality of life (HRQoL) of these patients in the future.

Objective　To explore the current status and risk factors of discrimination perception among patients with colorectal cancer, and to analyze its correlation with health-related quality of life (HRQoL). Methods　From August 2024 to May 2025, a questionnaire survey was conducted among 420 colorectal cancer patients who visited three top-tier hospitals in the central and western regions (Nanchang First Hospital, Anning First People's Hospital, and the High-tech Hospital of the First Affiliated Hospital of Nanchang University) using the Social Data Questionnaire, the Cancer Stigma Perception Scale (CSPDS), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Descriptive statistical analysis was used to assess the current status of patients' perception of discrimination. Single-factor ANOVA and multiple-factor linear regression were employed to analyze the risk factors for patients' perception of discrimination, and to explore its correlation with HRQoL. Results　There was a widespread perception of discrimination among 420 patients with colorectal cancer, with a score of 48(40,55).Multivariate linear regression analysis showed that financial hardship, history of intestinal fistula, and introverted personality were all risk factors for patients' perception of discrimination (P<0.05). The patients' perception of discrimination was negatively correlated with HRQoL, five functional domains, overall health, symptom domains, and financial hardship (P<0.05). Conclusions　The widespread perception of discrimination is detrimental to the recovery and improvement of the quality of life of patients with colorectal cancer. Early identification and proactive, effective measures to address this issue are key to reducing the perception of discrimination and can serve as a starting point for further enhancing the health-related quality of life (HRQoL) of these patients in the future.

Key words: Colorectal cancer, Perceived discrimination, Physical and mental health, Health-Related Quality of Life, Intervention measures,  , Relevance

摘要：

目的　探究结直肠癌患者的歧视知觉现状及危险因素，分析其与健康相关生命质量（HRQoL）的相关性。方法　采用社会资料调查表、癌症歧视知觉量表（CSPDS）及欧洲癌症研究与治疗组织生存质量量表（EORTC QLQ-C30），对2024年8月至2025年5月三家中西部三甲医院（南昌市第一医院、安宁市第一人民医院及南昌大学第一附属医院高新医院）就诊的420例结直肠癌患者进行问卷调查。采用描述性统计分析患者歧视知觉现状，通过单因素ANOVA、多因素线性回归分析患者歧视知觉的危险因素，并探索其与HRQoL的相关性。结果　420例结直肠癌患者普遍存在歧视知觉，得分为48（40，55）分。多因素线性回归分析表明财务困境、肠造瘘史及性格内向均是患者歧视知觉的危险因素（均P<0.05）；患者歧视知觉与HRQoL、5个功能领域、整体健康、症状领域及财务困境均呈负相关（均P<0.05）。结论　普遍存在的歧视知觉不利于结直肠癌症患者生命质量的恢复和提升，早期识别和积极有效的应对措施是减轻歧视知觉的关键，可作为未来进一步提升患者HRQoL的切入点。

关键词: 结直肠癌, 歧视知觉, 身心健康, 健康相关生命质量, 干预措施, 相关性