Abstract:

 Objective　To investigate the levels of serum S100 calcium-binding protein A12 (S100A12) and peripheral blood red cell distribution width (RDW) and monocyte percentage (Mono%) in patients with spinal tuberculosis and their clinical significance. Methods　A total of 80 patients with spinal tuberculosis admitted to Xianyang Central Hospital from February 2021 to May 2023 were selected as an observation group, including 44 males and 36 females, aged (41.78±8.58) years, and 60 healthy individuals who underwent physical examination during the same period were selected as a control group, including 33 males and 27 females, aged (39.49±9.90) years. The levels of serum S100A12 and peripheral blood RDW and Mono% of the two groups were detected, and the diagnostic efficacies of the three indexes for spinal tuberculosis were analyzed by the receiver operating characteristic curve (ROC). The observation group of 80 patients with spinal tuberculosis were followed up for 1 year, and were divided into a recurrence group (23 cases) and a non-recurrence group (57 cases) based on recurrence. The predictive efficacies of serum S100A12 and peripheral blood RDW and Mono% for spinal tuberculosis recurrence were analyzed. Independent sample t test was used for statistical analysis. Results　The levels of serum S100A12 and peripheral blood RDW and Mono% in the observation group were higher than those in control group [(149.08±43.76) ng/L vs. (88.36±20.26) ng/L, (14.44±1.55)% vs. (12.97±1.31)%, (9.27±1.62)% vs. (8.03±1.38)%], with statistically significant differences (all P<0.05). ROC analysis showed that the sensitivity of S100A12 was 73.8%, the specificity was 98.3%, and the area under the curve (AUC) was 0.894 in the diagnosis of spinal tuberculosis; the sensitivity of RDW was 68.8%, the specificity was 78.3%, and the AUC was 0.767; the sensitivity of Mono% was 68.8%, the specificity was 68.3%, and the AUC was 0.726. However, when S100A12, RDW, and Mono% were combined for diagnosis, the sensitivity and specificity were 87.5% and 95.0%, respectively, with an AUC of 0.948, indicating high diagnostic efficacy with combined testing. The levels of serum S100A12 and peripheral blood RDW and Mono% in the recurrence group were higher than those in the non-recurrence group [(177.36±47.59) ng/L vs. (137.67±36.76) ng/L, (15.40±1.55)% vs. (14.05±1.39)%, (9.91±1.68)% vs. (9.01±1.53)%], with statistically significant differences (all P<0.05). ROC analysis showed that the sensitivity of S100A12 was 56.5%, the specificity was 89.5%, and the AUC was 0.757 in predicting the recurrence of spinal tuberculosis; the sensitivity of RDW was 78.3%, the specificity was 68.4%, and the AUC was 0.755; the sensitivity of Mono% was 82.6%, the specificity was 56.1%, and the AUC was 0.698. However, when S100A12, RDW, and Mono% were combined for prediction, the sensitivity and specificity increased to 82.6% and 84.2%, respectively, with an AUC of 0.863, indicating high predictive efficacy with combined testing. Conclusion　Serum S100A12 and peripheral blood RDW and Mono% can be used to diagnose spinal tuberculosis and have certain value in predicting recurrence.

Key words:

Spinal tuberculosis; , S100 calcium-binding protein A12; , Red cell distribution width; , Monocyte percentage

摘要：

目的　探讨脊柱结核患者血清钙结合蛋白A12（S100A12）、外周血红细胞分布宽度（RDW）、单核细胞百分比（Mono%）水平及临床意义。方法　选择2021年2月至2023年5月咸阳市中心医院收治的脊柱结核患者80例作为观察组，包括男44例和女36例，年龄（41.78±8.58）岁；选择同期体检的健康者60例作为对照组，包括男33例和女27例，年龄（39.49±9.90）岁。检测两组受试者血清S100A12、外周血RDW、Mono%水平，采用受试者操作特征曲线（ROC）分析这3个指标对脊柱结核的诊断效能。观察组80例脊柱结核患者随访1年，根据是否复发分为复发组23例及未复发组57例，分析血清S100A12、外周血RDW、Mono%对脊柱结核复发的预测效能。采用独立样本t检验进行统计学分析。结果　观察组血清S100A12、外周血RDW、Mono%水平高于对照组［（149.08±43.76）ng/L比（88.36±20.26）ng/L、（14.44±1.55）%比（12.97±1.31）%、（9.27±1.62）%比（8.03±1.38）%］，差异均有统计学意义（均P<0.05）。ROC分析显示，S100A12诊断脊柱结核的灵敏度为73.8%，特异度为98.3%，曲线下面积（AUC）为0.894；RDW的灵敏度为68.8%，特异度为78.3%，AUC为0.767；Mono%的灵敏度为68.8%，特异度为68.3%，AUC为0.726；S100A12、RDW及Mono%联合诊断时，灵敏度和特异度分别为87.5%和95.0%，AUC为0.948。复发组血清S100A12、外周血RDW、Mono%水平高于未复发组［（177.36±47.59）ng/L比（137.67±36.76）ng/L、（15.40±1.55）%比（14.05±1.39）%、（9.91±1.68）%比（9.01±1.53）%］，差异均有统计学意义（均P<0.05）。ROC分析显示，S100A12预测脊柱结核复发的灵敏度为56.5%，特异度为89.5%，AUC为0.757；RDW的灵敏度为78.3%，特异度为68.4%，AUC为0.755；Mono%的灵敏度为82.6%，特异度为56.1%，AUC为0.698；S100A12、RDW及Mono%联合预测时，灵敏度和特异度分别为82.6%和84.2%，AUC为0.863。结论　血清S100A12、外周血RDW、Mono%可用于诊断脊柱结核，并对预测患者是否复发有一定价值。

关键词:

脊柱结核, 钙结合蛋白A12, 红细胞分布宽度, 单核细胞百分比