Research progress on regulation mechanisms of synaptic plasticity and its relationship with nervous system diseases

doi:10.3760/cma.j.cn441417-20240926-12007

Abstract

Abstract:

The regulatory mechanisms of synaptic plasticity are complex and diverse, and are closely related to many diseases of the nervous system. Impaired synaptic plasticity is found in many neurodegenerative and demyelinating diseases. What is synaptic plasticity? Which factors regulate synaptic plasticity? Can we slow down the progression of the diseases and improve the prognosis regulating synaptic plasticity? In this review, we summarize the regulatory mechanisms of synaptic plasticity and its relationship with nervous system diseases, and explore new therapeutic targets and possible mechanisms for treatment.

Key words: Synaptic plasticity, , Microglia, , Oxidative stress, , Neuroinflammation, , Progress

摘要：

突触可塑性的调节机制复杂多样，与神经系统多种疾病密切相关。在众多神经系统退行性疾病和脱髓鞘疾病中，都可发现突触可塑性受损。什么是突触可塑性？突触可塑性受到哪些因素调节？是否可以通过调节突触可塑性来减缓疾病进展、改善预后？本文归纳和总结了突触可塑性的调节机制及其与神经系统疾病的关系，以及寻求新的治疗靶点及可能的机制进行治疗。

关键词: 突触可塑性, 小胶质细胞, 氧化应激, 神经炎症, 进展

Wang Linhua, Huo Yingqian, Li Tingting, Liu Yanmin, Xi Yalin, Wang Meiling.

Research progress on regulation mechanisms of synaptic plasticity and its relationship with nervous system diseases [J]. International Medicine and Health Guidance News, 2025, 31(12): 1968-1971.

汪临华霍颖倩李婷婷刘晏民席娅琳王美玲. 突触可塑性的调节机制及其与神经系统疾病关系的研究进展 [J]. 国际医药卫生导报, 2025, 31(12): 1968-1971.

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