A control study of serum hormone levels in children with autism spectrum
disorder

doi:10.3760/cma.j.issn.1007-1245.2022.12.016

Abstract

Abstract:

Objective　To investigate the differences of several serum hormone levels between ASD and normal children. Methods　A case-control study was conducted. A total of 120 ASD children (68 males / 52 females, aged 24-108 months) and 120 normal control children (68 males / 52 females, aged 24-109 months) were collected according to the diagnostic criteria of the fifth edition of The Diagnostic and Statistical Manual of Mental Disorders (DSM-V) in Hunan Provincial Maternal and Child Health Care Hospital from June 2018 to December 2020. Serum levels of progesterone (P), testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), cortisol hormone (CORT), and adrenocorticotropic hormone (ACTH) were determined by electrochemiluminescence. Wilcoxon rank sum test was used for the measurement data, and χ² test was used for the count data. Results　Serum levels of P, LH, CORT, and ACTH in the ASD children were 0.61 (0.36, 0.95) nmol/L, 0.38 (0.26, 0.45) IU/L, 345.28 (223.98, 465.50) nmol/L, and 10.41 (6.43, 16.65) pg/ml, respectively, which were significantly higher than those in the control group [0.16 (0.16, 0.16) nmol/L, 0.25 (0.21, 0.32) IU/L, 167.80 (125.15, 203.45) nmol/L, and 8.49 (5.50, 14.74) pg/ml] (all P<0.05); there were no statistically significant differences in serum levels of T, FSH, and GH between the two groups (all P>0.05). In the ASD children, the levels of FSH and GH in the females were 2.66 (1.32, 3.80) IU/L and 3.68 (0.90, 6.37) μg/L, respectively, which were higher than those in the males [0.93 (0.65, 1.31) IU/L and 1.56 (0.53, 3.95) μg/L] (both P<0.05); there were no statistically significant differences in serum P, T, LH, CORT, and ACTH levels between the males and the females (all P>0.05). Conclusion　The levels of serum P, LH, CORT, and ACTH in children with ASD increase, without significant gender difference, suggesting that their changes are closely related with ASD.

Key words: Autism spectrum disorder, Hormone, Progesterone, Testosterone, Follicle stimulating hormone, Luteinizing hormone, Growth hormone, Cortisol hormone, Adrenocorticotropic hormone

摘要： 目的　探讨孤独症谱系障碍（autism spectrum disorder，ASD）儿童与正常儿童血清激素水平的差异。方法　采用病例对照的研究方法，按照美国《精神障碍诊断和统计手册》第五版（DSM-Ⅴ）诊断标准收集2018年6月至2020年12月湖南省妇幼保健院120例ASD儿童（男68例/女52例，月龄24～108个月）和120例正常对照儿童（男68例/女52例，月龄24～109个月）。采用电化学发光法测定血清孕酮（P）、睾酮（T）、卵泡刺激素（FSH）、促黄体生成素（LH）、生长激素（GH）、皮质醇激素（CORT）、促肾上腺皮质激素（ACTH）水平。计量资料采用Wilcoxon秩和检验，计数资料采用χ²检验。结果　ASD儿童血清P、LH、CORT、ACTH水平分别为0.61（0.36，0.95）nmol/L、0.38（0.26，0.45）IU/L、345.28（223.98，465.50）nmol/L、10.41（6.43，16.65）pg/ml，高于对照组的0.16（0.16，0.16）nmol/L、0.25（0.21，0.32）IU/L、167.80（125.15，203.45）nmol/L、8.49（5.50，14.74）pg/ml（均P<0.05）；两组血清T、FSH、GH水平比较差异均无统计学意义（均P>0.05）。ASD儿童中，女性血清FSH、GH水平分别为2.66（1.32，3.80）IU/L、3.68（0.90，6.37）μg/L，高于男性0.93（0.65，1.31）IU/L、1.56（0.53，3.95）μg/L（均P<0.05）；血清P、T、LH、CORT、ACTH水平男女比较差异均无统计学意义（均P>0.05）。结论　ASD儿童血清P、LH、CORT、ACTH水平升高，无明显性别差异，提示其水平变化与ASD的发生密切相关。

关键词: 孤独症谱系障碍, 激素, 孕酮, 睾酮, 卵泡刺激素, 促黄体生成素, 生长激素, 皮质醇激素, 促肾上腺皮质激素

He Weijun, Xiong Xiyue, Lou Mingxing, Peng Ying, Wang Yichao. A control study of serum hormone levels in children with autism spectrum disorder[J]. International Medicine and Health Guidance News, 2022, 28(12): 1699-1703.

何伟军, 熊喜悦, 娄明星, 彭颖, 王益超. 孤独症谱系障碍儿童血清激素水平对照研究[J]. 国际医药卫生导报, 2022, 28(12): 1699-1703.

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A control study of serum hormone levels in children with autism spectrum disorder

孤独症谱系障碍儿童血清激素水平对照研究

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