Correlation between PTH and hs-cTnI levels in patients undergoing
single-center maintenance hemodialysis

doi:10.3760/cma.j.issn.1007-1245.2022.12.010

International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (12): 1670-1673.DOI: 10.3760/cma.j.issn.1007-1245.2022.12.010

• Scientific Research • Previous Articles Next Articles

Correlation between PTH and hs-cTnI levels in patients undergoing single-center maintenance hemodialysis

Lei Zihan, Wang Yuquan, Su Yanyan, Chen Siqi, Wang Qi, Yang Shen

Department of Nephrology, Huadu District People's Hospital of Guangzhou, Huadu Hospital of Southern Medical University, Guangzhou 510800, China

Received:2022-02-15 Online:2022-06-15 Published:2022-06-27
Contact: Yang Shen, Email: yangs1158@163.com
Supported by:
Science and Technology Plan Project of Huadu District, Guangzhou (20-HDWS-025, 20-HDWS-006);

Guangzhou Medical Key Discipline Construction Project (2021-2023);

Scientific Research Fund Project of Huadu District People's Hospital of Guangzhou (2021C06)

单中心维持性血液透析患者PTH与hs-cTnI水平的相关性研究

雷子涵汪玉泉苏妍妍陈思奇王琦杨椹

南方医科大学附属花都医院广州市花都区人民医院肾病学科，广州　510800

通讯作者: 杨椹，Email：yangs1158@163.com
基金资助:
广州市花都区科技计划项目（20-HDWS-025、20-HDWS-006）；

广州市医学重点学科建设项目（2021-2023）；

广州市花都区人民医院院内科研基金项目（2021C06）

Abstract

Abstract: Objective　To investigate the correlation between parathyroid hormone (PTH) and high-sensitivity troponin I (hs-cTnI) in patients undergoing maintenance hemodialysis. Methods　A retrospective study was conducted on 290 patients with chronic kidney disease (CKD) at stage 5 undergoing maintenance hemodialysis in Huadu Hospital of Southern Medical University from January to June 2020. The patients were divided into 3 groups according to the PTH level, and the correlation between PTH level and hs-cTnI positive rate was analyzed. The data were statistically analyzed by independent sample t test, univariate analysis of variance, rank-sum test, χ² test, and logistic regression equation. Results　A total of 290 eligible maintenance hemodialysis patients were included, aged (58.94±14.16) years, with male patients of 57.59% (167/290), a median dialysis age of 31 months, PTH of (52.23±46.97) pmol/L, and a positive rate of hs-cTnI of 5.86% (17/290). Univariate analysis showed that the proportion of males and the levels of B-type natriuretic peptide, urea nitrogen, myoglobin, serum calcium, and PTH before dialysis in the hs-cTnI positive (>0.1 μg/L) patients were significantly higher than those in the hs-cTnI negative patients, with statistically significant differences (all P<0.05). Multivariate logistic regression analysis showed that every 10.00 pmol/L increase of PTH increased the hs-cTnI positive effect value in hemodialysis patients by 14% (OR=1.14, 95%CI: 1.01-1.27, P=0.029). Conclusion　The PTH level is associated with myocardial injury in maintenance hemodialysis patients.

Key words: Hemodialysis, High-sensitivity troponin I, Parathyroid hormone

摘要： 目的　探讨维持性血液透析患者甲状旁腺素（PTH）与超敏肌钙蛋白I（hs-cTnI）水平的相关性。方法　回顾性分析2020年1月至6月在南方医科大学附属花都医院维持性血液透析的慢性肾脏病（CKD）5期患者290例为研究对象。按照PTH水平分为3组，分析PTH水平与hs-cTnI阳性的相关关系。数据采用独立样本t检验、单变量方差分析、秩和检验、χ²检验及logistic回归方程等进行统计分析。结果　纳入290例符合入选条件的维持性血液透析患者，年龄（58.94±14.16）岁，其中男性占比57.59%（167/290），透析龄中位数为31个月，PTH（52.23±46.97）pmol/L，hs-cTnI阳性率为5.86%（17/290）。单因素分析结果显示，hs-cTnI阳性（>0.1 μg/L）的维持性血液透析患者男性占比、透析前B型钠尿肽、尿素氮、肌红蛋白、血钙、PTH水平均显著高于hs-cTnI阴性的患者，差异均有统计学意义（均P<0.05）。多元logistic回归分析显示，PTH每增加10.00 pmol/L，血液透析患者hs-cTnI阳性的效应值增加14%（OR=1.14，95%CI：1.01～1.27，P=0.029）。结论　维持性血液透析患者PTH水平与心肌损伤存在一定关联。

关键词: 血液透析, 超敏肌钙蛋白I, 甲状旁腺素

Lei Zihan, Wang Yuquan, Su Yanyan, Chen Siqi, Wang Qi, Yang Shen. Correlation between PTH and hs-cTnI levels in patients undergoing single-center maintenance hemodialysis[J]. International Medicine and Health Guidance News, 2022, 28(12): 1670-1673.

雷子涵, 汪玉泉, 苏妍妍, 陈思奇, 王琦, 杨椹. 单中心维持性血液透析患者PTH与hs-cTnI水平的相关性研究[J]. 国际医药卫生导报, 2022, 28(12): 1670-1673.

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Correlation between PTH and hs-cTnI levels in patients undergoing single-center maintenance hemodialysis

单中心维持性血液透析患者PTH与hs-cTnI水平的相关性研究

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