Abstract: Objective　To study the effect of transcervical resection of polyps (TCRP) combined with leuprorelin on the levels of sex hormones and postoperative recurrence in patients with endometrial polyps. Methods　The clinical data of 280 patients with endometrial polyps who were treated at Mengyin County People' s Hospital between January 2015 and August 2020 were collected. The patients were divided into a control group (120 cases) and an observation group (160 cases) according to the treatment methods. The control group were 26-55 (40.12±4.18) years old, with a disease course of 4-11 (6.02±1.17) months. The observation group were 28-55 (39.63±4.21) years old, with a disease course of 3-10 (5.76±1.20) months. The control group were treated by TCRP, and the observation group by TCRP and leuprorelin. The levels of sex hormones and postoperative recurrence were compared between the two groups. The enumeration data were compared between these two groups by χ² test, and the measurement data by independent-sample t test. Results　The total clinical effective rate was 95.00% (152/160) in the observation group, and was 88.33% (106/120) in the control group, with a statistical difference (χ²=4.210, P=0.040). Before the treatment, there was no statistical difference in the endometrial thickness between the two groups (P>0.05). One, three, and six months after the treatment, the endometrial thicknesses of the two groups declined, and those in the observation group were lower than those in the control group (all P<0.001). There were no statistical differences in the levels of estradiol (E2), progesterone (P), and follicle-stimulating hormone (FSH) between the two groups before the treatment (all P>0.05); after treatment, the levels of the above indicators of the two groups declined, and those in the observation group were significantly lower than those in the control group (all P<0.001). After the treatment, the recurrence rate and the incidences of complications were significantly lower and more patients had normal menstruation in the observation group than in the control group (all P<0.05). Conclusion　TCRP combined with leuprorelin for patients with endometrial polyps has a significant efficacy and good recovery of postoperative hormones, and can effectively reduce the recurrence rate and complications and maintain the patients' menstruation normal after surgery.

Key words:

"> Transcervical resection of polyps, Leuprorelin, Endometrial polyps, Sex hormones, Recurrence

摘要： 目的　研究宫腔镜子宫内膜息肉电切术（TCRP）联合亮丙瑞林治疗子宫内膜息肉对患者性激素水平及术后复发的影响。方法　收集2015年1月至2020年8月在蒙阴县人民医院治疗的280例子宫内膜息肉患者的临床资料，按治疗方式分为对照组（120例）和观察组（160例）。对照组患者年龄26～55（40.12±4.18）岁，病程4～11（6.02±1.17）个月；观察组患者年龄28～55（39.63±4.21）岁，病程3～10（5.76±1.20）个月。对照组采用TCRP术治疗，观察组采用TCRP联合亮丙瑞林治疗。比较两组患者的性激素水平和术后复发情况。计数资料组间比较采用χ²检验，计量资料组间比较采用独立样本t检验。结果　观察组和对照组患者临床总有效率分别为95.00%（152/160）和88.33%（106/120），差异有统计学意义（χ²=4.210，P=0.040）。治疗前，两组患者的子宫内膜厚度比较差异无统计学意义（P>0.05）；治疗后1、3、6个月，两组患者的子宫内膜厚度均有减小，且观察组患者厚度均明显小于对照组（均P<0.001）。治疗前，两组患者的雌二醇（E2）、孕酮（P）、卵泡刺激素（FSH）水平比较差异均无统计学意义（均P>0.05）；治疗后，两组患者上述指标水平均有下降，且观察组患者下降幅度均明显大于对照组（均P<0.001）。治疗后，观察组患者复发率和并发症发生率均显著低于对照组，月经保持正常的人数显著高于对照组，两组比较差异均有统计学意义（均P<0.05）。结论　采用TCRP联合亮丙瑞林治疗子宫内膜息肉疗效显著，术后患者激素水平有较好的恢复，可有效降低复发率及并发症，使患者术后能够保持月经正常。

关键词: 宫腔镜子宫内膜息肉电切术, 亮丙瑞林, 子宫内膜息肉, 性激素, 复发