Abstract:

Objective　To study the effects of Jianpi Chushi Jiangzhuo Zhongyao Daichayin combined with needle-sleeve pot in treatment of simple obesity patients on their insulin resistance and body composition. Methods　In this prospective study, 103 patients with simple obesity treated in Korla Hospital, Second Division, Xinjiang Production and Construction Corps and 30th Regiment Hospital, Second Division, Xinjiang Production and Construction Corps from January 2022 to July 2022 were randomly divided into a control group (51 cases) and an observation group (52 cases). There were 30 females and 21 males in the control group; they were 20-56 (38.46±5.69) years old. There were 30 females and 22 males in the observation group; they were 21-56 (39.16±5.93) years old. The control group were treated with orlistat, and the observation group with Jianpi Chushi Jiangzhuo Zhongyao Daichayin combined with needle-sleeve pot. The clinical efficacies, obesity indicators, insulin resistance, body composition, and adverse reactions were compared between the two groups. χ² and t tests were applied. Results　After the treatment, the body weight, body mass index (BMI), and waist circumference (WC) of the observation group were lower than those of the control group [(70.24±4.16) kg vs. (75.32±4.21) kg, (26.39±2.15) kg/m² vs. (28.45±2.33) kg/m², and (93.42±2.53) cm vs. (96.02±2.75) cm], with statistical differences (t=6.16, 4.67, and 5.00; all P<0.05). After the treatment, the percentage of body fat and area of visceral fat in the observation group were lower than those in the control group [(34.11±1.87)% vs. (36.13±2.12)% and (122.64±3.24) cm² vs. (126.54±3.22) cm²], with statistical differences (t=5.13 and 6.13; both P<0.05). After the treatment, the basal metabolic rate of the observation group was higher than that of the control group [(1 523.43±121.35) kcal vs. (1 461.32±132.43) kcal], with a statistical difference (t=2.48, P<0.05). After the treatment, the fasting insulin (FINS) level and insulin resistance index (Homa-IR) in the observation group were lower than those in the control group [(20.21±2.54) mU/L vs. (27.32±2.21) mU/L and (2.28±0.41) vs. (3.41±0.43)], with statistical differences (t=15.14 and 13.65; both P<0.05). The effective rate of the observation group was higher than that of the control group [92.31% (48/52) vs. 74.51% (38/51)], with a statistical difference (χ²=4.70, P<0.05). Conclusion　Jianpi Chushi Jiangzhuo Zhongyao Daichayin combined with needle sleeve pot in the treatment of simple obesity patients is effective, can reduce their obesity and improve insulin resistance, and has high safety.

Key words:

Insulin resistance, Traditional Chinese medicine, Needle-sleeve pot, Obesity

摘要：

目的　研究健脾除湿降浊中药代茶饮联合针套罐对治疗单纯性肥胖患者胰岛素抵抗及人体成分的影响。方法　本研究为前瞻性研究，选取新疆生产建设兵团第二师库尔勒医院及新疆生产建设兵团第二师三十团医院2022年1月至7月期间103例单纯性肥胖患者随机分组，对照组51例，女30例，男21例，年龄20～56（38.46±5.69）岁，给予奥利司他治疗。观察组52例，女30例，男22例，年龄21～56（39.16±5.93）岁，给予健脾除湿降浊中药代茶饮联合针套罐治疗。对比两组患者临床疗效、肥胖指标、胰岛素抵抗、人体成分和不良反应。统计学方法采用χ²检验、t检验。结果　观察组治疗后，体质量、体质量指数（BMI）、腰围（WC）均低于对照组［（70.24±4.16）kg比（75.32±4.21）kg、（26.39±2.15）kg/m²比（28.45±2.33）kg/m²、（93.42±2.53）cm比（96.02±2.75）cm］，差异均有统计学意义（t=6.16、4.67、5.00，均P<0.05）；观察组治疗后，体脂百分比、内脏脂肪面积均低于对照组［（34.11±1.87）％比（36.13±2.12）％、（122.64±3.24）cm²比（126.54±3.22）cm²］，基础代谢率高于对照组［（1 523.43±121.35）kcal比（1 461.32±132.43）kcal］，差异均有统计学意义（t=5.13、6.13、2.48，均P<0.05）；观察组治疗后，空腹胰岛素（FINS）和胰岛素抵抗指数（Homa-IR）均低于对照组［（20.21±2.54）mU/L比（27.32±2.21）mU/L、（2.28±0.41）比（3.41±0.43）］，差异均有统计学意义（t=15.14、13.65，均P<0.05）；观察组治疗有效率为92.31％（48/52），高于对照组［74.51％（38/51）］，差异有统计学意义（χ²=4.70，P<0.05）。结论　健脾除湿降浊中药代茶饮联合针套罐治疗单纯性肥胖患者效果确切，能够减轻患者肥胖程度，改善胰岛素抵抗，安全性高。

关键词:

胰岛素抵抗, 中药, 针套罐, 肥胖