Research progress of Actinidia chinensis root against malignant tumors

doi:10.3760/cma.j.issn.1007-1245.2022.08.034

Abstract

Abstract: Actinidia chinensis root is a common traditional Chinese medicine with multiple functions. It has been proved that Actinidia chinensis root has anti-tumor effect and is now widely used in the treatment of various tumors. This paper reviewed the researches on the mechanism of Actinidia chinensis root against various malignant tumors to provide a new research basis for clinical use of Actinidia chinensis root to prevent and treat tumors.

Key words: Actinidia chinensis root, Traditional Chinese medicine, Anti-tumor, Review

摘要： 藤梨根是一味常见的且具有多种功效的中药。据研究证明藤梨根具有抗肿瘤功效，现被广泛应用于各种肿瘤的治疗中。本文结合藤梨根提取物及成分对抗各种恶性肿瘤研究及机制探讨方面展开综述，为临床利用藤梨根防治肿瘤提供新的研究基础。

关键词: 藤梨根, 中药, 抗肿瘤, 综述

Zhou Mingxuan, Li Jianchang. Research progress of Actinidia chinensis root against malignant tumors[J]. International Medicine and Health Guidance News, 2022, 28(8): 1176-1179.

周明轩, 李建厂. 藤梨根在恶性肿瘤中的研究进展[J]. 国际医药卫生导报, 2022, 28(8): 1176-1179.

References

[1] Fang T, Fang Y, Xu X, et al. Actinidia chinensis planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial- mesenchymal transition[J]. J Ethnopharmacol, 2019, 231: 474-485. DOI: 10.1016/j.jep.2018.11.014.

[2] He X, Fang J, Chen X, et al. Actinidia chinensis planch.: a review of chemistry and pharmacology[J]. Front Pharmacol, 2019, 10: 1236. DOI: 10.3389/fphar. 2019. 01236.

[3] Wei LB, Ma SY, Liu HX, et al. Cytotoxic triterpenoids from roots of actinidia chinensis[J]. Chem Biodivers, 2018, 15(2):e1700454-1-e1700454-6. DOI: 10.1002/cbdv. 201700454.

[4] Zhu WJ, Yu DH, Zhao M, et al. Antiangiogenic triterpenes isolated from Chinese herbal medicine actinidia chinensis planch[J]. Anticancer Agents Med Chem, 2013, 13(2): 195-198. DOI: 10.2174/1871520611313020002.

[5] 黄初升,马思远,刘红星,等. 山梨猕猴桃根化学成分及细胞毒活性研究[J]. 中国中药杂志,2017, 42(14):2714-2718. DOI: 10.19540/j.cnki.cjcmm.20170419.006.

[6] Pistritto G, Trisciuoglio D, Ceci C, et al. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies[J]. Aging (Albany NY), 2016, 8(4): 603-619. DOI: 10.18632/aging.100934.

[7] Lv J, Wang L, Shen H, et al. Regulatory roles of OASL in lung cancer cell sensitivity to actinidia chinensis planch root extract (acRoots) [J]. Cell Biol Toxicol, 2018, 34(3): 207-218. DOI: 10.1007/s10565-018-9422-4.

[8] Naderali E, Valipour B, Khaki AA, et al. Positive effects of PI3K/Akt signaling inhibition on PTEN and P53 in prevention of acute lymphoblastic leukemia tumor cells[J]. Adv Pharm Bull, 2019, 9(3): 470-480. DOI: 10.15171/apb.2019.056.

[9] Cheng QL, Li HL, Huang ZQ, et al. 2β, 3β, 23-trihydroxy-urs-12-ene-28-olic acid (TUA) isolated from actinidia chinensis radix inhibits NCI-H460 cell proliferation by decreasing NF-κB expression[J]. Chem Biol Interact, 2015, 240: 1-11. DOI: 10.1016/j.cbi.2015. 06.038.

[10] Sokolova O, Naumann M. NF-κB signaling in gastric cancer[J]. Toxins (Basel), 2017, 9(4): 119. DOI: 10.3390/toxins9040119.

[11] Grazioli P, Orlando A, Giordano N, et al. NF-κB1 regulates immune environment and outcome of notch-dependent t-cell acute lymphoblastic leukemia[J]. Front Immunol, 2020, 11: 541. DOI: 10.3389/fimmu.2020.00541.

[12] Fang T, Hou J, He M, et al. Actinidia chinensis planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression[J]. Cell Biol Toxicol, 2016, 32(6): 499-511. DOI: 10.1007/s10565-016-9351-z.

[13] Hester A, Salzmann B, Rahmeh M, et al. EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells[J]. Onco Targets Ther, 2019, 12:6053-6068. DOI: 10.2147/OTT.S204919.

[14] Fang T, Zhao Z, Yuan F, et al. Actinidia chinensis planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting the DLX2/TARBP2/JNK/AKT pathway[J]. J Ethnopharmacol, 2020, 251: 112529. DOI: 10.1016/j.jep.2019.112529.

[15] Hou J, Wang L, Wu D. The root of Actinidia chinensis inhibits hepatocellular carcinomas cells through LAMB3[J]. Cell Biol Toxicol, 2018, 34(4): 321-332. DOI: 10.1007/s10565-017-9416-7.

[16] Zhang H, Pan YZ, Cheung M, et al. LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway[J]. Cell Death Dis, 2019, 10(3): 230. DOI: 10.1038/s41419-019-1320-z.

[17] Zhu Z, Song J, Guo Y, et al. LAMB3 promotes tumour progression through the AKT-FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer[J]. Oncogene, 2020, 39(24): 4666-4680. DOI: 10.1038/s41388-020-1321-5.

[18] Hu W, Wu C, Yuan C, et al. Ethanol extracted from radix of actinidia chinensis inhibits human colon tumor through inhibiting notch-signaling pathway[J]. J Cancer, 2021, 12(3): 622-629. DOI: 10.7150/jca.51275.

[19] Zhang D, Gao C, Li R, et al. TEOA, a triterpenoid from Actinidia eriantha, induces autophagy in SW620 cells via endoplasmic reticulum stress and ROS-dependent mitophagy[J]. Arch Pharm Res, 2017, 40(5): 579-591. DOI: 10.1007/s12272-017-0899-9.

[20] Gao Z, Deng G, Li Y, et al. Actinidia chinensis planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression[J]. Biomed Pharmacother, 2020, 126: 110092. DOI: 10.1016/j.biopha.2020.110092.

[21] Cheng QL, Li HL, Li YC, et al. CRA(Crosolic Acid) isolated from actinidia valvata dunn.radix induces apoptosis of human gastric cancer cell line BGC823 in vitro via down-regulation of the NF-κB pathway[J]. Food Chem Toxicol, 2017, 105: 475-485. DOI: 10.1016/j.fct.2017.05.021.

[22] Zhao X, Wen F, Wang W, et al. Actinidia arguta (Hardy Kiwi) root extract exerts anti-cancer effects via mcl-1-mediated apoptosis in cholangiocarcinoma[J]. Nutr Cancer, 2019, 71(2): 246-256. DOI: 10.1080/01635581. 2018.1557218.

[23] Niu H, Song D, Sun Y, et al. Preparation and sulfation of an α-glucan from actinidia chinensis roots and their potential activities[J]. Int J Biol Macromol, 2016, 92: 981-987. DOI: 10.1016/j.ijbiomac.2016.07.091.

[24] He M, Hou J, Wang L, et al. Actinidia chinensis planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9[J]. Oncotarget, 2017, 8(26):42136-42148. DOI: 10.18632/oncotarget. 15010.