Molecular imaging mechanisms and precise diagnosis and treatment of HRMR-VWI in BA-PACI

doi:10.3760/cma.j.cn441417-20250402-20001

Abstract

Abstract:

Basilar artery plaque-related acute cerebral infarction (BA-PACI) is a prevalent ischemic cerebrovascular disease, with high mortality and disability rates. Its diagnosis and treatment endure clinical challenges. High-resolution magnetic resonance vessel wall imaging (HRMR-VWI), leveraging its superior spatial resolution and multi-sequence imaging capabilities, not only delineates fine arterial and branch structures with exceptional clarity, but also precisely characterizes plaque composition, morphological features, and spatial distribution. This technology enables the visualization of the plaque compositions, inflammatory reaction, etc., improves the diagnostic efficacy, and is helpful for individualized diagnosis in early stage, precise treatment, and prognosis evaluation. This review systematically summarize the progress of the molecular imaging mechanisms and precise diagnosis and treatment of HRMR-VWI in BA-PACI, and explores the three-dimension relation of plaque composition-morphology-localization, its value for the evaluation of prognosis and recurrence, and its potentials and challenges in clinical diagnosis and treatment.

Key words:

Magnetic resonance, Basilar artery plaque-related acute cerebral infarction, High-resolution magnetic resonance vessel wall imaging, , Plaque, Progress

摘要：

基底动脉斑块性急性脑梗死（basilar artery plaque-related acute cerebral infarction，BA-PACI）是一种常见的缺血性脑血管疾病，具有高致死率和致残率，其诊断和治疗一直是临床上的难点。高分辨磁共振血管壁成像（high-resolution magnetic resonance vessel wall imaging，HRMR-VWI）凭借其优越的空间分辨率与多序列成像优势，不仅可以清晰显示动脉及分支细微结构，还可以精准表征血管壁斑块的成分构成、形态学特征及空间分布，有助于BA-PACI斑块成分/炎症反应等具体机制过程的可视化，显著提升疾病诊断效能，并有助于个体化早期诊断、精准治疗及预后评估。本文系统综述HRMR-VWI在BA-PACI中的分子影像机制及精准诊疗的应用进展，重点探讨斑块成分-形态-位置的三维关联性及其对预后和复发的评估价值，以及该技术在临床诊疗转化中的潜力与挑战。

关键词:

磁共振, 基底动脉斑块性急性脑梗死, 高分辨磁共振血管壁成像, 斑块, 进展

Li Shuxia, Wang Aijie, Huang Ranran, Qin Jing, Zhang Shouqiang, Zhang Yafei, Zhang Guowei.

Molecular imaging mechanisms and precise diagnosis and treatment of HRMR-VWI in BA-PACI [J]. International Medicine and Health Guidance News, 2025, 31(20): 3345-3349.

李淑霞王爱杰黄冉冉秦静张首强张亚飞张国伟.

HRMR-VWI在BA-PACI中的分子影像机制与精准诊疗进展 [J]. 国际医药卫生导报, 2025, 31(20): 3345-3349.

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