Abstract:

Objective　To analyze the accuracy of multi-slice spiral computed tomography (MSCT) combined with serum carbohydrate antigen 125 (CA125), squamous cell carcinoma antigen (SCC), gastrin-releasing peptide precursor (ProGRP), and neuron-specific enolase (NSE) in the diagnosis of lung cancer. Methods　A total of 92 patients with lung cancer admitted to Longxian Hospital of Traditional Chinese Medicine from December 2018 to September 2023 were selected as a malignant group, and 110 patients with benign lung lesions were selected as a benign group. All patients were confirmed by surgical pathological examination. MSCT and serum CA125, SCC, ProGRP, and NSE levels were detected on the next day after admission. The MSCT signs and serum levels of CA125, SCC, ProGRP, and NSE were compared between the two groups. The results of MSCT examination were counted. The diagnostic value of MSCT combined with serum tumor markers in lung cancer was analyzed by the receiver operating characteristic curve (ROC). χ² test and independent sample t test were used for statistical analysis. Results　In the benign group, there were 78 males and 32 females, aged (67.37±6.71) years, with a body mass index of (22.36±2.16) kg/m²; in the malignant group, there were 73 males and 19 females, aged (67.78±6.49) years, with a body mass index of (22.49±2.51) kg/m²; there were no statistically significant differences (all P>0.05). The proportions of malignant component lobe sign, bronchial inflation sign, burr sign, pleural indentation sign, vacuole sign, and ground glass nodule in the malignant group were higher than those in the benign group (all P<0.05). Seventy-five of 92 patients with lung cancer were detected by MSCT, with a detection rate of 81.52%; 69 of 110 patients with benign lung lesions were detected by MSCT, with a detection rate of 62.73%. Serum levels of CA125, SCC, ProGRP, and NSE in the malignant group were higher than those in the benign group (all P<0.05). The area under the curve (AUC) of MSCT combined with serum CA125, SCC, ProGRP, and NSE in the diagnosis of lung cancer was 0.873, higher than that of the five alone (all P<0.05). Conclusions　There are obvious differences in MSCT signs and serum levels of CA125, SCC, ProGRP, and NSE between patients with lung cancer and patients with benign lung lesions. MSCT combined with serum CA125, SCC, ProGRP, and NSE can effectively improve the diagnostic efficiency for lung cancer.

Key words:

Lung cancer, Multi-slice spiral computed tomography, Carbohydrate antigen 125, Squamous cell carcinoma antigen, Gastrin releasing peptide precursor, Neuron specific enolase, Accuracy

摘要：

目的　分析多层螺旋计算机断层扫描（MSCT）检查联合血清糖类抗原125（CA125）、鳞状细胞癌抗原（SCC）、胃泌素释放肽前体（ProGRP）、神经元特异性烯醇化酶（NSE）诊断肺癌的准确性。方法　以2018年12月至2023年9月陇县中医医院收治的92例肺癌患者作为恶性组，110例肺部良性病变患者作为良性组，所有患者均经手术病理检查确诊，并在入院后次日行MSCT检查及血清CA125、SCC、ProGRP、NSE水平检测，比较两组MSCT征象及血清CA125、SCC、ProGRP、NSE水平，统计两组MSCT检查结果，采用受试者操作特征曲线（ROC）分析MSCT联合血清肿瘤标志物对肺癌的诊断价值。采用χ²检验、独立样本t检验进行统计学分析。结果　良性组男78例，女32例，年龄（67.37±6.71）岁，体重指数（22.36±2.16）kg/m²；恶性组男73例，女19例，年龄（67.78±6.49）岁，体重指数（22.49±2.51）kg/m²；差异均无统计学意义（均P>0.05）。恶性组分叶征、支气管充气征、毛刺征、胸膜凹陷征、空泡征、磨玻璃结节比例均高于良性组（均P<0.05）。92例肺癌患者MSCT检出75例，检出率为81.52%；110例肺部良性病变患者MSCT检出69例，检出率为62.73%。恶性组血清CA125、SCC、ProGRP、NSE水平均高于良性组（均P<0.05）。MSCT联合血清CA125、SCC、ProGRP、NSE诊断肺癌的曲线下面积（AUC）为0.873，大于五者单独诊断（均P<0.05）。结论　肺癌患者与肺部良性病变患者MSCT征象及血清CA125、SCC、ProGRP、NSE水平存在明显差异，MSCT联合血清CA125、SCC、ProGRP、NSE可有效提高对肺癌的诊断效能。

关键词:

肺癌, 多层螺旋计算机断层扫描, 糖类抗原125, 鳞状细胞癌抗原, 胃泌素释放肽前体, 神经元特异烯醇化酶, 准确性