关键词:

变应性鼻炎, 丙酸氟替卡松鼻喷雾剂, 温针灸, 免疫功能, 睡眠质量

Abstract:

Objective　To investigate the impact of integrating warm needle acupuncture with fluticasone propionate nasal spray on the immune function and sleep quality in individuals experiencing allergic rhinitis. Methods　A total of 462 patients with allergic rhinitis who received treatment in the outpatient department of acupuncture and moxibustion and the outpatient department of otolaryngology in Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine from May 2021 to October 2023 were selected as the study objects, and were divided into 3 groups with 154 cases in each group by the random number table method. There were 85 males and 69 females in the heated needle group, the age was (33.56±4.15) years old, and the course of disease was (2.35±0.73) years. There were 87 males and 67 females in the medication group, the age was (34.02±4.34) years old, and the course of disease was (2.37±0.54) years. There were 80 males and 74 females in the combined therapy group, the age was (33.89±4.26) years old, and the course of disease was (2.41±0.76) years. The heated needle group received warm needle acupuncture treatment, the medication group was given fluticasone propionate nasal spray, and the combined therapy group received both warm needle acupuncture and fluticasone propionate nasal spray treatment for one month. The clinical efficacies of the three groups were compared, along with inflammation markers and immune function before and after treatment. The nasal resistance, nasal ventilation area, and ciliary movement rate were measured before and after treatment. The sleep status and quality of life were assessed by the Pittsburgh Sleep Quality Index (PSQI) and Rhinitis Quality of Life Questionnaire (RQLQ). The occurrence of adverse reactions in patients was recorded. Analysis of variance, paired t test, and χ² test were used. Results　After treatment, the total effective rate of the combined therapy group [96.10% (148/154)] was higher than those of the heated needle group [83.77% (129/154)] and the medication group [81.82% (126/154)] (all P<0.05). The inflammatory indexes and nasal resistance of the combined therapy group were lower than those of the heated needle group and the medication group, but the immune function indexes, nasal ventilation area, and ciliary movement rate were better than those of the heated needle group and the medication group (all P<0.05). The PSQI score [(6.42±1.02) points] and RQLQ score [(39.52±5.03) points] of the combined therapy group were lower than those of the heated needle group [(9.30±1.52) points and (53.48±6.35) points] and the medication group [(9.35±1.48) points and (54.36±6.42) points] (all P<0.05). The total incidence of adverse reactions in the medication group [14.29% (22/154)] was higher than those in the heated needle group [2.60% (4/154)] and the combined therapy group [4.55% (7/154)] (all P<0.05). Conclusion　The combination of warm needle acupuncture and fluticasone propionate nasal spray has been shown to improve the clinical outcomes of allergic rhinitis patients, along with boosting their immune system performance and sleep quality.

Key words:

Allergic rhinitis, Fluticasone propionate nasal spray, Warm needle acupuncture, Immune function, Sleep quality